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1. 发明申请

WO2006110621A3 MULTIPLEXED BIOMARKERS FOR MONITORING THE ALZHEIMER'S DISEASE STATE OF A SUBJECT 审中-公开
标题翻译：用于监测受试者的阿尔茨海默病状态的多重生物标志物
公开(公告)号：WO2006110621A3
公开(公告)日：2011-05-26
申请号：PCT/US2006013234
申请日：2006-04-10
申请人： CORNELL RES FOUNDATION INC , LEE KELVIN H , RELKIN NORMAN R , FINEHOUT ERIN
发明人： LEE KELVIN H , RELKIN NORMAN R , FINEHOUT ERIN
IPC分类号： G01N33/00 , G01N33/53 , G06F7/00
CPC分类号： G01N33/6896 , G01N2800/2821
摘要： The present invention relates to a method for diagnosing a subject's Alzheimer's disease state. The method involves providing a database containing information relating to protein expression levels associated and not associated with Alzheimer's disease. The database includes information relating to at least a majority of the following proteins: albumin, alpha-1-antitrypsin, apolipoprotin E, apolipoprotein J, complement component 3, contactin, fibrin beta, Ig heavy chain, Ig light chain, neuronal pentraxin receptor, plasminogen, proSAAS, retinol-binding protein, transthyretin, and vitamin D binding protein. Information relating to proteins found in one or more cerebrospinal fluid samples from a subject is also provided and a database is used to analyze the information from the subject to diagnose the subject's Alzheimer's disease state. Also disclosed is a computer readable medium and a system, both useful in carrying out the present invention.
摘要翻译：本发明涉及一种用于诊断受试者的阿尔茨海默病状态的方法。该方法包括提供一个数据库，其中包含与阿尔茨海默病相关并且不伴有蛋白质表达水平的信息。该数据库包括至少大部分以下蛋白质的信息：白蛋白，α-1-抗胰蛋白酶，载脂蛋白E，载脂蛋白J，补体成分3，接合蛋白，纤维蛋白β，Ig重链，Ig轻链，神经元pentraxin受体，纤溶酶原，proSAAS，视黄醇结合蛋白，转甲状腺素蛋白和维生素D结合蛋白。还提供与来自受试者的一个或多个脑脊液样品中发现的蛋白质有关的信息，并且使用数据库来分析来自受试者的信息以诊断受试者的阿尔茨海默病状态。还公开了一种可用于实现本发明的计算机可读介质和系统。

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