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1. 发明公开

EP1413316A1 Bifunctional conjugates or fusion proteins 审中-公开
标题翻译： Bifunktionelle Konjugate oder Fusionsproteine
公开(公告)号：EP1413316A1
公开(公告)日：2004-04-28
申请号：EP02405838.0
申请日：2002-09-27
申请人： Robert, Bruno , Donda, Alena , Cesson, Valérie , Mach, Jean-Pierre
发明人： Robert, Bruno , Donda, Alena , Cesson, Valérie , Mach, Jean-Pierre
IPC分类号： A61K47/48
CPC分类号： C07K16/32 , A61K47/6811 , A61K47/6849 , A61K47/6851 , A61K47/6853 , A61K2039/505 , C07K14/70539 , C07K16/28 , C07K16/3007 , C07K2317/54 , C07K2317/55 , C07K2319/00
摘要： The invention relates to the coupling or to the genetically fusing of two different proteins: one, which has the property of binding selectively to a target cell, such as an antibody or a ligand for a receptor overexpressed on target cells, and one consisting of a monomorphic MHC class I related protein, such as MIC-A or -B, or ULBP, or CD1d. This conjugate or fusion protein is designed to be localized in vivo on the surface of the target cells such as tumor cells or cells involved in neoangiogenesis. The high density of these monomorphic MHC class I related proteins will activate effector cells such as NK, NKT or other T cells with the objective to kill the targeted cells. The advantage of these MHC class I related molecules is that since they are monomorphic, the same conjugate or fusion protein can be used in every patient. Furthermore, the NK or NKT cells being involved in innate immunity , the reaction will be more rapid than that of acquired immunity and will involve a much higher population than antigen-specific MHC restricted T cells
摘要翻译：包含一种或多种CD1d复合物和抗体或其对细胞表面标志物特异性的片段的化合物是新的。 CD1d复合物包含CD1d和β2-微球蛋白分子，并与抗体或其片段连接。还包括以下独立权利要求：（1）在哺乳动物中诱导抗肿瘤反应的方法，包括向哺乳动物施用上述化合物; 和（2）哺乳动物中预防或治疗自身免疫/炎性或感染性疾病的方法，包括向哺乳动物施用上述化合物。活动：细胞抑制抗炎; 免疫抑制; 抗菌; 神经保护; 降血糖; 抗关节炎; 抗风湿; 眼科; 胃肠道根; Nephrotropic; 抗甲状腺; 拟甲状腺素; 肌肉根; 银屑病; 皮肤; 抗贫血; 嗜肝; 抗溃疡。没有给出生物数据。作用机制：抗体治疗。

2. 发明申请

WO2008103392A3 MODULATION OF NKT CELL ACTIVITY WITH ANTIGEN-LOADED CDID MOLECULES 审中-公开
标题翻译： NKT细胞活性与抗原载体CDID分子的调节
公开(公告)号：WO2008103392A3
公开(公告)日：2008-12-04
申请号：PCT/US2008002256
申请日：2008-02-21
申请人： DONDA ALENA , MACH JEAN-PIERRE , STIRNEMANN KATHRIN , ZAUDERER MAURICE
发明人： DONDA ALENA , MACH JEAN-PIERRE , STIRNEMANN KATHRIN , ZAUDERER MAURICE
IPC分类号： A61K38/00 , A61K39/00 , A61K45/00 , C07K4/00 , C07K14/00
CPC分类号： A61K39/385 , A61K39/39 , A61K2039/55516 , A61K2039/55561 , A61K2039/55572 , A61K2039/55594 , A61K2039/6018 , C07K16/32 , C07K2319/00
摘要： The invention is directed to methods of modulating an immune response in an animal, comprising administering a composition comprising one or more soluble CDId complexes, in particular non-specific soluble CDId complexes. Soluble CDId complexes comprise a soluble CDId polypeptide, a ß2-microglobulin polypeptide, and a ceramide-like glycolipid antigen bound to the CDId antigen binding groove, and in certain embodiments, an immunogen. The administration of compositions of the present invention affects the activity of CD Id-restricted NKT cells, and in particular, allows for multiple administrations without causing CD Id-restricted NKT cell anergy.
摘要翻译：本发明涉及调节动物免疫应答的方法，其包括施用包含一种或多种可溶性CD1a络合物，特别是非特异性可溶性CD1a复合物的组合物。可溶性CD1d复合物包含与CD1d抗原结合槽结合的可溶性CD1d多肽，β2-微球蛋白多肽和神经酰胺样糖脂抗原，并且在某些实施方案中，是免疫原。本发明组合物的施用影响CD1d限制性NKT细胞的活性，特别是允许多次施用而不引起CD1受限制的NKT细胞无反应性。

3. 发明申请

WO2004029206A3 TARGETED CD1D MOLECULES 审中-公开
标题翻译：目标CD1D分子
公开(公告)号：WO2004029206A3
公开(公告)日：2004-10-07
申请号：PCT/US0330238
申请日：2003-09-26
申请人： VACCINEX INC , ZAUDERER MAURICE , ROBERT BRUNO , DONDA ALENA , CESSON VALERIE , MACH JEAN-PIERRE
发明人： ZAUDERER MAURICE , ROBERT BRUNO , DONDA ALENA , CESSON VALERIE , MACH JEAN-PIERRE
IPC分类号： A61K39/00 , A61K39/385 , A61K39/44 , C07K14/74 , C07K16/28 , C07K16/30
CPC分类号： C07K16/32 , A61K47/6811 , A61K47/6849 , A61K47/6851 , A61K47/6853 , A61K2039/505 , C07K14/70539 , C07K16/28 , C07K16/3007 , C07K2317/54 , C07K2317/55 , C07K2319/00
摘要： The invention is directed to a compound comprising one or more CD1d complexes in association with an antibody specific for a cell surface marker. The CD1d complexes comprise a CD1d, a ss2-microglobulin molecule, and may further comprise an antigen bound to the CD1d binding groove. The invention is further directed to methods of inhibiting or stimulating an immune response with the CD1d-antibody compounds, in particular anti-tumor and autoimmunity responses.
摘要翻译：本发明涉及包含一种或多种与特异于细胞表面标志物的抗体结合的CD1d复合物的化合物。 CD1d复合物包含CD1d，β2-微球蛋白分子，并且还可以包含与CD1d结合槽结合的抗原。本发明进一步涉及用CD1d抗体化合物抑制或刺激免疫应答的方法，特别是抗肿瘤和自身免疫应答。

4. 发明申请

WO2008103392A2 MODULATION OF NKT CELL ACTIVITY WITH ANTIGEN-LOADED CDID MOLECULES 审中-公开
标题翻译：用抗原负载的CDID分子调节NKT细胞活性
公开(公告)号：WO2008103392A2
公开(公告)日：2008-08-28
申请号：PCT/US2008/002256
申请日：2008-02-21
申请人： DONDA, Alena , MACH, Jean-pierre , STIRNEMANN, Kathrin , ZAUDERER, Maurice
发明人： DONDA, Alena , MACH, Jean-pierre , STIRNEMANN, Kathrin , ZAUDERER, Maurice
IPC分类号： A61K39/00 , A61K38/00 , C12N5/06 , A61K39/395 , A61P37/00
CPC分类号： A61K39/385 , A61K39/39 , A61K2039/55516 , A61K2039/55561 , A61K2039/55572 , A61K2039/55594 , A61K2039/6018 , C07K16/32 , C07K2319/00
摘要： The invention is directed to methods of modulating an immune response in an animal, comprising administering a composition comprising one or more soluble CDId complexes, in particular non-specific soluble CDId complexes. Soluble CDId complexes comprise a soluble CDId polypeptide, a β2-microglobulin polypeptide, and a ceramide-like glycolipid antigen bound to the CDId antigen binding groove, and in certain embodiments, an immunogen. The administration of compositions of the present invention affects the activity of CD Id-restricted NKT cells, and in particular, allows for multiple administrations without causing CD Id-restricted NKT cell anergy.
摘要翻译：本发明涉及调节动物免疫应答的方法，包括施用包含一种或多种可溶性CDId复合物，特别是非特异性可溶性CDId复合物的组合物。可溶性CD1d复合物包含可溶性CDId多肽，β2-微球蛋白多肽和与CD1d抗原结合沟相结合的神经酰胺类糖脂抗原，并且在某些实施方案中包含免疫原。本发明组合物的施用影响CD1d-限制性NKT细胞的活性，并且具体而言，允许多次施用而不引起CD1d-限制性NKT细胞无反应性。

5. 发明申请

WO2004029206A2 TARGETED CD1D MOLECULES 审中-公开
标题翻译：目标CD1D分子
公开(公告)号：WO2004029206A2
公开(公告)日：2004-04-08
申请号：PCT/US2003/030238
申请日：2003-09-26
申请人： VACCINEX, INC. , ROBERT, Bruno , DONDA, Alena , CESSON, Valerie , MACH, Jean-Pierre , ZAUDERER, Maurice
发明人： ROBERT, Bruno , DONDA, Alena , CESSON, Valerie , MACH, Jean-Pierre , ZAUDERER, Maurice
IPC分类号： C12N
CPC分类号： C07K16/32 , A61K47/6811 , A61K47/6849 , A61K47/6851 , A61K47/6853 , A61K2039/505 , C07K14/70539 , C07K16/28 , C07K16/3007 , C07K2317/54 , C07K2317/55 , C07K2319/00
摘要： The invention is directed to a compound comprising one or more CD1d complexes in association with an antibody specific for a cell surface marker. The CD1d complexes comprise a CD1d, a ß2-microglobulin molecule, and may further comprise an antigen bound to the CD1d binding groove. The invention is further directed to methods of inhibiting or stimulating an immune response with the CD1d-antibody compounds, in particular anti-tumor and autoimmunity responses.
摘要翻译：本发明涉及包含一种或多种CD1d复合物的化合物以及对细胞表面标记特异性的抗体。 CD1d复合物包含CD1d，β1-微球蛋白分子，并且可以进一步包含与CD1d结合沟相结合的抗原。本发明进一步涉及抑制或刺激CD1d-抗体化合物的免疫应答，特别是抗肿瘤和自身免疫应答的方法。

6. 发明专利

AU2003275254A8 Targeted cd1d molecules 未知
公开(公告)号：AU2003275254A8
公开(公告)日：2004-04-19
申请号：AU2003275254
申请日：2003-09-26
申请人： DONDA ALENA , VACCINEX INC , MACH JEAN PIERRE , ROBERT BRUNO , CESSON VALERIE
发明人： CESSON VALERIE , MACH JEAN-PIERRE , ZAUDERER MAURICE , ROBERT BRUNO , DONDA ALENA
IPC分类号： A61K39/00 , A61K39/385 , A61K39/44 , C07K14/74 , C07K16/28 , C07K16/30

7. 发明专利

AU2003275254A1 TARGETED CD1D MOLECULES 未知
公开(公告)号：AU2003275254A1
公开(公告)日：2004-04-19
申请号：AU2003275254
申请日：2003-09-26
申请人： DONDA ALENA , CESSON VALERIE , MACH JEAN PIERRE , VACCINEX INC , ROBERT BRUNO
发明人： CESSON VALERIE , MACH JEAN-PIERRE , ZAUDERER MAURICE , ROBERT BRUNO , DONDA ALENA
IPC分类号： A61K39/00 , A61K39/385 , A61K39/44 , C07K14/74 , C07K16/28 , C07K16/30

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