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1. 发明申请

WO2013040212A2 UNIQUE TRANSCRIPTIONAL SIGNATURES IN THE BLOOD OF CLINICAL RESPONDERS 审中-公开
标题翻译：在临床应答者血液中的唯一转录签名
公开(公告)号：WO2013040212A2
公开(公告)日：2013-03-21
申请号：PCT/US2012/055168
申请日：2012-09-13
申请人： BAYLOR RESEARCH INSTITUTE , PALUCKA, Anna, Karolina , ROSELLO-URGELL, Jose , BANCHEREAU, Jacques, F. , FAY, Joseph , CHAUSSABEL, Damien
发明人： PALUCKA, Anna, Karolina , ROSELLO-URGELL, Jose , BANCHEREAU, Jacques, F. , FAY, Joseph , CHAUSSABEL, Damien
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/178
摘要： A method for using the blood transcriptional profile of patients with stage IV melanoma to generate networks associated with the possibility of prolonged survival and networks associated with clinical responses to dendritic cell (DC) vaccination as measured by tumor regression are disclosed herein.
摘要翻译：利用IV期黑素瘤患者的血液转录特征来生成与长期存活的可能性相关的网络和通过肿瘤消退测量的与对树突细胞（DC）疫苗接种的临床反应有关的网络的方法在此公开。

2. 发明申请

WO2007044450A3 COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER 审中-公开
标题翻译：用于治疗癌症的组合物和方法
公开(公告)号：WO2007044450A3
公开(公告)日：2009-04-23
申请号：PCT/US2006038940
申请日：2006-10-06
申请人： BAYLOR RES INST , BANCHEREAU JACQUES F , PALUCKA ANNA KAROLINA
发明人： BANCHEREAU JACQUES F , PALUCKA ANNA KAROLINA
IPC分类号： A61K39/00 , A61K38/00
CPC分类号： A01K67/0271 , A01K2227/105 , A01K2267/0331 , A61K38/1793 , A61K38/2086 , A61K39/395 , A61K45/06
摘要： The present invention includes compositions and methods for the treatment of cancers by controlling the type of immune response mounted against the tumor, and more particularly, the treatment of tumors with cytokine antagonists to change the type of helper T cell response and inhibition of angiogenesis, prevention of formation of metastasis and prevention of formation of tumor stroma.
摘要翻译：本发明包括通过控制针对肿瘤的免疫应答的类型来治疗癌症的组合物和方法，更具体地，用细胞因子拮抗剂治疗肿瘤以改变辅助性T细胞应答的类型和抑制血管发生，预防形成转移和预防肿瘤基质的形成。

3. 发明申请

WO2008024642A3 GENE EXPRESSION SIGNATURES IN BLOOD LEUKOCYTES PERMIT DIFFERENTIAL DIAGNOSIS OF ACUTE INFECTIONS 审中-公开
标题翻译：基因表达特征在急性白血病患者血清白细胞介素的差异诊断中的价值
公开(公告)号：WO2008024642A3
公开(公告)日：2008-12-04
申请号：PCT/US2007075713
申请日：2007-08-10
申请人： BAYLOR RES INST , UNIV TEXAS , BANCHEREAU JACQUES F , PALUCKA ANNA KAROLINA , RAMILO OCTAVIO , CHAUSSABEL DAMIEN
发明人： BANCHEREAU JACQUES F , PALUCKA ANNA KAROLINA , RAMILO OCTAVIO , CHAUSSABEL DAMIEN
IPC分类号： C12Q1/68 , C12P19/34 , G01N33/48
CPC分类号： C12Q1/6883 , C12Q2600/112 , C12Q2600/156 , C12Q2600/158
摘要： The present invention includes compositions, systems and methods for the early detection and consistent determination of the extent, type and nature of a host immune response and the nature of the infectious disease using gene expression data.
摘要翻译：本发明包括用于使用基因表达数据早期检测和一致确定宿主免疫应答的程度，类型和性质以及传染病性质的组合物，系统和方法。

4. 发明申请

WO2007044648A3 ONCOHUMOUSE 审中-公开
公开(公告)号：WO2007044648A3
公开(公告)日：2007-12-06
申请号：PCT/US2006039354
申请日：2006-10-06
申请人： BAYLOR RES INST , BACHEREAU JACQUES F , PALUCKA ANNA KAROLINA
发明人： BACHEREAU JACQUES F , PALUCKA ANNA KAROLINA
IPC分类号： G01N33/00 , A01K67/00 , C12N5/00
CPC分类号： A01K67/0271 , A01K2227/105 , A01K2267/0331 , A01K2267/0381
摘要： The present invention includes a model system and use of the same for the study, manipulation and focusing of the human immune in a mammal, e.g., a nonhuman mammal that is immune deficient with one or more human hematopoietic progenitor cells and one or more human tumor cell lines.
摘要翻译：本发明包括模型系统及其用于研究，操纵和聚焦哺乳动物（例如，与一种或多种人类造血祖细胞和一种或多种人肿瘤免疫缺陷的非人类哺乳动物）的研究，操作和聚焦的用途细胞系。

5. 发明申请

WO2006086586A3 ANTI-INTERFERON ALPHA MONOCLONAL ANTIBODIES AND METHODS FOR USE 审中-公开
标题翻译：抗干扰素α单克隆抗体及其使用方法
公开(公告)号：WO2006086586A3
公开(公告)日：2006-10-12
申请号：PCT/US2006004643
申请日：2006-02-09
申请人： BAYLOR RES INST , BANCHEREAU JACQUES , PRILLIMAN KILEY , PASCUAL VIRGINIA , PALUCKA ANNA KAROLINA
发明人： BANCHEREAU JACQUES , PRILLIMAN KILEY , PASCUAL VIRGINIA , PALUCKA ANNA KAROLINA
IPC分类号： C07K16/24 , A61K39/395
CPC分类号： C07K16/249 , A61K2039/505 , C07K2317/24 , C07K2317/76
摘要： The present invention includes compositions and methods that include antibodies that selectively neutralize a bioactivity of at least two interferon alpha ("IFNa") protein subtypes for the protein subtypes A, 2, B2, C, F, G, H2, 1, Jl, K, 4a, 4b and WA, but does not neutralize at least one bioactivity of IFNa protein subtype D. Examples of bioactivity for measurement include activation of the MxA promoter or antiviral activity and variants, derivatives and fragments thereof. The invention also includes host cells, hybridomas and plasmacytomas that produce antibodies. Because of their unique selectivity and affinity, the antibodies of the present invention are useful to detect IFNa subtypes in sample or tissue and/or for therapeutic applications that include, but are not limited to the treatment and/or amelioration of an IFNa related disorder such as SLE, lupus, type I diabetes, psoriasis, AIDS and Graft versus Host Disease.
摘要翻译：本发明包括组合物和方法，其包括选择性中和蛋白质亚型A，2，B2，C，F，G，H 2，1，J1， K，4a，4b和WA，但不中和IFNα蛋白亚型D的至少一种生物活性。用于测量的生物活性的实例包括MxA启动子或抗病毒活性的活化及其变体，衍生物和片段。本发明还包括产生抗体的宿主细胞，杂交瘤和浆细胞瘤。由于其独特的选择性和亲和力，本发明的抗体可用于检测样品或组织中的IFNα亚型和/或用于包括但不限于治疗和/或改善IFNα相关病症的治疗应用，例如如SLE，狼疮，I型糖尿病，牛皮癣，AIDS和移植物抗宿主病。

6. 发明申请

WO2012015662A1 IL-18 RECEPTOR AS A NOVEL TARGET OF REGULATORY T CELLS IN CANCER 审中-公开
标题翻译： IL-18受体作为癌症中调节性T细胞的新目标
公开(公告)号：WO2012015662A1
公开(公告)日：2012-02-02
申请号：PCT/US2011/044848
申请日：2011-07-21
申请人： BAYLOR RESEARCH INSTITUTE , UENO, Hideki , BANCHEREAU, Jacques F. , PALUCKA, Anna Karolina
发明人： UENO, Hideki , BANCHEREAU, Jacques F. , PALUCKA, Anna Karolina
IPC分类号： A61K39/395 , A61K38/20
CPC分类号： A61K38/20 , A61K38/164 , A61K38/168 , A61K38/465 , A61K45/06 , A61K47/6849 , A61K47/6851 , A61K51/1027 , A61K51/1045 , C07K16/2866 , G01N33/505 , G01N33/57407 , G01N33/6869 , G01N2333/54 , G01N2800/52 , A61K2300/00
摘要： Compositions and methods for use in preventing, inhibiting or reducing tumor cell growth comprising an effective amount of an active agent that kills IL-18 Receptor expressing T cells in admixture with a suitable diluent or carrier are described herein.
摘要翻译：本文描述了用于预防，抑制或减少肿瘤细胞生长的组合物和方法，其包含有效量的杀死IL-18受体表达T细胞的活性剂与合适的稀释剂或载体混合。

7. 发明申请

WO2011091319A3 DENDRITIC CELL VACCINES 审中-公开
标题翻译： DENDRITIC细胞疫苗
公开(公告)号：WO2011091319A3
公开(公告)日：2011-11-17
申请号：PCT/US2011022147
申请日：2011-01-21
申请人： BAYLOR RES INST , BANCHEREAU JACQUES F , MONTES MONICA , PALUCKA ANNA KAROLINA , SLOAN LOUIS M , LEVY YVES , AGENCE NATIONALE DE RECH S SUR LE SIDA ET LES HEPATITIS VIRALES
发明人： BANCHEREAU JACQUES F , MONTES MONICA , PALUCKA ANNA KAROLINA , SLOAN LOUIS M , LEVY YVES
IPC分类号： A61K39/12 , A61K31/18 , A61K38/04 , A61K38/16 , A61K39/21 , A61P31/18 , C12N5/0784
CPC分类号： C12N5/0639 , A61K39/12 , A61K39/21 , A61K2039/5154 , A61K2039/545 , A61K2039/6018 , C07K14/005 , C12N2501/052 , C12N2501/22 , C12N2501/24 , C12N2740/16222 , C12N2740/16234 , C12N2740/16322 , C12N2740/16334
摘要： Compositions and methods for the prophylaxis and treatment of human immunodeficiency virus (HIV) infections are disclosed herein. More specifically the present invention discloses describes an autologous dendritic cell (DC) vaccine product derived by culturing a patient's monocytes with granulocyte macrophage colony stimulating factor (GM-CSF) and interferon alpha 2b (IFN-a), loading the DC with a mixture of five lipopeptides of Gag, Nef and Pol HIV antigens, and, optionally activating the DC with lipopolysaccharide (LPS).
摘要翻译：本文公开了预防和治疗人类免疫缺陷病毒（HIV）感染的组合物和方法。更具体地，本发明公开了一种通过用粒细胞巨噬细胞集落刺激因子（GM-CSF）和干扰素α2b（IFN-α）培养患者的单核细胞衍生的自体树突状细胞（DC）疫苗产品， 5种Gag，Nef和Pol HIV抗原的脂肽，以及任选地用脂多糖（LPS）活化DC。

8. 发明申请

WO2009149382A2 ANTI-CD8 ANTIBODIES BLOCK PRIMING OF CYTOTOXIC EFFECTORS AND LEAD TO GENERATION OF REGULATORY CD8+T CELLS 审中-公开
标题翻译：抗CD8抗体阻断细胞毒性作用的细胞因子并导致调节性CD8 + T细胞的产生
公开(公告)号：WO2009149382A2
公开(公告)日：2009-12-10
申请号：PCT/US2009/046464
申请日：2009-06-05
申请人： BAYLOR RESEARCH INSTITUTE , BANCHEREAU, Jacques, F. , KLECHEVSKY, Eynav , PALUCKA, Anna, Karolina
发明人： BANCHEREAU, Jacques, F. , KLECHEVSKY, Eynav , PALUCKA, Anna, Karolina
IPC分类号： C07K16/28 , A61K39/395 , A61P37/06
CPC分类号： C07K16/2815 , A61K39/001 , A61K2035/122 , A61K2039/505 , C07K2317/73 , C12N5/0636 , C12N5/064 , C12N2501/22 , C12N2501/24 , C12N2501/26 , C12N2501/505
摘要： The present invention includes compositions and methods for inducing tolerance in a subject in need thereof comprising providing the subject with an effective amount of an anti-CD8 antibody sufficient in induce CD8 + T cell immune tolerance to allogeneic antigens.
摘要翻译：本发明包括用于在有需要的受试者中诱导耐受性的组合物和方法，其包括向受试者提供有效量的足以诱导对同种异体抗原的CD8 + T细胞免疫耐受的抗CD8抗体。

9. 发明申请

WO2008021976A3 ANTI-INTERFERON ALPHA MONOCLONAL ANTIBODIES AND METHODS FOR USE 审中-公开
标题翻译：抗干扰素ALPHA单克隆抗体及其使用方法
公开(公告)号：WO2008021976A3
公开(公告)日：2008-11-13
申请号：PCT/US2007075616
申请日：2007-08-09
申请人： BAYLOR RES INST , BANCHEREAU JACQUES , PRILLIMAN KILEY , PASCUAL VIRGINIA , PALUCKA ANNA KAROLINA
发明人： BANCHEREAU JACQUES , PRILLIMAN KILEY , PASCUAL VIRGINIA , PALUCKA ANNA KAROLINA
IPC分类号： C07K16/00 , A61K39/395 , C12P21/08 , G01N33/53
CPC分类号： C07K16/249 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/76
摘要： The present invention includes compositions and methods that include antibodies that selectively neutralize a bioactivity of at least two interferon alpha ("IFNa") protein subtypes for the protein subtypes A, 2, B2, C, F, G, H2, 1, J1, K, 4a, 4b and WA, but does not neutralize at least one bioactivity of IFNa protein subtype D. Examples of bioactivity for measurement include activation of the MxA promoter or antiviral activity and variants, derivatives and fragments thereof. The invention also includes host cells, hybridomas and plasmacytomas that produce antibodies. Because of their unique selectivity and affinity, the antibodies of the present invention are useful to detect IFNa subtypes in sample or tissue and/or for therapeutic applications that include, but are not limited to the treatment and/or amelioration of an IFNa related disorder such as SLE, lupus, type 1 diabetes, psoriasis, AIDS and Graft versus Host Disease.
摘要翻译：本发明包括组合物和方法，其包括选择性中和至少两种干扰素α（“IFNa”）蛋白亚型对于蛋白亚型A，2，B2，C，F，G，H2，1，J1的生物活性的抗体， K，4a，4b和WA，但不中和IFNa蛋白亚型D的至少一种生物活性。用于测量的生物活性的实例包括MxA启动子的活化或抗病毒活性及其变体，衍生物和片段。本发明还包括产生抗体的宿主细胞，杂交瘤和浆细胞瘤。由于其独特的选择性和亲和性，本发明的抗体可用于检测样品或组织和/或治疗应用中的IFNα亚型，包括但不限于IFNα相关病症的治疗和/或改善，例如如SLE，狼疮，1型糖尿病，牛皮癣，艾滋病和移植物抗宿主病。

10. 发明申请

WO2006086586A2 ANTI-INTERFERON ALPHA MONOCLONAL ANTIBODIES AND METHODS FOR USE 审中-公开
标题翻译：抗干扰素ALPHA单克隆抗体及其使用方法
公开(公告)号：WO2006086586A2
公开(公告)日：2006-08-17
申请号：PCT/US2006/004643
申请日：2006-02-09
申请人： BAYLOR RESEARCH INSTITUTE , BANCHEREAU, Jacques , PRILLIMAN, Kiley , PASCUAL, Virginia , PALUCKA, Anna Karolina
发明人： BANCHEREAU, Jacques , PRILLIMAN, Kiley , PASCUAL, Virginia , PALUCKA, Anna Karolina
CPC分类号： C07K16/249 , A61K2039/505 , C07K2317/24 , C07K2317/76
摘要： The present invention includes compositions and methods that include antibodies that selectively neutralize a bioactivity of at least two interferon alpha ("IFNα") protein subtypes for the protein subtypes A, 2, B2, C, F, G, H2, 1, Jl, K, 4a, 4b and WA, but does not neutralize at least one bioactivity of IFNα protein subtype D. Examples of bioactivity for measurement include activation of the MxA promoter or antiviral activity and variants, derivatives and fragments thereof. The invention also includes host cells, hybridomas and plasmacytomas that produce antibodies. Because of their unique selectivity and affinity, the antibodies of the present invention are useful to detect IFNα subtypes in sample or tissue and/or for therapeutic applications that include, but are not limited to the treatment and/or amelioration of an IFNα related disorder such as SLE, lupus, type I diabetes, psoriasis, AIDS and Graft versus Host Disease.
摘要翻译：本发明包括组合物和方法，其包括选择性中和至少两种干扰素α（“IFNa”）蛋白亚型对于蛋白质亚型A，2，B2，C，F，G，H2，1，J1的生物活性的抗体， K，4a，4b和WA，但不中和IFNa蛋白亚型D的至少一种生物活性。用于测量的生物活性的实例包括MxA启动子的活化或抗病毒活性及其变体，衍生物和片段。本发明还包括产生抗体的宿主细胞，杂交瘤和浆细胞瘤。由于其独特的选择性和亲和性，本发明的抗体可用于检测样品或组织和/或治疗应用中的IFNα亚型，包括但不限于IFNα相关病症的治疗和/或改善，作为SLE，狼疮，I型糖尿病，牛皮癣，艾滋病和移植物抗宿主病。

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