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1. 发明申请

WO2006110621A2 MULTIPLEXED BIOMARKERS FOR MONITORING THE ALZHEIMER'S DISEASE STATE OF A SUBJECT 审中-公开
标题翻译：用于监测受试者的阿尔茨海默病状态的多重生物标志物
公开(公告)号：WO2006110621A2
公开(公告)日：2006-10-19
申请号：PCT/US2006/013234
申请日：2006-04-10
申请人： CORNELL RESEARCH FOUNDATION, INC. , LEE, Kelvin, H. , RELKIN, Norman, R. , FINEHOUT, Erin
发明人： LEE, Kelvin, H. , RELKIN, Norman, R. , FINEHOUT, Erin
IPC分类号： G01N33/53
CPC分类号： G01N33/6896 , G01N2800/2821
摘要： The present invention relates to a method for diagnosing a subject's Alzheimer's disease state. The method involves providing a database containing information relating to protein expression levels associated and not associated with Alzheimer's disease. The database includes information relating to at least a majority of the following proteins: albumin, alpha-1-antitrypsin, apolipoprotin E, apolipoprotein J, complement component 3, contactin, fibrin beta, Ig heavy chain, Ig light chain, neuronal pentraxin receptor, plasminogen, proSAAS, retinol-binding protein, transthyretin, and vitamin D binding protein. Information relating to proteins found in one or more cerebrospinal fluid samples from a subject is also provided and a database is used to analyze the information from the subject to diagnose the subject's Alzheimer's disease state. Also disclosed is a computer readable medium and a system, both useful in carrying out the present invention.
摘要翻译：本发明涉及一种用于诊断受试者的阿尔茨海默病状态的方法。该方法包括提供一个数据库，其中包含与阿尔茨海默病相关并且不伴有蛋白质表达水平的信息。该数据库包括至少大部分以下蛋白质的信息：白蛋白，α-1-抗胰蛋白酶，载脂蛋白E，载脂蛋白J，补体成分3，接合蛋白，纤维蛋白β，Ig重链，Ig轻链，神经元pentraxin受体，纤溶酶原，proSAAS，视黄醇结合蛋白，转甲状腺素蛋白和维生素D结合蛋白。还提供与来自受试者的一个或多个脑脊液样品中发现的蛋白质有关的信息，并且使用数据库来分析来自受试者的信息以诊断受试者的阿尔茨海默病状态。还公开了一种可用于实现本发明的计算机可读介质和系统。

2. 发明申请

WO2012082849A1 METHOD FOR ELECTROELUTING GENETIC MATERIAL FROM DRIED SAMPLES 审中-公开
标题翻译：从干燥样品中电化遗传材料的方法
公开(公告)号：WO2012082849A1
公开(公告)日：2012-06-21
申请号：PCT/US2011/064823
申请日：2011-12-14
申请人： GENERAL ELECTRIC COMPANY , FINEHOUT, Erin Jean , NELSON, John Richard , SPOONER, Patrick McCoy
发明人： FINEHOUT, Erin Jean , NELSON, John Richard , SPOONER, Patrick McCoy
IPC分类号： C25B7/00 , G01N27/447 , C07H21/00
CPC分类号： C12N15/101
摘要： In accordance with the present disclosure, a method for extracting genetic material from a biological sample stored on a solid medium is provided. The method includes obtaining the solid medium, wherein the biological sample is applied on the solid medium, and the solid medium includes chemicals that lysed the biological sample and preserved the genetic material. The method also includes electroeluting the genetic material directly from the solid medium to a subsequent medium.
摘要翻译：根据本公开，提供了从存储在固体培养基上的生物样品中提取遗传物质的方法。该方法包括获得固体培养基，其中将生物样品施加在固体培养基上，固体培养基包括裂解生物样品并保存遗传物质的化学物质。该方法还包括将遗传物质直接从固体培养基中电泳至后续培养基。

3. 发明申请

WO2011067221A1 METHODS AND SYSTEMS FOR PROCESSING SAMPLES ON POROUS SUBSTRATES 审中-公开
标题翻译：用于处理多孔基板上样品的方法和系统
公开(公告)号：WO2011067221A1
公开(公告)日：2011-06-09
申请号：PCT/EP2010/068457
申请日：2010-11-30
申请人： WHATMAN INTERNATIONAL LTD , SHOEMAKER, Philip, Alexander , GRIFFIN, Weston, Blaine , FINEHOUT, Erin, J. , WANG, Xuefeng , SHAIKH, Kashan, A. , GODDARD, Greg, D.
发明人： SHOEMAKER, Philip, Alexander , GRIFFIN, Weston, Blaine , FINEHOUT, Erin, J. , WANG, Xuefeng , SHAIKH, Kashan, A. , GODDARD, Greg, D.
IPC分类号： G01N35/10 , B01L3/00 , G01N1/38 , G01N1/40 , G01N30/60
CPC分类号： G01N1/4055 , B01L3/5025 , B01L3/50255 , B01L2200/025 , B01L2200/0689 , B01L2300/0627 , B01L2300/0829 , B01L2300/0832 , G01N1/34 , G01N1/405 , G01N1/4077 , G01N30/7233 , G01N35/00029 , G01N35/1095 , G01N2001/4061 , G01N2001/4088 , G01N2030/009 , G01N2030/062 , G01N2035/00128 , Y10T436/24 , Y10T436/25 , Y10T436/25375 , Y10T436/255
摘要： Methods and systems for processing samples fixed to a porous substrate generally comprising, a compressor defining one or more fluid isolation areas, a support, for the porous substrate, having an opening corresponding to one or more of the fluid isolation areas of the compressor, an actuator that causes at least a portion of the compressor to press against the porous substrate, a fluid inlet having access to the fluid isolation area at least when the compressor is pressed against the porous substrate, and a fluid outlet to receive fluid, through the opening in the support corresponding to the fluid isolation area of the compressor, at least when the compressor is pressed against the porous substrate.
摘要翻译：用于处理固定到多孔基材的样品的方法和系统通常包括限定一个或多个流体隔离区域的压缩机，用于多孔基材的支撑体，其具有对应于压缩机的一个或多个流体隔离区域的开口，致动器，其使至少一部分压缩机压靠多孔基底，至少当压缩机被压靠在多孔基底上时，流体入口至少进入流体隔离区域，以及流体出口以接收流体，通过开口在对应于压缩机的流体隔离区域的支撑件中，至少当压缩机被压靠在多孔基底上时。

4. 发明申请

WO2006110621A3 MULTIPLEXED BIOMARKERS FOR MONITORING THE ALZHEIMER'S DISEASE STATE OF A SUBJECT 审中-公开
标题翻译：用于监测受试者的阿尔茨海默病状态的多重生物标志物
公开(公告)号：WO2006110621A3
公开(公告)日：2011-05-26
申请号：PCT/US2006013234
申请日：2006-04-10
申请人： CORNELL RES FOUNDATION INC , LEE KELVIN H , RELKIN NORMAN R , FINEHOUT ERIN
发明人： LEE KELVIN H , RELKIN NORMAN R , FINEHOUT ERIN
IPC分类号： G01N33/00 , G01N33/53 , G06F7/00
CPC分类号： G01N33/6896 , G01N2800/2821
摘要： The present invention relates to a method for diagnosing a subject's Alzheimer's disease state. The method involves providing a database containing information relating to protein expression levels associated and not associated with Alzheimer's disease. The database includes information relating to at least a majority of the following proteins: albumin, alpha-1-antitrypsin, apolipoprotin E, apolipoprotein J, complement component 3, contactin, fibrin beta, Ig heavy chain, Ig light chain, neuronal pentraxin receptor, plasminogen, proSAAS, retinol-binding protein, transthyretin, and vitamin D binding protein. Information relating to proteins found in one or more cerebrospinal fluid samples from a subject is also provided and a database is used to analyze the information from the subject to diagnose the subject's Alzheimer's disease state. Also disclosed is a computer readable medium and a system, both useful in carrying out the present invention.
摘要翻译：本发明涉及一种用于诊断受试者的阿尔茨海默病状态的方法。该方法包括提供一个数据库，其中包含与阿尔茨海默病相关并且不伴有蛋白质表达水平的信息。该数据库包括至少大部分以下蛋白质的信息：白蛋白，α-1-抗胰蛋白酶，载脂蛋白E，载脂蛋白J，补体成分3，接合蛋白，纤维蛋白β，Ig重链，Ig轻链，神经元pentraxin受体，纤溶酶原，proSAAS，视黄醇结合蛋白，转甲状腺素蛋白和维生素D结合蛋白。还提供与来自受试者的一个或多个脑脊液样品中发现的蛋白质有关的信息，并且使用数据库来分析来自受试者的信息以诊断受试者的阿尔茨海默病状态。还公开了一种可用于实现本发明的计算机可读介质和系统。

5. 发明申请

WO2011067309A1 METHODS AND SYSTEMS TO PREVENT PUNCH LOSS DURING AUTOMATED SAMPLE PROCESSING 审中-公开
标题翻译：在自动样品加工过程中防止冲击损失的方法和系统
公开(公告)号：WO2011067309A1
公开(公告)日：2011-06-09
申请号：PCT/EP2010/068682
申请日：2010-12-02
申请人： WHATMAN INTERNATIONAL LTD , SHOEMAKER, Philip, Alexander , FINEHOUT, Erin , GRIFFIN, Weston, Blaine
发明人： SHOEMAKER, Philip, Alexander , FINEHOUT, Erin , GRIFFIN, Weston, Blaine
IPC分类号： C12M1/16 , G01N1/28 , G01N35/04
CPC分类号： G01N1/286 , G01N2001/288 , G01N2035/042
摘要： Automated methods and systems for punching out pieces of a porous substrate for biological samples comprising: loading the porous substrate onto a support comprising a die and an opening; moving a receptacle support in at least a z-direction to position a receptacle relative to the support so that an opening in the receptacle is aligned and substantially flush with the opening in the support; actuating a punching head so that the punching head passes through the die, thereby punching a piece out of the porous substrate; and actuating an ejector pin to eject the punched piece from the porous substrate support and into the receptacle aligned with the opening in the support.
摘要翻译：用于冲切用于生物样品的多孔基材片的自动方法和系统，包括：将所述多孔基材装载到包括模头和开口的支撑件上; 在至少z方向上移动容器支撑件以相对于支撑件定位容器，使得容器中的开口对齐并且基本上与支撑件中的开口齐平; 致动冲压头，使冲头通过冲模，从而从多孔基材上冲出一块; 并且致动顶针以将冲压件从多孔基底支撑件推出并进入与支撑件中的开口对准的容器中。

6. 发明申请

WO2010016795A1 FLUORESCENCE DETECTION SYSTEM AND METHOD 审中-公开
标题翻译：荧光检测系统及方法
公开(公告)号：WO2010016795A1
公开(公告)日：2010-02-11
申请号：PCT/SE2009/050918
申请日：2009-08-04
申请人： GENERAL ELECTRIC COMPANY , GE HEALTHCARE BIO-SCIENCES AB , BARASH, Eugene , FINEHOUT, Erin , PIETRZYKOWSKI, Matthew, Damian , XIA, Hua , ZHU, Li
发明人： BARASH, Eugene , FINEHOUT, Erin , PIETRZYKOWSKI, Matthew, Damian , XIA, Hua , ZHU, Li
IPC分类号： G01N27/447 , G01N21/64 , G01N33/487
CPC分类号： G01N21/645 , B01L3/5027 , G01J3/02 , G01J3/0208 , G01J3/0218 , G01J3/08 , G01J3/4406 , G01N21/6408 , G01N2021/6419 , G01N2021/6484 , G01N2201/0826 , G01N2201/0833
摘要： A fluorescence detection system comprises a light source configured to produce an excitation light, an optical lens and a fiber bundle. The optical lens is configured to focus the excitation light to a sample to emit fluorescence and to collect the fluorescence. The fiber bundle probe comprises a transmitting fiber configured to transmit the excitation light to the optical lens, and a first receiving fiber configured to deliver the collected fluorescence. The fluorescence detection system further comprises a first detector configured to detect the fluorescence delivered by the receiving fiber to generate a response signal, and a processing unit configured to determine information about the samples by analyzing the response signal. Additionally, a fluorescence detection method is also presented.
摘要翻译：荧光检测系统包括被配置为产生激发光，光学透镜和光纤束的光源。光学透镜被配置为将激发光聚焦到样品以发射荧光并收集荧光。纤维束探针包括被配置为将激发光透射到光学透镜的发射光纤和被配置为传送所收集的荧光的第一接收光纤。荧光检测系统还包括第一检测器，其被配置为检测由接收光纤传送的荧光以产生响应信号;以及处理单元，被配置为通过分析响应信号来确定关于样本的信息。另外，还提出了荧光检测方法。

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