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1. 发明申请

WO2010144494A3 SYSTEM FOR AUTOMATING ANIMAL TESTING PROTOCOLS 审中-公开
标题翻译：自动化动物试验方案系统
公开(公告)号：WO2010144494A3
公开(公告)日：2011-12-01
申请号：PCT/US2010037834
申请日：2010-06-08
申请人： PURDUE RESEARCH FOUNDATION , GARNER JOSEPH P , MURPHY MICHELLE CHING , FOX EDWARD A
发明人： GARNER JOSEPH P , MURPHY MICHELLE CHING , FOX EDWARD A
IPC分类号： A01K1/03 , A01K29/00
CPC分类号： A01K1/031 , A01K29/005
摘要： In one aspect, the present invention provides a housing system for conducting high throughput animal experiments. The housing system includes a home cage, at least one rotatable turnstile enclosed by housing to form two or more isolation chambers, a means for animal identification, and one or more action stations functionally coupled to one or more isolation chambers. The turnstile includes a plurality of one or more separation members rotatable about a vertical axis, each isolation chamber bounded by one or more separation members. The action stations contain one or more devices facilitating completion of at least one animal-directed or experimentor-initiated action. In a preferred embodiment, the home cage is sufficiently sized to house a plurality of small animals, such as mice. Tunnel passageways may be connected to the home cage, including one or more tunnel passageways containing a rotatable turnstile. Additional embodiments include rotatable turnstiles, rotatable turnstile assemblies, and methods of conducting high throughput animal experiments using the devices and systems described herein.
摘要翻译：一方面，本发明提供一种用于进行高通量动物实验的壳体系统。壳体系统包括家庭笼，至少一个由壳体封闭以形成两个或多个隔离室的旋转十字门，用于动物识别的装置以及功能上耦合到一个或多个隔离室的一个或多个动作站。十字转门包括可绕垂直轴线旋转的多个一个或多个分离构件，每个隔离室由一个或多个分离构件限定。动作站包含一个或多个装置，促进完成至少一个动物导向或实验者启动的动作。在优选实施例中，家庭笼具有足够的尺寸以容纳多个小动物，例如小鼠。隧道通道可以连接到家庭笼，包括一个或多个包含可旋转十字门的隧道通道。另外的实施例包括可旋转的旋转门，可旋转的旋转门组件，以及使用本文所述的装置和系统进行高通量动物实验的方法。

2. 发明申请

WO2010144494A2 SYSTEM FOR AUTOMATING ANIMAL TESTING PROTOCOLS 审中-公开
标题翻译：自动化动物试验方案系统
公开(公告)号：WO2010144494A2
公开(公告)日：2010-12-16
申请号：PCT/US2010/037834
申请日：2010-06-08
申请人： PURDUE RESEARCH FOUNDATION , GARNER, Joseph, P. , MURPHY, Michelle, Ching , FOX, Edward, A.
发明人： GARNER, Joseph, P. , MURPHY, Michelle, Ching , FOX, Edward, A.
IPC分类号： A01K1/03
CPC分类号： A01K1/031 , A01K29/005
摘要： In one aspect, the present invention provides a housing system for conducting high throughput animal experiments. The housing system includes a home cage, at least one rotatable turnstile enclosed by housing to form two or more isolation chambers, a means for animal identification, and one or more action stations functionally coupled to one or more isolation chambers. The turnstile includes a plurality of one or more separation members rotatable about a vertical axis, each isolation chamber bounded by one or more separation members. The action stations contain one or more devices facilitating completion of at least one animal-directed or experimentor-initiated action. In a preferred embodiment, the home cage is sufficiently sized to house a plurality of small animals, such as mice. Tunnel passageways may be connected to the home cage, including one or more tunnel passageways containing a rotatable turnstile. Additional embodiments include rotatable turnstiles, rotatable turnstile assemblies, and methods of conducting high throughput animal experiments using the devices and systems described herein.
摘要翻译：一方面，本发明提供一种用于进行高通量动物实验的壳体系统。壳体系统包括家庭笼，至少一个由壳体封闭以形成两个或多个隔离室的旋转十字门，用于动物识别的装置以及功能上耦合到一个或多个隔离室的一个或多个动作站。十字转门包括可绕垂直轴线旋转的多个一个或多个分离构件，每个隔离室由一个或多个分离构件限定。动作站包含一个或多个装置，促进完成至少一个动物导向或实验者启动的动作。在优选实施例中，家庭笼具有足够的尺寸以容纳多个小动物，例如小鼠。隧道通道可以连接到家庭笼，包括一个或多个包含可旋转十字门的隧道通道。另外的实施例包括可旋转的旋转门，可旋转的旋转门组件，以及使用本文所述的装置和系统进行高通量动物实验的方法。

3. 发明申请

WO2010085645A2 COMPOUND TACTILE STIMULUS DEVICE SYSTEM 审中-公开
标题翻译：复合手机刺激装置系统
公开(公告)号：WO2010085645A2
公开(公告)日：2010-07-29
申请号：PCT/US2010/021805
申请日：2010-01-22
申请人： PURDUE RESEARCH FOUNDATION , GARNER, Joseph, P.
发明人： GARNER, Joseph, P.
IPC分类号： A01K67/00 , A01K29/00 , A01K15/00 , A61D99/00
CPC分类号： A01K15/02 , A01K1/031 , A61B5/16
摘要： A system for presenting compound tactile stimuli to a test subject includes a compound tactile stimulus device comprised of a plurality of overlapping stimulus presentation members, each stimulus presentation member including one or more stimulus exemplars related by a specified dimensional property. The device includes manual or automated means for moving and aligning the stimulus presentation members relative to one another to form a predetermined compound tactile stimulus comprised of at least two tactile stimulus exemplars, including at least one exemplar having one or more open spaces allowing the test subject to discriminate between the stimulus exemplars underlying the compound tactile stimulus by extending one or sensory members through the one or more open spaces. The system may include the compound tactile stimulus device integrated into an automated living environment providing automated compound tactile stimulus presentation, including automatic generation of behavioral data under conditions that are less susceptible to experimental bias by minimizing artificial or unnatural testing conditions that may otherwise confound the results.
摘要翻译：用于向受检对象呈现复合触觉刺激的系统包括由多个重叠的刺激呈现构件组成的复合触觉刺激装置，每个刺激呈现构件包括一个或多个由特定尺寸特性相关的刺激样本。该装置包括用于相对于彼此移动和对准刺激呈现构件的手动或自动装置，以形成由至少两个触觉刺激样本组成的预定的复合触觉刺激，包括至少一个具有一个或多个允许测试对象的开放空间的样本通过将一个或感觉成员延伸通过一个或多个开放空间来区分复合触觉刺激之下的刺激样本。该系统可以包括集成到自动化生活环境中的复合触觉刺激装置，其提供自动复合触觉刺激呈现，包括在不太容易受到实验偏倚的条件下自动产生行为数据，通过最小化可能混淆结果的人为或非自然测试条件。

4. 发明申请

WO2013019916A3 NESTING MATERIAL BALING AND DISPENSING SYSTEM FOR MOUSE ENVIRONMENTAL ENRICHMENT 审中-公开
标题翻译：小鼠环境富集的试验材料分配和分配系统
公开(公告)号：WO2013019916A3
公开(公告)日：2013-04-18
申请号：PCT/US2012049254
申请日：2012-08-02
申请人： PURDUE RESEARCH FOUNDATION , GARNER JOSEPH P , LOSSIE AMY C
发明人： GARNER JOSEPH P , LOSSIE AMY C
IPC分类号： A01K1/03 , A01K67/00
CPC分类号： A01K1/0155 , A01K1/0152 , B65B27/12 , B65B55/12
摘要： A standardized nesting material for use in laboratory environments for rodents includes a latrining substrate, and at least one bale unit formed to include a fibrous scaffolding material, and an insulating material. The bale units are of standardized size and can be packaged and sterilized to provide improved wellbeing of the animals; reduced feed and labor costs; and improved scientific quality of the studies conducted on the animals.
摘要翻译：用于啮齿动物的实验室环境中的标准化嵌套材料包括拉紧基底，以及至少一个形成为包括纤维脚手架材料的包单元和绝缘材料。包单位是标准化的大小，可以包装和消毒，以改善动物的福祉; 减少饲料和人工成本; 并提高了对动物研究的科学质量。

5. 发明申请

WO2013019916A2 NESTING MATERIAL BALING AND DISPENSING SYSTEM FOR MOUSE ENVIRONMENTAL ENRICHMENT 审中-公开
标题翻译：用于小鼠环境培育的材料平衡和分配系统
公开(公告)号：WO2013019916A2
公开(公告)日：2013-02-07
申请号：PCT/US2012/049254
申请日：2012-08-02
申请人： PURDUE RESEARCH FOUNDATION , GARNER, Joseph, P. , LOSSIE, Amy, C.
发明人： GARNER, Joseph, P. , LOSSIE, Amy, C.
IPC分类号： A01K1/03 , A01K67/00
CPC分类号： A01K1/0155 , A01K1/0152 , B65B27/12 , B65B55/12
摘要： A standardized nesting material for use in laboratory environments for rodents includes a latrining substrate, and at least one bale unit formed to include a fibrous scaffolding material, and an insulating material. The bale units are of standardized size and can be packaged and sterilized to provide improved wellbeing of the animals; reduced feed and labor costs; and improved scientific quality of the studies conducted on the animals.
摘要翻译：用于啮齿动物的实验室环境中的标准化嵌套材料包括一个厕所衬底，以及形成为包括纤维脚手架材料和绝缘材料的至少一个捆包单元。捆包单位具有标准尺寸，可以包装和消毒，以改善动物的健康; 减少饲料和劳动力成本; 提高对动物进行研究的科学素质。

6. 发明申请

WO2010085645A3 COMPOUND TACTILE STIMULUS DEVICE SYSTEM 审中-公开
标题翻译：复合触觉刺激装置系统
公开(公告)号：WO2010085645A3
公开(公告)日：2010-11-11
申请号：PCT/US2010021805
申请日：2010-01-22
申请人： PURDUE RESEARCH FOUNDATION , GARNER JOSEPH P
发明人： GARNER JOSEPH P
IPC分类号： A01K67/00 , A01K15/00 , A01K29/00 , A61D99/00
CPC分类号： A01K15/02 , A01K1/031 , A61B5/16
摘要： A system for presenting compound tactile stimuli to a test subject includes a compound tactile stimulus device comprised of a plurality of overlapping stimulus presentation members, each stimulus presentation member including one or more stimulus exemplars related by a specified dimensional property. The device includes manual or automated means for moving and aligning the stimulus presentation members relative to one another to form a predetermined compound tactile stimulus comprised of at least two tactile stimulus exemplars, including at least one exemplar having one or more open spaces allowing the test subject to discriminate between the stimulus exemplars underlying the compound tactile stimulus by extending one or sensory members through the one or more open spaces. The system may include the compound tactile stimulus device integrated into an automated living environment providing automated compound tactile stimulus presentation, including automatic generation of behavioral data under conditions that are less susceptible to experimental bias by minimizing artificial or unnatural testing conditions that may otherwise confound the results.
摘要翻译：用于向测试对象呈现复合触觉刺激的系统包括由多个重叠刺激呈现构件组成的复合触觉刺激装置，每个刺激呈现构件包括由指定的尺寸特性相关的一个或多个刺激样本。该装置包括用于使刺激呈现构件相对于彼此移动和对准以形成预定的复合触觉刺激的手动或自动装置，所述预定复合触觉刺激包括至少两个触觉刺激示例，包括具有一个或多个开放空间的至少一个示例，通过使一个或多个感觉构件穿过一个或多个开放空间来区分复合触觉刺激下的刺激示例。该系统可以包括集成到自动化生活环境中的复合触觉刺激设备，其提供自动复合触觉刺激呈现，包括通过最小化可能会混淆结果的人造或非自然测试条件，在对实验偏差较不敏感的条件下自动生成行为数据。

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