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1. 发明授权

US6133043A Magnetic particle based electrochemiluminescent detection apparatus and method 失效
标题翻译：基于磁性粒子的电化学发光检测装置及方法
公开(公告)号：US6133043A
公开(公告)日：2000-10-17
申请号：US66704
申请日：1998-04-27
申请人： David B. Talley , Jonathan K. Leland
发明人： David B. Talley , Jonathan K. Leland
IPC分类号： G01N21/66 , G01N21/69 , G01N21/76 , G01N21/78 , G01N33/543 , G01N33/553 , G01N33/58 , G01N35/00
CPC分类号： G01N21/76 , G01N21/69 , G01N33/54326 , G01N33/582 , G01N35/0098
摘要： A method and apparatus for measuring electrochemiluminescence from a sample composition are described wherein magnetically responsive electrochemiluminescent active species are captured on the electrode with the aid of a capture magnet having a configuration such that the magnetic flux lines (or the magnetic field gradient) of at least one magnetic field source therein are compressed and/or dispersed. This capture magnet improves the distribution of the magnetically responsive electrochemiluminescent active species on the electrode surface and reduces interference with the photomultiplier tube, thereby enhancing the ECL signal and improving sensitivity. The improved capture and distribution also allows for shorter assay times.
摘要翻译：描述了一种用于从样品组合物测量电化学发光的方法和装置，其中磁响应电化学发光活性物质借助捕获磁体捕获在电极上，该捕获磁体具有以下结构：使得至少一个磁通量线（或磁场梯度）至少其中一个磁场源被压缩和/或分散。这种捕获磁体改善了磁响应电化学发光活性物质在电极表面上的分布，并减少了对光电倍增管的干扰，从而增强了ECL信号并提高了灵敏度。改进的捕获和分布也允许更短的测定时间。

2. 发明授权

US5945344A Electrochemiluminescence method 失效
标题翻译：电化学发光法
公开(公告)号：US5945344A
公开(公告)日：1999-08-31
申请号：US986709
申请日：1997-12-08
申请人： Stephanie A. Hayes , Jonathan K. Leland , David B. Talley
发明人： Stephanie A. Hayes , Jonathan K. Leland , David B. Talley
IPC分类号： G01N21/69 , G01N21/76
CPC分类号： G01N21/69 , G01N21/76
摘要： The invention is a method for conducting an electrochemiluminescent assay that includes contacting a sample containing an analyte of interest with a first electrical waveform, followed by contacting the sample with a second electrical waveform that has been modulated in an amount derived from a pre-determined gain extension factor.
摘要翻译：本发明是用于进行电化学发光测定的方法，其包括将含有目标分析物的样品与第一电波形接触，然后使样品与已经以预定增益得到的量调制的第二电波形接触延伸因子。

3. 发明授权

US6039345A System and method for sensing vehicle door edge movement 失效
标题翻译：感应车门边缘运动的系统和方法
公开(公告)号：US6039345A
公开(公告)日：2000-03-21
申请号：US7990
申请日：1998-01-16
申请人： Leonard S. Cech , Michael R. Sewell , Edward J. Gillis , David B. Talley
发明人： Leonard S. Cech , Michael R. Sewell , Edward J. Gillis , David B. Talley
IPC分类号： B60R21/00 , B60R21/01 , G01P15/11 , B60R21/32
CPC分类号： B60R21/0136 , G01P15/11 , B60R2021/0006
摘要： In accordance with a preferred embodiment, a vehicle crash discrimination system (10) comprises a plurality of coil sensors (18) permanently mounted to a vehicle pillar, and a magnet 20 either mounted to a door (14) edge surface juxtaposed to the coils, or to the pillar if a suitable ferromagnetic flux collector is mounted on the door edge. The shape, size and spacing of the coils is predetermined to provide output signals in the coils responsive to the change in the magnetic field caused by movement of the door surface. The change in magnetic field is analyzed to indicate a vehicle crash.
摘要翻译：根据优选实施例，车辆碰撞识别系统（10）包括永久地安装到车辆支柱的多个线圈传感器（18）和安装到与所述线圈并置的门（14）边缘表面的磁体20，或者如果在门边缘上安装合适的铁磁通量收集器，则连接到支柱。线圈的形状，尺寸和间距是预定的，以响应于由门表面的移动引起的磁场变化来提供线圈中的输出信号。分析磁场的变化以指示车辆碰撞。

4. 发明授权

US5744367A Magnetic particle based electrochemiluminescent detection apparatus and method 失效
公开(公告)号：US5744367A
公开(公告)日：1998-04-28
申请号：US339237
申请日：1994-11-10
申请人： David B. Talley , Jonathan K. Leland
发明人： David B. Talley , Jonathan K. Leland
IPC分类号： G01N21/66 , G01N21/69 , G01N21/76 , G01N21/78 , G01N33/543 , G01N33/553 , G01N33/58 , G01N35/00
CPC分类号： G01N21/76 , G01N21/69 , G01N33/54326 , G01N33/582 , G01N35/0098
摘要： A method and apparatus for measuring electrochemiluminescence from a sample composition are described wherein magnetically responsive electrochemiluminescent active species are captured on the electrode with the aid of a capture magnet having a configuration such that the magnetic flux lines (or the magnetic field gradient) of at least one magnetic field source therein are compressed and/or dispersed. This capture magnet improves the distribution of the magnetically responsive electrochemiluminescent active species on the electrode surface and reduces interference with the photomultiplier tube, thereby enhancing the ECL signal and improving sensitivity. The improved capture and distribution also allows for shorter assay times.

5. 发明授权

US06203060B1 System and method for sensing vehicle door edge movement 失效
标题翻译：感应车门边缘运动的系统和方法
公开(公告)号：US06203060B1
公开(公告)日：2001-03-20
申请号：US09482130
申请日：2000-01-12
申请人： Leonard S. Cech , Michael R. Sewell , Edward J. Gillis , David B. Talley
发明人： Leonard S. Cech , Michael R. Sewell , Edward J. Gillis , David B. Talley
IPC分类号： B60R2132
CPC分类号： B60R21/0136 , B60R2021/0006 , G01P13/00 , G01P15/11
摘要： A side impact crash is sensed from the motion of an edge wall of a vehicle door at a location distal to the door hinge in a direction of swing of the door. The rotation of the door about the hinge responsive to a side impact of the door magnifies the measured motion for a point of impact between the hinge and the sensing location. The motion may comprise acceleration, velocity or a relative motion such as relative velocity. The activation of safety restraint system is responsive to the sensed motion. In another embodiment, a side impact crash is sensed with a magnetic circuit comprising at least one coil and at least one permanent magnet, wherein an axis between the north and south poles of the magnet is substantially perpendicular to an axis about which at least one coil is wound. The relative motion is in a direction substantially perpendicular to the axis about which at least one coil is wound.
摘要翻译：从门铰链的远离门铰链的位置处的车门的边缘壁的运动感测到侧面碰撞碰撞。响应于门的侧面碰撞，围绕铰链的门的旋转将测量的运动放大到铰链和感测位置之间的冲击点。运动可以包括加速度，速度或诸如相对速度的相对运动。安全限制系统的激活响应于感测到的运动。在另一个实施例中，用包括至少一个线圈和至少一个永磁体的磁路感测到侧面碰撞碰撞，其中磁体的北极和南极之间的轴线基本上垂直于至少一个线圈是伤口。相对运动是在基本上垂直于至少一个线圈缠绕的轴线的方向上。

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