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1. 发明授权

EP0956858B1 Pharmaceutical compositions containing Lactobacillus brevis and Lactobacillus salivarius for treatment of vaginal infections 失效
标题翻译：含有短乳杆菌和唾液乳杆菌用于治疗阴道感染的药物组合物
公开(公告)号：EP0956858B1
公开(公告)日：2001-10-31
申请号：EP98830264.2
申请日：1998-04-30
申请人： Cavaliere Vesely, Renata Maria Anna , De Simone, Claudio
发明人： Cavaliere Vesely, Renata Maria Anna , De Simone, Claudio
IPC分类号： A61K35/74 , A61K9/00 , A61P15/02
CPC分类号： A61K9/0034 , A61K9/0007 , A61K9/2054 , A61K9/209 , A61K35/747 , A61K2300/00

2. 发明公开

EP0956858A1 Pharmaceutical compositions containing lactobacilli for treatment of vaginal infections 失效
标题翻译：乳酸杆菌属植物疫霉菌Zusammensetzungen zur Behandlung von Vaginainfektionen
公开(公告)号：EP0956858A1
公开(公告)日：1999-11-17
申请号：EP98830264.2
申请日：1998-04-30
申请人： Cavaliere Vesely, Renata Maria Anna , De Simone, Claudio
发明人： Cavaliere Vesely, Renata Maria Anna , De Simone, Claudio
IPC分类号： A61K35/74 , A61K9/00
CPC分类号： A61K9/0034 , A61K9/0007 , A61K9/2054 , A61K9/209 , A61K35/747 , A61K2300/00
摘要： Use of an association of lactobacilli for preparation of a pharmaceutical composition for treatment of vaginosis and vaginitis. Said bacteria association comprises the Lactobacillus brevis and Lactobacillus salivarius subs. salicinius species, possibly in combination with one or more species selected from Lactobacillus salivarius subs. salivarius, Lactobacillus jensenii, Lactobacillus catenaforme, Lactobacillus minutus and Lactobacillus gasseri.
A pharmaceutical composition comprising said association of lactobacilli adapted for treatment of vaginosis and vaginitis.
摘要翻译：使用乳杆菌联合制备用于治疗阴道炎和阴道炎的药物组合物。所述细菌结合物包括短乳杆菌（Lactobacillus brevis）和唾液乳杆菌（Lactobacillus salivarius）。 salicinius物种，可能与选自唾液乳杆菌的一种或多种物质组合。唾液，詹氏乳杆菌，嗜酸乳杆菌，细乳杆菌和加氏乳杆菌。一种药物组合物，其包含适于治疗阴道炎和阴道炎的乳酸杆菌结合物。

3. 发明公开

EP0847244A1 ENTERAL DIETARY COMPOSITIONS COMPRISING $i(STREPTOCOCCUS THERMOPHILUS) AND $i(BIFIDOBACTERIUM LONGUM) 有权
标题翻译：膳食组合物含肠内嗜热链球菌UNDBIFIDOBACTERIUM茇
公开(公告)号：EP0847244A1
公开(公告)日：1998-06-17
申请号：EP97925276.0
申请日：1997-06-03
申请人： Cavaliere Vesely, Renata Maria Anna , De Simone, Claudio
发明人： Cavaliere Vesely, Renata Maria Anna , De Simone, Claudio
IPC分类号： A23C9 , A23L1 , A61K35
CPC分类号： A61K35/745 , A23C9/1234 , A23L29/065 , A23Y2240/75 , A23Y2300/55 , A61K35/744 , Y10S435/975 , A61K2300/00
摘要： Enteral compositions containing Streptococcus thermophilus and Bifidobacterium longum, each at a concentration equal to or greater than 1x1011 CFU per gram, are useful as adjuncts for enteral formulations and as oral nutritional supplements. The compositions can be administered before, during or at the end of an enteral formulation administration. The compositions can be administered separately or mixed with the enteral formulation. The compositions can also be employed at the end of the daily administration in order to prevent the colonization of the enteral tube by other pathogens. The compositions can also be used as supplement to any liquid, creamy or pasty foodstuff.

4. 发明公开

EP0795604A2 Strains of bacteria with altered metabolism of bile acids and their use 失效
标题翻译：细菌菌株与胆汁酸和其使用的代谢改变
公开(公告)号：EP0795604A2
公开(公告)日：1997-09-17
申请号：EP97830040.8
申请日：1997-02-05
申请人： Cavaliere Vesely, Renata Maria Anna , De Simone, Claudio
发明人： Cavaliere Vesely, Renata Maria Anna , De Simone, Claudio
IPC分类号： C12N1/20
CPC分类号： C12R1/225 , A61K31/575 , A61K31/7016 , A61K35/744 , A61K35/747 , C12R1/46 , A61K2300/00
摘要： Strains of bacteria characterized by exhibiting: (a) a 7Ó-dehydroxylase activity of less than 50%, and (b) a bile acid deconjugation activity of less than 50%, and descendants, mutants and derivatives thereof preserving activities (a) and (b); and a pharmaceutical composition comprising one or more of such strains and useful of same for preventing and treating deseases associated with or caused by an altered metabolism of bile acids.
摘要翻译：通过展示为特征的细菌菌株：（a）中的小于50％的70脱羟基酶活性，和（b）低于50％的胆汁酸去缀合活性，以及后代，突变体和其衍生物保持活动（a）和（二）; 和药物组合物包含一种或多种供试菌株的和的相同用于预防和治疗相关或由至胆汁酸改变的代谢引起的deseases有用。

5. 发明公开

EP1481681A1 Lactic acid bacteria combination and compositions thereof 审中-公开
标题翻译： Milchsäurebakterienkombinationund deren Zusammensetzungen
公开(公告)号：EP1481681A1
公开(公告)日：2004-12-01
申请号：EP03425349.2
申请日：2003-05-30
申请人： De Simone, Claudio
发明人： De Simone, Claudio
IPC分类号： A61K35/74 , A23L1/03
CPC分类号： A61K35/745 , A23K10/18 , A23L29/065 , A23L33/135 , A23Y2220/65 , A23Y2240/75 , A23Y2300/49 , A61K35/741 , A61K35/744 , A61K35/747
摘要： The present invention provides prophylaxis and treatment of dismicrobial conditions by means of combinations of highly concentrated lactic acid bacteria, compositions containing them suitable for administration to mammals, their use as medicaments or food supplements, in particular suitable for the prevention and/or treatment of a number of diseases, in particular imbalances of the natural flora of mammals.
According to the general concept of the present invention, the lactic acid bacteria combination consists of:

(a) from about 5% to about 95% by weight of total combination of Lactobacillus pentosus and
(b) from about 5% to about 95% by weight of total combination of at least one strain of Streptococcus thermophilus and/or Lactobacillus paracasei and/or Lactobacillus helveticus; and/or mutants or derivatives of (a) and/or (b).

Examples of diseases or disturbances to be treated are imbalances of bacteria flora, inflammatory condition or a degenerative disease of the gastrointestinal tract, liver, pancreas, vagina, mouth, anus or any fistolous tract.
摘要翻译：乳酸菌组合（I）包含5-95重量％的戊糖酸乳杆菌的总组合和5-95重量％的嗜热链球菌和/或乳酸链球菌和/或L.helveticus的总组合和/或它们的突变体或衍生物，是新的。对于包含（I），与赋形剂混合的组合物（II），还包括独立权利要求。活性：抗炎; 胃肠道根; 抗溃疡; 泻药; 止泻; 低血压; 抗菌; 降血糖; 抑制细胞生长; 免疫抑制。体内测定乳酸菌组成的抗腹泻活性。接受氟嘧啶治疗继发性腹膜炎的32例癌症患者接受治疗。 16例患者接受嗜热链球菌5.71X101> 1>，副干酪乳杆菌7.93X101> 0>，苦参杆菌1.59X101> 0>嗜酸乳杆菌3.18X101> 0>，L.helveticus 1.59X101> 0> B. 1.42X101> 1>，B.lactis 2.12X109>，B.bifidum 1.42X101> 1>，每天两包，共4天。在这段时间结束时，16名治疗的患者中有9例解除了腹泻。作用机理：调节COX-2活性; 灭活细胞因子（要求保护）。

6. 发明公开

EP0941056A1 SPHINGOMYELINASE COMPOSITIONS AND USE THEREOF 失效
标题翻译：组合物基于鞘磷脂酶及其用途
公开(公告)号：EP0941056A1
公开(公告)日：1999-09-15
申请号：EP97946038.0
申请日：1997-11-14
申请人： De Simone, Claudio
发明人： De Simone, Claudio
IPC分类号： A61K8 , A61K38 , A61P17 , A61Q1 , A61Q11 , A61Q19 , C12N1
CPC分类号： A61K8/66 , A61K38/465 , A61K2800/70 , A61Q19/00 , C12Y301/04012 , Y10S435/853 , Y10S435/854 , Y10S435/855 , Y10S435/856 , Y10S435/857 , Y10S435/885
摘要： The use of sphingomyelinase to increase the levels of skin and mucosal ceramides, as well as dermatological and cosmetic compositions containing same which are suitable for topical application are disclosed.

7. 发明公开

EP0555618A3 Dietetic and/or pharmaceutical compositions containing lyophilized lactic bacteria, their preparation and use 失效
标题翻译：含有LYOPHILIZE LACTIC BACTERIA的药物和/或药物组合物，其制备和使用
公开(公告)号：EP0555618A3
公开(公告)日：1994-06-22
申请号：EP92830653.9
申请日：1992-12-04
申请人： Cavaliere Vesely, Renata Maria Anna , De Simone, Claudio
发明人： Cavaliere Vesely, Renata Maria Anna , De Simone, Claudio
IPC分类号： A23L1/03 , A61K35/74
CPC分类号： A61K35/744 , A23L29/065 , A23Y2220/67 , A23Y2240/75 , A23Y2300/55 , A61K35/745 , A61K35/747 , A61K45/06 , A61K2300/00
摘要： Pharmaceutical compositions containing highly-concentrated lyophilized lactic bacteria in combination with pharmacologically acceptable excipients and optionally suitable physiologically compatible drugs, are adapted for restoring the intestinal mucous membrane mass and modulating the epithelial cell kinetics and the enzyme potential of the intestine when they have been altered as a result of stress conditions, and in, addition in case of gastroenteritis, colitis, constipation, diarrhoea, for recolonizing the intestine after food disorders, surgical interventions, chemotherapy or contagious deseases, hepatopathies resulting from toxic, metabolic or infectious causes, as adjuvants for controlling hyperammonemia and endotoxinemia while liver insufficiency is in progress, in case of lack of humoral immunity and of mucosal and systemic cell-mediated immunity associated with secondary immunological deficiency diseases, for hyperlipoproteinemia and hypercholesteremia, and as adjuvants in diabetes therapy.
摘要翻译：含有高度浓缩的冻干乳酸菌与药理学上可接受的赋形剂和任选合适的生理上相容的药物组合的药物组合物适于恢复肠粘膜质量并调节肠上皮细胞的动力学和肠电位，当它们被改变为应激条件的结果，以及在肠胃炎，结肠炎，便秘，腹泻，食物障碍，外科手术，化学疗法或传染性疾病之后肠道重新肠化的情况下的添加，由有毒，代谢或感染原因引起的肝病，作为辅助剂控制高氨血症和内毒素血症，而肝功能不全正在进行中，在缺乏体液免疫和与次级免疫缺陷疾病相关的粘膜和全身细胞介导的免疫，高脂蛋白血症和高胆固醇血症的情况下，以及作为直径的佐剂 betes疗法。

8. 发明授权

EP0795604B1 Strains of bacteria with altered metabolism of bile acids and their use 失效
标题翻译：细菌菌株与胆汁酸和其使用的代谢改变
公开(公告)号：EP0795604B1
公开(公告)日：2003-08-06
申请号：EP97830040.8
申请日：1997-02-05
申请人： De Simone, Claudio , Vesely, Marco Emilio , Vesely, Leonardo , Vesely, Alessandro , Vesely, Sara , Vesely, Marina Eva
发明人： De Simone, Claudio , Cavaliere Vesely, Renata Maria Anna
IPC分类号： A61K35/74 , C12R1/46 , C12R1/225 , C12N1/20
CPC分类号： C12R1/225 , A61K31/575 , A61K31/7016 , A61K35/744 , A61K35/747 , C12R1/46 , A61K2300/00

9. 发明公开

EP0555618A2 Dietetic and/or pharmaceutical compositions containing lyophilized lactic bacteria, their preparation and use 失效
标题翻译：冻干的细菌膳食或药物组合物含有，制备及其用途。
公开(公告)号：EP0555618A2
公开(公告)日：1993-08-18
申请号：EP92830653.9
申请日：1992-12-04
申请人： Cavaliere Vesely, Renata Maria Anna , De Simone, Claudio
发明人： Cavaliere Vesely, Renata Maria Anna , De Simone, Claudio
IPC分类号： A23L1/03 , A61K35/74
CPC分类号： A61K35/744 , A23L29/065 , A23Y2220/67 , A23Y2240/75 , A23Y2300/55 , A61K35/745 , A61K35/747 , A61K45/06 , A61K2300/00
摘要： Pharmaceutical compositions containing highly-concentrated lyophilized lactic bacteria in combination with pharmacologically acceptable excipients and optionally suitable physiologically compatible drugs, are adapted for restoring the intestinal mucous membrane mass and modulating the epithelial cell kinetics and the enzyme potential of the intestine when they have been altered as a result of stress conditions, and in, addition in case of gastroenteritis, colitis, constipation, diarrhoea, for recolonizing the intestine after food disorders, surgical interventions, chemotherapy or contagious deseases, hepatopathies resulting from toxic, metabolic or infectious causes, as adjuvants for controlling hyperammonemia and endotoxinemia while liver insufficiency is in progress, in case of lack of humoral immunity and of mucosal and systemic cell-mediated immunity associated with secondary immunological deficiency diseases, for hyperlipoproteinemia and hypercholesteremia, and as adjuvants in diabetes therapy.
摘要翻译：药物组合物含有高浓度的冻干乳酸菌组合与药理学上可接受的赋形剂和任选的合适的生理上相容的药物，被angepasst用于恢复肠粘膜质量和调制上皮细胞动力学和肠的酶潜在当它们havebeen改变作为的应力条件的结果，并在，除了在胃肠炎，结肠炎，便秘，腹泻，用于食品障碍，外科手术，化疗或传染性deseases后recolonising肠，hepatopathies从毒性，代谢或感染原因引起的情况下，作为佐剂控制高氨血症和内毒素血症，而肝功能不全正在进行中，在缺乏体液免疫和粘膜，并用二次免疫缺陷性疾病，高脂蛋白血症为高胆固醇血症和相关的全身细胞介导的免疫的情况下，并且如在直径佐剂 betes治疗。

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