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1. 发明授权

US09629984B2 Medical balloon and balloon catheter assembly 有权
公开(公告)号：US09629984B2
公开(公告)日：2017-04-25
申请号：US13593801
申请日：2012-08-24
申请人： Thomas Lysgaard , Steen Aggerholm , David A. Drewes
发明人： Thomas Lysgaard , Steen Aggerholm , David A. Drewes
IPC分类号： A61M29/00 , A61M25/10 , A61L29/04 , A61L29/18 , A61M25/01 , A61B90/00
CPC分类号： A61M25/1011 , A61B2090/3925 , A61L29/04 , A61L29/18 , A61M25/0108 , A61M25/10 , A61M25/1027 , A61M25/1029 , A61M2025/1013 , A61M2025/1075 , A61M2025/1079
摘要： A medical balloon (10) of a balloon catheter assembly (70) includes a balloon wall (22) formed of at least two layers (30, 32). The first layer (30) is made of an impervious polymeric material. The second layer (32), which is integral with the first layer (30) is made of a radiopaque and/or echogenic material and a polymeric material. In the preferred embodiment, there is provided 60 to 80% by weight of radiopaque material in the second layer (32). It has been found that these concentrations of radiopaque material provide good visibility of the balloon under ultrasonic imaging.

2. 发明授权

US09604036B2 Cutting balloon with connector and dilation element 有权
公开(公告)号：US09604036B2
公开(公告)日：2017-03-28
申请号：US13462458
申请日：2012-05-02
申请人： David G. Burton , Darin G. Schaeffer , David A. Drewes
发明人： David G. Burton , Darin G. Schaeffer , David A. Drewes
IPC分类号： A61M25/10 , A61B17/3207 , A61B17/22
CPC分类号： A61B17/320725 , A61B2017/22061 , A61M25/10 , A61M25/1027 , A61M25/1029 , A61M25/1038 , A61M25/104 , A61M29/02 , A61M2025/1086 , B29C49/04 , B29C49/20 , B29C2049/2017 , B29K2067/003 , B29K2077/00 , B29L2031/7543
摘要： A balloon catheter is provided that may be used to dilate hardened regions of a stenosis. The balloon catheter is provided with one or more dilation elements that extend along a surface of a balloon. Each dilation element is connected to an outer surface of the balloon by a connector. The connector is sufficiently sized and designed to undergo stress-induced plastic deformation incurred during blow molding so that a significant portion of each of the dilation elements does not become absorbed into the wall of the final blow molded balloon, thereby maintaining the structural integrity of each of the dilation elements.

3. 发明授权

US08192675B2 Cutting balloon with connector and dilation element 有权
标题翻译：切割气球与连接器和膨胀元件
公开(公告)号：US08192675B2
公开(公告)日：2012-06-05
申请号：US12399705
申请日：2009-03-06
申请人： David G. Burton , Darin G. Schaeffer , David A. Drewes
发明人： David G. Burton , Darin G. Schaeffer , David A. Drewes
IPC分类号： B29C49/04
CPC分类号： A61B17/320725 , A61B2017/22061 , A61M25/10 , A61M25/1027 , A61M25/1029 , A61M25/1038 , A61M25/104 , A61M29/02 , A61M2025/1086 , B29C49/04 , B29C49/20 , B29C2049/2017 , B29K2067/003 , B29K2077/00 , B29L2031/7543
摘要： A balloon catheter is provided that may be used to dilate hardened regions of a stenosis. The balloon catheter is provided with one or more dilation elements that extend along a surface of a balloon. Each dilation element is connected to an outer surface of the balloon by a connector. The connector is sufficiently sized and designed to undergo stress-induced plastic deformation incurred during blow molding so that a significant portion of each of the dilation elements does not become absorbed into the wall of the final blow molded balloon, thereby maintaining the structural integrity of each of the dilation elements.
摘要翻译：提供了可用于扩张狭窄的硬化区域的气囊导管。球囊导管设置有沿着气球表面延伸的一个或多个扩张元件。每个扩张元件通过连接器连接到气囊的外表面。该连接器具有足够的尺寸和设计，以在吹塑过程中产生应力引起的塑性变形，使得每个膨胀元件的大部分不会被吸收到最终吹塑气球的壁中，从而保持每个膨胀元件的结构完整性的膨胀元素。

4. 发明申请

US20090171323A1 Catheter assembly and fluid supply apparatus therefor 审中-公开
标题翻译：导管组件及其供液装置
公开(公告)号：US20090171323A1
公开(公告)日：2009-07-02
申请号：US12005177
申请日：2007-12-26
申请人： Tyson L. Rugenstein , Michael R. Kurrus , David A. Drewes, JR. , Gregory A. Frankland
发明人： Tyson L. Rugenstein , Michael R. Kurrus , David A. Drewes, JR. , Gregory A. Frankland
IPC分类号： A61M25/18
CPC分类号： A61M25/0028 , A61M39/223 , A61M2025/0037 , A61M2206/20
摘要： A catheter assembly includes a multi-lumen catheter and fluid supply apparatus for supplying fluid to said multi-lumen catheter. The fluid supply apparatus includes an inlet element for coupling to a supply of catheter fluid, a plurality of fluid outlet elements arranged to be each coupled to a respective lumen of the catheter and a flow splitter arranged between the inlet element and the outlet elements. The flow splitter is able to split or divert flow of fluid from the inlet to at least one of the plurality of outlets. For this purpose, the preferred embodiment includes a gate for directing fluid flow to one or more of the outlet elements. There may also be provided a diffuser and a nozzle.
摘要翻译：导管组件包括用于向所述多腔导管供应流体的多腔导管和流体供应装置。流体供应装置包括用于联接到导管流体供应的入口元件，多个流体出口元件，其布置成各自联接到导管的相应内腔，以及布置在入口元件和出口元件之间的分流器。分流器能够将流体从入口流到多个出口中的至少一个出口。为此，优选实施例包括用于将流体流引导到一个或多个出口元件的门。也可以设置扩散器和喷嘴。

5. 发明申请

US20080132836A1 BALLOON CATHETER HAVING IMPROVED BALLOON FOLDING CAPABILITY 有权
标题翻译：具有改进的气球折叠能力的气球导管
公开(公告)号：US20080132836A1
公开(公告)日：2008-06-05
申请号：US11926767
申请日：2007-10-29
申请人： David G. Burton , David A. Drewes , Eric R. Hennessy , Darin G. Schaeffer
发明人： David G. Burton , David A. Drewes , Eric R. Hennessy , Darin G. Schaeffer
IPC分类号： A61M25/10
CPC分类号： A61M25/10 , A61M25/1038 , A61M2025/1004
摘要： The present invention provides apparatus and methods for facilitating folding of a balloon before, during or after a medical procedure. In a first embodiment, the apparatus generally comprises at least one catheter shaft member, a balloon disposed on a distal region of the catheter shaft member, and at least one folding member disposed along at least a proximal region of the balloon. The folding member may comprise at least one radially-outward projecting member integrally formed with or attached to the balloon, or an internally-formed groove in the balloon, which is adapted to promote twisting of the balloon to reduce the profile of the balloon in the deflated state. Optionally, biasing members may be disposed between the folding member and an adjacent portion of the balloon to promote folding of the balloon in a clockwise or counter-clockwise direction.
摘要翻译：本发明提供了用于在医疗过程之前，期间或之后便于折叠气囊的装置和方法。在第一实施例中，该装置通常包括至少一个导管轴构件，设置在导管轴构件的远侧区域上的气囊，以及沿气囊的至少近侧区域设置的至少一个折叠构件。折叠构件可以包括与球囊一体地形成或附接到球囊上的至少一个径向向外突出的构件，或者球囊中的内部形成的凹槽，其适于促进气球的扭转，以减小球囊的轮廓放气状态可选地，偏压构件可以设置在折叠构件和球囊的相邻部分之间，以促进气囊沿顺时针或逆时针方向的折叠。

6. 发明授权

US06592550B1 Medical device including improved expandable balloon 有权
公开(公告)号：US06592550B1
公开(公告)日：2003-07-15
申请号：US09663747
申请日：2000-09-15
申请人： Scott E. Boatman , David G. Burton , Michael C. Hoffa , David R. Lessard , David A. Drewes, Jr. , Maggie A. Z. Hupcey
发明人： Scott E. Boatman , David G. Burton , Michael C. Hoffa , David R. Lessard , David A. Drewes, Jr. , Maggie A. Z. Hupcey
IPC分类号： A61M3100
CPC分类号： C08G69/48 , A61L29/06 , C08F283/04 , C08L77/00 , C08F218/16
摘要： A medical device (10) includes a catheter shaft (11) including inner and outer catheter shafts (12 and 14), and an expandable balloon (18) carried by the catheter shaft (11). The balloon (18) is made from an irradiation cross-linked mixture of a polyamide elastomer and at least one additional cross-linking reactant. The polyamide elastomer can be a polyester amide, a polyether ester amide or a polyether amide, and is preferably a nylon block copolymer. The cross-linking reactant can be: (a) a difunctional material, (b) a trifunctional material, (c) a tetrafunctional material, or (d) an aromatic molecule containing at least two ring substituents, each of the ring substituents having labile hydrogens at a benzylic site therein. The cross-linking reactant can also be diallyl phthalate or meta-phenylene dimaleimide. Irradiation is carried out by exposure to an electron beam or to ultraviolet, X- or gamma radiation, preferably at a total fluence of about 0.5 to about 20 megarads. The amount of the cross-linking reactant is selected to avoid the formation of gelling during the process by which the balloon (18) is made, and the amount of the cross-linking agent and the irradiation fluence are selected to give the balloon a strength generally about equal to that which would be obtained by mere irradiation.

7. 发明授权

US5300048A Flexible, highly radiopaque plastic material catheter 失效
标题翻译：灵活，高度不透射线的塑料导管
公开(公告)号：US5300048A
公开(公告)日：1994-04-05
申请号：US60746
申请日：1993-05-12
申请人： David A. Drewes, Jr. , Fred T. Parker
发明人： David A. Drewes, Jr. , Fred T. Parker
IPC分类号： A61B6/12 , A61L29/00 , A61M25/00 , A61M25/01
CPC分类号： A61M25/0108 , A61M2025/0163
摘要： A flexible plastic material catheter having a distal tubular member portion with a greater than 75 weight percent loading of a radiopaque agent for radiographic viewing. The catheter comprises an elongated member having a proximal portion and a distal end portion with a flexible, radiopaque plastic material having a durometer lower than that of the proximal portion. The plastic material of the distal end portion comprises a homogeneous and evenly dispersed composition of a 20 weight percent base thermoplastic, elastomer material such as a polyether block amide and 80 weight percent loading of a radiopaque agent such as tungsten. This distal end portion plastic material exhibits a durometer of approximately 47 on the Shore D scale, whereas the polyether block amide material exhibits a durometer of approximately 40 on the Shore D scale. The flex modulus of the polyether block amide material is in a range of 23,000 to 75,000 pounds per square inch. The proximal end portion comprises a base thermoplastic material such as a polyamide elastomer material and a radiopaque agent of bismuth oxychloride.
摘要翻译：一种柔性塑料材料导管，其具有远端管状部件，其具有大于75重量％的用于放射照相观察的不透射线剂的负载。导管包括细长构件，其具有近端部分和远端部分，该远端部分具有柔性的不透射线的塑料材料，该塑料材料的硬度低于近端部分的硬度。远端部分的塑料材料包括均匀和均匀分散的20重量％的基础热塑性弹性体材料如聚醚嵌段酰胺和80重量％的不透射线剂如钨的负载的组合物。该远端部分塑料材料在肖氏D刻度上表现出大约47的硬度，而聚醚嵌段酰胺材料在肖氏D刻度表现出大约40的硬度。聚醚嵌段酰胺材料的挠曲模量在23,000至75,000磅/平方英寸的范围内。近端部分包括诸如聚酰胺弹性体材料的基底热塑性材料和氯氧化铋的不透射线剂。

8. 发明申请

US20100163159A1 LARGE DIAMETER DELIVERY CATHETER/SHEATH 有权
标题翻译：大直径输送管/管
公开(公告)号：US20100163159A1
公开(公告)日：2010-07-01
申请号：US12719228
申请日：2010-03-08
申请人： Jay A. Dittman , David A. Drewes, JR.
发明人： Jay A. Dittman , David A. Drewes, JR.
IPC分类号： B29C53/60
CPC分类号： A61M25/0012 , A61M25/0045 , A61M25/005 , A61M25/0053 , A61M25/0108 , A61M25/0662 , A61M2025/0047 , A61M2025/0059
摘要： A large diameter, flexible, kink-resistant, delivery catheter or sheath for percutaneous delivery of a contained and implantable medical device in the vasculature of a patient. The delivery catheter or sheath includes a reinforcement such as a flat wire coil with uniform spacing between the turns, which is compression fitted about an inner, lubricous PTFE tube. The delivery catheter or sheath further includes an outer tube of a heat formable polyamide material which is heat formed and compressed through the spaces between the turns of the wire coil to mechanically connect to a roughened outer surface of the inner tube. A polymeric radiopaque marker tube may be positioned at the distal end of the coil and between the inner and outer tubes for radiographic visualization. A side port may also be positioned thereat for the infusion of contrast media.
摘要翻译：大直径，柔性，扭结的输送导管或护套，用于经皮递送患者脉管系统中的容纳和可植入的医疗装置。输送导管或护套包括一个加强件，例如扁平线圈之间，在匝之间具有均匀的间隔，其被压配合在内部的，润滑的PTFE管周围。递送导管或护套还包括可热成型的聚酰胺材料的外管，其通过线圈的匝之间的空间热形成和压缩，以机械地连接到内管的粗糙的外表面。聚合物不透射线标记管可以定位在线圈的远端处，并且位于内管和外管之间用于放射照相可视化。侧端口也可以放置在其中用于输注造影剂。

9. 发明授权

US07704245B2 Large diameter delivery catheter/sheath 有权
标题翻译：大直径输送导管/护套
公开(公告)号：US07704245B2
公开(公告)日：2010-04-27
申请号：US10823176
申请日：2004-04-13
申请人： Jay A. Dittman , David A. Drewes, Jr.
发明人： Jay A. Dittman , David A. Drewes, Jr.
IPC分类号： A61M25/00
CPC分类号： A61M25/0012 , A61M25/0045 , A61M25/005 , A61M25/0053 , A61M25/0108 , A61M25/0662 , A61M2025/0047 , A61M2025/0059
摘要： A large diameter delivery catheter or sheath for percutaneous delivery of a contained and implantable medical device in the vasculature of a patient. The delivery catheter or sheath includes a reinforcement such as a flat wire coil with uniform spacing between the turns. The reinforcement is compression fitted about an inner, lubricous PTFE tube having a substantially uniform inner diameter of from 16 to 30 French. The delivery catheter or sheath further includes an outer tube of a heat formable polyamide material having a durometer of about 30 to 60 on the Shore D scale. The outer tube is heat formed and compressed through the spaces between the turns of the wire coil to mechanically connect to a roughened outer surface of the inner tube. A polymeric radiopaque marker tube may be positioned at the distal end of the coil and between the inner and outer tubes for radiographic visualization.
摘要翻译：用于在患者的脉管系统中经皮递送包含和可植入的医疗装置的大直径输送导管或护套。递送导管或护套包括一个加强件，例如在匝之间具有均匀间隔的扁线线圈。加强件压缩安装在具有16至30法国的基本上均匀的内径的内部润滑PTFE管周围。递送导管或护套还包括在肖氏D刻度上具有约30至60的硬度的可热成型聚酰胺材料的外管。外管通过线圈的匝之间的空间热成形和压缩，以机械地连接到内管的粗糙的外表面。聚合物不透射线标记管可以定位在线圈的远端处，并且位于内管和外管之间用于放射照相可视化。

10. 发明申请

US20090234283A1 Cutting Balloon With Connector and Dilation Element 有权
标题翻译：切割气球与连接器和扩张元素
公开(公告)号：US20090234283A1
公开(公告)日：2009-09-17
申请号：US12399705
申请日：2009-03-06
申请人： David G. BURTON , Darin G. Schaeffer , David A. Drewes
发明人： David G. BURTON , Darin G. Schaeffer , David A. Drewes
IPC分类号： A61M25/10 , B29C49/00
CPC分类号： A61B17/320725 , A61B2017/22061 , A61M25/10 , A61M25/1027 , A61M25/1029 , A61M25/1038 , A61M25/104 , A61M29/02 , A61M2025/1086 , B29C49/04 , B29C49/20 , B29C2049/2017 , B29K2067/003 , B29K2077/00 , B29L2031/7543
摘要： A balloon catheter is provided that may be used to dilate hardened regions of a stenosis. The balloon catheter is provided with one or more dilation elements that extend along a surface of a balloon. Each dilation element is connected to an outer surface of the balloon by a connector. The connector is sufficiently sized and designed to undergo stress-induced plastic deformation incurred during blow molding so that a significant portion of each of the dilation elements does not become absorbed into the wall of the final blow molded balloon, thereby maintaining the structural integrity of each of the dilation elements.
摘要翻译：提供了可用于扩张狭窄的硬化区域的气囊导管。球囊导管设置有沿着气球表面延伸的一个或多个扩张元件。每个扩张元件通过连接器连接到气囊的外表面。该连接器具有足够的尺寸和设计，以在吹塑过程中产生应力引起的塑性变形，使得每个膨胀元件的大部分不会被吸收到最终吹塑气球的壁中，从而保持每个膨胀元件的结构完整性的膨胀元素。

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