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1. 发明授权

US5501949A Particle bound binding component immunoassay 失效
标题翻译：颗粒结合组分免疫测定
公开(公告)号：US5501949A
公开(公告)日：1996-03-26
申请号：US290487
申请日：1994-08-15
申请人： David L. Marshall
发明人： David L. Marshall
IPC分类号： G01N33/538 , G01N33/543 , G01N33/558 , G01N33/569 , C12Q1/70
CPC分类号： G01N33/558 , G01N33/538 , G01N33/54306 , G01N33/54313 , G01N33/56927 , Y10S435/97 , Y10S435/975 , Y10S436/81 , Y10S436/815 , Y10S436/818 , Y10S436/824
摘要： An immunoassay method for the detection or quantitation of an analyte suspected of being in a solution comprising: (a) combining said specimen, a first binding component, insoluble particles, and second binding component labelled with a signal generating material in a solid phase retention and separation apparatus having a sufficient pore size such that said particles are trapped within said filter yet permitting rapid passage of fluid therethrough in such a manner that an immunological reaction occurs if analyte is present in said specimen, resulting in the formation of an immunocomplex of insolublized first binding component:analyte:second labelled binding component on or within said filter means; (b) separating bound from unbound material; and (c) determining the presence and/or amount of signal produced which is correlative with the amount of analyte present in the solution.
摘要翻译：用于检测或定量疑似在溶液中的分析物的免疫测定方法，包括：（a）将所述样品，第一结合组分，不溶性颗粒和用固相保留的信号产生材料标记的第二结合组分合并，以及分离装置具有足够的孔径，使得所述颗粒被捕获在所述过滤器内，但允许流体快速通过其中，使得如果所述样品中存在分析物，则发生免疫反应，导致形成免疫复合物分析物：所述过滤装置上或其内的第二标记结合组分; （b）从未结合的物质分离结合物; 和（c）确定产生的信号的存在和/或量与溶液中存在的分析物的量相关。

2. 发明授权

US5236826A Immunoassay for the detection or quantitation of an analyte 失效
标题翻译：用于检测或定量分析物的免疫测定
公开(公告)号：US5236826A
公开(公告)日：1993-08-17
申请号：US630365
申请日：1990-12-18
申请人： David L. Marshall
发明人： David L. Marshall
IPC分类号： G01N33/538 , G01N33/543 , G01N33/558 , G01N33/569
CPC分类号： G01N33/538 , G01N33/54306 , G01N33/54313 , G01N33/558 , G01N33/56927 , G01N33/56983
摘要： An immunoassay method for the detection or quantitation of an analyte suspected of being in a solution comprising: (a) combining said specimen, a first binding component, insoluble particles, and second binding component labelled with a signal generating material in a solid phase retention and separation apparatus having a sufficient pore size such that said particles are trapped within said filter yet permitting rapid passage of fluid therethrough in such a manner that an immunological reaction occurs if analyte is present in said specimen, resulting in the formation of an immunocomplex of insolubilized first binding component:analyte:second labelled binding component on or within said filter means; (b) separating bound from unbound material; and (c) determining the presence and/or amount of signal produced which is correlative with the amount of analyte present in the solution.
摘要翻译：用于检测或定量疑似在溶液中的分析物的免疫测定方法，包括：（a）将所述样品，第一结合组分，不溶性颗粒和用固相保留的信号产生材料标记的第二结合组分合并，以及分离装置具有足够的孔径，使得所述颗粒被捕获在所述过滤器内，但允许流体快速通过，使得如果分析物存在于所述样品中，则发生免疫反应，导致形成不溶性第一的免疫复合物分析物：所述过滤装置上或其内的第二标记结合组分; （b）从未结合的物质分离结合物; 和（c）确定产生的信号的存在和/或量与溶液中存在的分析物的量相关。

3. 发明申请

US20100311325A1 SYSTEMS AND METHODS FOR THROUGH-THE-EARTH COMMUNICATIONS 审中-公开
标题翻译：通过接地通信的系统和方法
公开(公告)号：US20100311325A1
公开(公告)日：2010-12-09
申请号：US12793651
申请日：2010-06-03
申请人： David L. Marshall
发明人： David L. Marshall
IPC分类号： H04B13/02 , H01Q1/50
CPC分类号： H04B13/02
摘要： Systems and methods for wirelessly sending signals through the earth between transmitting and receiving antennas are disclosed, wherein the communicating antennas are of the types that generate significant far field radiation and may interact substantially through the emission and absorption of electromagnetic radiation in addition to magnetic coupling. Frequencies are typically chosen which may be much higher than those conventionally used for through-the-earth (TTE) communications. In many situations where TTE communication is desired, the electromagnetic coupling and associated magnetic coupling produced and utilized by these certain types of antennas provide greater effective communications ranges when compared with the ranges that are obtainable with antennas interacting predominately by magnetic coupling alone.
摘要翻译：公开了用于在发射天线和接收天线之间通过地球无线发送信号的系统和方法，其中通信天线是产生显着的远场辐射的类型，并且除了磁耦合之外，它们可以基本上通过电磁辐射的发射和吸收相互作用。通常选择的频率可能比通常用于通过地球（TTE）通信的频率高得多。在需要TTE通信的许多情况下，与通过主要仅通过磁耦合相互作用的天线可获得的范围相比，由这些某些类型的天线产生和利用的电磁耦合和相关的磁耦合提供了更有效的通信范围。

4. 发明授权

US07249983B2 Sleeveless stamped and formed socket contact 有权
标题翻译：无袖冲压成形插座触点
公开(公告)号：US07249983B2
公开(公告)日：2007-07-31
申请号：US11134828
申请日：2005-05-19
申请人： David G. Meyer , Brice I. Byford , David L. Marshall , Robin D. Reed
发明人： David G. Meyer , Brice I. Byford , David L. Marshall , Robin D. Reed
IPC分类号： H01R4/10
CPC分类号： H01R4/185 , H01R4/206 , H01R13/111
摘要： An electrical contact includes a crimping section for securing a wire and a flute section for receiving a pin. The flute section includes fixed engagement members and a resilient cantilever member that engages the pin within the flute section.
摘要翻译：电触点包括用于固定电线的压接部分和用于接收销的槽部分。凹槽部分包括固定的接合构件和与凹槽部分内的销接合的弹性悬臂构件。

5. 外观设计

USD300463S Diagnostic tester for biological fluids 失效
公开(公告)号：USD300463S
公开(公告)日：1989-03-28
申请号：US880486
申请日：1986-06-30
申请人： Edward M. Nemec , Miles G. Hossom , David L. Marshall
设计人： Edward M. Nemec , Miles G. Hossom , David L. Marshall

6. 发明授权

US4530900A Soluble insoluble polymers in enzymeimmunoassay 失效
标题翻译：可溶性不溶性聚合物在酶免疫测定中
公开(公告)号：US4530900A
公开(公告)日：1985-07-23
申请号：US417281
申请日：1982-09-13
申请人： David L. Marshall
发明人： David L. Marshall
IPC分类号： G01N33/539 , G01N33/548 , G01N33/54 , C12N9/96
CPC分类号： G01N33/539 , G01N33/548 , Y10S435/969 , Y10S435/971 , Y10S436/815 , Y10S436/824 , Y10S436/828
摘要： The invention pertains to an improved heterogeneous enzymeimmunoassay involving the use of a reversibly soluble polymeric substance acting as the support for the antibody. In the direct method the antigen to be detected and an enzyme labeled antigen are bound by antibody which is chemically linked to the soluble polymeric substance. The polymer is rendered insoluble and removed from the test solution. After resolubilization into a solution containing substrate for the enzyme label, the assay for antigen is completed by determination of enzymatic activity. In the indirect method, the antigen to be detected and an enzyme labeled antigen are incubated with a primary antibody unattached to the polymeric substance. After addition of a second antibody which is chemically linked to the polymeric substance, the polymer is rendered insoluble and the assay is performed as in the direct method described above.
摘要翻译：本发明涉及一种改进的异源酶免疫测定法，其涉及使用作为抗体载体的可逆溶解聚合物质。在直接法中，待检测的抗原和酶标记的抗原通过与可溶性聚合物质化学连接的抗体结合。使聚合物变得不溶，并从测试溶液中除去。在重新溶解成含有酶标记底物的溶液后，通过测定酶活性来完成抗原测定。在间接方法中，将待检测的抗原和酶标记的抗原与未附着于聚合物质的一抗孵育。加入与聚合物质化学连接的第二抗体后，使聚合物变得不溶，并按照上述直接方法进行测定。

7. 发明授权

US4211763A Anion exchange resin in the determination of thyroid function 失效
标题翻译：阴离子交换树脂测定甲状腺功能
公开(公告)号：US4211763A
公开(公告)日：1980-07-08
申请号：US876074
申请日：1978-02-08
申请人： David L. Marshall , William C. Herndon
发明人： David L. Marshall , William C. Herndon
IPC分类号： G01N33/78 , G01N33/16 , A61K43/00
CPC分类号： G01N33/78 , Y10S436/804
摘要： In the determination of thyroid function in the triiodothyronine uptake and thyroxine tests, a tablet formed from a strongly basic anion exchange resin is used as a secondary binding agent to separate the bound and unbound radioactive thyroid hormone.
摘要翻译：在三碘甲腺原氨酸摄取和甲状腺素检测中甲状腺功能的测定中，使用由强碱性阴离子交换树脂形成的片剂作为二级结合剂，分离结合和未结合的放射性甲状腺激素。

8. 发明申请

US20150102963A1 DIFFERENTIAL SIGNAL STRENGTH DETERMINATION SYSTEMS AND METHODS 审中-公开
标题翻译：差分信号强度测定系统及方法
公开(公告)号：US20150102963A1
公开(公告)日：2015-04-16
申请号：US14512384
申请日：2014-10-11
申请人： David L. Marshall
发明人： David L. Marshall
IPC分类号： G01S3/14
CPC分类号： G01S3/38 , G01S3/046
摘要： A differential signal strength direction determination systems (DSSDDS) may be programmed to provide an output that will enable an individual to determine a direction in which a source of a signal of interest is located with increased accuracy. The programming of the DSSDSS may improve accuracy by consolidating corresponding parts of a signal over time, by modifying a signal strength scale to enable an individual to better discern between the strengths of various signals and/or by providing a user-perceptible output that enables an individual to better discern between the strengths of various signals.
摘要翻译：差分信号强度方向确定系统（DSSDDS）可以被编程以提供输出，该输出将使得个体能够以增加的精度来确定感兴趣的信号的源所在的方向。 DSSDSS的编程可以通过整合信号的相应部分来随时间推移来提高精度，通过修改信号强度标度以使得个体能够更好地辨别各种信号的强度和/或通过提供用户可感知的输出，使得能够个人更好地辨别各种信号的优势。

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