专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

EP2392262A1 Methods and systems for locating and acoustically illuminating a desired target area 审中-公开
标题翻译：一种用于所希望的目标区域的定位和声学照明的方法和系统
公开(公告)号：EP2392262A1
公开(公告)日：2011-12-07
申请号：EP11177783.5
申请日：2004-06-03
申请人： PhysioSonics, Inc. , The University of Washington , Mourad, Pierre , Mohr, Brandt , Kliot, Michel , Frederickson, Robert C. A. , Thompson, Lee R. , Seawall, Jason
发明人： Mourad, Pierre , Mohr, Brandt , Kliot, Michel , Frederickson, Robert C. A. , Thompson, Lee R. , Seawall, Jason
IPC分类号： A61B8/06
CPC分类号： A61B8/06 , A61B5/031 , A61B5/4064 , A61B5/7267 , A61B8/0808 , A61B8/4444 , A61B8/4472 , A61B8/4483 , A61B8/485 , A61B8/58
摘要： A plurality of acoustic source and/or detector elements are employed in a scanning mode to acoustically illuminate and acquire acoustic data from numerous sites within a larger target area. Based on the acoustic data collected in the scanning mode, a localised site within the target area is selected as the target site for focused acoustic illumination and/or probing. Elements of the acoustic source/detector array are focused on the selected target site in an automated fashion. Thereafter, the target area is periodically scanned and the acoustic focus repositioned, as required, to maintain the focus of the acoustic source at the desired target site.
摘要翻译：声源和/或检测器元件中的多个扫描模式被采用以声学照亮和较大的目标区域内获取来自许多位点的声数据。基于在扫描模式收集到的声音数据，所述目标区域内的局部部位被选择作为目标的网站聚焦声照明和/或探测。声源/检测器阵列的元件被聚焦在自动化的方式所选择的目标部位上。那里以后，目标区域被定期扫描和声学重点重新定位，根据需要，维持声源的焦点在期望的目标站点。

2. 发明公开

EP1633234A2 SYSTEMS AND METHODS FOR DETERMINING INTRACRANIAL PRESSURE NON-INVASIVELY AND ACOUSTIC TRANSDUCER ASSEMBLIES FOR USE IN SUCH SYSTEMS 审中-公开
标题翻译：系统和方法颅骨内的压力和传感器安排无创确定FOR USE在这些系统
公开(公告)号：EP1633234A2
公开(公告)日：2006-03-15
申请号：EP04754563.7
申请日：2004-06-03
申请人： Allez Physionix Limited , University of Washington , Mourad, Pierre , Mohr, Brandt , Kliot, Michel , Frederickson, Robert C. A. , Thompson, Lee R. , Seawall, Jason
发明人： MOURAD, Pierre , MOHR, Brandt , KLIOT, Michel , FREDERICKSON, Robert, C., A. , THOMPSON, LEE, R. , SEAWALL, Jason
IPC分类号： A61B1/00
CPC分类号： A61B8/06 , A61B5/031 , A61B5/4064 , A61B5/7267 , A61B8/0808 , A61B8/4444 , A61B8/4472 , A61B8/4483 , A61B8/485 , A61B8/58
摘要： Systems and methods for determining ICP based on parameters that can be measured using non-invasive or minimally invasive techniques are provided, wherein a non-linear relationship is used to determine ICP based on one or more variable inputs. The first variable input relates to one or more properties of a cranial blood vessel and/or blood flow, such as acoustic backscatter from an acoustic transducer having a focus trained on a cranial blood vessel, flow velocity in a cranial blood vessel, and the like. Additional variables, such as arterial blood pressure (ABP), may be used in combination with a first variable input relating to one or more properties of a cranial blood vessel, such as flow velocity of the middle cerebral artery (MCA) to derive ICP using a non-linear relationship. Methods and systems for locating target areas based on their acoustic properties and for acoustic scanning of an area, identification of a target area of interest based on acoustic properties, and automated focusing of an acoustic source and/or detector on a desired target area are also provided. Acoustic transducer assemblies are described.

3. 发明公开

EP1633234A4 SYSTEMS AND METHODS FOR DETERMINING INTRACRANIAL PRESSURE NON-INVASIVELY AND ACOUSTIC TRANSDUCER ASSEMBLIES FOR USE IN SUCH SYSTEMS 审中-公开
标题翻译：系统和方法颅骨内的压力和传感器安排无创确定FOR USE在这些系统
公开(公告)号：EP1633234A4
公开(公告)日：2009-05-13
申请号：EP04754563
申请日：2004-06-03
申请人： PHYSIOSONICS INC , UNIV WASHINGTON , MOURAD PIERRE , MOHR BRANDT , KLIOT MICHEL , FREDERICKSON ROBERT C A , THOMPSON LEE R , SEAWALL JASON
发明人： MOURAD PIERRE , MOHR BRANDT , KLIOT MICHEL , FREDERICKSON ROBERT C A , THOMPSON LEE R , SEAWALL JASON
IPC分类号： A61B8/00 , A61B5/03 , A61B8/02 , A61B8/06 , A61B8/12 , A61B8/14
CPC分类号： A61B8/06 , A61B5/031 , A61B5/4064 , A61B5/7267 , A61B8/0808 , A61B8/4444 , A61B8/4472 , A61B8/4483 , A61B8/485 , A61B8/58
摘要： Systems and methods for determining ICP based on parameters that can be measured using non-invasive or minimally invasive techniques are provided, wherein a non-linear relationship is used to determine ICP based on one or more variable inputs. The first variable input relates to one or more properties of a cranial blood vessel and/or blood flow, such as acoustic backscatter from an acoustic transducer having a focus trained on a cranial blood vessel, flow velocity in a cranial blood vessel, and the like. Additional variables, such as arterial blood pressure (ABP), may be used in combination with a first variable input relating to one or more properties of a cranial blood vessel, such as flow velocity of the middle cerebral artery (MCA) to derive ICP using a non-linear relationship. Methods and systems for locating target areas based on their acoustic properties and for acoustic scanning of an area, identification of a target area of interest based on acoustic properties, and automated focusing of an acoustic source and/or detector on a desired target area are also provided. Acoustic transducer assemblies are described.

4. 发明申请

WO2007040645A1 SYSTEMS AND METHODS FOR NON-INVASIVE DETECTION AND MONITORING OF CARDIAC AND BLOOD PARAMETERS 审中-公开
标题翻译：用于非侵入性检测和监测心脏和血液参数的系统和方法
公开(公告)号：WO2007040645A1
公开(公告)日：2007-04-12
申请号：PCT/US2006/018237
申请日：2006-05-11
申请人： ALLEZ PHYSIONIX LTD. , UNIVERSITY OF WASHINGTON , KLIOT, Michel , FREDERICKSON, Robert, C., A. , FORGHANI, Kamran , MOURAD, Pierre, D.
发明人： KLIOT, Michel , FREDERICKSON, Robert, C., A. , FORGHANI, Kamran , MOURAD, Pierre, D.
IPC分类号： A61B5/02 , A61B5/00 , A61B8/00 , A61B8/12 , A61B8/14
CPC分类号： A61B8/06 , A61B5/0002 , A61B5/0205 , A61B5/08 , A61B5/145 , A61B5/681 , A61B5/6814 , A61B5/6822 , A61B5/6828 , A61B5/6831 , A61B8/04 , A61B8/0816 , A61B8/4472 , A61B8/485 , A61B8/543 , A61B8/56 , A61B8/58
摘要： Methods and systems for long term monitoring of one or more physiological parameters such as respiration, heart rate, body temperature, electrical heart activity, blood oxygenation, blood flow velocity, blood pressure, intracranial pressure, the presence of emboli in the blood stream and electrical brain activity are provided. Data is acquired non-invasively using ambulatory data acquisition techniques.
摘要翻译：用于长期监测一种或多种生理参数的方法和系统，例如呼吸，心率，体温，电心脏活动，血氧饱和度，血流速度，血压，颅内压，血液中血栓和电气的存在提供大脑活动。使用流动数据采集技术非侵入性地获取数据。

5. 发明申请

WO2010033875A1 ACOUSTIC PALPATION USING NON-INVASIVE ULTRASOUND TECHNIQUES TO IDENTIFY AND LOCALIZE TISSUE ELICITING BIOLOGICAL RESPONSES 审中-公开
标题翻译：使用非侵入式超声技术识别和定位组织适应生物反应的声学性PALPATION
公开(公告)号：WO2010033875A1
公开(公告)日：2010-03-25
申请号：PCT/US2009/057588
申请日：2009-09-18
申请人： PHYSIOSONICS, INC. , UNIVERSITY OF WASHINGTON , JARVIK, Jeffrey, G. , MOURAD, Pierre, D. , KLIOT, Michel , FREDERICKSON, Robert, C., A.
发明人： JARVIK, Jeffrey, G. , MOURAD, Pierre, D. , KLIOT, Michel , FREDERICKSON, Robert, C., A.
IPC分类号： A61B8/12
CPC分类号： A61B8/08 , A61B5/0053 , A61B5/4824 , A61B8/0808 , A61B8/4218 , A61B8/4472 , A61B2018/00642 , A61N7/02 , A61N2007/0078
摘要： Methods and systems for identifying and spatially localizing tissues having certain physiological properties or producing certain biological responses, such as the sensation of pain, in response to the application of intense focused ultrasound (acoustic probing or palpation) are provided. In some embodiments, targeted acoustic probing may be guided or visualized using imaging techniques such as ultrasound imaging or other types of non-invasive imaging techniques.
摘要翻译：提供了用于鉴定和空间定位具有某些生理特性的组织的空间定位方法和系统，或者响应于强聚焦超声（声学探测或触诊）的应用而产生某些生物反应，例如疼痛的感觉。在一些实施例中，使用诸如超声成像或其他类型的非侵入性成像技术的成像技术可以引导或可视化目标声学探测。

6. 发明申请

WO2004107963A3 NON-INVASIVE DETERMINATION OF INTRACRANIAL PRESSURE VIA ACOUSTIC TRANSDUCERS 审中-公开
标题翻译：通过声学传感器非侵入式确定压力
公开(公告)号：WO2004107963A3
公开(公告)日：2007-05-31
申请号：PCT/US2004017992
申请日：2004-06-03
申请人： ALLEZ PHYSIONIX LTD , UNIV WASHINGTON , MOURAD PIERRE , MOHR BRANDT , KLIOT MICHEL , FREDERICKSON ROBERT C A , THOMPSON LEE R , SEAWALL JASON
发明人： MOURAD PIERRE , MOHR BRANDT , KLIOT MICHEL , FREDERICKSON ROBERT C A , THOMPSON LEE R , SEAWALL JASON
IPC分类号： A61B8/00 , A61B5/03 , A61B8/02 , A61B8/06 , A61B8/12 , A61B8/14
CPC分类号： A61B8/06 , A61B5/031 , A61B5/4064 , A61B5/7267 , A61B8/0808 , A61B8/4444 , A61B8/4472 , A61B8/4483 , A61B8/485 , A61B8/58
摘要： Systems and methods for determining ICP based on parameters that can be measured using non-invasive or minimally invasive techniques are provided, wherein a non-linear relationship is used to determine ICP based on one or more variable inputs. The first variable input relates to one or more properties of a cranial blood vessel and/or blood flow, such as acoustic backscatter from an acoustic transducer having a focus trained on a cranial blood vessel, flow velocity in a cranial blood vessel, and the like. Additional variables, such as arterial blood pressure (ABP), may be used in combination with a first variable input relating to one or more properties of a cranial blood vessel, such as flow velocity of the middle cerebral artery (MCA) to derive ICP using a non-linear relationship. Methods and systems for locating target areas based on their acoustic properties and for acoustic scanning of an area, identification of a target area of interest based on acoustic properties, and automated focusing of an acoustic source and/or detector on a desired target area are also provided. Acoustic transducer assemblies are described.
摘要翻译：提供了基于可以使用非侵入性或微创技术测量的参数来确定ICP的系统和方法，其中使用非线性关系来基于一个或多个可变输入来确定ICP。第一可变输入涉及颅血管和/或血流的一种或多种性质，例如来自具有在颅血管上训练的焦点的声学换能器的声学后向散射，颅血管中的流速等。附加变量，例如动脉血压（ABP）可以与与颅血管的一种或多种性质（例如大脑中动脉（MCA）的流速）相关的第一可变输入组合使用，以便使用非线性关系。基于它们的声学特性和对于区域的声学扫描来定位目标区域的方法和系统也基于声学特性识别目标区域，以及声源和/或检测器在期望的目标区域上的自动聚焦也是提供。描述了声学换能器组件。

7. 发明申请

WO1992021354A1 METHODS AND COMPOSITIONS BASED ON INHIBITION OF CELL INVASION AND FIBROSIS BY ANIONIC POLYMERS 审中-公开
标题翻译：基于静电聚合物抑制细胞侵入和纤维化的方法和组合物
公开(公告)号：WO1992021354A1
公开(公告)日：1992-12-10
申请号：PCT/US1992004474
申请日：1992-05-29
申请人： GLIATECH, INC. , ROUFA, Dikla , HAREL, Adrian , FREDERICKSON, Robert, C., A.
发明人： GLIATECH, INC.
IPC分类号： A61K31/725
CPC分类号： A61K31/734 , A61K31/727 , A61K31/728 , A61K31/737 , A61K31/738 , A61K38/1703 , A61K38/39 , A61L27/20 , A61L27/34 , A61L31/042 , Y10S530/857 , Y10S623/915 , Y10S623/924 , Y10S977/788 , Y10S977/793 , Y10S977/795 , Y10S977/908 , Y10S977/91 , A61K31/715 , A61K2300/00 , C08L5/00 , C08L5/02 , C08L5/04
摘要： The present invention relates to the discovery that biocompatible anionic polymers can effectively inhibit fibrosis, scar formation, and surgical adhesions. The invention is predicated on the discovery that anionic polymers effectively inhibit invasion of cells associated with detrimental healing processes, and in particular, that the effectiveness of an anionic polymer at inhibiting cell invasion correlates with the anionic charge density of the polymer. Thus, the present invention provides a large number of materials for use in methods of inhibiting fibrosis and fibroblast invasion. Anionic polymers for use in the invention include but are not limited to natural proteoglycans, and the glycosaminoglycan moieties of proteoglycans. Additionally, anionic carbohydrates and other anionic polymers may be used. The anionic polymers dextran sulfate and pentosan polysulfate are preferred. In a more preferred embodiment, dextran sulfate, in which the sulfur content is greater than about 10 % by weight, may be used. In a more preferred embodiment, the average molecular weight is about 40,000 to 500,000 Daltons. The present invention provides compositions and methods to inhibit fibrosis and scarring associated with surgery. The invention further provides compositions and methods to inhibit glial cell invasion, detrimental bone growth and neurite outgrowth. In a preferred embodiment, the inhibitory compositions further comprise an adhesive protein.
摘要翻译：本发明涉及生物相容性阴离子聚合物可有效抑制纤维化，瘢痕形成和手术粘连的发现。本发明基于以下发现：阴离子聚合物有效地抑制与有害愈合过程相关的细胞的侵袭，特别是阴离子聚合物抑制细胞侵袭的有效性与聚合物的阴离子电荷密度相关。因此，本发明提供了大量用于抑制纤维化和成纤维细胞侵袭的方法的材料。用于本发明的阴离子聚合物包括但不限于天然蛋白聚糖和蛋白聚糖的糖胺聚糖部分。此外，可以使用阴离子碳水化合物和其它阴离子聚合物。阴离子聚合物硫酸葡聚糖和聚山梨糖多糖是优选的。在更优选的实施方案中，可以使用其中硫含量大于约10重量％的硫酸葡聚糖。在更优选的实施方案中，平均分子量为约40,000至500,000道尔顿。本发明提供抑制与手术相关的纤维化和瘢痕形成的组合物和方法。本发明还提供抑制胶质细胞侵袭，有害的骨生长和神经突生长的组合物和方法。在优选的实施方案中，抑制组合物还包含粘合蛋白。

8. 发明申请

WO2004107963A2 SYSTEMS AND METHODS FOR DETERMINING INTRACRANIAL PRESSURE NON-INVASIVELY AND ACOUSTIC TRANSDUCER ASSEMBLIES FOR USE IN SUCH SYSTEMS 审中-公开
标题翻译：用于确定在这些系统中使用的非侵入性和声学传感器组件的系统和方法
公开(公告)号：WO2004107963A2
公开(公告)日：2004-12-16
申请号：PCT/US2004/017992
申请日：2004-06-03
申请人： ALLEZ PHYSIONIX LIMITED , UNIVERSITY OF WASHINGTON , MOURAD, Pierre , MOHR, Brandt , KLIOT, Michel , FREDERICKSON, Robert, C., A. , THOMPSON, LEE, R.
发明人： MOURAD, Pierre , MOHR, Brandt , KLIOT, Michel , FREDERICKSON, Robert, C., A. , THOMPSON, LEE, R.
IPC分类号： A61B
CPC分类号： A61B8/06 , A61B5/031 , A61B5/4064 , A61B5/7267 , A61B8/0808 , A61B8/4444 , A61B8/4472 , A61B8/4483 , A61B8/485 , A61B8/58
摘要： Systems and methods for determining ICP based on parameters that can be measured using non-invasive or minimally invasive techniques are provided, wherein a non-linear relationship is used to determine ICP based on one or more variable inputs. The first variable input relates to one or more properties of a cranial blood vessel and/or blood flow, such as acoustic backscatter from an acoustic transducer having a focus trained on a cranial blood vessel, flow velocity in a cranial blood vessel, and the like. Additional variables, such as arterial blood pressure (ABP), may be used in combination with a first variable input relating to one or more properties of a cranial blood vessel, such as flow velocity of the middle cerebral artery (MCA) to derive ICP using a non-linear relationship. Methods and systems for locating target areas based on their acoustic properties and for acoustic scanning of an area, identification of a target area of interest based on acoustic properties, and automated focusing of an acoustic source and/or detector on a desired target area are also provided. Acoustic transducer assemblies are described.
摘要翻译：提供了基于可以使用非侵入性或微创技术测量的参数来确定ICP的系统和方法，其中使用非线性关系来基于一个或多个可变输入来确定ICP。第一可变输入涉及颅血管和/或血流的一种或多种性质，例如来自具有在颅血管上训练的焦点的声学换能器的声学后向散射，颅血管中的流速等。附加变量，例如动脉血压（ABP）可以与与颅血管的一种或多种性质（例如大脑中动脉（MCA）的流速）相关的第一可变输入组合使用，以便使用非线性关系。基于它们的声学特性和对于区域的声学扫描来定位目标区域的方法和系统也基于声学特性识别目标区域，以及声源和/或检测器在期望的目标区域上的自动聚焦也是提供。描述了声学换能器组件。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式