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1. 发明申请

US20140047585A1 SCANNING PROBE MICROSCOPY CANTILEVER COMPRISING AN ELECTROMAGNETIC SENSOR 有权
标题翻译：扫描探头包含电磁传感器的显微镜
公开(公告)号：US20140047585A1
公开(公告)日：2014-02-13
申请号：US13570666
申请日：2012-08-09
申请人： Jens Hofrichter , Felix Holzner , folkert Horst , Philip Paul
发明人： Jens Hofrichter , Felix Holzner , folkert Horst , Philip Paul
IPC分类号： G01Q70/08
CPC分类号： G01Q20/02 , G01Q20/00 , G01Q20/04 , G01Q60/24 , G01Q60/38 , G01Q70/02
摘要： An apparatus and method directed to a scanning probe microscopy cantilever. The apparatus includes body and an electromagnetic sensor having a detectable electromagnetic property varying upon deformation of the body. The method includes scanning the surface of a material with the cantilever, such that the body of the cantilever undergoes deformations and detecting the electromagnetic property varying upon deformation of the body of the cantilever.
摘要翻译：一种针对扫描探针显微镜悬臂的装置和方法。该装置包括主体和电磁传感器，该电磁传感器具有在身体变形时变化的可检测的电磁特性。该方法包括用悬臂扫描材料的表面，使得悬臂的主体经历变形并检测在悬臂体的变形时变化的电磁特性。

2. 发明申请

US20120199487A1 MICROFLUIDIC SYSTEM AND METHOD FOR ASSEMBLING AND FOR SUBSEQUENTLY CULTIVATING, AND SUBSEQUENT ANALYSIS OF COMPLEX CELL ARRANGEMENTS 有权
标题翻译：用于组装和后续培养的微流体系统和方法以及复合细胞安排的后续分析
公开(公告)号：US20120199487A1
公开(公告)日：2012-08-09
申请号：US13427733
申请日：2012-03-22
申请人： Martin STELZLE , Brigitte Angres , Massimo Kubon , Julia Schuette , Britta Hagmeyer , Felix Holzner
发明人： Martin STELZLE , Brigitte Angres , Massimo Kubon , Julia Schuette , Britta Hagmeyer , Felix Holzner
IPC分类号： G01N27/447
CPC分类号： C12M23/16 , B01L3/5027 , C12M21/08 , C12M33/00 , C12M35/02
摘要： The present invention provides an apparatus and a method to assemble organotypical tissues which can then be perfused and investigated under preferably physiological conditions. This is achieved by a microfluidic system for assembling and subsequently cultivating complex cell arrangements, comprising: a three-dimensional microstructure in which the cell arrangement is assembled and cultivated, at least two microchannel segments running in the microstructure and defining a flow direction, through which microchannel segments the microstructure can be perfused from outside with a medium, whereby the microchannel segments run approximately parallel or equidistant to one another at least in sections, a wall structure which separates the at least two microchannel segments and in which at least one aperture connecting the at least two microchannel segments is provided, and an electrode arrangement provided in or on the microstructure in order to generate an inhomogeneous electric field in the region of the at least one aperture.
摘要翻译：本发明提供了一种组装器官组织的装置和方法，其可以在优选的生理条件下进行灌注和研究。这通过用于组装和随后培养复杂细胞结构的微流体系统实现，其包括：其中组装和培养细胞排列的三维微结构，在微结构中运行并限定流动方向的至少两个微通道区段，微通道段可以从外部用介质灌注微结构，由此微通道段至少在部分上相互平行或等距离地延伸，壁结构分隔至少两个微通道段，其中至少一个孔连接提供至少两个微通道段，以及设置在微结构中或其上的电极布置，以便在至少一个孔的区域中产生不均匀的电场。

3. 发明授权

US08875311B2 Scanning probe microscopy cantilever comprising an electromagnetic sensor 有权
标题翻译：扫描探针显微镜悬臂包括电磁传感器
公开(公告)号：US08875311B2
公开(公告)日：2014-10-28
申请号：US13570666
申请日：2012-08-09
申请人： Jens Hofrichter , Felix Holzner , Folkert Horst , Philip Paul
发明人： Jens Hofrichter , Felix Holzner , Folkert Horst , Philip Paul
IPC分类号： G01Q20/02 , G01Q20/00 , G01Q60/38 , G01Q70/02 , G01Q60/24 , G01Q20/04
CPC分类号： G01Q20/02 , G01Q20/00 , G01Q20/04 , G01Q60/24 , G01Q60/38 , G01Q70/02
摘要： An apparatus and method directed to a scanning probe microscopy cantilever. The apparatus includes body and an electromagnetic sensor having a detectable electromagnetic property varying upon deformation of the body. The method includes scanning the surface of a material with the cantilever, such that the body of the cantilever undergoes deformations and detecting the electromagnetic property varying upon deformation of the body of the cantilever.
摘要翻译：一种针对扫描探针显微镜悬臂的装置和方法。该装置包括主体和电磁传感器，该电磁传感器具有在身体变形时变化的可检测的电磁特性。该方法包括用悬臂扫描材料的表面，使得悬臂的主体经历变形并检测在悬臂体的变形时变化的电磁特性。

4. 发明申请

US20120328773A1 ACCURATE DEPOSITION OF NANO-OBJECTS ON A SURFACE 有权
标题翻译：精确沉积在表面上的纳米对象
公开(公告)号：US20120328773A1
公开(公告)日：2012-12-27
申请号：US13456596
申请日：2012-04-26
申请人： Urs T. Duerig , Felix Holzner , Cyrill Kuemin , Armin W. Knoll , Philip Paul , Heiko Wolf
发明人： Urs T. Duerig , Felix Holzner , Cyrill Kuemin , Armin W. Knoll , Philip Paul , Heiko Wolf
IPC分类号： B05D5/12 , B82Y30/00
CPC分类号： B82B3/0076 , B05D5/12 , B82B3/0014 , B82Y30/00 , B82Y40/00 , C23C14/04 , C23C18/04 , C23C18/06 , C23C18/08
摘要： The invention notably concerns a method for depositing nano-objects on a surface. The method includes: providing a substrate with surface patterns on one face thereof; providing a transfer layer on said face of the substrate; functionalizing areas on a surface of the transfer layer parallel to said face of the substrate, at locations defined with respect to said surface patterns, such as to exhibit enhanced binding interactions with nano-objects; depositing nano-objects and letting them get captured at the functionalized areas; and thinning down the transfer layer by energetic stimulation to decompose the polymer into evaporating units, until the nano-objects reach the surface of the substrate. The invention also provides a semiconductor device which includes a substrate and nano-objects accurately disposed on the substrate
摘要翻译：本发明特别涉及用于在表面上沉积纳米物体的方法。该方法包括：在其一个表面上提供具有表面图案的基底; 在所述基板的所述表面上提供转印层; 在与所述表面图案限定的位置处平行于所述基板的所述表面平行于所述转印层的表面上的功能化区域，例如与纳米物体呈现增强的结合相互作用; 沉积纳米物体并使其在功能化区域被捕获; 并通过能量刺激来减少转移层，以将聚合物分解成蒸发单元，直到纳米物体到达基底表面。本发明还提供一种半导体器件，其包括衬底和准确地设置在衬底上的纳米物体

5. 发明授权

US08268152B2 Microfluidic system and method for assembling and for subsequently cultivating, and subsequent analysis of complex cell arrangements 有权
标题翻译：微流体系统以及用于组装和随后培养以及随后分析复杂细胞装置的方法
公开(公告)号：US08268152B2
公开(公告)日：2012-09-18
申请号：US12896714
申请日：2010-10-01
申请人： Martin Stelzle , Brigitte Angres , Massimo Kubon , Julia Schuette , Britta Hagmeyer , Felix Holzner
发明人： Martin Stelzle , Brigitte Angres , Massimo Kubon , Julia Schuette , Britta Hagmeyer , Felix Holzner
IPC分类号： B01D57/02
CPC分类号： C12M23/16 , B01L3/5027 , C12M21/08 , C12M33/00 , C12M35/02
摘要： A microfluidic system (12) for assembling and subsequently investigating complex cell arrangements has a three-dimensional microstructure (11) in which the cell culture is assembled, cultivated and investigated. At least two microchannel segments (16, 17) through which the microstructure (11) can be perfused from outside with a medium (21, 22) run in the microstructure (11), whereby the microchannel segments (16, 17) run at least in sections approximately parallel or equidistant to one another. The two microchannel segments (16, 17) are separated from one another by a wall structure (25) in which at least one aperture (26) connecting the two microchannel segments (16, 17) is provided. An electrode arrangement (27) is provided in or on the microstructure (11) in order to generate an inhomogeneous electric field (28) in the region of the at least one aperture (26). A cell arrangement is assembled in this microstructure (11) by supplying medium (21, 22) with cells (23, 24) for assembling the cell culture in the microstructure (11), with the inhomogeneous electric field (28) determined by the microstructure (11) bringing about the assembling of the cell arrangement from the supplied cells (23, 24).
摘要翻译：用于组装和随后调查复合细胞装置的微流体系统（12）具有其中组装，培养和研究细胞培养物的三维微结构（11）。至少两个微通道段（16,17），微结构（11）可以通过该微通道段（16,17）从外部用介质（21,22）灌注到微结构（11）中，由此微通道段（16,17）至少运行在大致彼此平行或等距的部分。两个微通道段（16,17）通过壁结构（25）彼此分开，其中提供连接两个微通道段（16,17）的至少一个孔（26）。在微结构（11）中或其上设置电极装置（27），以在所述至少一个孔（26）的区域中产生不均匀的电场（28）。通过向培养基（21,22）提供用于将细胞培养物组装在微结构（11）中的细胞（23,24），通过由微结构（11,22）确定的不均匀电场（28），在该微结构（11）（11）使得从所提供的电池（23,24）组装电池装置。

6. 发明申请

US20110079513A1 MICROFLUIDIC SYSTEM AND METHOD FOR ASSEMBLING AND FOR SUBSEQUENTLY CULTIVATING, AND SUBSEQUENT ANALYSIS OF COMPLEX CELL ARRANGEMENTS 有权
标题翻译：用于组装和后续培养的微流体系统和方法以及复合细胞安排的后续分析
公开(公告)号：US20110079513A1
公开(公告)日：2011-04-07
申请号：US12896714
申请日：2010-10-01
申请人： Martin Stelzle , Brigitte Angres , Massimo Kubon , Julia Schuette , Britta Hagmeyer , Felix Holzner
发明人： Martin Stelzle , Brigitte Angres , Massimo Kubon , Julia Schuette , Britta Hagmeyer , Felix Holzner
IPC分类号： G01N27/447
CPC分类号： C12M23/16 , B01L3/5027 , C12M21/08 , C12M33/00 , C12M35/02
摘要： A microfluidic system (12) for assembling and subsequently investigating complex cell arrangements has a three-dimensional microstructure (11) in which the cell culture is assembled, cultivated and investigated. At least two microchannel segments (16, 17) through which the microstructure (11) can be perfused from outside with a medium (21, 22) run in the microstructure (11), whereby the microchannel segments (16, 17) run at least in sections approximately parallel or equidistant to one another. The two microchannel segments (16, 17) are separated from one another by a wall structure (25) in which at least one aperture (26) connecting the two microchannel segments (16, 17) is provided. An electrode arrangement (27) is provided in or on the microstructure (11) in order to generate an inhomogeneous electric field (28) in the region of the at least one aperture (26). A cell arrangement is assembled in this microstructure (11) by supplying medium (21, 22) with cells (23, 24) for assembling the cell culture in the microstructure (11), with the inhomogeneous electric field (28) determined by the microstructure (11) bringing about the assembling of the cell arrangement from the supplied cells (23, 24).
摘要翻译：用于组装和随后调查复合细胞装置的微流体系统（12）具有其中组装，培养和研究细胞培养物的三维微结构（11）。至少两个微通道段（16,17），微结构（11）可以通过该微通道段（16,17）从外部用介质（21,22）灌注到微结构（11）中，由此微通道段（16,17）至少运行在大致彼此平行或等距的部分。两个微通道段（16,17）通过壁结构（25）彼此分开，其中提供连接两个微通道段（16,17）的至少一个孔（26）。在微结构（11）中或其上设置电极装置（27），以在所述至少一个孔（26）的区域中产生不均匀的电场（28）。通过向培养基（21,22）提供用于将细胞培养物组装在微结构（11）中的细胞（23,24），通过由微结构（11,22）确定的不均匀电场（28），在该微结构（11）（11）使得从所提供的电池（23,24）组装电池装置。

7. 发明授权

US08968543B2 Microfluidic system and method for assembling and for subsequently cultivating, and subsequent analysis of complex cell arrangements 有权
标题翻译：微流体系统以及用于组装和随后培养以及随后分析复杂细胞装置的方法
公开(公告)号：US08968543B2
公开(公告)日：2015-03-03
申请号：US13427733
申请日：2012-03-22
申请人： Martin Stelzle , Brigitte Angres , Massimo Kubon , Julia Schuette , Britta Hagmeyer , Felix Holzner
发明人： Martin Stelzle , Brigitte Angres , Massimo Kubon , Julia Schuette , Britta Hagmeyer , Felix Holzner
IPC分类号： B01D57/02 , C12M3/06 , C12M3/00 , C12M1/42 , C12M1/26 , B01L3/00
CPC分类号： C12M23/16 , B01L3/5027 , C12M21/08 , C12M33/00 , C12M35/02
摘要： The present invention provides an apparatus and a method to assemble organotypical tissues which can then be perfused and investigated under preferably physiological conditions. This is achieved by a microfluidic system for assembling and subsequently cultivating complex cell arrangements, comprising: a three-dimensional microstructure in which the cell arrangement is assembled and cultivated, at least two microchannel segments running in the microstructure and defining a flow direction, through which microchannel segments the microstructure can be perfused from outside with a medium, whereby the microchannel segments run approximately parallel or equidistant to one another at least in sections, a wall structure which separates the at least two microchannel segments and in which at least one aperture connecting the at least two microchannel segments is provided, and an electrode arrangement provided in or on the microstructure in order to generate an inhomogeneous electric field in the region of the at least one aperture.
摘要翻译：本发明提供了一种组装器官组织的装置和方法，其可以在优选的生理条件下进行灌注和研究。这通过用于组装和随后培养复杂细胞结构的微流体系统实现，其包括：其中组装和培养细胞排列的三维微结构，在微结构中运行并限定流动方向的至少两个微通道区段，微通道段可以从外部用介质灌注微结构，由此微通道段至少在部分上相互平行或等距离地延伸，壁结构分隔至少两个微通道段，其中至少一个孔连接提供至少两个微通道段，以及设置在微结构中或其上的电极布置，以便在至少一个孔的区域中产生不均匀的电场。

8. 发明授权

US08592955B2 Accurate deposition of nano-objects on a surface 有权
标题翻译：将纳米物体精确沉积在表面上
公开(公告)号：US08592955B2
公开(公告)日：2013-11-26
申请号：US13606326
申请日：2012-09-07
申请人： Urs T Duerig , Felix Holzner , Cyrill Kuemin , Armin W. Knoll , Philip Paul , Heiko Wolf
发明人： Urs T Duerig , Felix Holzner , Cyrill Kuemin , Armin W. Knoll , Philip Paul , Heiko Wolf
IPC分类号： H01L23/58 , H01L29/06 , H01L23/48 , H01L23/52 , H01L29/40 , H01L23/544
CPC分类号： B82B3/0076 , B05D5/12 , B82B3/0014 , B82Y30/00 , B82Y40/00 , C23C14/04 , C23C18/04 , C23C18/06 , C23C18/08
摘要： The invention notably concerns a method for depositing nano-objects on a surface. The method includes: providing a substrate with surface patterns on one face thereof; providing a transfer layer on said face of the substrate; functionalizing areas on a surface of the transfer layer parallel to said face of the substrate, at locations defined with respect to said surface patterns, such as to exhibit enhanced binding interactions with nano-objects; depositing nano-objects and letting them get captured at the functionalized areas; and thinning down the transfer layer by energetic stimulation to decompose the polymer into evaporating units, until the nano-objects reach the surface of the substrate. The invention also provides a semiconductor device which includes a substrate and nano-objects accurately disposed on the substrate.
摘要翻译：本发明特别涉及用于在表面上沉积纳米物体的方法。该方法包括：在其一个表面上提供具有表面图案的基底; 在所述基板的所述表面上提供转印层; 在与所述表面图案限定的位置处平行于所述基板的所述表面平行于所述转印层的表面上的功能化区域，例如与纳米物体呈现增强的结合相互作用; 沉积纳米物体并使其在功能化区域被捕获; 并通过能量刺激来减少转移层，以将聚合物分解成蒸发单元，直到纳米物体到达基底表面。本发明还提供一种半导体器件，其包括衬底和准确地设置在衬底上的纳米物体。

9. 发明授权

US08821965B2 Accurate deposition of nano-objects on a surface 有权
标题翻译：将纳米物体精确沉积在表面上
公开(公告)号：US08821965B2
公开(公告)日：2014-09-02
申请号：US13456596
申请日：2012-04-26
申请人： Urs T. Duerig , Felix Holzner , Cyrill Kuemin , Armin W. Knoll , Philip Paul , Heiko Wolf
发明人： Urs T. Duerig , Felix Holzner , Cyrill Kuemin , Armin W. Knoll , Philip Paul , Heiko Wolf
IPC分类号： B05D5/12 , B82Y30/00 , B82Y40/00 , B82B3/00 , C23C14/04 , C23C18/04 , C23C18/06 , C23C18/08
CPC分类号： B82B3/0076 , B05D5/12 , B82B3/0014 , B82Y30/00 , B82Y40/00 , C23C14/04 , C23C18/04 , C23C18/06 , C23C18/08
摘要： The invention notably concerns a method for depositing nano-objects on a surface. The method includes: providing a substrate with surface patterns on one face thereof; providing a transfer layer on said face of the substrate; functionalizing areas on a surface of the transfer layer parallel to said face of the substrate, at locations defined with respect to said surface patterns, such as to exhibit enhanced binding interactions with nano-objects; depositing nano-objects and letting them get captured at the functionalized areas; and thinning down the transfer layer by energetic stimulation to decompose the polymer into evaporating units, until the nano-objects reach the surface of the substrate. The invention also provides a semiconductor device which includes a substrate and nano-objects accurately disposed on the substrate
摘要翻译：本发明特别涉及用于在表面上沉积纳米物体的方法。该方法包括：在其一个表面上提供具有表面图案的基底; 在所述基板的所述表面上提供转印层; 在与所述表面图案限定的位置处平行于所述基板的所述表面平行于所述转印层的表面上的功能化区域，例如与纳米物体呈现增强的结合相互作用; 沉积纳米物体并使其在功能化区域被捕获; 并通过能量刺激来减少转移层，以将聚合物分解成蒸发单元，直到纳米物体到达基底表面。本发明还提供一种半导体器件，其包括衬底和准确地设置在衬底上的纳米物体

10. 发明申请

US20130009287A1 ACCURATE DEPOSITION OF NANO-OBJECTS ON A SURFACE 有权
标题翻译：精确沉积在表面上的纳米对象
公开(公告)号：US20130009287A1
公开(公告)日：2013-01-10
申请号：US13606326
申请日：2012-09-07
申请人： Urs T. Duerig , Felix Holzner , Cyrill Kuemin , Armin W. Knoll , Philip Paul , Heiko Wolf
发明人： Urs T. Duerig , Felix Holzner , Cyrill Kuemin , Armin W. Knoll , Philip Paul , Heiko Wolf
IPC分类号： H01L29/02
CPC分类号： B82B3/0076 , B05D5/12 , B82B3/0014 , B82Y30/00 , B82Y40/00 , C23C14/04 , C23C18/04 , C23C18/06 , C23C18/08
摘要： The invention notably concerns a method for depositing nano-objects on a surface. The method includes: providing a substrate with surface patterns on one face thereof; providing a transfer layer on said face of the substrate; functionalizing areas on a surface of the transfer layer parallel to said face of the substrate, at locations defined with respect to said surface patterns, such as to exhibit enhanced binding interactions with nano-objects; depositing nano-objects and letting them get captured at the functionalized areas; and thinning down the transfer layer by energetic stimulation to decompose the polymer into evaporating units, until the nano-objects reach the surface of the substrate. The invention also provides a semiconductor device which includes a substrate and nano-objects accurately disposed on the substrate.
摘要翻译：本发明特别涉及用于在表面上沉积纳米物体的方法。该方法包括：在其一个表面上提供具有表面图案的基底; 在所述基板的所述表面上提供转印层; 在与所述表面图案限定的位置处平行于所述基板的所述表面平行于所述转印层的表面上的功能化区域，例如与纳米物体呈现增强的结合相互作用; 沉积纳米物体并使其在功能化区域被捕获; 并通过高能刺激来减薄转移层，以将聚合物分解成蒸发单元，直到纳米物体到达基底表面。本发明还提供一种半导体器件，其包括衬底和准确地设置在衬底上的纳米物体。

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