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1. 发明授权

US5580748A Diagnostic tests for alzheimers disease 失效
标题翻译：阿尔茨海默病的诊断试验
公开(公告)号：US5580748A
公开(公告)日：1996-12-03
申请号：US56456
申请日：1993-05-03
申请人： Daniel L. Alkon , Rene Etcheberrigaray , Etsuro Ito , Gary E. Gibson
发明人： Daniel L. Alkon , Rene Etcheberrigaray , Etsuro Ito , Gary E. Gibson
IPC分类号： C07K14/47 , C07K16/18 , G01N33/50 , G01N33/68 , C12Q1/02 , C12Q1/00
CPC分类号： G01N33/6872 , C07K14/4711 , C07K16/18 , G01N33/5091 , G01N33/6896 , G01N2800/2821 , Y10S436/811
摘要： The present invention is a method for the diagnosis of Alzheimer's disease using human cells. Specifically, the method detects differences between potassium channels in cells from Alzheimer's patient and normal donors, and differences in intracellular calcium concentrations between Alzheimer's and normal cells in response to chemicals known to increase intracellular calcium levels.
摘要翻译：本发明是使用人细胞诊断阿尔茨海默氏病的方法。具体地，该方法检测来自阿尔茨海默病患者和正常供体的细胞中的钾通道之间的差异，以及响应于已知增加细胞内钙水平的化学物质的阿尔茨海默氏症和正常细胞之间的细胞内钙浓度的差异。

2. 发明申请

US20190106727A1 Method for Measuring Protein and Nucleic Acid with Ultrahigh Sensitivity 审中-公开
公开(公告)号：US20190106727A1
公开(公告)日：2019-04-11
申请号：US16089488
申请日：2017-03-07
申请人： Etsuro Ito , TAUNS LABORATORIES, INC.
发明人： Etsuro Ito , Toshiaki Miura , Teruki Yoshimura , Satoshi Watabe
IPC分类号： C12Q1/32 , C12Q1/00 , G01N21/78 , G01N33/569 , G01N33/58
摘要： The present invention pertains to an enzymatic measurement method using an antibody-enzyme complex or a nucleic acid probe measurement method using an enzyme-labeled nucleic acid probe, in both of which the quantification of a product of a reaction by an enzyme in the antibody-enzyme complex or the enzyme-labeled nucleic acid probe is performed by generating thio-NAD(P)H by an enzymatic cycling reaction using NAD(P)H, thio-NAD(P), and a dehydrogenase (DH), and measuring the amount of the generated thio-NAD(P)H or measuring a change in color caused by the generated thio-NAD(P)H. An enzymatic reaction system in which NAD(P) generated from NAD(P)H by the enzymatic cycling reaction is selectively reduced, is caused to coexist with the enzymatic cycling reaction. The present invention also pertains to a kit for enzyme immunoassay, and a kit for nucleic acid probe measurement. In the enzymatic cycling reaction, the detection sensitivity is increased by increasing the amount of thio-NAD(P)H generated per unit time with respect to a predetermined amount of a substrate (reduced), and combining the same with an enzyme immunoassay, etc., enables quantification, etc., of a protein or nucleic acid with high sensitivity.

3. 发明申请

US20180106727A1 ULTRA-HIGH-SENSITIVE ASSAY OF PROTEIN AND NUCLEIC ACID AND KIT, AND NOVEL ENZYME SUBSTRATE 审中-公开
公开(公告)号：US20180106727A1
公开(公告)日：2018-04-19
申请号：US15845702
申请日：2017-12-18
申请人： Etsuro ITO , Satoshi WATABE , Toshiaki MIURA , Teruki YOSHIMURA
发明人： Etsuro ITO
IPC分类号： G01N21/78 , G01N21/25 , C12Q1/00 , C12Q1/34 , C12Q1/42 , C12Q1/28
CPC分类号： G01N21/78 , C12Q1/008 , C12Q1/28 , C12Q1/34 , C12Q1/42 , G01N21/25 , G01N2333/90209 , G01N2333/916 , G01N2333/924
摘要： Provided is a ultra-high-sensitivity assay in which the assay can be made on a commonly used assay apparatus such as an absorptiometer and a plate reader or with naked eyes. The high-sensitivity assay in which the assay can be made on a commonly used assay apparatus or with naked eyes can be provided by combining an enzyme cycling method using thio-NAD(P) as a coenzyme, a labeling enzyme and a substrate for the labeling enzyme optimally, and by amplifying thio-NAD(P)H, which is a signaling substance, exponentially and then quantifying the thio-NAD(P)H colorimetrically.

4. 发明授权

US5753826A Flow meter having a vibration dampener 失效
标题翻译：具有振动阻尼器的流量计
公开(公告)号：US5753826A
公开(公告)日：1998-05-19
申请号：US697416
申请日：1996-08-23
申请人： Osamu Kashimura , Etsuro Ito , Michihiko Tsuruoka
发明人： Osamu Kashimura , Etsuro Ito , Michihiko Tsuruoka
IPC分类号： G01F1/32 , H01L29/06
CPC分类号： G01F1/3263 , G01F1/3209
摘要： The invention concerns a Karman's vortex flow meter including dampening members for absorbing vibrations. A stopper is provided to permit limited movement between an amplifier casing and a supporting stand containing a flow detector. The stopper is coupled to one of the supporting stand and the casing and extends into a hole in the other of the supporting stand and the casing. The flow meter includes an elastic member positioned in the hole between the stopper and the other of the supporting stand and the casing so that the stopper and the other of the supporting stand and the casing are out of direct contact. The elastic member absorbs vibrations and prevents direct contact of the components to ensure accurate flow measurement.
摘要翻译：本发明涉及卡曼的涡流流量计，其包括用于吸收振动的阻尼构件。提供止动件以允许放大器壳体和容纳流量检测器的支撑架之间的有限运动。止动件联接到支撑架和壳体中的一个并延伸到支撑架和壳体中的另一个中的孔中。流量计包括定位在止动件和支撑架和壳体中的另一个之间的孔中的弹性构件，使得止动件和支撑架和壳体中的另一个不直接接触。弹性构件吸收振动并防止部件的直接接触以确保精确的流量测量。

5. 发明申请

US20140017675A1 ULTRA-HIGH-SENSITIVE ASSAY OF PROTEIN AND NUCLEIC ACID AND KIT, AND NOVEL ENZYME SUBSTRATE 有权
标题翻译：蛋白质和核酸和试剂盒的超高敏感性测定和新型酶基质
公开(公告)号：US20140017675A1
公开(公告)日：2014-01-16
申请号：US14006317
申请日：2012-03-23
申请人： Etsuro Ito
发明人： Etsuro Ito
IPC分类号： G01N21/78
CPC分类号： G01N21/78 , C12Q1/008 , C12Q1/28 , C12Q1/34 , C12Q1/42 , G01N21/25 , G01N2333/90209 , G01N2333/916 , G01N2333/924
摘要： Provided is a ultra-high-sensitivity assay in which the assay can be made on a commonly used assay apparatus such as an absorptiometer and a plate reader or with naked eyes. The high-sensitivity assay in which the assay can be made on a commonly used assay apparatus or with naked eyes can be provided by combining an enzyme cycling method using thio-NAD(P) as a coenzyme, a labeling enzyme and a substrate for the labeling enzyme optimally, and by amplifying thio-NAD(P)H, which is a signaling substance, exponentially and then quantifying the thio-NAD(P)H colorimetrically.
摘要翻译：提供了一种超高灵敏度测定法，其中可以在常用的测定装置如吸光计和平板读数器或用肉眼进行测定。可以通过组合使用硫代NAD（P）作为辅酶，标记酶和底物的酶循环方法，在常规测定装置或肉眼上进行测定的高灵敏度测定法标记酶最佳，并通过扩增作为信号传导物质的硫代NAD（P）H，以比色法定量硫代NAD（P）H。

6. 发明授权

US5602338A Differential pressure detecting apparatus 失效
标题翻译：差压检测装置
公开(公告)号：US5602338A
公开(公告)日：1997-02-11
申请号：US434710
申请日：1995-05-04
申请人： Mitsuru Tamai , Etsuro Ito , Masahiro Osakabe , Seiji Suzuki
发明人： Mitsuru Tamai , Etsuro Ito , Masahiro Osakabe , Seiji Suzuki
IPC分类号： G01L13/06 , G01L9/00 , G01L13/02 , G01L19/00 , G01L19/06 , G01L19/14 , G01L15/00
CPC分类号： G01L19/14 , G01L13/025 , G01L9/0072
摘要： A differential pressure detecting apparatus includes a columnar main body wherein a differential pressure detection portion is inserted into a closed-end hole having a countersunk portion and formed in the outer circumferential surface of said main body at right angles to the axis of the main body, wherein a first seal diaphragm for receiving one of introduced pressures relating to a differential pressure to be measured is provided in one end surface of the main body, and wherein the main body has a hole provided for transmitting the received introduced pressure to the differential pressure detection portion; a disc-like sub-body inserted into the countersunk portion of the closed-end hole, wherein a second seal diaphragm for receiving the other introduced pressure is provided in the outer end surface of the sub-body, and wherein a hole is provided for transmitting the received introduced pressure to the differential pressure detection portion; a cover provided on the one end surface of the main body, and having a hole for the one introduced pressure for the first seal diaphragm; and another cover provided on the outer circumferential surface of the main body, and having a hole for the other introduced pressure for the second seal diaphragm.
摘要翻译：差压检测装置包括柱状主体，其中差压检测部分插入到具有埋头部分的封闭端孔中，并且形成在与本体的轴线成直角的所述主体的外周表面中，其特征在于，在所述主体的一个端面设置有用于接受与要测量的压差有关的导入压力中的一个的第一密封膜，其中，所述主体具有用于将所述接受的引入压力传递到所述差压检测一部分; 插入到所述封闭端孔的埋头部的盘状副体，其中，在所述副体的外端面设置有用于接收另一导入压力的第二密封膜，并且，设置有用于将所接收的引入的压力传递到差压检测部分; 盖体，设置在主体的一个端面上，并具有用于第一密封膜片的一个引入压力的孔; 以及设置在主体的外周面上的另一个盖，并且具有用于第二密封隔膜的另一个引入压力的孔。

7. 发明授权

US11221299B2 Ultra-high-sensitive assay of protein and nucleic acid and kit, and novel enzyme substrate 有权
公开(公告)号：US11221299B2
公开(公告)日：2022-01-11
申请号：US15845702
申请日：2017-12-18
申请人： Etsuro Ito , Satoshi Watabe , Toshiaki Miura , Teruki Yoshimura
发明人： Etsuro Ito
IPC分类号： G01N21/78 , G01N21/25 , C12Q1/00 , C12Q1/34 , C12Q1/42 , C12Q1/28
摘要： Provided is a ultra-high-sensitivity assay in which the assay can be made on a commonly used assay apparatus such as an absorptiometer and a plate reader or with naked eyes. The high-sensitivity assay in which the assay can be made on a commonly used assay apparatus or with naked eyes can be provided by combining an enzyme cycling method using thio-NAD(P) as a coenzyme, a labeling enzyme and a substrate for the labeling enzyme optimally, and by amplifying thio-NAD(P)H, which is a signaling substance, exponentially and then quantifying the thio-NAD(P)H colorimetrically.

8. 发明授权

US09851309B2 Ultra-high-sensitive assay of protein and nucleic acid and kit, and novel enzyme substrate 有权
公开(公告)号：US09851309B2
公开(公告)日：2017-12-26
申请号：US14006317
申请日：2012-03-23
申请人： Etsuro Ito
发明人： Etsuro Ito
IPC分类号： G01N21/78 , G01N21/25 , C12Q1/00 , C12Q1/28 , C12Q1/34 , C12Q1/42
CPC分类号： G01N21/78 , C12Q1/008 , C12Q1/28 , C12Q1/34 , C12Q1/42 , G01N21/25 , G01N2333/90209 , G01N2333/916 , G01N2333/924
摘要： Provided is a ultra-high-sensitivity assay in which the assay can be made on a commonly used assay apparatus such as an absorptiometer and a plate reader or with naked eyes. The high-sensitivity assay in which the assay can be made on a commonly used assay apparatus or with naked eyes can be provided by combining an enzyme cycling method using thio-NAD(P) as a coenzyme, a labeling enzyme and a substrate for the labeling enzyme optimally, and by amplifying thio-NAD(P)H, which is a signaling substance, exponentially and then quantifying the thio-NAD(P)H colorimetrically.

9. 发明授权

US5563350A Karman's vortex flow meter 失效
标题翻译：卡曼的涡流流量计
公开(公告)号：US5563350A
公开(公告)日：1996-10-08
申请号：US263339
申请日：1994-06-21
申请人： Osamu Kashimura , Etsuro Ito
发明人： Osamu Kashimura , Etsuro Ito
IPC分类号： G01F1/32 , H01L29/06
CPC分类号： G01F1/3263 , G01F1/3209 , G01F1/3245
摘要： A Karman's vortex flow meter eliminates the problem of external vibration resonating an amplifier casing to lower measurement accuracy of a vortex detecting section. In the flow meter, O-rings fit in two annular grooves formed on an outer surface of a supporting stand hollow cylinder. A casing fits onto the hollow cylinder of the supporting stand with the two O-rings being placed therebetween. A pair of blind holes or recesses formed in the hollow cylinder diametrically oppose one another and are located between the two O-rings. Bolts inserted into the recesses with gaps spaced around their end portions serve as stoppers by limiting axial movement of the casing with respect to the hollow cylinder.
摘要翻译：卡曼的涡流流量计消除了外部振动使放大器壳体谐振以降低涡流检测部分的测量精度的问题。在流量计中，O形圈装配在形成在支撑架中空圆柱体的外表面上的两个环形槽中。套管装配在支撑架的中空圆柱体上，其中两个O形环被放置在其间。形成在中空圆柱体中的一对盲孔或凹槽直径相对地相对并且位于两个O形环之间。通过限制壳体相对于中空圆柱体的轴向运动，插入到具有围绕其端部间隔开的间隙的凹部中的螺栓用作塞子。

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