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1. 发明申请

WO03036296A9 COMPOSITIONS AND METHODS FOR MODELING SACCHAROMYCES CEREVISIAE METABOLISM 审中-公开
标题翻译：组合物和方法用于建模细胞因子代谢
公开(公告)号：WO03036296A9
公开(公告)日：2004-05-13
申请号：PCT/US0234394
申请日：2002-10-24
申请人： UNIV CALIFORNIA , PALSSON BERNHARD O , FAMILI IMANDOKHT , FU PENGCHENG , NIELSEN JENS B , FORSTER JOCHEN
发明人： PALSSON BERNHARD O , FAMILI IMANDOKHT , FU PENGCHENG , NIELSEN JENS B , FORSTER JOCHEN
IPC分类号： G06F17/30 , G06F19/12 , G06F19/18 , G01N33/48
CPC分类号： G06F19/12 , G06F19/18 , Y02A90/26 , Y02E50/343
摘要： The invention provides an in silica model for determining a S. cerevisiae physiological function. The model includes a data structure relating a plurality of S. cerevisiae reactants to a plurality of S. cerevisiae reactions, a constraint set for the plurality of S. cerevisiae reactions, and commands for determining a distribution of flux through the reactions that is predictive ofa s. cerevisiae physiological function. A model of the invention can further include a gene database containing information characterizing the associated gene or genes. The invention further provides methods for making an in silica S. cerevisiae model and methods for determining a S. cerevisiae physiological function using a model of the invention.
摘要翻译：本发明提供了用于确定酿酒酵母生理功能的二氧化硅模型。该模型包括将多个酿酒酵母反应物与多个酿酒酵母反应相关联的数据结构，针对多个酿酒酵母反应的约束集，以及用于确定通过预测的反应的通量分布的命令秒。酿酒酵母生理功能。本发明的模型还可以包括含有表征相关基因或基因的信息的基因数据库。本发明还提供了使用本发明的模型制备二氧化硅酿酒酵母模型和确定酿酒酵母生理功能的方法的方法。

2. 发明申请

WO2010093365A1 METHODS AND COMPOSITIONS FOR GENETIC ENGINEERING OF CYANOBACTERIA TO PRODUCE ETHANOL 审中-公开
标题翻译：用于生产乙醇的氰尿酸的遗传工程的方法和组合物
公开(公告)号：WO2010093365A1
公开(公告)日：2010-08-19
申请号：PCT/US2009/033959
申请日：2009-02-12
申请人： HELIO BIOTECHNOLOGY CORPORATION , FU, Pengcheng
发明人： FU, Pengcheng
IPC分类号： C12N15/31 , C12N15/52 , C12N15/63 , C12P7/06
CPC分类号： C12N9/88 , C12P7/065 , C12Y401/01001 , Y02E50/17
摘要： Provided herein are compositions and methods for genetic engineering of cyanobacteria to produce ethanol. In one aspect, the present invention provides a polynucleotide construct comprising a copper ion inductive promoter and a sequence encoding a pyruvate decarboxylase (pdc) enzyme. In another aspect, the present invention provides a genetically engineered cyanobacterium comprising the polynucleotide construct of the invention, wherein the cyanobacterium is capable of producing ethanol after a period of fermentation. In yet another aspect, the present invention discloses a method of producing ethanol by genetically modifying cyanobacteria using the polynucleotide construct of the invention.
摘要翻译：本文提供了用于生产乙醇的蓝细菌遗传工程的组合物和方法。一方面，本发明提供了包含铜离子诱导启动子和编码丙酮酸脱羧酶（pdc）酶的序列的多核苷酸构建体。在另一方面，本发明提供了包含本发明的多核苷酸构建体的遗传工程化蓝细菌，其中蓝细菌在发酵期后能够产生乙醇。在另一方面，本发明公开了使用本发明的多核苷酸构建体通过遗传修饰蓝细菌来生产乙醇的方法。

3. 发明申请

WO2007084477A1 METHODS AND COMPOSITIONS FOR ETHANOL PRODUCING CYANOBACTERIA 审中-公开
标题翻译：乙醇生产细胞因子的方法和组合物
公开(公告)号：WO2007084477A1
公开(公告)日：2007-07-26
申请号：PCT/US2007/001071
申请日：2007-01-16
申请人： UNIVERSITY OF HAWAII , FU, Pengcheng, Patrick , DEXTER, Jason
发明人： FU, Pengcheng, Patrick , DEXTER, Jason
IPC分类号： C12N15/11 , C12N15/63
CPC分类号： C12N9/88 , C12N9/0006 , C12N9/0008 , C12N13/00 , C12P7/065 , Y02E50/17
摘要： The present invention relates to methods and systems for the production of ethanol by cyanobacteria. More specifically, the methods can be used to produce ethanol using genetically engineered light responsive cyanobacteria.
摘要翻译：本发明涉及通过蓝细菌生产乙醇的方法和系统。更具体地，该方法可用于使用遗传工程化的光反应性蓝细菌来生产乙醇。

4. 发明申请

WO0229032A2 WHOLE CELL ENGINEERING BY MUTAGENIZING A SUBSTANTIAL PORTION OF A STARTING GENOME, COMBINING MUTATIONS, AND OPTIONALLY REPEATING 审中-公开
标题翻译：通过将起始基因组的重要部分，组合突变和可选择重复的整体细胞工程整合
公开(公告)号：WO0229032A2
公开(公告)日：2002-04-11
申请号：PCT/US0131004
申请日：2001-10-01
申请人： DIVERSA CORP , SHORT JAY M , FU PENGCHENG , LATTERICH MARTIN , WEI JING , LEVIN MICHAEL
发明人： SHORT JAY M , FU PENGCHENG , LATTERICH MARTIN , WEI JING , LEVIN MICHAEL
IPC分类号： C12N15/10 , C12N15/82 , G01N33/534 , G01N33/68 , C12N15/00
CPC分类号： C12N15/1089 , C12N15/102 , C12N15/1027 , C12N15/1058 , C12N15/8241 , G01N33/534 , G01N33/6848 , G01N2800/52
摘要： An invention comprising cellular transformation, directed evolution, and screening methods for creating novel transgenic organisms having desirable properties. In one embodiment, this invention provides a method of generating a transgenic organism, such as a microbe or a plant, having a plurality of traits that are differentially activatable. This invention also provides a method of retooling genes and gene pathways by the introduction of regulatory sequences, such as promoters, that are operable in an intended host, this conferring operability to a novel gene pathway when it is introduced into an intended host. For example a novel man-made gene pathway, generated based on microbially-derived progenitor templates, that is operable in a plant cell. This invention also provides a method of generating novel host organisms having increased expression of desirable traits, recombinant genes, and gene products. This invention provides novel methods for determining polypeptide profiles, and protein expression variations, which methods are applicable to all sample types disclosed herein. The present invention provides methods of simultaneously identifying and quantifying individual proteins in complex protein mixtures. Additionally this invention provides methods for cellular and metabolic engineering of new and modified phenotypes by using "on-line" or "real-time" metabolic flux analysis.
摘要翻译：一种包含细胞转化，定向进化和用于产生具有所需性质的新型转基因生物的筛选方法的发明。在一个实施方案中，本发明提供了产生具有差异可激活的多种性状的转基因生物体如微生物或植物的方法。本发明还提供了通过引入可在预期宿主中操作的调节序列（例如启动子）来重新组合基因和基因途径的方法，当将其导入预期的宿主时，这赋予了新基因途径的可操作性。例如，基于微生物来源的祖细胞模板产生的新型人造基因途径，其可在植物细胞中操作。本发明还提供了产生具有所需性状，重组基因和基因产物表达增加的新型宿主生物的方法。本发明提供了用于确定多肽谱和蛋白质表达变化的新方法，该方法适用于本文公开的所有样品类型。本发明提供同时鉴定和定量复合蛋白质混合物中的各种蛋白质的方法。此外，本发明通过使用“在线”或“实时”代谢通量分析提供新的和修饰的表型的细胞和代谢工程的方法。

5. 发明申请

WO2003036296A1 COMPOSITIONS AND METHODS FOR MODELING SACCHAROMYCES CEREVISIAE METABOLISM 审中-公开
标题翻译：组合物和方法用于建模细胞因子代谢
公开(公告)号：WO2003036296A1
公开(公告)日：2003-05-01
申请号：PCT/US2002/034394
申请日：2002-10-24
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , TECHNICAL UNIVERSITY OF DENMARK , PALSSON, Bernhard, O. , FAMILI, Imandokht , FU, Pengcheng , NIELSEN, Jens, B. , FORSTER, Jochen
发明人： PALSSON, Bernhard, O. , FAMILI, Imandokht , FU, Pengcheng , NIELSEN, Jens, B. , FORSTER, Jochen
IPC分类号： G01N33/48
CPC分类号： G06F19/12 , G06F19/18 , Y02A90/26 , Y02E50/343
摘要： The invention provides an in silica model for determining a S. cerevisiae physiological function. The model includes a data structure relating a plurality of S. cerevisiae reactants to a plurality of S. cerevisiae reactions, a constraint set for the plurality of S. cerevisiae reactions, and commands for determining a distribution of flux through the reactions that is predictive ofa s. cerevisiae physiological function. A model of the invention can further include a gene database containing information characterizing the associated gene or genes. The invention further provides methods for making an in silica S. cerevisiae model and methods for determining a S. cerevisiae physiological function using a model of the invention.
摘要翻译：本发明提供了用于确定S的二氧化硅模型。酿酒酵母生理功能。该模型包括与多个S相关的数据结构。酿酒酵母对多种酿酒酵母反应物的反应物，用于多个酿酒酵母反应的约束集，以及用于确定通量的分布的命令预测的反应。生理功能。本发明的模型还可以包括含有表征相关基因或基因的信息的基因数据库。本发明进一步提供了制备二氧化硅酿酒酵母模型的方法和用于测定酿酒酵母的方法，生理功能使用本发明的模型。

6. 发明申请

WO2002029032A3 WHOLE CELL ENGINEERING BY MUTAGENIZING A SUBSTANTIAL PORTION OF A STARTING GENOME, COMBINING MUTATIONS, AND OPTIONALLY REPEATING 审中-公开
公开(公告)号：WO2002029032A3
公开(公告)日：2002-04-11
申请号：PCT/US2001/031004
申请日：2001-10-01
申请人： DIVERSA CORPORATION , SHORT, Jay, M. , FU, Pengcheng , LATTERICH, Martin , WEI, Jing , LEVIN, Michael
发明人： SHORT, Jay, M. , FU, Pengcheng , LATTERICH, Martin , WEI, Jing , LEVIN, Michael
IPC分类号： G01N33/68
摘要： An invention comprising cellular transformation, directed evolution, and screening methods for creating novel transgenic organisms having desirable properties. In one embodiment, this invention provides a method of generating a transgenic organism, such as a microbe or a plant, having a plurality of traits that are differentially activatable. This invention also provides a method of retooling genes and gene pathways by the introduction of regulatory sequences, such as promoters, that are operable in an intended host, this conferring operability to a novel gene pathway when it is introduced into an intended host. For example a novel man-made gene pathway, generated based on microbially-derived progenitor templates, that is operable in a plant cell. This invention also provides a method of generating novel host organisms having increased expression of desirable traits, recombinant genes, and gene products. This invention provides novel methods for determining polypeptide profiles, and protein expression variations, which methods are applicable to all sample types disclosed herein. The present invention provides methods of simultaneously identifying and quantifying individual proteins in complex protein mixtures. Additionally this invention provides methods for cellular and metabolic engineering of new and modified phenotypes by using "on-line" or "real-time" metabolic flux analysis.

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