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1. 发明授权

US07420061B2 Process for preparing prodrugs of benzenesulfonamide-containing COX-2 inhibitors 有权
标题翻译：制备含苯磺酰胺的COX-2抑制剂前药的方法
公开(公告)号：US07420061B2
公开(公告)日：2008-09-02
申请号：US10939852
申请日：2004-09-13
申请人： John J. Talley , James W. Malecha , Stephen Bertenshaw , Matthew J. Graneto , Jeffery S. Carter , Jinglin Li , Srinivasan R. Nagarajan , David L. Brown , Donald J. Rogier, Jr. , Thomas D. Penning , Ish K. Khanna , Xiangdong Xu , Richard M. Weier
发明人： John J. Talley , James W. Malecha , Stephen Bertenshaw , Matthew J. Graneto , Jeffery S. Carter , Jinglin Li , Srinivasan R. Nagarajan , David L. Brown , Donald J. Rogier, Jr. , Thomas D. Penning , Ish K. Khanna , Xiangdong Xu , Richard M. Weier
IPC分类号： C07D263/04
CPC分类号： C07D207/33 , A61K31/18 , A61K31/415 , A61K31/42 , A61K31/635 , C07C311/16 , C07C311/51 , C07C2601/10 , C07D231/12 , C07D233/64 , C07D261/08 , C07D263/32 , C07D307/58 , C07D401/04 , C07D417/04 , C07D495/04
摘要： Prodrugs of COX-2 inhibitors are described as being useful in treating inflammation and inflammation-related disorders.
摘要翻译：描述了COX-2抑制剂的前药用于治疗炎症和炎症相关疾病。

2. 发明授权

US06951949B2 Substituted pyrazolyl benzenesulfonamides for the treatment of inflammation 有权
公开(公告)号：US06951949B2
公开(公告)日：2005-10-04
申请号：US10700019
申请日：2003-11-03
申请人： John J Talley , Thomas D Penning , Paul W Collins , Donald J Rogier, Jr. , James W Malecha , Julie M Miyashiro , Stephen R Bertenshaw , Ish K Khanna , Matthew J Graneto , Roland S Rogers , Jeffery S Carter , Stephen H. Docter , Stella S Yu
发明人： John J Talley , Thomas D Penning , Paul W Collins , Donald J Rogier, Jr. , James W Malecha , Julie M Miyashiro , Stephen R Bertenshaw , Ish K Khanna , Matthew J Graneto , Roland S Rogers , Jeffery S Carter , Stephen H. Docter , Stella S Yu
IPC分类号： C07D231/12 , C07D231/14 , C07D231/16 , C07D231/54 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , C07D495/04
CPC分类号： C07D409/04 , C07D231/12 , C07D231/14 , C07D231/16 , C07D231/54 , C07D401/04 , C07D403/04 , C07D405/04 , C07D495/04
摘要： A class of pyrazolyl benzenesulfonamide compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula II: wherein R2 is selected from hydrido, alkyl, haloalkyl, alkoxycaronyl, cyano, cyanoalkyl, carboxyl, aminocaronyl, alkylaminocarbonyl, cycloalklaminocarbonyl, arylaminocarbonyl, carboxyalkylaminocarbonyl, carboxyalkyl, aralkoxycarbonylalkylaminocarbonyl, amioncarbonylalkyl, alkoxycarbonylcyanoalkenyl and hydroxyalkyl; wherein R3 is selected from hydrido, alkyl, cyano, hydroxyalkyl, cycloalkyl, alkylsulfonyl and halo; and wherein R4 is selected from aralkenyl, aryl, cycloalkyl, cycloalkenyl and heterocyclic; wherein R4 is optionally substituted at a substitutable position with one or more radicals selected from halo alkylthio, alkylsulfonyl, cyano, nitro, haloalkyl, alkyl, hydroxyl, alkenyl, hydroxyalkyl, carboxyl, cycloalkyl, alkylamino, dialkylamino, alkoxycarbonyl, aminocarbonyl, alkoxy, haloalkoxy, sulfamyl, heterocyclic and amino; provided R2 and R3 are not both hydrido; further provided that R2 is not carboxyl or methyl when R3 is hydrido and when R4 is phenyl; further provided that R4 is not triazolyl when R2 is methyl; further provided that R4 is not arakenyl when R2 is carboxyl, aminocarbonyl or ethoxycarbonyl; further provided that R4 is not phenyl when R2 is methyl and R3 is carboxyl; and further provided that R4 is not unsubstituted thienyl when R2 is trifluoromethyl; or a pharmaceutically-acceptable salt thereof.

3. 发明授权

US06716991B1 Process for preparing a substituted pyrazolyl benzenesulfonamide for the treatment of inflammation 失效
标题翻译：制备用于治疗炎症的取代的吡唑基苯磺酰胺的方法
公开(公告)号：US06716991B1
公开(公告)日：2004-04-06
申请号：US10378781
申请日：2003-03-04
申请人： John J Talley , Thomas D Penning , Paul W Collins , Donald J Rogier, Jr. , James W Malecha , Julie M Miyashiro , Stephen R Bertenshaw , Ish K Khanna , Matthew J Graneto , Roland S Rogers , Jeffery S Carter , Stephen H. Doctor , Stella S Yu
发明人： John J Talley , Thomas D Penning , Paul W Collins , Donald J Rogier, Jr. , James W Malecha , Julie M Miyashiro , Stephen R Bertenshaw , Ish K Khanna , Matthew J Graneto , Roland S Rogers , Jeffery S Carter , Stephen H. Doctor , Stella S Yu
IPC分类号： C07D23112
CPC分类号： C07D409/04 , C07D231/12 , C07D231/14 , C07D231/16 , C07D231/54 , C07D401/04 , C07D403/04 , C07D405/04 , C07D495/04
摘要： A class of pyrazolyl benzenesulfonamide compounds is descrbed for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula II: wherein R2 is selected from hydrido, alkyl, haloalkyl, alkoxycarbonyl, cyano, cyanoalkyl, carboxyl, aminocarbonyl, alkylaminocarbonyl, cycloalkylaminocarbonyl, arylaminocarbonyl, carboxyalkylaminocarbonyl, carboxyalkyl, aralkoxycarbonylalkylaminocarbonyl, aminocarbonylalkyl, alkoxycarbonylcyanoalkenyl and hydroxyalkyl; wherein R3 is selected from hydrido, alkyl, cyano, hydroxyalkyl, cycloalkyl, alkylsulforyl and halo; and wherein R4 is selected from aralkenyl, aryl, cycloalkyl, cycloalkenyl and heterocyclic; wherein R4 is optionally substituted at a substitutable position with one or more radicals selected from halo, alkylthio, alkylsulfonyl, cyano, nitro, haloalkyl, alkyl, hydroxyl, alkenyl, hydroxyalkyl, carboxy, cycloalkyl, alkylamino, dialkylamino, alkoxycarbonyl, aminocarbonyl, alkoxy, haloalkoxy, sulfamyl, heterocyclic and amino; provided R2 and R3 are not both hydrido; further provided that R2 is not carboxyl or methyl when R3 is hydrido and when R4 is phenyl; further provided that R4 is not triazolyl when R2 is methyl; further provided that R4 is not aralkenyl when R2 is carboxyl, aminocarbonyl or ethoxycarbonyl; further provided that R4 is not phenyl when R2 is methyl and R3 is carboxyl; and further provided that R4 is not unsubstituted thienyl when R2 is trifluoromethyl; or a pharmceutically-acceptable salt thereof.
摘要翻译：描述了一类吡唑基苯磺酰胺化合物用于治疗炎症和炎症相关疾病。特别感兴趣的化合物由式II定义：其中R 2选自氢化，烷基，卤代烷基，烷氧基羰基，氰基，氰基烷基，羧基，氨基羰基，烷基氨基羰基，环烷基氨基羰基，芳基氨基羰基，羧基烷基氨基羰基，羧基烷基，芳烷氧基羰基烷基氨基羰基，氨基羰基烷基，烷氧羰基氰基烯基和羟烷基其中R 3选自氢，烷基，氰基，羟基烷基，环烷基，烷基磺酰基和卤素; 其中R 4选自芳烯基，芳基，环烷基，环烯基和杂环; 其中R 4在可取代的位置任选被一个或多个选自卤素，烷硫基，烷基磺酰基，氰基，硝基，卤代烷基，烷基，羟基，烯基，羟基烷基，羧基，环烷基，烷基氨基，二烷基氨基，烷氧基羰基，氨基羰基，烷氧基，卤代烷氧基，氨磺酰基，杂环和氨基; 条件是R 2和R 3都不是氢的; 进一步提供当R 3是氢的时，当R 4是苯基时，R 2不是羧基或甲基; 进一步提供当R 2是甲基时，R 4不是三唑基; 进一步提供当R 2是羧基时，R 4不是芳烯基，氨基羰基或乙氧基羰基; 进一步提供当R 2是甲基且R 3是羧基时，R 4不是苯基; 并且进一步提供当R 2为三氟甲基时R 4为未取代的噻吩基; 或其药学上可接受的盐。

4. 发明授权

US06586603B1 Substituted pyrazolyl benzenesulfonamides for the treatment of inflammation 失效
公开(公告)号：US06586603B1
公开(公告)日：2003-07-01
申请号：US10274679
申请日：2002-10-21
申请人： John J Talley , Thomas D Penning , Paul W Collins , Donald J Rogier, Jr. , James W Malecha , Julie M Miyashiro , Stephen R. Bertenshaw , Ish K Khanna , Matthew J Graneto , Roland S Rogers , Jeffery S Carter , Stephen H Docter , Stella S Yu
发明人： John J Talley , Thomas D Penning , Paul W Collins , Donald J Rogier, Jr. , James W Malecha , Julie M Miyashiro , Stephen R. Bertenshaw , Ish K Khanna , Matthew J Graneto , Roland S Rogers , Jeffery S Carter , Stephen H Docter , Stella S Yu
IPC分类号： C07D23112
CPC分类号： C07D403/04 , C07D231/12 , C07D231/14 , C07D231/16 , C07D231/54 , C07D401/04 , C07D405/04 , C07D409/04 , C07D495/04
摘要： A class of pyrazolyl benzenesulfonamide compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula II: wherein R2 is selected from hydrido, alkyl, haloalkyl, alkoxycarbonyl, cyano, cyanoalkyl, carboxyl, aminocarbonyl, alkylaminocarbonyl, cycloalkylaminocarbonyl, arylaminocarbonyl, carboxyalkylaminocarbonyl, carboxyalkyl, aralkoxycarbonylalkylaminocarbonyl, aminocarbonylalkyl, alkoxycarbonylcyanoalkenyl and hydroxyalkyl; wherein R3 is selected from hydrido, alkyl, cyano, hydroxyalkyl, cycloalkyl, alkylsulfonyl and halo; and wherein R4 is selected from aralkenyl, aryl, cycloalkyl, cycloalkenyl and heterocyclic; wherein R4 is optionally substituted at a substitutable position with one or more radicals selected from halo, alkylthio, alkylsulfonyl, cyano, nitro, haloalkyl, alkyl, hydroxyl, alkenyl, hydroxyalkyl, carboxyl, cycloalkyl, alkylamino, dialkylamino, alkoxycarbonyl, aminocarbonyl, alkoxy, haloalkoxy, sulfamyl, heterocyclic and amino; provided R2 and R3 are not both hydrido; further provided that R2 is not carboxyl or methyl when R3 is hydrido and when R4 is phenyl; further provided that R4 is not triazolyl when R2 is methyl; further provided that R4 is not aralkenyl when R2 is carboxyl, aminocarbonyl or ethoxycarbonyl; further provided that R4 is not phenyl when R2 is methyl and R3 is carboxyl; and further provided that R4 is not unsubstituted thienyl when R2 is trifluoromethyl; or a pharmaceutically-acceptable salt thereof.

5. 发明授权

US06436967B1 Process for preparing prodrugs of benzenesulfonamide-containing cox-2 inhibitors 有权
标题翻译：制备含苯磺酰胺的cox-2抑制剂的前药的方法
公开(公告)号：US06436967B1
公开(公告)日：2002-08-20
申请号：US09661859
申请日：2000-09-14
申请人： John J Talley , James W Malecha , Stephen Bertenshaw , Matthew J Graneto , Jeffery Carter , Jinglin Li , Srinivasan Nagarajan , David L Brown , Donald J Rogier, Jr. , Thomas D Penning , Ish K Khanna , Xiangdong Xu , Richard M Weier
发明人： John J Talley , James W Malecha , Stephen Bertenshaw , Matthew J Graneto , Jeffery Carter , Jinglin Li , Srinivasan Nagarajan , David L Brown , Donald J Rogier, Jr. , Thomas D Penning , Ish K Khanna , Xiangdong Xu , Richard M Weier
IPC分类号： A61K3144
CPC分类号： C07D207/33 , A61K31/18 , A61K31/415 , A61K31/42 , A61K31/635 , C07C311/16 , C07C311/51 , C07C2601/10 , C07D231/12 , C07D233/64 , C07D261/08 , C07D263/32 , C07D307/58 , C07D401/04 , C07D417/04 , C07D495/04
摘要： This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to prodrugs of compounds which selectively inhibit cyclooxygenase-2. The use of non-steroidal antiinflammatory drugs (NSAIDs) in treating pain and the swelling associated with inflammation also produce severe side effects, including life threatening ulcers. The recent discovery of an inducible enzyme associated with inflammation (“prostaglandin G/H synthase II” or “cyclooxygenase-2 (COX-2)”) provides a viable target of inhibition which more effectively reduces inflammation and produces fewer and less drastic side effects.
摘要翻译：本发明涉及抗炎药物领域，具体涉及选择性抑制环加氧酶-2的化合物的前药。非甾体抗炎药（NSAID）在治疗疼痛和与炎症有关的肿胀中的应用也产生严重的副作用，包括危及生命的溃疡。最近发现与炎症相关的可诱导酶（“前列腺素G / H合酶II”或“环加氧酶-2（COX-2）”）提供了可行的抑制靶标，其更有效地减少炎症并产生越来越少的副作用。

6. 发明授权

US6034256A Substituted benzopyran derivatives for the treatment of inflammation 失效
标题翻译：取代苯并吡喃衍生物用于治疗炎症
公开(公告)号：US6034256A
公开(公告)日：2000-03-07
申请号：US062537
申请日：1998-04-17
申请人： Jeffery S Carter , Mark G Obukowicz , Balekudru Devadas , John J Talley , David L Brown , Matthew J Graneto , Stephen R Bertenshaw , Donald J Rogier, Jr. , Srinivasan R Nagarajan , Cathleen E Hanau , Susan J Hartmann , Cindy L Ludwig , Suzanne Metz
发明人： Jeffery S Carter , Mark G Obukowicz , Balekudru Devadas , John J Talley , David L Brown , Matthew J Graneto , Stephen R Bertenshaw , Donald J Rogier, Jr. , Srinivasan R Nagarajan , Cathleen E Hanau , Susan J Hartmann , Cindy L Ludwig , Suzanne Metz
IPC分类号： A61K31/35 , A61K31/352 , A61K31/36 , A61K31/382 , A61K31/4184 , A61K31/436 , A61K31/4375 , A61K31/47 , A61P29/00 , A61P43/00 , C07D215/54 , C07D311/22 , C07D311/58 , C07D311/92 , C07D335/06 , C07D401/12 , C07D405/04 , C07D407/04 , C07D407/12 , C07D409/04 , C07D471/04 , C07D491/04 , C07D491/052 , C07D493/04 , A61K31/44 , A61K31/535 , C07D311/04 , C07D413/00
CPC分类号： C07D335/06 , C07D215/54 , C07D311/22 , C07D311/58 , C07D311/92 , C07D401/12 , C07D405/04 , C07D407/04 , C07D407/12 , C07D409/04 , C07D471/04 , C07D491/04 , C07D493/04
摘要： A class of benzopyran, derivatives is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I' ##STR1## wherein X, A.sup.1, A.sup.2, A.sup.3, A.sup.4, R, R", R.sup.1 and R.sup.2 are as described in the specification.
摘要翻译：描述了一类苯并吡喃衍生物用于治疗环氧合酶-2介导的病症。特别感兴趣的化合物由式I'定义，其中X，A1，A2，A3，A4，R，R“，R1和R2如说明书中所述。

7. 发明授权

US5753688A Substituted pyrazolyl benzenesulfonamides for the treatment of gastrointestinal conditions 失效
标题翻译：取代的吡唑基苯磺酰胺用于治疗胃肠道疾病
公开(公告)号：US5753688A
公开(公告)日：1998-05-19
申请号：US534757
申请日：1995-09-27
申请人： John J. Talley , Thomas D. Penning , Paul W. Collins , Donald J. Rogier, Jr. , James W. Malecha , Julie M. Miyashiro , Stephen R. Bertenshaw , Ish K. Khanna , Matthew J. Graneto , Roland S. Rogers , Jeffery S. Carter
发明人： John J. Talley , Thomas D. Penning , Paul W. Collins , Donald J. Rogier, Jr. , James W. Malecha , Julie M. Miyashiro , Stephen R. Bertenshaw , Ish K. Khanna , Matthew J. Graneto , Roland S. Rogers , Jeffery S. Carter
IPC分类号： A61K31/415 , A61K31/4155 , A61K31/416 , A61K31/4178 , A61K31/4245 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/4439 , A61K31/495 , A61K31/496 , A61K31/497 , A61K31/505 , A61K31/506 , A61P5/14 , A61P9/00 , A61P19/02 , A61P25/04 , A61P25/06 , A61P29/00 , C07D231/12 , C07D231/14 , C07D231/16 , C07D231/18 , C07D231/54 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D495/04 , A61K31/63
CPC分类号： C07D495/04 , C07D231/12 , C07D231/14 , C07D231/16 , C07D231/54 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04
摘要： A class of pyrazolyl benzenesulfonamide compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula I: ##STR1## or a pharmaceutically-acceptable salt thereof.
摘要翻译：描述了一类吡唑基苯磺酰胺化合物用于治疗炎症和炎症相关疾病。特别感兴趣的化合物由式I定义：其中（I）或其药学上可接受的盐。

8. 发明授权

US5434178A 1,3,5 trisubstituted pyrazole compounds for treatment of inflammation 失效
标题翻译：用于治疗炎症的1,3,5三取代吡唑化合物
公开(公告)号：US5434178A
公开(公告)日：1995-07-18
申请号：US160517
申请日：1993-11-30
申请人： John J. Talley , Donald J. Rogier, Jr.
发明人： John J. Talley , Donald J. Rogier, Jr.
IPC分类号： A61K31/415 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61P25/04 , A61P29/00 , C07D231/12 , C07D231/16 , C07D401/04 , C07D405/04 , C07D409/04 , C07D231/14
CPC分类号： C07D231/12 , C07D231/16 , C07D405/04 , C07D409/04
摘要： A class of 1,3,5-triaryl or heteroaryl pyrazoles is described for the treatment of inflammation, including treatment of pain and disorders such as arthritis. Compounds of particular interest are of Formula I ##STR1## wherein R.sup.1 is lower alkylsulfonyl or sulfamyl; wherein R.sup.2 is aryl or heteroaryl; wherein R.sup.2 is optionally substituted at substitutable positions with one or more radicals selected from halo, lower alkoxy, lower alkyl, nitro, lower alkylthio, amino, lower haloalkyl, hydroxyl, carboxyl, N-monoalkylamino, N,N-dialkylamino, cyano, alkoxycarbonyl and acylamino; wherein R.sup.3 is selected from hydrido, lower alkyl, lower haloalkyl, cyano, carboxyl, alkoxycarbonyl, amino, acyl, acylamino, halo and alkylsulfonylamino; wherein R.sup.4 is aryl or heteroaryl; wherein R.sup.4 is optionally substituted at a substitutable position with one or more radicals selected from halo, lower alkoxy, lower alkyl, nitro, lower alkylthio, amino, lower haloalkyl, hydroxyl, carboxyl, N-monoalkylamino, N,N-dialkylamino, cyano, alkoxycarbonyl and acylamino; provided R.sup.2 and R.sup.4 cannot be phenyl or substituted triazole, when R.sup.1 is sulfamyl; further provided R.sup.2 cannot be 4-methoxyphenyl or 4-methylphenyl when R.sup.4 is 4-methoxyphenyl or 4-methylphenyl and when R.sup.1 is sulfamyl; and further provided that R.sup.2 cannot be tetrazole when R.sup.4 is fluorophenyl, and when R.sup.1 is methylsulfonyl; or a pharmaceutically-acceptable salt thereof.
摘要翻译：描述了一类1,3,5-三芳基或杂芳基吡唑用于治疗炎症，包括治疗疼痛和疾病如关节炎。特别感兴趣的化合物是式I的化合物，其中R 1是低级烷基磺酰基或亚磺酰基; 其中R2是芳基或杂芳基; 其中R2任选在可取代的位置被一个或多个选自卤素，低级烷氧基，低级烷基，硝基，低级烷硫基，氨基，低级卤代烷基，羟基，羧基，N-单烷基氨基，N，N-二烷基氨基，氰基，烷氧羰基和酰氨基; 其中R 3选自氢，低级烷基，低级卤代烷基，氰基，羧基，烷氧基羰基，氨基，酰基，酰氨基，卤素和烷基磺酰基氨基; 其中R4是芳基或杂芳基; 其中R 4在可取代位置任选被一个或多个选自卤素，低级烷氧基，低级烷基，硝基，低级烷硫基，氨基，低级卤代烷基，羟基，羧基，N-单烷基氨基，N，N-二烷基氨基，氰基，烷氧基羰基和酰氨基; 当R1是亚磺酰基时，R2和R4不能是苯基或取代的三唑; 进一步提供当R 4是4-甲氧基苯基或4-甲基苯基时，当R 1是亚磺酰基时，R 2不能是4-甲氧基苯基或4-甲基苯基; 并且进一步提供当R 4为氟苯基时，R 2不能为四唑，并且当R 1为甲基磺酰基时; 或其药学上可接受的盐。

9. 发明授权

US07312333B2 Retroviral protease inhibitors 失效
标题翻译：逆转录病毒蛋白酶抑制剂
公开(公告)号：US07312333B2
公开(公告)日：2007-12-25
申请号：US11331344
申请日：2006-01-13
申请人： John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , Kathryn L. Reed , Ko-Chung Lin , John N. Freskos , Michael Clare , Donald J. Rogier, Jr. , Robert M. Heintz , Michael L. Vazquez , Richard A. Mueller
发明人： John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , Kathryn L. Reed , Ko-Chung Lin , John N. Freskos , Michael Clare , Donald J. Rogier, Jr. , Robert M. Heintz , Michael L. Vazquez , Richard A. Mueller
IPC分类号： C07D471/00
CPC分类号： C07D401/12 , C07D207/16 , C07D211/60 , C07D217/26
摘要： N-heterocyclic moiety containing hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
摘要翻译：含有羟基胺化合物的N-杂环部分作为逆转录病毒蛋白酶抑制剂是有效的，特别是作为HIV蛋白酶抑制剂。

10. 发明授权

US07138411B2 Substituted benzopyran derivatives for the treatment of inflammation 失效
标题翻译：取代苯并吡喃衍生物用于治疗炎症
公开(公告)号：US07138411B2
公开(公告)日：2006-11-21
申请号：US10303150
申请日：2002-11-22
申请人： Jeffery S Carter , Mark G Obukowicz , Balekudru Devadas , John J Talley , David L Brown , Matthew J Graneto , Stephen R Bertenshaw , Donald J Rogier, Jr. , Srinivasan Raj Nagarajan , Cathleen E Hanau , Susan J Hartmann , Cindy L Ludwig , Suzanne Metz , Donald E Korte
发明人： Jeffery S Carter , Mark G Obukowicz , Balekudru Devadas , John J Talley , David L Brown , Matthew J Graneto , Stephen R Bertenshaw , Donald J Rogier, Jr. , Srinivasan Raj Nagarajan , Cathleen E Hanau , Susan J Hartmann , Cindy L Ludwig , Suzanne Metz , Donald E Korte
IPC分类号： A61K31/47 , A61K31/38 , A61K31/35 , C07D307/77 , C07D335/04
CPC分类号： C07D215/54 , C07D311/22 , C07D311/58 , C07D311/92 , C07D335/06 , C07D401/12 , C07D405/04 , C07D407/04 , C07D407/12 , C07D409/04 , C07D471/04 , C07D491/04 , C07D493/04
摘要： A class of benzopyrans, benzothiopyrans, dihydroquinolines, dihydronaphthalenes, and analogs thereof, is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I′ wherein X, A1, A2, A3, A4, R, R″, R1 and R2 are as described in the specification.
摘要翻译：描述了一类苯并吡喃，苯并噻喃，二氢喹啉，二氢萘及其类似物，用于治疗环氧合酶-2介导的病症。特别感兴趣的化合物由式I'定义，其中X，A 1，A 2，A 3，A 4， SUP>，R，R“，R”1“和”R“2如说明书中所述。

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