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1. 发明授权

US08670121B1 Wavelength-tunable detector for label-independent optical reader 有权
标题翻译：用于标签无关光学读取器的波长可调检测器
公开(公告)号：US08670121B1
公开(公告)日：2014-03-11
申请号：US13613974
申请日：2012-09-13
申请人： David Andrew Pastel , Cameron John Tovey
发明人： David Andrew Pastel , Cameron John Tovey
IPC分类号： G01N21/25
CPC分类号： G01N21/774
摘要： A wavelength-tunable detector for use in a label-independent optical reader for reading at least one resonant waveguide grating (RWG) biosensor is disclosed. The wavelength-tunable detector includes a tunable wavelength filter. Broadband light is made incident upon the RWG biosensor to produce resonantly reflected light, which is then passed through the tunable wavelength filter whose central wavelength is adjusted, such as by varying the filter angle of the tunable wavelength filter. This generates filtered resonantly reflected light, which is detected by a photodetector that generates an electrical signal in response thereto. The electrical signal is representative of the detected spectrum, which includes the center resonant wavelength of the RWG biosensor. A controller can be used to determine the center resonant wavelength from the electrical signal.
摘要翻译：公开了一种用于读取至少一个谐振波导光栅（RWG）生物传感器的标签无关光学读取器中的波长可调检测器。波长可调检测器包括可调波长滤波器。宽带光入射到RWG生物传感器上以产生共振的反射光，然后通过调节中心波长的可调谐波长滤波器，例如通过改变可调谐波长滤波器的滤光角度。这产生滤波的共振反射光，该光被由响应于此产生电信号的光电检测器检测。电信号表示检测到的光谱，其包括RWG生物传感器的中心谐振波长。可以使用控制器来确定来自电信号的中心谐振波长。

2. 发明申请

US20110102799A1 Multi-Grating Biosensor For Label-Independent Optical Readers 有权
标题翻译：用于标签无关光学读取器的多光栅生物传感器
公开(公告)号：US20110102799A1
公开(公告)日：2011-05-05
申请号：US12915856
申请日：2010-10-29
申请人： Steven R. Matejka , Robert Adam Modavis , David Andrew Pastel , Garrett Andrew Piech
发明人： Steven R. Matejka , Robert Adam Modavis , David Andrew Pastel , Garrett Andrew Piech
IPC分类号： G01N21/55 , G02B6/10
CPC分类号： G01N21/7743 , G01N21/253 , G01N21/276
摘要： A multi-grating resonant waveguide (RWG) biosensor for an optical reader system having a spatial resolution limit is disclosed. The multi-grating RWG biosensor includes one or more signal-grating regions and one or more reference-grating regions. The multi-grating RWG biosensor can also include a non-resonance region that spatially separates the one or more signal-grating regions, that spatially separates the one or more reference-grating regions, and that spatially separates the one or more reference-grating regions from the one or more signal-grating regions. The non-resonance region can have a minimum width greater than the optical reader system spatial resolution limit. The RWG biosensor can have an asymmetric split-grating configuration. Methods of measuring a signal resonant wavelength of a multi-grating RWG biosensor using an optical reader having a spatial resolution limit are also disclosed.
摘要翻译：公开了一种具有空间分辨率极限的光学读取器系统的多光栅谐振波导（RWG）生物传感器。多光栅RWG生物传感器包括一个或多个信号光栅区域和一个或多个参考光栅区域。多光栅RWG生物传感器还可以包括空间上分离一个或多个信号光栅区域的非共振区域，其在空间上分离一个或多个参考光栅区域，并且在空间上分离一个或多个参考光栅区域从一个或多个信号光栅区域。非共振区域可以具有大于光学读取器系统空间分辨率极限的最小宽度。 RWG生物传感器可以具有非对称分裂光栅配置。还公开了使用具有空间分辨率极限的光学读取器来测量多光栅RWG生物传感器的信号谐振波长的方法。

3. 发明授权

US09897535B2 Optical reader systems and methods for microplate position detection 有权
公开(公告)号：US09897535B2
公开(公告)日：2018-02-20
申请号：US13356956
申请日：2012-01-24
申请人： Ronald C Hollenbeck , David Andrew Pastel , Hak C. Sim , Cameron J. Tovey , Cynthia L. Wida
发明人： Ronald C Hollenbeck , David Andrew Pastel , Hak C. Sim , Cameron J. Tovey , Cynthia L. Wida
IPC分类号： G01J3/447 , G01B11/00 , G01J3/30 , G01B11/14 , G01N21/00 , G01N21/25 , G01N21/77
CPC分类号： G01N21/253 , G01N21/7743
摘要： Optical reader systems and methods with accurate microplate position detection capability are disclosed. The optical reader systems having scanning optical systems that are configured to scan select position-detecting features on the microplate to accurately determine their respective positions. The measurement of the positions of the position-detecting features can also be used to calibrate the optical reader system to reduce or eliminate adverse positioning effects from system non-linearities that arise from one or more of the system components, including the scanning optical system.

4. 发明申请

US20140071450A1 Wavelength-Tunable Detector For Label-Independent Optical Reader 有权
标题翻译：用于标签无关光学读取器的波长可调检测器
公开(公告)号：US20140071450A1
公开(公告)日：2014-03-13
申请号：US13613974
申请日：2012-09-13
申请人： David Andrew Pastel , Cameron John Tovey
发明人： David Andrew Pastel , Cameron John Tovey
IPC分类号： G01J3/51
CPC分类号： G01N21/774
摘要： A wavelength-tunable detector for use in a label-independent optical reader for reading at least one resonant waveguide grating (RWG) biosensor is disclosed. The wavelength-tunable detector includes a tunable wavelength filter. Broadband light is made incident upon the RWG biosensor to produce resonantly reflected light, which is then passed through the tunable wavelength filter whose central wavelength is adjusted, such as by varying the filter angle of the tunable wavelength filter. This generates filtered resonantly reflected light, which is detected by a photodetector that generates an electrical signal in response thereto. The electrical signal is representative of the detected spectrum, which includes the center resonant wavelength of the RWG biosensor. A controller can be used to determine the center resonant wavelength from the electrical signal.
摘要翻译：公开了一种用于读取至少一个谐振波导光栅（RWG）生物传感器的标签无关光学读取器中的波长可调检测器。波长可调检测器包括可调波长滤波器。宽带光入射到RWG生物传感器上以产生共振的反射光，然后通过调节中心波长的可调谐波长滤波器，例如通过改变可调波长滤波器的滤光角度。这产生滤波的共振反射光，该光被由响应于此产生电信号的光电检测器检测。电信号表示检测到的光谱，其包括RWG生物传感器的中心谐振波长。可以使用控制器来确定来自电信号的中心谐振波长。

5. 发明授权

US08614789B2 Microplate mount system and sensing methods 有权
标题翻译：微孔板安装系统和感测方法
公开(公告)号：US08614789B2
公开(公告)日：2013-12-24
申请号：US13032303
申请日：2011-02-22
申请人： David Noblett , Robert E. Krug , Steven Liebold , Mark Francis Krol , David Andrew Pastel , Ravi Marala , Dawn Neumann
发明人： David Noblett , Robert E. Krug , Steven Liebold , Mark Francis Krol , David Andrew Pastel , Ravi Marala , Ken Neumann
IPC分类号： G01N21/01
CPC分类号： G01N35/028 , B01L9/523 , B01L2200/025 , B01L2300/0829
摘要： The invention is a microplate mounting system for mounting a microplate relative to an optical reader to control an angle of incidence of an interrogation beam at the microplate and includes a reference plane with at least one set of mount features that engage one or both of the bottom of the microplate and the skirt of the and a first positioning mechanism that provides a reversible and predetermined separation in the z direction between a plane formed by the bottom of the microplate and the reader, to control the angle of incidence of the interrogation beam at the microplate by reversibly controlling the relative positioning of the microplate in the z direction through the engagement between the bottom and/or skirt of the microplate and the at least one set of mount features.
摘要翻译：本发明是一种微板安装系统，用于相对于光学读取器安装微板，以控制询问光束在微板处的入射角，并包括具有至少一组安装特征的参考平面，所述至少一组安装特征接合底部的一个或两个的微板和第一定位机构的第一定位机构，其在由微板的底部形成的平面和读取器之间在z方向上提供可逆和预定的分离，以控制询问光束的入射角微板通过可逆地控制微板在z方向上的相对定位，通过微板的底部和/或裙部与至少一组安装特征之间的接合。

6. 发明申请

US20120212748A1 OPTICAL READER SYSTEMS AND METHODS FOR MICROPLATE POSITION DETECTION 有权
标题翻译：光学读取器系统和微阵列位置检测方法
公开(公告)号：US20120212748A1
公开(公告)日：2012-08-23
申请号：US13356956
申请日：2012-01-24
申请人： Ronald C. Hollenbeck , David Andrew Pastel , Hak C. Sim , Cameron J. Tovey , Cynthia L. Wida
发明人： Ronald C. Hollenbeck , David Andrew Pastel , Hak C. Sim , Cameron J. Tovey , Cynthia L. Wida
IPC分类号： G01B11/14 , G01D18/00
CPC分类号： G01N21/253 , G01N21/7743
摘要： Optical reader systems and methods with accurate microplate position detection capability are disclosed. The optical reader systems having scanning optical systems that are configured to scan select position-detecting features on the microplate to accurately determine their respective positions. The measurement of the positions of the position-detecting features can also be used to calibrate the optical reader system to reduce or eliminate adverse positioning effects from system non-linearities that arise from one or more of the system components, including the scanning optical system.
摘要翻译：公开了具有精确的微板位置检测能力的光学读取器系统和方法。具有扫描光学系统的光学读取器系统被配置为扫描微板上的选择位置检测特征以精确地确定它们各自的位置。位置检测特征的位置的测量还可以用于校准光学读取器系统，以减少或消除由包括扫描光学系统的一个或多个系统组件产生的系统非线性的不利的定位效应。

7. 发明申请

US20110267623A1 Multi-Wavelength Reference Microplate For Label-Independent Optical Reader 审中-公开
标题翻译：用于标签无关光学读取器的多波长参考微孔板
公开(公告)号：US20110267623A1
公开(公告)日：2011-11-03
申请号：US12915904
申请日：2010-10-29
申请人： Steven R. Matejka , Robert Adam Modavis , David Andrew Pastel , Jeffrey G Ulbrandt
发明人： Steven R. Matejka , Robert Adam Modavis , David Andrew Pastel , Jeffrey G Ulbrandt
IPC分类号： G01N21/47
CPC分类号： G01N21/278 , B01L2200/148 , B01L2300/0829 , G01N21/7743 , G01N2201/13
摘要： A multi-wavelength reference microplate for a label-independent optical reader is disclosed. The microplate includes a support plate that supports a plurality of reference wells. At least one of the reference wells is configured as a multi-wavelength reference well having disposed therein two or more resonant waveguide grating sections that respectively reflect two or more different reference resonant wavelengths within the light source wavelength band. Methods for making and using the microplates are also disclosed.
摘要翻译：公开了一种用于标签无关光学读取器的多波长参考微孔板。微板包括支撑多个参考孔的支撑板。参考阱中的至少一个被配置为多波长参考阱，其中布置有分别反射光源波长带内的两个或更多个不同参考谐振波长的两个或更多个谐振波导光栅部分。还公开了制造和使用微孔板的方法。

8. 发明授权

US08619260B2 Multi-grating biosensor for label-independent optical readers 有权
标题翻译：用于标签无关光学读取器的多光栅生物传感器
公开(公告)号：US08619260B2
公开(公告)日：2013-12-31
申请号：US12915856
申请日：2010-10-29
申请人： Steven R Matejka , Robert Adam Modavis , David Andrew Pastel , Garrett Andrew Piech , Christopher L. Timmons
发明人： Steven R Matejka , Robert Adam Modavis , David Andrew Pastel , Garrett Andrew Piech , Christopher L. Timmons
IPC分类号： G01N21/55 , G01J3/30 , G01J3/28
CPC分类号： G01N21/7743 , G01N21/253 , G01N21/276
摘要： A multi-grating resonant waveguide (RWG) biosensor for an optical reader system having a spatial resolution limit is disclosed. The multi-grating RWG biosensor includes one or more signal-grating regions and one or more reference-grating regions. The multi-grating RWG biosensor can also include a non-resonance region that spatially separates the one or more signal-grating regions, that spatially separates the one or more reference-grating regions, and that spatially separates the one or more reference-grating regions from the one or more signal-grating regions. The non-resonance region can have a minimum width greater than the optical reader system spatial resolution limit. The RWG biosensor can have an asymmetric split-grating configuration. Methods of measuring a signal resonant wavelength of a multi-grating RWG biosensor using an optical reader having a spatial resolution limit are also disclosed.
摘要翻译：公开了一种具有空间分辨率极限的光学读取器系统的多光栅谐振波导（RWG）生物传感器。多光栅RWG生物传感器包括一个或多个信号光栅区域和一个或多个参考光栅区域。多光栅RWG生物传感器还可以包括在空间上分离一个或多个信号光栅区域的非共振区域，其在空间上分离一个或多个参考光栅区域，并且在空间上分离一个或多个参考光栅区域从一个或多个信号光栅区域。非共振区域可以具有大于光学读取器系统空间分辨率极限的最小宽度。 RWG生物传感器可以具有非对称分裂光栅配置。还公开了使用具有空间分辨率极限的光学读取器来测量多光栅RWG生物传感器的信号谐振波长的方法。

9. 发明申请

US20110273706A1 MICROPLATE MOUNT SYSTEM AND SENSING METHODS 有权
标题翻译：麦克风系统和感测方法
公开(公告)号：US20110273706A1
公开(公告)日：2011-11-10
申请号：US13032303
申请日：2011-02-22
申请人： David Noblett , Robert E. Krug , Steven Liebold , Mark Francis Krol , David Andrew Pastel , Ravi Marala , Ken Neumann , Dawn Neumann
发明人： David Noblett , Robert E. Krug , Steven Liebold , Mark Francis Krol , David Andrew Pastel , Ravi Marala , Ken Neumann , Dawn Neumann
IPC分类号： G01N21/01
CPC分类号： G01N35/028 , B01L9/523 , B01L2200/025 , B01L2300/0829
摘要： The invention is a microplate mounting system for mounting a microplate relative to an optical reader to control an angle of incidence of an interrogation beam at the microplate and includes a reference plane with at least one set of mount features that engage one or both of the bottom of the microplate and the skirt of the and a first positioning mechanism that provides a reversible and predetermined separation in the z direction between a plane formed by the bottom of the microplate and the reader, to control the angle of incidence of the interrogation beam at the microplate by reversibly controlling the relative positioning of the microplate in the z direction through the engagement between the bottom and/or skirt of the microplate and the at least one set of mount features.
摘要翻译：本发明是一种微板安装系统，用于相对于光学读取器安装微板，以控制询问光束在微板处的入射角，并包括具有至少一组安装特征的参考平面，所述至少一组安装特征接合底部的一个或两个的微板和第一定位机构的第一定位机构，其在由微板的底部形成的平面和读取器之间在z方向上提供可逆和预定的分离，以控制询问光束的入射角微板通过可逆地控制微板在z方向上的相对定位，通过微板的底部和/或裙部与至少一组安装特征之间的接合。

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