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1. 发明公开

EP0063480A1 Doorway security device 失效
标题翻译： SicherheitsvorrichtungfürTüren。
公开(公告)号：EP0063480A1
公开(公告)日：1982-10-27
申请号：EP82301952.6
申请日：1982-04-15
申请人： Ferguson, Ronald Collins
发明人： Ferguson, Ronald Collins
IPC分类号： E05C11/00 , E05C19/00
CPC分类号： E05B63/24 , E05C19/002
摘要： A chamfered fly edge of a hinged door (1) is engageable by an abutment member (5) hinged to the facing jamb (4) of a doorway. A rotatable cam member (6) is also mounted in the jamb (4) and is movable between positions which respectively allow the abutment member (5) to be hinged clear of the fly edge of the door (1) and so allow the door (1) to be opened and closed, and press the abutment member (5) into engagement with the fly edge of the closed door (1) and thus secure it against forcible opening. The rotation of the cam member (6) is effected from the movement of a key-operated bolt (11) of the door (1).
摘要翻译：铰接门（1）的倒角的飞边可通过铰接到门口的面对侧壁（4）的邻接构件（5）接合。可旋转的凸轮构件（6）也安装在侧柱（4）中并且可在分别允许抵接构件（5）铰接到门（1）的飞边的位置之间移动，并且因此允许门 1）被打开和关闭，并且将抵接构件（5）按压到与关闭的门（1）的飞边接合，从而将其固定以防止强制打开。凸轮构件（6）的旋转由门（1）的键操作螺栓（11）的移动来实现。

2. 发明申请

WO2019005587A1 3-(1H-PYRAZOL-4-YL)PYRIDINE ALLOSTERIC MODULATORS OF THE M4 MUSCARINIC ACETYLCHOLINE RECEPTOR 审中-公开
公开(公告)号：WO2019005587A1
公开(公告)日：2019-01-03
申请号：PCT/US2018/038888
申请日：2018-06-22
申请人： MERCK SHARP & DOHME CORP. , MSD R&D (CHINA) CO., LTD. , ACTON, John, J., III , BAO, Jianming , DENG, Qiaolin , EGBERTSON, Melissa , FERGUSON, Ronald, III , GAO, Xiaolei , HARRISON, Scott Timothy , KNOWLES, Sandra, L. , LI, Chunsing , LO, Michael Man-Chu , MAZZOLA, Robert, D., Jr. , MENG, Zhaoyang , NA, Meng , RUDD, Michael, T. , SELYUTIN, Oleg, B. , TELLERS, David, M. , TONG, Ling , ZHANG, Fengqi
发明人： ACTON, John, J., III , BAO, Jianming , DENG, Qiaolin , EGBERTSON, Melissa , FERGUSON, Ronald, III , GAO, Xiaolei , HARRISON, Scott Timothy , KNOWLES, Sandra, L. , LI, Chunsing , LO, Michael Man-Chu , MAZZOLA, Robert, D., Jr. , MENG, Zhaoyang , NA, Meng , RUDD, Michael, T. , SELYUTIN, Oleg, B. , TELLERS, David, M. , TONG, Ling , ZHANG, Fengqi
IPC分类号： A61K31/4155 , C07D231/10
摘要： The present invention is directed to pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.

3. 发明申请

WO2019000236A1 3-(1H-PYRAZOL-4-YL)PYRIDINE ALLOSTERIC MODULATORS OF M4 MUSCARINIC ACETYLCHOLINE RECEPTOR 审中-公开
公开(公告)号：WO2019000236A1
公开(公告)日：2019-01-03
申请号：PCT/CN2017/090384
申请日：2017-06-27
申请人： MERCK SHARP & DOHME CORP. , MSD R & D (CHINA) CO., LTD. , ACTON, John J. , BAO, Jianming , DENG, Qiaolin , EGBERTSON, Melissa , FERGUSON, Ronald , GAO, Xiaolei , HARRISON, Scott Timothy , KNOWLES, Sandra L. , LI, Chunsing , LO, Michael Man-Chu , MAZZOLA, Robert D., Jr. , NA, Meng , MENG, Zhaoyang , RUDD, Michael T. , SELYUTIN, Oleg , TELLERS, David M. , TONG, Ling , ZHANG, Fengqi
发明人： ACTON, John J. , BAO, Jianming , DENG, Qiaolin , EGBERTSON, Melissa , FERGUSON, Ronald , GAO, Xiaolei , HARRISON, Scott Timothy , KNOWLES, Sandra L. , LI, Chunsing , LO, Michael Man-Chu , MAZZOLA, Robert D., Jr. , NA, Meng , MENG, Zhaoyang , RUDD, Michael T. , SELYUTIN, Oleg , TELLERS, David M. , TONG, Ling , ZHANG, Fengqi
IPC分类号： C07D231/10 , C07D213/04 , A61K31/455 , A61P25/00
摘要： Disclosed are pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor, uses of the compounds described herein in the potential treatment of prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved, compositions comprising these compounds, uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.

4. 发明申请

WO2015089847A1 SPIROCYCLIC HETEROCYCLE COMPOUNDS USEFUL AS HIV INTEGRASE INHIBITORS 审中-公开
标题翻译：作为艾滋病毒整合抑制剂的螺环化合物
公开(公告)号：WO2015089847A1
公开(公告)日：2015-06-25
申请号：PCT/CN2013/090156
申请日：2013-12-20
申请人： MERCK SHARP & DOHME CORP. , GRAHAM, Thomas H. , LIU, Wensheng , YU, Tao , ZHANG, Yonglian , WADDELL, Sherman T. , WAI, John S. , COLEMAN, Paul J. , SANDERS, John M. , EMBREY, Mark W. , WALJI, Abbas , FERGUSON, Ronald Dale II , MARCO, Christina Ng Di , STEELE, Thomas , HU, Lihong , PENG, Xuanjia
发明人： GRAHAM, Thomas H. , LIU, Wensheng , YU, Tao , ZHANG, Yonglian , WADDELL, Sherman T. , WAI, John S. , COLEMAN, Paul J. , SANDERS, John M. , EMBREY, Mark W. , WALJI, Abbas , FERGUSON, Ronald Dale II , MARCO, Christina Ng Di , STEELE, Thomas , HU, Lihong , PENG, Xuanjia
IPC分类号： C07D471/20 , C07D493/20 , C07D495/20 , C07D471/22 , A61K31/499 , A61K31/53 , A61K31/55 , A61P31/18
CPC分类号： A61K31/53 , A61K31/427 , A61K31/499 , A61K31/513 , A61K31/52 , A61K31/55 , A61K31/675 , A61K45/06 , C07D471/20 , C07D471/22 , C07D475/10 , C07D491/10 , C07D491/20 , C07D495/10 , C07D495/20 , C07F9/65616 , A61K2300/00
摘要： Disclosed are Spirocyclic Heterocycle Compounds of Formula (I) and pharmaceutically acceptable salts thereof, where A, B, X, Y, R 1 , R 2 and R 11 are as defined herein. Composition comprising at least one Spirocyclic Heterocycle Compound, and methods of using the Spirocyclic Heterocycle Compounds for treating or preventing HIV infection in a subject are also disclosed.
摘要翻译：公开了式（I）的螺环杂环化合物及其药学上可接受的盐，其中A，B，X，Y，R 1，R 2和R 11如本文所定义。还公开了包含至少一种螺环杂环化合物的组合物，以及使用螺环杂环化合物治疗或预防受试者中HIV感染的方法。

5. 发明申请

WO2015065866A1 INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL 审中-公开
标题翻译：肾脏外部药物通道的抑制剂
公开(公告)号：WO2015065866A1
公开(公告)日：2015-05-07
申请号：PCT/US2014/062316
申请日：2014-10-27
申请人： MERCK SHARP & DOHME CORP. , PASTERNAK, Alexander , TANG, Haifeng , FRIE, Jessica , FERGUSON, Ronald Dale , GUO, Zhiqiang , SHI, Zhi-Cai , CATO, Brian , FU, Qinghong
发明人： PASTERNAK, Alexander , TANG, Haifeng , FRIE, Jessica , FERGUSON, Ronald Dale , GUO, Zhiqiang , SHI, Zhi-Cai , CATO, Brian , FU, Qinghong
IPC分类号： C07D405/06
CPC分类号： C07D405/06 , A61K31/427 , A61K31/433 , A61K31/4439 , A61K31/4525 , A61K31/454 , A61K31/4545 , A61K45/06 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D513/04
摘要： The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.
摘要翻译：本发明提供式I化合物及其药学上可接受的盐，它们是ROMK（Kir1.1）通道的抑制剂。这些化合物可以用作利尿剂和/或利尿钠剂，并且用于治疗和预防包括心血管疾病如高血压，心力衰竭和慢性肾脏疾病以及与过量的盐和水保留有关的病症的医学病症。

6. 发明申请

WO2013063214A1 NOVEL COMPOUNDS THAT ARE ERK INHIBITORS 审中-公开
标题翻译：新的化合物是ERK抑制剂
公开(公告)号：WO2013063214A1
公开(公告)日：2013-05-02
申请号：PCT/US2012/061836
申请日：2012-10-25
申请人： MERCK SHARP & DOHME CORP. , LIM, Jongwon , KELLEY, Elizabeth Helen , METHOT, Joey, L. , ZHOU, Hua , PETROCCHI, Alessia , MANSOOR, Umar Faruk , FISCHER, Christian , O'BOYLE, Brendan, M. , GUERIN, David Joseph , BIENSTOCK, Corey, E. , BOYCE, Christopher, W. , DANIELS, Matthew, H. , FALCONE, Danielle , FERGUSON, Ronald, D., II , FEVRIER, Salem , HUANG, Xianhai , LIPFORD, Kathryn Ann , SLOMAN, David, L. , WILSON, Kevin , ZHOU, Wei , WITTER, David , MALETIC, Milana, M. , SILIPHAIVANH, Phieng
发明人： LIM, Jongwon , KELLEY, Elizabeth Helen , METHOT, Joey, L. , ZHOU, Hua , PETROCCHI, Alessia , MANSOOR, Umar Faruk , FISCHER, Christian , O'BOYLE, Brendan, M. , GUERIN, David Joseph , BIENSTOCK, Corey, E. , BOYCE, Christopher, W. , DANIELS, Matthew, H. , FALCONE, Danielle , FERGUSON, Ronald, D., II , FEVRIER, Salem , HUANG, Xianhai , LIPFORD, Kathryn Ann , SLOMAN, David, L. , WILSON, Kevin , ZHOU, Wei , WITTER, David , MALETIC, Milana, M. , SILIPHAIVANH, Phieng
IPC分类号： A61K9/66
CPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D519/00
摘要： Disclosed are the ERK inhibitors of formula (1): and the pharmaceutically acceptable salts thereof. Also disclosed are methods of treating cancer using the compounds of formula (1).
摘要翻译：公开了式（1）的ERK抑制剂及其药学上可接受的盐。还公开了使用式（1）的化合物治疗癌症的方法。

7. 发明申请

WO2010057042A2 ANGLED LIGHT INTEGRATOR FOR A DISPLAY DEVICE 审中-公开
标题翻译：用于显示装置的倾斜光集成器
公开(公告)号：WO2010057042A2
公开(公告)日：2010-05-20
申请号：PCT/US2009064463
申请日：2009-11-13
申请人： SEIKO EPSON CORP , FERGUSON RONALD , KISER DAVID KERRY
发明人： FERGUSON RONALD , KISER DAVID KERRY
IPC分类号： G03B21/14 , G03B21/20 , H04N5/225
CPC分类号： G02B27/0994 , G03B21/208
摘要： A light integrator for a display device is provided. The light integrator may include a first light tunnel configured to receive a light beam, increase the uniformity of the light distribution in the light beam, and output the light beam, the first light tunnel having a first optical axis. The light integrator may further include a redirection component configured to receive the light beam from the first light tunnel and redirect the light beam to a second light tunnel configured to further increase the uniformity of the light distribution in the light beam and transmit the light beam to downstream optical components, the second light tunnel having a second optical axis forming an angle less than 180 degrees and non-perpendicular with the first optical axis.
摘要翻译：提供了一种用于显示装置的光积分器。光积分器可以包括被配置为接收光束，增加光束中的光分布的均匀性并且输出光束的第一光通道，第一光通道具有第一光轴。光积分器还可以包括重定向部件，其被配置为接收来自第一光通道的光束并将光束重定向到第二光通道，该第二光通道被配置为进一步增加光束中的光分布的均匀性并且将光束传输到下游光学部件，所述第二光隧道具有第二光轴，所述第二光轴形成小于180度且与所述第一光轴不垂直的角度。

8. 发明申请

WO2005083596A3 REORGANIZATION AND REPAIR OF AN ICF CATALOG WHILE OPEN AND IN-USE IN A DIGITAL DATA STORAGE SYSTEM 审中-公开
标题翻译：在数字数据存储系统中打开和使用ICF目录的重新组织和修复
公开(公告)号：WO2005083596A3
公开(公告)日：2006-06-29
申请号：PCT/US2005005414
申请日：2005-02-18
申请人： MAINSTAR SOFTWARE CORP , PACE RICHARD G , HASEGAWA MARTIN K , FERGUSON RONALD K
发明人： PACE RICHARD G , HASEGAWA MARTIN K , FERGUSON RONALD K
IPC分类号： G06F17/30
CPC分类号： G06F17/30067 , Y10S707/99953 , Y10S707/99955
摘要： MVS mainframe computer systems employ the ICF (Integrated Catalog Facility) catalog environment to manage numerous data sets. To provide 24x7 availability of those data sets, the BCS (250,270) must be re-organized while leaving the catalog open to access by applications. To perform a re-org while open, a data CI correlation table (500) is constructed (314) and used to lay the data CIs into a backup file in logical order (316), so that they can be loaded into the new BCS (324) without sorting, thereby reducing downtime. Additionally, if the BCS is damaged during normal operation, repair of the structure must also be performed to ensure that correct access is maintained to all data that is cataloged in the BCS. Throughout the re-org process, structural integrity checks are performed on the data and index component of the BCS, and if errors are encountered, they can be repaired.
摘要翻译： MVS大型计算机系统采用ICF（综合目录设施）目录环境来管理大量数据集。为了提供这些数据集的24x7可用性，必须重新组织BCS（250,270），同时将目录打开以供应用程序访问。为了在打开时执行重新组织，构建数据CI相关表（500）（314）并且用于以逻辑顺序将数据CI置于备份文件（316）中，使得它们可以被加载到新的BCS （324），无需排序，从而减少停机时间。另外，如果BCS在正常操作期间损坏，还必须对结构进行修复，以确保对BCS中编目的所有数据进行正确的访问。在整个重组过程中，对BCS的数据和索引组件执行结构完整性检查，如果遇到错误，则可以进行修复。

9. 发明申请

WO2005083596A2 REORGANIZATION AND REPAIR OF AN ICF CATALOG WHILE OPEN AND IN-USE IN A DIGITAL DATA STORAGE SYSTEM 审中-公开
标题翻译：在数字数据存储系统中打开和使用ICF目录的重新组织和修复
公开(公告)号：WO2005083596A2
公开(公告)日：2005-09-09
申请号：PCT/US2005/005414
申请日：2005-02-18
申请人： MAINSTAR SOFTWARE CORPORATION , PACE, Richard G. , HASEGAWA, Martin K. , FERGUSON, Ronald K.
发明人： PACE, Richard G. , HASEGAWA, Martin K. , FERGUSON, Ronald K.
IPC分类号： G06F17/30
CPC分类号： G06F17/30067 , Y10S707/99953 , Y10S707/99955
摘要： MVS mainframe computer systems employ the ICF (Integrated Catalog Facility) catalog environment to manage numerous data sets. To provide 24x7 availability of those data sets, the BCS (250,270) must be re-organized while leaving the catalog open to access by applications. To perform a re-org while open, a data CI correlation table (500) is constructed (314) and used to lay the data CIs into a backup file in logical order (316), so that they can be loaded into the new BCS (324) without sorting, thereby reducing downtime. Additionally, if the BCS is damaged during normal operation, repair of the structure must also be performed to ensure that correct access is maintained to all data that is cataloged in the BCS. Throughout the re-org process, structural integrity checks are performed on the data and index component of the BCS, and if errors are encountered, they can be repaired.
摘要翻译： MVS大型计算机系统采用ICF（综合目录设施）目录环境来管理大量数据集。为了提供这些数据集的24x7可用性，必须重新组织BCS（250,270），同时将目录打开以供应用程序访问。为了在打开时执行重新组织，构建数据CI相关表（500）（314）并且用于以逻辑顺序将数据CI置于备份文件（316）中，使得它们可以被加载到新的BCS （324），无需排序，从而减少停机时间。另外，如果BCS在正常操作期间损坏，还必须对结构进行修复，以确保对BCS中编目的所有数据进行正确的访问。在整个重组过程中，对BCS的数据和索引组件执行结构完整性检查，如果遇到错误，则可以进行修复。

10. 发明申请

WO2018112843A1 HETEROARYL PIPERIDINE ETHER ALLOSTERIC MODULATORS OF THE M4 MUSCARINIC ACETYLCHOLINE RECEPTOR 审中-公开
公开(公告)号：WO2018112843A1
公开(公告)日：2018-06-28
申请号：PCT/CN2016/111530
申请日：2016-12-22
申请人： MERCK SHARP & DOHME CORP. , MSD R&D (CHINA) CO., LTD. , BAO, Jianming , FERGUSON, Ronald , GAO, Xiaolei , HARRISON, Scott , KNOWLES, Sandra L. , LO, Michael Man-Chu , MAZZOLA, Robert D. Jr. , SCHUBERT, Jeffrey W.
发明人： BAO, Jianming , FERGUSON, Ronald , GAO, Xiaolei , HARRISON, Scott , KNOWLES, Sandra L. , LO, Michael Man-Chu , MAZZOLA, Robert D. Jr. , SCHUBERT, Jeffrey W.
IPC分类号： C07D403/12 , C07D403/14 , C07D413/14 , A61K31/495 , A61P25/18
摘要： The present invention is directed to heteroarylpiperidine ether compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.

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