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1. 发明公开

EP0240243A2 Tube sheet welding 失效
标题翻译： Schweissen einerRöhre在einer魔杖。
公开(公告)号：EP0240243A2
公开(公告)日：1987-10-07
申请号：EP87302619.9
申请日：1987-03-26
申请人： Noe, Renato R. , Fox, Edward A.
发明人： Noe, Renato R. , Fox, Edward A.
IPC分类号： B21D39/04
CPC分类号： B21D39/066 , Y10T29/49375 , Y10T29/49806
摘要： An improved method for the explosive expansion and welding of tubes (14) to tube sheet (10) includes trepanning (at 22) the rear face (20) of the tube sheet to form integral collars (28) around each tube-receiving bore in the tube sheet.
The collars prevent accumulation of corrosive material in a gap between the tube and tube sheet bore, and provide support to the tube wall when the tube is explosively expanded beyond the region of the tube surrounded by the collar.
摘要翻译：用于管（14）到管板（10）的爆炸膨胀和焊接的改进方法包括在管板的后表面（22）处切割（22），以在每个管接收孔周围形成一体的环（28）管板。套环防止腐蚀性材料在管和管板孔之间的间隙中积聚，并且当管爆炸性地膨胀超过由套环包围的管的区域时，向管壁提供支撑。

2. 发明公开

EP0240243A3 Tube sheet welding 失效
标题翻译：管板焊接
公开(公告)号：EP0240243A3
公开(公告)日：1989-11-08
申请号：EP87302619.9
申请日：1987-03-26
申请人： Noe, Renato R. , Fox, Edward A.
发明人： Noe, Renato R. , Fox, Edward A.
IPC分类号： B21D39/04
CPC分类号： B21D39/066 , Y10T29/49375 , Y10T29/49806
摘要： An improved method for the explosive expansion and welding of tubes (14) to tube sheet (10) includes trepanning (at 22) the rear face (20) of the tube sheet to form integral collars (28) around each tube-receiving bore in the tube sheet. The collars prevent accumulation of corrosive material in a gap between the tube and tube sheet bore, and provide support to the tube wall when the tube is explosively expanded beyond the region of the tube surrounded by the collar.
摘要翻译：用于管（14）到管板（10）的爆炸膨胀和焊接的改进方法包括在管板的后表面（22）处切割（22），以在每个管接收孔周围形成一体的环（28）管板。套环防止腐蚀性材料在管和管板孔之间的间隙中积聚，并且当管爆炸性地膨胀超过由套环包围的管的区域时，向管壁提供支撑。

3. 发明申请

WO2010144494A3 SYSTEM FOR AUTOMATING ANIMAL TESTING PROTOCOLS 审中-公开
标题翻译：自动化动物试验方案系统
公开(公告)号：WO2010144494A3
公开(公告)日：2011-12-01
申请号：PCT/US2010037834
申请日：2010-06-08
申请人： PURDUE RESEARCH FOUNDATION , GARNER JOSEPH P , MURPHY MICHELLE CHING , FOX EDWARD A
发明人： GARNER JOSEPH P , MURPHY MICHELLE CHING , FOX EDWARD A
IPC分类号： A01K1/03 , A01K29/00
CPC分类号： A01K1/031 , A01K29/005
摘要： In one aspect, the present invention provides a housing system for conducting high throughput animal experiments. The housing system includes a home cage, at least one rotatable turnstile enclosed by housing to form two or more isolation chambers, a means for animal identification, and one or more action stations functionally coupled to one or more isolation chambers. The turnstile includes a plurality of one or more separation members rotatable about a vertical axis, each isolation chamber bounded by one or more separation members. The action stations contain one or more devices facilitating completion of at least one animal-directed or experimentor-initiated action. In a preferred embodiment, the home cage is sufficiently sized to house a plurality of small animals, such as mice. Tunnel passageways may be connected to the home cage, including one or more tunnel passageways containing a rotatable turnstile. Additional embodiments include rotatable turnstiles, rotatable turnstile assemblies, and methods of conducting high throughput animal experiments using the devices and systems described herein.
摘要翻译：一方面，本发明提供一种用于进行高通量动物实验的壳体系统。壳体系统包括家庭笼，至少一个由壳体封闭以形成两个或多个隔离室的旋转十字门，用于动物识别的装置以及功能上耦合到一个或多个隔离室的一个或多个动作站。十字转门包括可绕垂直轴线旋转的多个一个或多个分离构件，每个隔离室由一个或多个分离构件限定。动作站包含一个或多个装置，促进完成至少一个动物导向或实验者启动的动作。在优选实施例中，家庭笼具有足够的尺寸以容纳多个小动物，例如小鼠。隧道通道可以连接到家庭笼，包括一个或多个包含可旋转十字门的隧道通道。另外的实施例包括可旋转的旋转门，可旋转的旋转门组件，以及使用本文所述的装置和系统进行高通量动物实验的方法。

4. 发明申请

WO2010144494A2 SYSTEM FOR AUTOMATING ANIMAL TESTING PROTOCOLS 审中-公开
标题翻译：自动化动物试验方案系统
公开(公告)号：WO2010144494A2
公开(公告)日：2010-12-16
申请号：PCT/US2010/037834
申请日：2010-06-08
申请人： PURDUE RESEARCH FOUNDATION , GARNER, Joseph, P. , MURPHY, Michelle, Ching , FOX, Edward, A.
发明人： GARNER, Joseph, P. , MURPHY, Michelle, Ching , FOX, Edward, A.
IPC分类号： A01K1/03
CPC分类号： A01K1/031 , A01K29/005
摘要： In one aspect, the present invention provides a housing system for conducting high throughput animal experiments. The housing system includes a home cage, at least one rotatable turnstile enclosed by housing to form two or more isolation chambers, a means for animal identification, and one or more action stations functionally coupled to one or more isolation chambers. The turnstile includes a plurality of one or more separation members rotatable about a vertical axis, each isolation chamber bounded by one or more separation members. The action stations contain one or more devices facilitating completion of at least one animal-directed or experimentor-initiated action. In a preferred embodiment, the home cage is sufficiently sized to house a plurality of small animals, such as mice. Tunnel passageways may be connected to the home cage, including one or more tunnel passageways containing a rotatable turnstile. Additional embodiments include rotatable turnstiles, rotatable turnstile assemblies, and methods of conducting high throughput animal experiments using the devices and systems described herein.
摘要翻译：一方面，本发明提供一种用于进行高通量动物实验的壳体系统。壳体系统包括家庭笼，至少一个由壳体封闭以形成两个或多个隔离室的旋转十字门，用于动物识别的装置以及功能上耦合到一个或多个隔离室的一个或多个动作站。十字转门包括可绕垂直轴线旋转的多个一个或多个分离构件，每个隔离室由一个或多个分离构件限定。动作站包含一个或多个装置，促进完成至少一个动物导向或实验者启动的动作。在优选实施例中，家庭笼具有足够的尺寸以容纳多个小动物，例如小鼠。隧道通道可以连接到家庭笼，包括一个或多个包含可旋转十字门的隧道通道。另外的实施例包括可旋转的旋转门，可旋转的旋转门组件，以及使用本文所述的装置和系统进行高通量动物实验的方法。

5. 发明申请

WO03039327A3 METHODS AND COMPOSITIONS FOR THE DIAGNOSIS OF CANCER SUSCEPTIBILITIES AND DEFECTIVE DNA REPAIR MECHANISMS AND TREATMENT THEREOF 审中-公开
标题翻译：用于诊断癌症可疑性和缺陷性DNA修复机制的方法和组合物及其治疗
公开(公告)号：WO03039327A3
公开(公告)日：2003-08-14
申请号：PCT/US0218153
申请日：2002-06-06
申请人： DANA FARBER CANCER INST INC , UNIV OREGON HEALTH & SCIENCE , D ANDREA ALAN D , TANIGUCHI TOSHIYASU , TIMMERS CYNTHIA , GROMPE MARKUS , FOX EDWARD A
发明人： D ANDREA ALAN D , TANIGUCHI TOSHIYASU , TIMMERS CYNTHIA , GROMPE MARKUS , FOX EDWARD A
IPC分类号： C07K14/47 , C07K16/18 , C12Q1/68 , G01N33/50 , G01N33/53 , G01N33/574 , C07H21/04 , C12P19/34
CPC分类号： G01N33/57484 , C12Q1/6886 , C12Q2600/156 , C12Q2600/158 , G01N2500/00 , G01N2800/52
摘要： Methods and compositions for the diagnosis of cancer susceptibilities, defective DNA repair mechanisms and treatments thereof are provided. Among sequences provided here, the FANCD2 gene has been identified, and probes and primers are provided for screening patients in genetic-based tests and for diagnosing fanconi Anemia and cancer. The FANCD2 gene can be targeted in vivo for preparing experimental mouse models for use in screening new therapeutic agents for treating conditions involving defective DNA repair. The FANCD2 polypeptide has been sequenced and has been shown to exist in two isoforms identified as FANCD2-S and the monubiiquinated FANCD-L form. Antibodies including polyclonal and monoclonal antibodies have been prepared that distinguish the two isoforms and have been used in diagnostic tests to determine whether a subject has an intact Fanconi Anemia/BRCA pathway.
摘要翻译：提供了用于诊断癌症易感性，缺陷DNA修复机制及其治疗的方法和组合物。在这里提供的序列中，已经鉴定了FANCD2基因，并提供了探针和引物，用于筛选基因型测试中的患者，并用于诊断fanconi贫血和癌症。可以在体内靶向FANCD2基因，以制备用于筛选用于治疗涉及有缺陷的DNA修复的病症的新治疗剂的实验小鼠模型。 FANCD2多肽已被测序，并已显示存在于被鉴定为FANCD2-S的两种同种型和独立的FANCD-L形式中。已经制备了包括多克隆和单克隆抗体的抗体，其区分两种同种型并且已经用于诊断测试以确定受试者是否具有完整的范可尼贫血/ BRCA途径。

6. 发明申请

WO2003039327A2 METHODS AND COMPOSITIONS FOR THE DIAGNOSIS OF CANCER SUSCEPTIBILITIES AND DEFECTIVE DNA REPAIR MECHANISMS AND TREATMENT THEREOF 审中-公开
标题翻译：用于诊断癌症易感性和缺陷性DNA修复机制的方法和组合物及其治疗
公开(公告)号：WO2003039327A2
公开(公告)日：2003-05-15
申请号：PCT/US2002/018153
申请日：2002-06-06
申请人： DANA-FARBER CANCER INSTITUTE , OREGON HEALTH AND SCIENCE UNIVERSITY , D'ANDREA, Alan, D. , TANIGUCHI, Toshiyasu , TIMMERS, Cynthia , GROMPE, Markus , FOX, Edward, A.
发明人： D'ANDREA, Alan, D. , TANIGUCHI, Toshiyasu , TIMMERS, Cynthia , GROMPE, Markus , FOX, Edward, A.
IPC分类号： A61B
CPC分类号： G01N33/57484 , C12Q1/6886 , C12Q2600/156 , C12Q2600/158 , G01N2500/00 , G01N2800/52
摘要： Methods and compositions for the diagnosis of cancer susceptibilities, defective DNA repair mechanisms and treatments thereof are provided. Among sequences provided here, the FANCD2 gene has been identified, and probes and primers are provided for screening patients in genetic-based tests and for diagnosing fanconi Anemia and cancer. The FANCD2 gene can be targeted in vivo for preparing experimental mouse models for use in screening new therapeutic agents for treating conditions involving defective DNA repair. The FANCD2 polypeptide has been sequenced and has been shown to exist in two isoforms identified as FANCD2-S and the monubiiquinated FANCD-L form. Antibodies including polyclonal and monoclonal antibodies have been prepared that distinguish the two isoforms and have been used in diagnostic tests to determine whether a subject has an intact Fanconi Anemia/BRCA pathway.
摘要翻译：提供了用于诊断癌症易感性，缺陷DNA修复机制及其治疗的方法和组合物。在此处提供的序列中，FANCD2基因已被鉴定，并且提供探针和引物用于在基于遗传的测试中筛查患者并用于诊断fanconi贫血症和癌症。 FANCD2基因可以在体内靶向用于制备用于筛选用于治疗涉及缺陷性DNA修复的病症的新治疗剂的实验性小鼠模型。 FANCD2多肽已经测序，并且已经显示存在两种同种型，被鉴定为FANCD2-S和单倍频FANCD-L形式。已经制备了包括多克隆和单克隆抗体的抗体，其区别两种同种型并且已经用于诊断测试以确定受试者是否具有完整的范可尼贫血/ BRCA途径。

7. 发明专利

CA1272892A TUBE SHEET WELDING 未知
公开(公告)号：CA1272892A
公开(公告)日：1990-08-21
申请号：CA532562
申请日：1987-03-20
申请人： NOE RENATO R , FOX EDWARD A
发明人： NOE RENATO R , FOX EDWARD A
IPC分类号： B21D39/06 , B21D39/04
摘要： An improved method for the explosive expansion and welding of tubes to tube sheet includes trepanning the rear face of the tube sheet to form integral collars around each tube-receiving bore in the tube sheet. The collars prevent accumulation of corrosive material in a gap between the tube and tube sheet bore, and provide support to the tube wall when the tube is explosively expanded beyond the region of the tube surrounded by the collar.

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