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    • 3. 发明申请
    • INHIBITING CYP3A4 INDUCTION
    • 抑制CYP3A4诱导
    • US20080124407A1
    • 2008-05-29
    • US11867299
    • 2007-10-04
    • David L. EatonKenneth ThummelChangcheng ZhouTheo Bammler
    • David L. EatonKenneth ThummelChangcheng ZhouTheo Bammler
    • A61K36/38A61K31/26A61P9/12A61K31/5517A61K31/497
    • A61K31/26A61K31/497A61K31/5517
    • The present invention is directed to a method of inhibiting CYP3A4 induction. The method involves administering a compound of the following formula: R1—X—(CH2)n—N═C═S with R1, X, and n defined herein, binds to a Pregnane X Receptor or Steroid and Xenobiotic Receptor (SXR or NR1I2) under conditions effective to inhibit CYP3A4 gene induction. The present invention also include a method of administering a compound, described herein, together with the CYP3A4 inducer to prevent a loss of efficacy in the subject to whom the CYP3A4 inducer is repeatedly administered. In addition, such compounds can be administered to block the interaction between a CYP3A4 inducer and another drug being administered that is a substrate of CYP3A4.
    • 本发明涉及抑制CYP3A4诱导的方法。 该方法包括给予下式化合物:<?in-line-formula description =“In-line Formulas”end =“lead”?> R 1 -X-(CH) &lt; N&gt; -NCS&lt;?in-line-formula description =“In-line Formulas”end =“tail”?> R&lt; 1&lt; 和n定义在有效抑制CYP3A4基因诱导的条件下与妊娠X受体或类固醇和异生素受体(SXR或NR1I2)结合。 本发明还包括与CYP3A4诱导剂一起施用本文所述的化合物以防止在重复施用CYP3A4诱导物的受试者中的功效丧失的方法。 此外,可以施用这样的化合物以阻断CYP3A4诱导剂与作为CYP3A4的底物的另一种正在给药的药物之间的相互作用。
    • 6. 发明授权
    • Electro-optical element including metallic films and methods for applying the same
    • 包括金属膜的电光元件及其应用方法
    • US07864398B2
    • 2011-01-04
    • US11682098
    • 2007-03-05
    • Gary J. DozemanHenry A. LutenGeorge A. NeumanWilliam L. TonarThomas F. GuarrLeroy J. KloeppnerDavid L. Eaton
    • Gary J. DozemanHenry A. LutenGeorge A. NeumanWilliam L. TonarThomas F. GuarrLeroy J. KloeppnerDavid L. Eaton
    • G02F1/15G02F1/153
    • G02F1/155B60R1/088B82Y20/00G02F2202/36Y10S359/90
    • A method for manufacturing an electrochromic element comprises providing a first substrate having first and second surfaces opposite one another and a first edge surface, providing a second substrate having third and fourth surfaces opposite one another and a second edge surface, wherein the third surfaces faces the second surface, and providing an electrochromic medium located between the first and second substrates, wherein the electrochromic medium has a light transmittance that is variable upon the application of electric field thereto. The method further complies applying a conductive layer on at least a portion of at least a select one of a first, second, third, and fourth surfaces and the first and second edge surfaces, wherein applying the conductive layer is accomplished at substantially atmospheric pressure and including applying at least a select one of metallic particles, an organometallic, a metallo-organic, and combinations thereof, and wherein the conductive layer has a bulk resistivity of less than or equal to 150 μΩ·cm. Other aspects of this invention comprise applying the conductive layer via ink jetting, ultrasonic spraying, auger pumping and jet pumping.
    • 一种制造电致变色元件的方法包括提供具有彼此相对的第一和第二表面的第一基底和第一边缘表面,提供具有彼此相对的第三和第四表面的第二基底和第二边缘表面,其中第三表面面向 并且提供位于第一和第二基板之间的电致变色介质,其中电致变色介质具有在施加电场时可变的透光率。 该方法进一步遵循在至少一部分第一,第二,第三和第四表面以及第一和第二边缘表面中的至少一部分上施加导电层,其中施加导电层是在大气压下完成的, 包括施加至少一种选择的金属颗粒,有机金属,金属有机物及其组合,并且其中导电层具有小于或等于150μΩ·cm的体电阻率。 本发明的其它方面包括通过喷墨,超声波喷涂,螺旋推送和喷射泵送来施加导电层。
    • 9. 发明授权
    • Magnetic stirring apparatus
    • 磁力搅拌器
    • US4483623A
    • 1984-11-20
    • US485476
    • 1983-04-15
    • David L. EatonWilliam P. Vann
    • David L. EatonWilliam P. Vann
    • B01F13/08B01F7/18
    • B01F13/0827
    • An improved magnetic stirring apparatus capable of suspending solids in a liquid medium comprising: a vessel for containing fluids and solids, having walls, a bottom, and an opening; a stirrer having a magnetic impeller and a shaft, a means for rotating the magnetic impeller; and a closure; wherein the improvement is characterized by:(a) the shaft having;(i) an upper portion; and(ii) a narrower lower portion; an upper bearing surface being formed where the lower portion extends outwardly to the upper portion;(b) an elongated shaft support member which(i) is attached to the closure; and(ii) has an aperture dimensioned and configured to receive the lower shaft portion and allow free rotation, opposed aperture margins forming a lower bearing surface; and(c) a sling bearing formed by the upper bearing surface engaging the lower bearing surface in the direction of the vessel bottom, thereby suspending the stirrer.
    • 一种能够将固体悬浮在液体介质中的改进的磁力搅拌装置,包括:用于容纳流体和固体的容器,具有壁,底部和开口; 具有磁性叶轮和轴的搅拌器,用于旋转磁性叶轮的装置; 和封闭; 其特征在于:(a)所述轴具有: (i)上部; 和(ii)较窄的下部; 形成上部支承表面,其中下部向外延伸到上部; (b)细长轴支撑构件,其(i)附接到所述封闭件; 和(ii)具有尺寸和构造成容纳下轴部分并允许自由旋转的孔,孔对置形成下支承面; 和(c)由所述上轴承表面在所述容器底部的方向上接合所述下支承表面形成的吊索轴承,从而悬挂所述搅拌器。