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1. 发明申请

WO2012136695A1 DEVICE COMPRISING ROWS OF MAGNETIC ELEMENTS IN CHANNELS AND COMPARTMENTS 审中-公开
标题翻译：包含通道和隔间的磁性元件的装置的装置
公开(公告)号：WO2012136695A1
公开(公告)日：2012-10-11
申请号：PCT/EP2012/056143
申请日：2012-04-04
申请人： BIOMAGNETICS AB , SVEDLINDH, Peter , BRUCAS, Rimantas , STJERNBERG BEJHED, Rebecca , OSCARSSON, Sven , GUNNARSSON, Klas , ERIKSSON, Kristofer
发明人： SVEDLINDH, Peter , BRUCAS, Rimantas , STJERNBERG BEJHED, Rebecca , OSCARSSON, Sven , GUNNARSSON, Klas , ERIKSSON, Kristofer
IPC分类号： B01L3/00 , B01L9/00 , G01N33/543
CPC分类号： B01L3/502761 , B01L3/502707 , B01L9/527 , B01L2300/088 , B01L2300/089 , B01L2400/043
摘要： A device comprises at least two compartments, said at least two compartments being in fluid connection via at least one channel, each channel comprising at least one row of magnetic elements, wherein each row of magnetic elements form a transportation line from one compartment through the at least one channel and further into at least one another compartment, wherein each magnetic element is a magnetic field source with directional properties determined by the direction of the element magnetization with respect to the element geometry, and wherein said magnetic elements comprise at least one ferromagnetic material, wherein said transportation line is adapted to transport magnetic beads when an external changing magnetic field is applied. Advantages of the invention include that it provides the possibility to move beads and/or a sample attached to beads and to analyze or separate molecules in separate compartments in a controlled way.
摘要翻译：一种装置包括至少两个隔间，所述至少两个隔室通过至少一个通道处于流体连接状态，每个通道包括至少一排磁性元件，其中每排磁性元件形成从一个隔室穿过该通道的输送线至少一个通道并且进一步进入至少另一个隔间，其中每个磁性元件是具有由所述元件磁化相对于所述元件几何形状的方向确定的定向特性的磁场源，并且其中所述磁性元件包括至少一个铁磁材料其中所述输送线适用于在施加外部变化磁场时运送磁珠。本发明的优点包括其提供移动珠子和/或连接到珠粒上的样品并以受控方式分析或分离分开的隔室中的分子的可能性。

2. 发明申请

WO2012013693A1 COVALENT IMMOBILIZATION OF MOLECULES COMPRISING AN AMINO GROUP 审中-公开
标题翻译：包含氨基的分子的共价固定
公开(公告)号：WO2012013693A1
公开(公告)日：2012-02-02
申请号：PCT/EP2011/062865
申请日：2011-07-27
申请人： LAB-ON-A-BEAD AB , OSCARSSON, Sven , ERIKSSON, Kristofer , NYHOLM, Leif
发明人： OSCARSSON, Sven , ERIKSSON, Kristofer , NYHOLM, Leif
IPC分类号： G01N33/543
CPC分类号： C07K17/10 , C07K17/14 , C12N11/00 , G01N33/54353
摘要： There is provided a method for covalent immobilization of at least one molecule comprising at least one amino group, said method comprising the sequential steps of: a) providing a surface comprising -SH groups, b) oxidizing the surface comprising -SH groups using redox reactions in the presence of noble metal ions, and c)contacting the surface with at least one molecule comprising at least one amino group to obtain a covalent binding of the at least one molecule to the surface, wherein said at least one amino group is involved in obtaining said covalent bond. The immobilized molecules are immobilized via stable covalent bonds. The method is more versatile since it can be performed as a one step method. All reaction steps are performed in aqueous solution. All steps can be performed at room temperature. The chemicals used are less expensive and less toxic compared to the prior art.
摘要翻译：提供了至少一种包含至少一个氨基的分子共价固定的方法，所述方法包括以下顺序步骤：a）提供包含-SH基团的表面，b）使用氧化还原反应氧化包含-SH基团的表面在贵金属离子的存在下，和c）使所述表面与至少一个包含至少一个氨基的分子接触，以获得所述至少一个分子与所述表面的共价结合，其中所述至少一个氨基参与获得所述共价键。固定化的分子通过稳定的共价键固定。该方法更通用，因为它可以作为一步法进行。所有反应步骤均在水溶液中进行。所有步骤均可在室温下进行。与现有技术相比，使用的化学品便宜且毒性较小。

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