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1. 发明申请

US20180008581A1 ANTIFIBROTIC COMPOUNDS AND USES THEREOF 审中-公开
公开(公告)号：US20180008581A1
公开(公告)日：2018-01-11
申请号：US15462859
申请日：2017-03-19
申请人： Bijoy PANICKER , Rama K. MISHRA , Dong Sung LIM , Lambertus J.W.M. OEHLEN , Dawoon JUNG
发明人： Bijoy PANICKER , Rama K. MISHRA , Dong Sung LIM , Lambertus J.W.M. OEHLEN , Dawoon JUNG
IPC分类号： A61K31/437 , A61K31/5377 , A61K31/496
CPC分类号： A61K31/4353 , A61K31/437 , A61K31/496 , A61K31/5377 , C07D401/02 , C07D401/14 , C07D471/04
摘要： The present invention provides compounds having the general structural formula (I) and pharmaceutically acceptable derivatives thereof, as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of any of a number of conditions or diseases involving abnormal or excessive fibrosis.

2. 发明申请

US20150158853A1 CYTOCHROME P450 INHIBITORS AND USES THEREOF 审中-公开
标题翻译：细胞色素P450抑制剂及其用途
公开(公告)号：US20150158853A1
公开(公告)日：2015-06-11
申请号：US14493976
申请日：2014-09-23
申请人： Bijoy Panicker , Dong Sung Lim , Rama K. Mishra , Lambertus J.W.M. Oehlen , James G. Tarrant , Xiaokang Zhu , Dawoon Jung
发明人： Bijoy Panicker , Dong Sung Lim , Rama K. Mishra , Lambertus J.W.M. Oehlen , James G. Tarrant , Xiaokang Zhu , Dawoon Jung
IPC分类号： C07D417/06 , C07D417/14
CPC分类号： C07D417/06 , C07D417/04 , C07D417/12 , C07D417/14
摘要： The present invention provides compounds having the general structural formula (I) and pharmaceutically acceptable derivatives thereof, as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of any of a number of conditions or diseases involving fibrosis and proliferation, and where anti-fibrotic or anti-proliferative activity is beneficial.
摘要翻译：本发明提供具有一般结构式（I）的化合物及其药学上可接受的衍生物，如本文中一般和本类和亚类所述，并且另外提供其药物组合物，以及用于治疗任何一种涉及纤维化和增殖的病症或疾病，其中抗纤维化或抗增殖活性是有益的。

3. 发明申请

US20130102643A1 CYTOCHROME P450 INHIBITORS AND USES THEREOF 有权
公开(公告)号：US20130102643A1
公开(公告)日：2013-04-25
申请号：US13700730
申请日：2011-06-01
申请人： Bijoy Panicker , Lambertus J.W.M. Oehlen , James G. Tarrant , Dong Sung Lim , Xiaokang Zhu , Dawoon Jung , Rama K. Mishra
发明人： Bijoy Panicker , Lambertus J.W.M. Oehlen , James G. Tarrant , Dong Sung Lim , Xiaokang Zhu , Dawoon Jung , Rama K. Mishra
IPC分类号： C07D417/06
CPC分类号： C07D417/06 , C07D417/04 , C07D417/12 , C07D417/14
摘要： The present invention provides compounds having the general structural formula (I) and pharmaceutically acceptable derivatives thereof, as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of any of a number of conditions or diseases involving fibrosis and proliferation, and where anti-fibrotic or anti-proliferative activity is beneficial.

4. 发明授权

US06538804B1 Planar waveguide-type optical amplifier switch 失效
标题翻译：平面波导型光放大器开关
公开(公告)号：US06538804B1
公开(公告)日：2003-03-25
申请号：US09433455
申请日：1999-11-04
申请人： Kyong Hon Kim , Yong Gyu Choi , Hak Kyu Lee , Min Yong Jeon , Joon Tae Ahn , Dong Sung Lim , Ho Young Kim , Do Il Chang
发明人： Kyong Hon Kim , Yong Gyu Choi , Hak Kyu Lee , Min Yong Jeon , Joon Tae Ahn , Dong Sung Lim , Ho Young Kim , Do Il Chang
IPC分类号： H01S300
CPC分类号： G02F1/3132 , G02F1/225 , H01S5/4068 , H01S5/50
摘要： A planar waveguide-type optical amplifier switch is disclosed. The switch is developed with the purpose of solving the problems that the conventional waveguide-type optical switch, which has been being used in the optical communication technique, has an optical loss and thereby requires an external optical amplifier which makes the whole devices not suitable for forming an integrated compact device. The disclosed switch performs switching function from the refractive index change in the optical waveguides induced by electrical or optical controls as well as amplifying function of the optical signal, when it passes through the waveguides, from use of optical waveguides formed of a fluorescence emitting material with an optical pumping and a wavelength division multiplexing (WDM) optical waveguide-type coupler. The optical amplifier switch scheme, which provides a simultaneous optical switching and amplification in an optical waveguide form, allows the device fabricable in a compact integrated manner and more useful in practical applications. The optical amplifier switch in accordance with the present invention can replace the conventional optical switches of the prior art, and can promote technical development in the areas of high-capacity optical communication systems, massive optical signal processing, optical switching, optical computing, and so on.
摘要翻译：公开了一种平面波导型光放大器开关。开关是为了解决在光通信技术中使用的常规波导型光开关具有光损耗并因此需要外部光放大器的问题而开发的，这使得整个器件不适合于形成集成的紧凑型装置。所公开的开关从通过电光或光控制引起的光波导中的折射率变化执行切换功能，以及当光信号通过波导时放大功能，使用由荧光发射材料形成的光波导与光泵浦和波分复用（WDM）光波导型耦合器。提供光波导形式的同时光切换和放大的光放大器开关方案允许该器件以紧凑的集成方式可制造并且在实际应用中更有用。根据本发明的光放大器开关可以代替现有技术的传统光开关，并且可以促进大容量光通信系统，大规模光信号处理，光交换，光计算等领域的技术发展。上。

5. 发明申请

US20140018401A1 CYTOCHROME P450 INHIBITORS AND USES THEREOF 有权
标题翻译：细胞色素P450抑制剂及其用途
公开(公告)号：US20140018401A1
公开(公告)日：2014-01-16
申请号：US13935517
申请日：2013-07-04
申请人： Bijoy Panicker , Dong Sung Lim , Rama K. Mishra , Lambertus J.W.M. Oehlen , James G. Tarrant , Xiaokang Zhu , Dawoon Jung
发明人： Bijoy Panicker , Dong Sung Lim , Rama K. Mishra , Lambertus J.W.M. Oehlen , James G. Tarrant , Xiaokang Zhu , Dawoon Jung
IPC分类号： C07D417/12
CPC分类号： C07D417/06 , C07D417/04 , C07D417/12 , C07D417/14
摘要： The present invention provides compounds having the general structural formula (I) and pharmaceutically acceptable derivatives thereof, as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of any of a number of conditions or diseases involving fibrosis and proliferation, and where anti-fibrotic or anti-proliferative activity is beneficial.
摘要翻译：本发明提供具有一般结构式（I）的化合物及其药学上可接受的衍生物，如本文中一般和本类和亚类所述，并且另外提供其药物组合物，以及用于治疗任何一种涉及纤维化和增殖的病症或疾病，其中抗纤维化或抗增殖活性是有益的。

6. 发明授权

US08513291B2 Cytochrome P450 inhibitors and uses thereof 有权
标题翻译：细胞色素P450抑制剂及其用途
公开(公告)号：US08513291B2
公开(公告)日：2013-08-20
申请号：US13700730
申请日：2011-06-01
申请人： Bijoy Panicker , Lambertus J. W. M. Oehlen , James G. Tarrant , Dong Sung Lim , Xiaokang Zhu , Dawoon Jung , Rama K. Mishra
发明人： Bijoy Panicker , Lambertus J. W. M. Oehlen , James G. Tarrant , Dong Sung Lim , Xiaokang Zhu , Dawoon Jung , Rama K. Mishra
IPC分类号： C07D277/66 , C07D277/74 , C07D277/82 , A61K31/428
CPC分类号： C07D417/06 , C07D417/04 , C07D417/12 , C07D417/14
摘要： The present invention provides compounds having the general structural formula (I) and pharmaceutically acceptable derivatives thereof, as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of any of a number of conditions or diseases involving fibrosis and proliferation, and where anti-fibrotic or anti-proliferative activity is beneficial.
摘要翻译：本发明提供具有一般结构式（I）的化合物及其药学上可接受的衍生物，如本文中一般和本类和亚类所述，并且另外提供其药物组合物，以及用于治疗任何一种涉及纤维化和增殖的病症或疾病，其中抗纤维化或抗增殖活性是有益的。

7. 发明申请

US20110098304A1 Small molecule inhibitors of PARP activity 审中-公开
标题翻译： PARP活性的小分子抑制剂
公开(公告)号：US20110098304A1
公开(公告)日：2011-04-28
申请号：US12592163
申请日：2009-11-19
申请人： Bijoy Panicker , Dawoon Jung , Xiaokang Zhu , David E. Smith , Dong Sung Lim
发明人： Bijoy Panicker , Dawoon Jung , Xiaokang Zhu , David E. Smith , Dong Sung Lim
IPC分类号： A61K31/502 , C07D237/32 , A61P25/16 , A61P9/10 , A61P25/28 , A61P9/12 , A61P3/10 , A61P13/12 , A61P1/16
CPC分类号： C07D237/32 , A61K31/502
摘要： Componds and pharmaceutical compositions are provided that inhibit the activity of poly ADP-ribose synthetase (PARP). Such componds are useful in the treatment of various diseases, conditions and injuries such as stroke, myocardial infarction, ischemia-perfusion injury in various organs, traumatic brain injury, atherosclerosis, inflammatory diseases and cancer.
摘要翻译：提供了抑制聚ADP-核糖合成酶（PARP）的活性的组合物和药物组合物。这样的化合物可用于治疗各种疾病，病症和损伤，例如中风，心肌梗死，各种器官中的缺血灌注损伤，创伤性脑损伤，动脉粥样硬化，炎性疾病和癌症。

8. 发明授权

US6160627A Optical fiber Mach-Zehnder interferometer filter 失效
标题翻译：光纤马赫 - 曾德尔干涉仪滤波器
公开(公告)号：US6160627A
公开(公告)日：2000-12-12
申请号：US315998
申请日：1999-05-21
申请人： Joon Tae Ahn , Hak Kyu Lee , Min Yong Jeon , Dong Sung Lim , Kyong Hon Kim , El Hang Lee
发明人： Joon Tae Ahn , Hak Kyu Lee , Min Yong Jeon , Dong Sung Lim , Kyong Hon Kim , El Hang Lee
IPC分类号： G02B6/34 , G01B9/02
CPC分类号： G02B6/29353
摘要： An optical fiber Mach-Zehnder interferometer optical filter is disclosed. The filter includes a stabilization light source for varying a first wavelength of a light signal for stabilizing a Mach-Zehnder interferometer, first and second optical fiber couplers for receiving an optical signal from the stabilization light source and an optical signal of a second wavelength different from a first wavelength inputted from an input port and dividing into two parts having the same intensity for thereby forming a Mach-Zehnder interferometer, a polarization controller connected with one side of the first optical fiber coupler for controlling a polarization of the interfered light of the interferometer, first and second wavelength division multiplex optical couplers connected with the second optical fiber coupler for separately outputting a first wavelength optical signal and a second wavelength optical signal, an optical fiber phase modulator connected with the other side of the first optical fiber coupler for varying the length of the optical fiber in accordance with a fed-back phase difference, and a stabilization circuit for receiving two optical signals of the first wavelength from the first and second wavelength division multiplex optical couplers and feeding back the phase difference to the optical fiber phase modulator for thereby implementing a constant optical path difference of the interferometer.
摘要翻译：公开了一种光纤马赫 - 曾德干涉仪滤光器。滤光器包括用于改变用于稳定马赫 - 曾德干涉仪的光信号的第一波长的稳定光源，用于从稳定光源接收光信号的第一和第二光纤耦合器以及不同于从输入端口输入的第一波长并分成具有相同强度的两个部分，从而形成马赫 - 策德尔干涉仪;偏振控制器，与第一光纤耦合器的一侧连接，用于控制干涉仪的干涉光的偏振与第二光纤耦合器连接的第一和第二波分复用光耦合器，用于分别输出第一波长光信号和第二波长光信号;光纤相位调制器，与第一光纤耦合器的另一侧连接，用于改变根据光纤的长度反馈相位差，以及稳定电路，用于从第一和第二波分复用光耦合器接收第一波长的两个光信号，并将相位差反馈到光纤相位调制器，从而实现恒定的光程差的干涉仪。

9. 发明授权

US08865752B2 Cytochrome P450 inhibitors and uses thereof 有权
标题翻译：细胞色素P450抑制剂及其用途
公开(公告)号：US08865752B2
公开(公告)日：2014-10-21
申请号：US13935517
申请日：2013-07-04
申请人： Bijoy Panicker , Dong Sung Lim , Rama K. Mishra , Lambertus J. W. M. Oehlen , James G. Tarrant , Xiaokang Zhu , Dawoon Jung
发明人： Bijoy Panicker , Dong Sung Lim , Rama K. Mishra , Lambertus J. W. M. Oehlen , James G. Tarrant , Xiaokang Zhu , Dawoon Jung
IPC分类号： C07D417/12 , A61K31/428 , C07D417/06 , C07D417/04 , C07D417/14
CPC分类号： C07D417/06 , C07D417/04 , C07D417/12 , C07D417/14
摘要： The present invention provides compounds having the general structural formula (I) and pharmaceutically acceptable derivatives thereof, as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of any of a number of conditions or diseases involving fibrosis and proliferation, and where anti-fibrotic or anti-proliferative activity is beneficial.
摘要翻译：本发明提供具有一般结构式（I）的化合物及其药学上可接受的衍生物，如本文中一般和本类和亚类所述，并且另外提供其药物组合物，以及用于治疗任何一种涉及纤维化和增殖的病症或疾病，其中抗纤维化或抗增殖活性是有益的。

10. 发明申请

US20130303567A1 SMALL MOLECULE INHIBITORS OF PARP ACTIVITY 审中-公开
标题翻译：小分子抑制剂PARP活性
公开(公告)号：US20130303567A1
公开(公告)日：2013-11-14
申请号：US13941510
申请日：2013-07-14
申请人： Bijoy Panicker , Dong Sung Lim , David E. Smith
发明人： Bijoy Panicker , Dong Sung Lim , David E. Smith
IPC分类号： C07D403/04 , C07D401/04
CPC分类号： C07D403/04 , C07D401/04
摘要： Compounds and pharmaceutical compositions are provided that inhibit the activity of poly ADP-ribose synthetase (PARP). Such compounds are useful in the treatment of various diseases, conditions and injuries such as stroke, myocardial infarction, ischemia-perfusion injury in various organs, traumatic brain injury, atherosclerosis, inflammatory diseases and cancer.
摘要翻译：提供了抑制聚ADP-核糖合成酶（PARP）的活性的化合物和药物组合物。这些化合物可用于治疗各种疾病，病症和损伤如中风，心肌梗死，各种器官的缺血灌注损伤，创伤性脑损伤，动脉粥样硬化，炎性疾病和癌症。

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