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1. 发明授权

US6017965A Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases 失效
公开(公告)号：US6017965A
公开(公告)日：2000-01-25
申请号：US763480
申请日：1996-12-11
申请人： Alan L. Mueller , Manuel F. Balandrin , Bradford C. VanWagenen , Scott T. Moe , Eric G. DelMar , Linda D. Artman , Robert M. Barmore , Daryl L. Smith
发明人： Alan L. Mueller , Manuel F. Balandrin , Bradford C. VanWagenen , Scott T. Moe , Eric G. DelMar , Linda D. Artman , Robert M. Barmore , Daryl L. Smith
IPC分类号： A61K31/135 , A61K31/136 , A61K31/137 , A61K31/138 , A61K31/155 , A61K31/165 , A61K31/295 , A61K31/381 , A61K31/40 , A61K31/4409 , A61K31/4462 , A61K31/4465 , C07C201/14 , C07C211/27 , C07C211/28 , C07C211/29 , C07C211/40 , C07C211/42 , C07C211/54 , C07C211/55 , C07C215/28 , C07C215/54 , C07C217/10 , C07C217/48 , C07C217/58 , C07C217/60 , C07C217/62 , C07C233/11 , C07C233/13 , C07C233/22 , C07C235/34 , C07C237/06 , C07C237/22 , C07C257/14 , C07C279/14 , C07D207/08 , C07D207/12 , C07D207/20 , C07D209/42 , C07D211/18 , C07D213/30 , C07D213/32 , C07D213/38 , C07D231/20 , C07D333/20
CPC分类号： C07D207/08 , A61K31/135 , A61K31/136 , A61K31/137 , A61K31/138 , A61K31/155 , A61K31/165 , A61K31/295 , A61K31/381 , A61K31/40 , A61K31/4409 , A61K31/4462 , A61K31/4465 , C07C211/27 , C07C211/28 , C07C211/29 , C07C211/40 , C07C211/42 , C07C211/54 , C07C211/55 , C07C215/28 , C07C215/54 , C07C217/10 , C07C217/48 , C07C217/58 , C07C217/60 , C07C217/62 , C07C233/11 , C07C233/13 , C07C233/22 , C07C235/34 , C07C237/06 , C07C237/22 , C07C257/14 , C07C279/14 , C07D207/12 , C07D207/20 , C07D209/42 , C07D211/18 , C07D213/30 , C07D213/32 , C07D213/38 , C07D231/20 , C07D333/20 , C07B2200/07 , C07C2101/02 , C07C2101/08 , C07C2101/14 , C07C2103/32
摘要： Method and compositions for treating a patient having a neurological disease or disorder, such as stroke, head trauma, spinal cord injury, spinal cord ischemia, ischemia- or hypoxia-induced nerve cell damage, epilepsy, anxiety, neuropsychiatric or cognitive deficits due to ischemia or hypoxia such as those that frequently occur as a consequence of cardiac surgery under cardiopulmonary bypass, or neurodegenerative diseases such as Alzheimer's Disease, Huntington's Disease, Parkinson's Disease, or amyotrophic lateral sclerosis (ALS).

2. 发明授权

US07112595B2 Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists 失效
公开(公告)号：US07112595B2
公开(公告)日：2006-09-26
申请号：US10699563
申请日：2003-11-03
申请人： Bradford Van Wagenen , Thomas M. Stormann , Scott T Moe , Susan M Sheehan , Donald McLeod , Daryl L Smith , Methvin Isaac , Abdelmalik Slassi , Ian Egle , Louise Edwards , Tomislav Stefanac , Tao Xin , Jalaj Arora , William Michne
发明人： Bradford Van Wagenen , Thomas M. Stormann , Scott T Moe , Susan M Sheehan , Donald McLeod , Daryl L Smith , Methvin Isaac , Abdelmalik Slassi , Ian Egle , Louise Edwards , Tomislav Stefanac , Tao Xin , Jalaj Arora , William Michne
IPC分类号： A61K31/44 , C07D401/02
CPC分类号： C07D213/75 , C07D213/55 , C07D213/78 , C07D213/79 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/04 , C07D405/04 , C07D405/14 , C07D413/04 , C07D413/14 , C07D417/04
摘要： The present invention provides compounds and pharmaceutical compositions that act as antagonists at metabotropic glutamate receptors, and that are useful for treating neurological diseases and disorders. Methods of preparing the compounds also are disclosed.

3. 发明授权

US07053104B2 Metabotropic glutamate receptor antagonists and their use for treating central nervous system diseases 失效
公开(公告)号：US07053104B2
公开(公告)日：2006-05-30
申请号：US10211523
申请日：2002-08-05
申请人： Bradford C. Van Wagenen , Scott T. Moe , Daryl L. Smith , Susan M. Sheehan , Irina Shcherbakova , Ruth Walton , Richard Trovato , Robert Barmore , Eric G. Delmar , Thomas M. Stormann
发明人： Bradford C. Van Wagenen , Scott T. Moe , Daryl L. Smith , Susan M. Sheehan , Irina Shcherbakova , Ruth Walton , Richard Trovato , Robert Barmore , Eric G. Delmar , Thomas M. Stormann
IPC分类号： A61K31/47 , C07D215/14
CPC分类号： C07D213/81 , C07D209/42 , C07D213/82 , C07D215/12 , C07D215/20 , C07D215/38 , C07D215/48 , C07D215/54 , C07D217/26 , C07D231/12 , C07D233/56 , C07D241/42 , C07D241/44 , C07D249/08 , C07D277/68 , C07D277/70 , C07D307/68 , C07D307/84 , C07D333/38 , C07D333/68 , C07D491/04
摘要： The present invention provides compounds, and pharmaceutical compositions containing those compounds, that are active at metabotropic glutamate receptors. The compounds are useful for treating neurological diseases and disorders. Methods of preparing the compounds also are disclosed.

4. 发明授权

US06660753B2 Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists 失效
标题翻译：杂多环化合物及其作为代谢型谷氨酸受体拮抗剂的用途
公开(公告)号：US06660753B2
公开(公告)日：2003-12-09
申请号：US10076618
申请日：2002-02-19
申请人： Bradford Van Wagenen , Thomas M. Stormann , Scott T. Moe , Susan M. Sheehan , Donald A. McLeod , Daryl L. Smith , Methvin Benjamin Isaac , Abdelmalik Slassi
发明人： Bradford Van Wagenen , Thomas M. Stormann , Scott T. Moe , Susan M. Sheehan , Donald A. McLeod , Daryl L. Smith , Methvin Benjamin Isaac , Abdelmalik Slassi
IPC分类号： C07D40102
CPC分类号： C07D213/75 , C07D213/55 , C07D213/78 , C07D213/79 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/04 , C07D405/04 , C07D405/14 , C07D413/04 , C07D413/14 , C07D417/04
摘要： The present invention provides compounds and pharmaceutical compositions that act as antagonists at metabotropic glutamate receptors, and that are useful for treating neurological diseases and disorders. Methods of preparing the compounds also are disclosed.
摘要翻译：本发明提供了作为代谢型谷氨酸受体拮抗剂的化合物和药物组合物，其可用于治疗神经疾病和病症。还公开了制备化合物的方法。

5. 发明授权

US5016003A Environmental control system for the handicapped 失效
标题翻译：残疾人环境管理系统
公开(公告)号：US5016003A
公开(公告)日：1991-05-14
申请号：US263439
申请日：1988-10-27
申请人： Richard F. Rice, Jr. , David M. Kelly , Daryl L. Smith
发明人： Richard F. Rice, Jr. , David M. Kelly , Daryl L. Smith
IPC分类号： G09B21/00 , H04M1/247
CPC分类号： H04M1/2474 , G09B21/00
摘要： An environmental control system for the handicapped provides a user interface which is totally integrated and programmable. An audible nested control option selection structure organizes logically related tasks and subtasks together so the user can access the tasks and subtasks in a natural fashion--providing an easy to learn user interface that is user friendly, minimizes frustration in accomplishing desired tasks, and also minimizes the time required to perform even complex control operations. Enhanced user interface features, including time encoding of control switch functions and synthesized speech prompting, further increases ease of operation and functionality. Interaction between different control channels allows the user to perform different tasks simultaneously. Enhanced telephone line manipulation is provided, including off-line assembly of telephone numbers for dialing which can be stored and easily accessed by the user through the unified audible sub-menu structure. Sharing of common hardware for multiple functions minimizes system cost, increases reliability and makes the system easier to use.
摘要翻译：残疾人环境控制系统提供完全集成和可编程的用户界面。可听见的嵌套控制选项选择结构将逻辑相关任务和子任务组合在一起，以便用户可以以自然的方式访问任务和子任务 - 提供易于学习的用户界面，最大程度地减少了实现所需任务的挫折感，并最大限度地减少执行甚至复杂的控制操作所需的时间。增强的用户界面功能，包括控制开关功能的时间编码和合成语音提示，进一步提高了操作和功能的便利性。不同控制通道之间的交互允许用户同时执行不同的任务。提供了增强的电话线操作，包括用于拨号的电话号码的离线组合，其可以由用户通过统一的可听的子菜单结构存储和容易地访问。共享多个功能的通用硬件可以最大限度地降低系统成本，提高可靠性，使系统更易于使用。

6. 发明授权

US06429207B1 Metabotropic glutamate receptor antagonists and their use for treating central nervous system diseases 失效
标题翻译：代谢型谷氨酸受体拮抗剂及其用于治疗中枢神经系统疾病的用途
公开(公告)号：US06429207B1
公开(公告)日：2002-08-06
申请号：US09573347
申请日：2000-05-19
申请人： Bradford C. Van Wagenen , Scott T. Moe , Daryl L. Smith , Susan M. Sheehan , Irina Shcherbakova , Richard Travato , Ruth Walton , Robert Barmore , Eric G. Delmar , Thomas M. Stormann
发明人： Bradford C. Van Wagenen , Scott T. Moe , Daryl L. Smith , Susan M. Sheehan , Irina Shcherbakova , Richard Travato , Ruth Walton , Robert Barmore , Eric G. Delmar , Thomas M. Stormann
IPC分类号： A61K31498
CPC分类号： C07D213/81 , C07D209/42 , C07D213/82 , C07D215/12 , C07D215/20 , C07D215/38 , C07D215/48 , C07D215/54 , C07D217/26 , C07D231/12 , C07D233/56 , C07D241/42 , C07D241/44 , C07D249/08 , C07D277/68 , C07D277/70 , C07D307/68 , C07D307/84 , C07D333/38 , C07D333/68 , C07D491/04
摘要： The present invention provides compounds, and pharmaceutical compositions containing those compounds, that are active at metabotropic glutamate receptors. The compounds are useful for treating neurological diseases and disorders. Methods of preparing the compounds also are disclosed.
摘要翻译：本发明提供了在代谢型谷氨酸受体中具有活性的化合物和含有那些化合物的药物组合物。该化合物可用于治疗神经疾病和病症。还公开了制备化合物的方法。

7. 发明授权

US5600311A Environmental control system with auxiliary control interface 失效
标题翻译：环境控制系统具有辅助控制界面
公开(公告)号：US5600311A
公开(公告)日：1997-02-04
申请号：US422881
申请日：1995-04-17
申请人： Richard F. Rice , David M. Kelly , Daryl L. Smith
发明人： Richard F. Rice , David M. Kelly , Daryl L. Smith
IPC分类号： A61F4/00 , G05B19/10 , H02B15/00
CPC分类号： A61F4/00 , G05B19/106 , H02B15/00 , G05B2219/23315 , G05B2219/2642 , Y02B70/3241 , Y04S20/227
摘要： An environmental control system for the severely disabled provides a "pass through" mode that allows a system output to mimic or emulate a user controlled switch input. The pass through mode permits a single user controlled switch to be shared among multiple systems for the disabled. In the normal mode, the user controlled switch controls various control functions provided by the environmental control system. In the "pass through" mode, the environmental control system operates "transparently" and passes the switch closures through to an electronically-controlled switch that appears electrically like a manually actuated switch to control other equipment for the disabled. The pass through mode is exited upon user actuation of the user controlled switch for more than a programmed time period and/or automatically upon occurrence of certain events (e.g., telephone ringing detection).
摘要翻译：严格禁用的环境控制系统提供了“通过”模式，允许系统输出模拟或模拟用户控制的开关输入。通过模式允许单个用户控制的交换机在被禁用的多个系统之间共享。在正常模式下，用户控制开关控制由环境控制系统提供的各种控制功能。在“通过”模式下，环境控制系统“透明地”操作，并将开关闭合件通过电子控制开关，电动开关如手动开关开关，以控制残疾人的其他设备。当用户操纵用户控制的开关超过编程的时间段时和/或在某些事件发生时自动地（例如，电话振铃检测），退出模式。

8. 发明授权

US5345226A Environmental control system for the handicapped 失效
标题翻译：残疾人环境管理系统
公开(公告)号：US5345226A
公开(公告)日：1994-09-06
申请号：US540780
申请日：1990-06-20
申请人： Richard F. Rice, Jr. , David M. Kelly , Daryl L. Smith
发明人： Richard F. Rice, Jr. , David M. Kelly , Daryl L. Smith
IPC分类号： G09B21/00 , H04M1/247 , H02B15/00
CPC分类号： H04M1/2474 , G09B21/00
摘要： An environmental control system for the handicapped provides a user interface which is totally integrated and programmable. An audible nested control option selection structure organizes logically related tasks and subtasks together so the user can access the tasks and subtasks in a natural fashion--providing an easy to learn user interface that is user friendly, minimizes frustration in accomplishing desired tasks, and also minimizes the time required to perform even complex control operations. Enhanced user interface features, including time encoding of control switch functions and synthesized speech prompting, further increases ease of operation and functionality. Interaction between different control channels allows the user to perform different tasks simultaneously. Enhanced telephone line manipulation is provided, including off-line assembly of telephone numbers for dialing which can be stored and easily accessed by the user through the unified audible sub-menu structure. Sharing of common hardware for multiple functions minimizes system cost, increases reliability and makes the system easier to use.
摘要翻译：残疾人环境控制系统提供完全集成和可编程的用户界面。可听见的嵌套控制选项选择结构将逻辑相关任务和子任务组合在一起，以便用户可以以自然的方式访问任务和子任务 - 提供易于学习的用户界面，最大程度地减少了实现所需任务的挫折感，并最大限度地减少执行甚至复杂的控制操作所需的时间。增强的用户界面功能，包括控制开关功能的时间编码和合成语音提示，进一步提高了操作和功能的便利性。不同控制通道之间的交互允许用户同时执行不同的任务。提供了增强的电话线操作，包括用于拨号的电话号码的离线组合，其可以由用户通过统一的可听的子菜单结构存储和容易地访问。共享多个功能的通用硬件可以最大限度地降低系统成本，提高可靠性，使系统更易于使用。

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