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1. 发明授权

US08037903B2 Micromachined electrowetting microfluidic valve 有权
标题翻译：微加工电润湿微流控阀
公开(公告)号：US08037903B2
公开(公告)日：2011-10-18
申请号：US12080794
申请日：2008-04-03
申请人： Mark Y. Wang , Zhiliang Wan , Harshal Surangalikar , Guanghua Wu , Erhan Ata
发明人： Mark Y. Wang , Zhiliang Wan , Harshal Surangalikar , Guanghua Wu , Erhan Ata
IPC分类号： F15C1/04
CPC分类号： F15C5/00 , B01L3/502738 , B01L2300/1833 , B01L2400/0427 , B01L2400/0442 , B01L2400/0688 , F16K99/0017 , F16K99/0019 , F16K99/0051 , Y10T137/2196 , Y10T137/2224
摘要： This invention relates to a systems and methods of controlling the flow of a fluid in a capillary or microfluidic channel. A first pair of electrodes can influence the wetting of a fluid front at a relatively hydrophobic surface in the channel. A second pair of electrodes can electrolytically generate a bubble that can stop fluid flow when it contacts the hydrophobic surface. Flow of a fluid in a channel can be stopped on contact with the hydrophobic surface and restarted when an electrostatic field reduces the contact angle of the fluid at the hydrophobic surface. The electrostatic field can be removed and the fluid stopped again when an electrolytically generated bubble contacts the hydrophobic surface to reestablish the blocking contact angle of the fluid, gas and surface.
摘要翻译：本发明涉及一种控制毛细管或微流体通道中的流体流动的系统和方法。第一对电极可以影响通道中相对疏水的表面处的流体前沿的润湿。第二对电极可以电解产生气泡，当气泡接触疏水表面时可以阻止流体流动。通道中的流体的流动可以在与疏水表面接触时停止，并且当静电场减小疏水表面处的流体的接触角时重新开始。当电解产生的气泡接触疏水表面以重新建立流体，气体和表面的阻塞接触角时，可以去除静电场并再次停止流体。

2. 发明申请

US20080257438A1 Micromachined electrowetting microfluidic valve 有权
标题翻译：微加工电润湿微流控阀
公开(公告)号：US20080257438A1
公开(公告)日：2008-10-23
申请号：US12080794
申请日：2008-04-03
申请人： Mark Y. Wang , Zhiliang Wan , Harshal Surangalikar , Guanghua Wu , Erhan Ata
发明人： Mark Y. Wang , Zhiliang Wan , Harshal Surangalikar , Guanghua Wu , Erhan Ata
IPC分类号： F15C1/06
CPC分类号： F15C5/00 , B01L3/502738 , B01L2300/1833 , B01L2400/0427 , B01L2400/0442 , B01L2400/0688 , F16K99/0017 , F16K99/0019 , F16K99/0051 , Y10T137/2196 , Y10T137/2224
摘要： This invention relates to a systems and methods of controlling the flow of a fluid in a capillary or microfluidic channel. A first pair of electrodes can influence the wetting of a fluid front at a relatively hydrophobic surface in the channel. A second pair of electrodes can electrolytically generate a bubble that can stop fluid flow when it contacts the hydrophobic surface. Flow of a fluid in a channel can be stopped on contact with the hydrophobic surface and restarted when an electrostatic field reduces the contact angle of the fluid at the hydrophobic surface. The electrostatic field can be removed and the fluid stopped again when an electrolytically generated bubble contacts the hydrophobic surface to reestablish the blocking contact angle of the fluid, gas and surface.
摘要翻译：本发明涉及一种控制毛细管或微流体通道中的流体流动的系统和方法。第一对电极可以影响通道中相对疏水的表面处的流体前沿的润湿。第二对电极可以电解产生气泡，当气泡接触疏水表面时可以阻止流体流动。通道中的流体的流动可以在与疏水表面接触时停止，并且当静电场减小疏水表面处的流体的接触角时重新开始。当电解产生的气泡接触疏水表面以重新建立流体，气体和表面的阻塞接触角时，可以去除静电场并再次停止流体。

3. 发明申请

US20050164158A1 Microfluidic sorting device 有权
标题翻译：微流控分选装置
公开(公告)号：US20050164158A1
公开(公告)日：2005-07-28
申请号：US10848972
申请日：2004-05-18
申请人： Mark Wang , Erhan Ata , Sadik Esener
发明人： Mark Wang , Erhan Ata , Sadik Esener
IPC分类号： G21K1/00 , H05H3/04 , B32B5/02
CPC分类号： H05H3/04 , Y10T428/24744
摘要： Small particles, for example 5 μm diameter microspheres or cells, within, and moving with, a fluid, normally water, that is flowing within microfluidic channels within a radiation-transparent substrate, typically molded PDMS clear plastic, are selectively manipulated, normally by being pushed with optical pressure forces, with laser light, preferably as arises from VCSELs operating in Laguerre-Gaussian mode, at branching junctions in the microfluidic channels so as to enter into selected downstream branches, thereby realizing particle switching and sorting, including in parallel. Transport of the small particles thus transpires by microfluidics while manipulation in the manner of optical tweezers arises either from pushing due to optical scattering force, or from pulling due to an attractive optical gradient force. Whether pushed or pulled, the particles within the flowing fluid may be optically sensed, and highly-parallel. low-cost, cell- and particle-analysis devices efficiently realized, including as integrated on bio-chips.
摘要翻译：选择性地操纵在通常模制的PDMS透明塑料的辐射透明基底内的微流体通道内流动的流体（通常为水）内的微粒，例如5微米直径的微球或细胞，通常是通过通过激光照射，优选地是以在Laguerre-Gaussian模式下操作的VCSEL产生的激光照射在微流体通道中的分支结处，从而进入选择的下游分支，从而实现包括并行的粒子切换和分选。小颗粒的传输从而由Microfluidics蒸腾作用而在操纵光学镊子的方式出现无论是从推由于光学散射力，或由于从拉至一个有吸引力的光学梯度力。无论是推动还是被拉动，流动流体中的颗粒可以被光学感测并且高度平行。低成本，细胞和粒子分析装置有效实现，包括集成在生物芯片上。

4. 发明申请

US20060280319A1 Micromachined Capacitive Microphone 审中-公开
标题翻译：微加工电容麦克风
公开(公告)号：US20060280319A1
公开(公告)日：2006-12-14
申请号：US11160071
申请日：2005-06-08
申请人： Yunlong Wang , Erhan Ata , Guanghua Wu
发明人： Yunlong Wang , Erhan Ata , Guanghua Wu
IPC分类号： H04R25/00
CPC分类号： H04R19/005 , B81B3/0072 , B81B2201/0257 , B81B2203/0127
摘要： This invention relates to a micromachined capacitive microphone having a shallowly corrugated diaphragm that is anchored at one or more locations on the support has a plurality of dimples to support itself and rest freely on the perforated backplate. The diaphragm whose ends are not anchored is bounded by the taps of edge rail. Also disclosed includes: a fixed perforated backplate having one or more regions; an adjustable cantilever formed by the diaphragm, the support and the backplate; a plurality of dimples maintaining vertical separation between diaphragm and backplate; and the patterning of conductor electrodes carried by diaphragm and backplate.
摘要翻译：本发明涉及一种微加工电容式麦克风，其具有在支撑体上的一个或多个位置处锚固的浅波形隔膜，其具有多个凹坑以支撑自身并且自由地搁置在多孔背板上。端部未锚定的隔膜由边缘导轨的水龙头限定。还公开了一种具有一个或多个区域的固定多孔背板; 由隔膜，支撑件和背板形成的可调节悬臂; 多个凹坑保持隔膜和背板之间的垂直分隔; 以及由隔膜和背板承载的导体电极的图案化。

5. 发明授权

US07014742B2 Positioning of organic and inorganic objects by electrophoretic forces, including for microlens alignment 失效
公开(公告)号：US07014742B2
公开(公告)日：2006-03-21
申请号：US10099133
申请日：2002-03-15
申请人： Aaron L. Birkbeck , Sadik C. Esener , Mihrimah Ozkan , Erhan Ata
发明人： Aaron L. Birkbeck , Sadik C. Esener , Mihrimah Ozkan , Erhan Ata
IPC分类号： G01N27/447 , G01N27/453 , G02F1/29
CPC分类号： B01D57/02 , B03C5/026 , G02B7/023 , G02B7/027
摘要： An adaptive alignment technique provides precise control and active positioning in, preferably, two-dimensions of sub-millimeter-sized objects such as, in one application, spherical mircolenses through the application of electrophoretic forces in a microfluidic wells. A lithographically patterned microfluidic well and electrodes can be addressed to position or align a spherical microlens to a corresponding laser light beam. The motion of the microlens is preferably controlled using CMOS compatible voltages (3V–1 μA) that are preferably applied to opposite electrodes in the microfluidic well, creating an electrical field in a well solution. By applying voltages to opposed electrode pairs, movement of spherical microlenses with sizes ranging from, most typically, 0.87 μm to 40 μm in directions parallel to the electrode surface is realized. Under a bias of 3 volts, the microspheres have electrophoretic velocities ranging from 13 to 16 μm/s. Optical alignment of the spherical microlens, as is preferably accomplished by use of feedback from a photo detector, serves to position the microlens for maximum efficiency. Microlenses or other optical elements may thus be aligned to optical fibers, VCSELs, LEDs, photodetectors, etc.

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