专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明专利

CA1027589A 2,7,10,15,18,23-HEXAMETHYLTETRACOSANE AND PROCESS FOR PREPARING THE SAME 未知
公开(公告)号：CA1027589A
公开(公告)日：1978-03-07
申请号：CA204074
申请日：1974-07-04
申请人： NISHIDA TAKASHI , NINAGAWA YOICHI , ITOI KAZUO , OMURA YOSHIAKI , TAMAI YOSHIN , HOSAGAI TAKEO , FUJITA YOSHIJI
发明人： NISHIDA TAKASHI , NINAGAWA YOICHI , ITOI KAZUO , OMURA YOSHIAKI , TAMAI YOSHIN , HOSAGAI TAKEO , FUJITA YOSHIJI
IPC分类号： A61K8/31 , A61Q19/00 , C07C1/00 , C07C1/22 , C07C1/24 , C07C9/12 , C07C9/14 , C07C9/22 , C07C11/02 , C07C27/00 , C07C29/17 , C07C29/42 , C07C31/125 , C07C33/048 , C07C67/00 , C10M169/00 , C07C9/16
摘要： 2,7,10,15,18,23-Hexamethyltetracosane is a novel compound. This compound is prepared [1] by hydrogenating 2,7,10,15,18,23-hexamethyltetracosa-1,6,18,23-tetraene-11,13-diyne-10, 15-diol [itself a novel compound] or 2,7,10,15,18,23-hexamethyltetracosa-11,13-diyne-10,15-diol, dehydrating the hydrogenated intermediates, and thence hydrogenating the dehydrated precursors, or [2] by selectively, partially hydrogenating the said 10,15-diol compounds and thence hydrogenolyzing the precursor diols, or [3] by hydrogenolyzing the said 10,15-diol compounds, or [4] by hydrogenolyzing the hydrogenated intermediates of the reaction [1]. The compound, 3,6,11-trimethyl-undeca-6,11-dien-1-yl-3-ol, a starting material intermediate, is also a novel compound.

2. 发明申请

WO1994017069A1 PYRAZOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS THEREOF 审中-公开
标题翻译：吡唑衍生物及其药物组合物
公开(公告)号：WO1994017069A1
公开(公告)日：1994-08-04
申请号：PCT/US1993012447
申请日：1993-12-30
申请人： THE UPJOHN COMPANY , KOH, Keiko , TANIGUCHI, Mikio , KUSHIDA, Hiroshi , MORITA, Osamu , YAMADA, Hiroyoshi , MUNESADA, Kiyotaka , KUNIHARA, Mineo , FUJITA, Yoshiji
发明人： THE UPJOHN COMPANY
IPC分类号： C07D487/18
CPC分类号： C07D487/04
摘要： The present invention provides novel pyrazole derivatives having the chemical formula (I), wherein the moiety (A) is (a), (b) or (c); and R is (B), which are useful for preventing or treating hypertension, congestive heart failure, renal failure, glaucoma and hyperuricemia and have high activity, provide rapid onset of action upon intravenous injection, can be administered orally, have low toxicity, and have a long duration of action.
摘要翻译：本发明提供具有化学式（I）的新型吡唑衍生物，其中（A）部分为（a），（b）或（c）。 R为（B），可用于预防或治疗高血压，充血性心力衰竭，肾功能衰竭，青光眼和高尿酸血症，具有高活性，静脉注射后可迅速起效，口服给药，毒性低，持续时间长。

3. 发明申请

WO1994021641A1 PROCESS FOR PRODUCTION OF AN IMIDAZOLE DERIVATIVE 审中-公开
标题翻译：制备咪唑衍生物的方法
公开(公告)号：WO1994021641A1
公开(公告)日：1994-09-29
申请号：PCT/US1994001949
申请日：1994-03-04
申请人： THE UPJOHN COMPANY , YAMADA, Hiroyoshi , MUNESADA, Kiyotaka , KOH, Keiko , TANIGUCHI, Mikio , FUJITA, Yoshiji
发明人： THE UPJOHN COMPANY
IPC分类号： C07D487/14
CPC分类号： C07D487/14
摘要： The object of the present invention is to improve the selectivity on reduction of the C ring double bond of an imidazole derivative having the hydrazine cross-linking structure represented by formula (I). The imidazole derivative is subjected to the reaction with a diimide (HN=NH).
摘要翻译：本发明的目的是提高具有由式（I）表示的肼交联结构的咪唑衍生物的C环双键还原的选择性。咪唑衍生物与二酰亚胺（HN = NH）反应。

4. 发明申请

WO1993008193A1 IMIDAZOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME 审中-公开
标题翻译：咪唑衍生物和含有其的药物组合物
公开(公告)号：WO1993008193A1
公开(公告)日：1993-04-29
申请号：PCT/US1992008584
申请日：1992-10-14
申请人： THE UPJOHN COMPANY , KOH, Keiko , TANIGUCHI, Mikio , ITOH, Noriie , KUSHIDA, Hiroshi , MORITA, Osamu , YAMADA, Hiroyoshi , MUNESADA, Kiyotaka , TSUZUKI, Kazuo , KUNIHARA, Mineo , FUJITA, Yoshiji
发明人： THE UPJOHN COMPANY
IPC分类号： C07D487/14
CPC分类号： C07D487/14
摘要： The present invention provides a novel imidazole derivative having chemical formula (I). These compounds are useful for preventing or treating hypertension or congestive heart failure and have high activity, rapid action upon intravenous injection, good oral absorbtion, low toxicity, and long-lasting action. Also provided are pharmaceutical compositions which contain these compounds.

5. 发明申请

WO1987005020A1 3,4-DIHYDRO-2H-BENZOPYRAN DERIVATIVES AND THEIR MEDICINAL USE 审中-公开
标题翻译： 3,4-二氢-2H-苯并噻吩衍生物及其药物用途
公开(公告)号：WO1987005020A1
公开(公告)日：1987-08-27
申请号：PCT/JP1987000106
申请日：1987-02-18
申请人： KURARAY CO., LTD. , YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. , EZIRI, Katsushi , KANEHIRA, Koichi , SHIONO, Manzo , FUJITA, Yoshiji , YAMAHARA, Jhoji , MARUYAMA, Yutaka , TERASAWA, Michio , OCHI, Hiroshi , TAHARA, Tetsuya
发明人： KURARAY CO., LTD. , YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD.
IPC分类号： C07D311/72
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D311/58 , C07D405/06 , C07D413/06
摘要： 3,4-Dihydro-2H-benzopyran derivatives represented by general formula (I), (wherein n represents an integer of 0, 2 or 3, R represents a nitrogen-containing heterocyclic group selected from among (II), R and R each represents a hydrogen atom or an optionally substituted alkyl, aralkyl, arylalkenyl, aryl or acyl group, and R represents a hydrogen atom or an alkyl group) and pharmacologically acceptable salts thereof. These compounds have an activity of inhibiting 5-lipoxigenase, anti-allergic effect, anti-histaminic effect, effect of preventing peroxidation of lipid, effect of inhibiting platelet agglutination, ect. and are useful as drugs for treating bronchial asthma, allergic disease, immune disease, inflammatory disease, Psoriasis vulgaris, brain blood trouble, ischemic disease, thrombosis, etc. Use of the compounds as drugs is also disclosed.
摘要翻译：由通式（I）表示的3,4-二氢-2H-苯并吡喃衍生物，其中n表示0或2或3的整数，R表示选自（II），R 1中的含氮杂环基，和R 2各自表示氢原子或任选取代的烷基，芳烷基，芳基烯基，芳基或酰基，R 3表示氢原子或烷基）及其药理学上可接受的盐。这些化合物具有抑制5-脂氧素发生酶，抗过敏作用，抗组胺作用，预防脂质过氧化作用，抑制血小板凝集的作用等作用。并且可用作治疗支气管哮喘，过敏性疾病，免疫疾病，炎性疾病，寻常型银屑病，脑血症，缺血性疾病，血栓形成等的药物。此外，还公开了化合物作为药物的用途。

6. 发明申请

WO2008126002A3 COMPOUND PROFILING METHOD 审中-公开
标题翻译：化合物分析方法
公开(公告)号：WO2008126002A3
公开(公告)日：2009-03-19
申请号：PCT/IB2008051308
申请日：2008-04-07
申请人： CYTOPATHFINDER INC , MIYAKE MASATO , FUJITA YOSHIJI
发明人： MIYAKE MASATO , FUJITA YOSHIJI
IPC分类号： G01N33/50
CPC分类号： G01N33/5026 , C12Q1/6886 , C12Q2600/178 , G01N33/5011 , G06F19/12
摘要： The present invention provides a method for deriving an upstream or downstream component of a component necessary for phenotypic alteration of a living organism, the method comprising the steps of: specifying a pathway of interest related to the phenotypic alteration and a reference pathway different from the pathway of interest, and specifying a stimulant of interest and a reference stimulant which respectively stimulate the pathway of interest and the reference pathway; giving the stimulant of interest to the living organism to identify a collection of components of interest necessary for the phenotypic alteration; giving the reference stimulant to the living organism to identify a collection of reference components necessary for the phenotypic alteration; calculating an intersection between the collections of the components of interest and the reference components; and calculating a differential collection by subtracting the intersection from the collection of components of interest.
摘要翻译：本发明提供了一种用于衍生生物体表型改变所必需的组分的上游或下游组分的方法，所述方法包括以下步骤：指定与所述表型改变相关的感兴趣途径和不同于所述途径的参考途径并且指定分别刺激感兴趣途径和参考途径的兴趣兴奋剂和参考刺激物; 给予活体有兴趣的兴奋剂，以确定表型改变所需的组成部分的集合; 给生物体提供参考刺激物，以鉴定表型改变所必需的参考组分的集合; 计算感兴趣组件的集合和参考组件之间的交集; 以及通过从所述关注部件的收集中减去所述交叉点来计算差分收集。

7. 发明申请

WO2008126002A2 COMPOUND PROFILING METHOD 审中-公开
标题翻译：化合物分析方法
公开(公告)号：WO2008126002A2
公开(公告)日：2008-10-23
申请号：PCT/IB2008/051308
申请日：2008-04-07
申请人： CYTOPATHFINDER, INC. , MIYAKE, Masato , FUJITA, Yoshiji
发明人： MIYAKE, Masato , FUJITA, Yoshiji
IPC分类号： G01N33/50 , A61P35/00 , G06F19/00
CPC分类号： G01N33/5026 , C12Q1/6886 , C12Q2600/178 , G01N33/5011 , G06F19/12
摘要： The present invention provides a method for deriving an upstream or downstream component of a component necessary for phenotypic alteration of a living organism, the method comprising the steps of: specifying a pathway of interest related to the phenotypic alteration and a reference pathway different from the pathway of interest, and specifying a stimulant of interest and a reference stimulant which respectively stimulate the pathway of interest and the reference pathway; giving the stimulant of interest to the living organism to identify a collection of components of interest necessary for the phenotypic alteration; giving the reference stimulant to the living organism to identify a collection of reference components necessary for the phenotypic alteration; calculating an intersection between the collections of the components of interest and the reference components; and calculating a differential collection by subtracting the intersection from the collection of components of interest.
摘要翻译：本发明提供了一种用于衍生生物体表型改变所必需的成分的上游或下游成分的方法，所述方法包括以下步骤：指定与所述表型改变相关的感兴趣途径和不同于所述途径的参考途径并且指定了分别刺激感兴趣途径和参考途径的兴趣兴奋剂和参考刺激物; 给予生物体感兴趣的兴奋剂，以确定表型改变所必需的组成部分的集合; 给生物体提供参考刺激物，以鉴定表型改变所必需的参考组分的集合; 计算感兴趣组件的集合和参考组件之间的交集; 以及通过从所述关注的部件的收集中减去所述交点来计算差分收集。

8. 发明申请

WO1995000517A1 PROCESS FOR PRODUCING IMIDAZOLE DERIVATIVE 审中-公开
标题翻译：制造咪唑衍生物的方法
公开(公告)号：WO1995000517A1
公开(公告)日：1995-01-05
申请号：PCT/US1994006028
申请日：1994-06-02
申请人： THE UPJOHN COMPANY , YAMADA, Hiroyoshi , MUNESADA, Kiyotaka , KOH, Keiko , TSUZUKI, Kazuo , TANIGUCHI, Mikio , FUJITA, Yoshiji
发明人： THE UPJOHN COMPANY
IPC分类号： C07D487/22
CPC分类号： C07D487/22
摘要： New synthesis of compound of formula (I).
摘要翻译：式（I）化合物的新合成。

9. 发明申请

WO1994007492A1 USE OF 4-HYDRAZONO-1,4-DIHYDRO-PYRIDINE AND/OR 4-HYDRAZINO-PYRIDINE DERIVATIVES FOR TREATMENT OF HYPERTENSION AND CONGESTIVE HEART FAILURE 审中-公开
标题翻译：使用4-羟基-1,4-二氢吡啶和/或4-羟基吡啶衍生物治疗高血压和焦虑性心脏衰竭
公开(公告)号：WO1994007492A1
公开(公告)日：1994-04-14
申请号：PCT/US1993008156
申请日：1993-09-03
申请人： THE UPJOHN COMPANY , TOMICH, Paul, Kosta , BOHANON, Michael, John , LAJINESS, Michael, S. , FUJITA, Yoshiji , TSUZUKI, Kazuo
发明人： THE UPJOHN COMPANY
IPC分类号： A61K31/44
CPC分类号： A61K31/44
摘要： The present invention provides the use of certain known 4-hydrazono-1,4-dihydro-pyridine and 4-hydrazino pyridine compounds for the treatment of hypertension and congestive heart failure.
摘要翻译：本发明提供某些已知的4-肼基-1,4-二氢吡啶和4-肼基吡啶化合物用于治疗高血压和充血性心力衰竭的用途。

10. 发明申请

WO1989005803A1 3,4-DIHYDRO-2H-1,3-BENZOXAZINE DERIVATIVES AND THEIR MEDICINAL USE 审中-公开
标题翻译： 3,4-二氢-2H-亚基-1,3-苯并恶唑衍生物及其药物用途
公开(公告)号：WO1989005803A1
公开(公告)日：1989-06-29
申请号：PCT/JP1988001306
申请日：1988-12-23
申请人： KURARAY CO., LTD. , SAKANE, Soichi , EZIRI, Katsushi , SHIONO, Manzo , FUJITA, Yoshiji , YAMAHARA, Johji
发明人： KURARAY CO., LTD.
IPC分类号： C07D265/16
CPC分类号： C07D265/16
摘要： 3,4-Dihydro-2H-1,3-benzoxazine derivatives represented by general formula (I) (wherein R represents a substituted alkyl group, a substituted aryl group or an optionally substituted heterocyclic group, and R , R and R each represents a hydrogen atom or a methyl group) or pharmacologically acceptable salts thereof are disclosed. These compounds have a pharmacological action of curing peptic ulcer or treating dysuria.
摘要翻译：由通式（I）表示的3,4-二氢-2H-1,3-苯并恶嗪衍生物（其中R 1表示取代的烷基，取代的芳基或任选取代的杂环基，R 2， R 3和R 4各自表示氢原子或甲基）或其药理学上可接受的盐。这些化合物具有治疗消化性溃疡或治疗排尿困难的药理作用。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式