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1. 发明授权

US06890440B2 Method and apparatus for enhancing filter bed performance 失效
标题翻译：提高滤床性能的方法和装置
公开(公告)号：US06890440B2
公开(公告)日：2005-05-10
申请号：US10632527
申请日：2003-08-01
申请人： Dennis Chilcote , Mike S. Gratz , Robert Clifford , John Mills , Gregory Vineretsky , Daniel McGraw , Alan Dunn , Bobby Dabbs , Karie Mars
发明人： Dennis Chilcote , Mike S. Gratz , Robert Clifford , John Mills , Gregory Vineretsky , Daniel McGraw , Alan Dunn , Bobby Dabbs , Karie Mars
IPC分类号： B01D24/22 , C02F3/04
CPC分类号： B01D24/22 , B01D24/46
摘要： In a vessel containing a filter bed and containing a mixed liquor containing suspended solids, a system disturbs/dislodges a sludge mat that settles on the filter bed. Thus, the system controls the sludge mat on the filter bed that otherwise may blind the filter bed and significantly reduce or stop process liquid flow into and through the filter bed. The system helps maintain effective vessel effluent flowrates with reduced requirements for filter bed backwashing or other filter bed maintenance. The system includes a sludge mat dislodging member that moves along the filter bed surface, preferably on but substantially not inside the filter bed, to disrupt/dislodge the sludge mat and/or prevent formation of the sludge mat. Preferably, the dislodging member is carried inside the vessel on a moving arm or arms that rotate in a plane parallel to the filter bed surface. The preferred sludge mat dislodging member(s) hang from the rotating arm(s) to slide along the top of the filter bed through the sludge mat. The sludge mat control methods and apparatus preferably are used during normal operation of the reactor/vessel, without requiring shutdown or interruption of the process. The methods and apparatus may be effective in sludge blanket microbial remediation reactors that require high flowrates of liquid effluent due to low residence times in a given vessel.
摘要翻译：在含有过滤床并含有含有悬浮固体的混合液的容器中，系统扰乱/移除沉降在过滤床上的污泥垫。因此，系统控制过滤床上的污泥垫，否则可能使过滤床蒙蔽，并显着地减少或停止过滤液体流入和通过过滤床。该系统有助于维持有效的容器流出物流量，同时减少过滤床反冲洗或其他过滤床维护的要求。该系统包括沿过滤床表面移动，优选地但基本上不在过滤床内部的污泥垫移动构件，以破坏/移除污泥垫和/或防止污泥垫的形成。优选地，移动构件在容器内承载在与滤床平面平行的平面内旋转的移动臂或臂上。优选的污泥垫移动构件从旋转臂悬挂以沿着过滤床的顶部通过污泥垫滑动。污泥板控制方法和装置优选在反应器/容器的正常操作期间使用，而不需要关闭或中断该方法。由于在给定的容器中的停留时间低，所以这些方法和装置可能对需要高流出液体流出物的污泥层微生物修复反应器是有效的。

2. 发明授权

US06843961B2 Reduction of contaminants in blood and blood products using photosensitizers and peak wavelengths of light 有权
标题翻译：使用光敏剂和光的峰值波长减少血液和血液制品中的污染物
公开(公告)号：US06843961B2
公开(公告)日：2005-01-18
申请号：US10357599
申请日：2003-02-03
申请人： Dennis J. Hlavinka , Raymond P. Goodrich , Laura Goodrich , Daniel McGraw
发明人： Dennis J. Hlavinka , Raymond P. Goodrich , Laura Goodrich , Daniel McGraw
IPC分类号： A61K31/00 , A61K31/28 , A61K31/555 , A61K31/60 , A61K31/603 , A61K31/695 , A61K31/7048 , A61K31/7135 , A61K33/00 , A61K33/14 , A61K33/32 , A61K35/18 , A61K41/00 , A61K45/06 , A61K47/48 , A61L2/00 , A61L2/08 , A61L2/10 , A61L2/24 , A61L2/26 , A61M1/36 , C07F11/00 , C07F13/00 , C07F15/02 , C07F17/00 , C12N13/00 , B01J19/00 , C12N1/00 , C12N9/00
CPC分类号： A61L2/24 , A61K31/00 , A61K31/28 , A61K31/555 , A61K31/60 , A61K31/603 , A61K31/695 , A61K31/7048 , A61K31/7135 , A61K33/00 , A61K33/14 , A61K33/32 , A61K35/18 , A61K41/0019 , A61K41/0057 , A61K41/0071 , A61K45/06 , A61K47/52 , A61L2/0011 , A61L2/0047 , A61L2/0076 , A61L2/0088 , A61L2/08 , A61L2/10 , A61L2/26 , A61L2202/14 , A61L2202/22 , A61M1/3681 , A61M1/3683 , C07F11/005 , C07F13/005 , C07F15/02 , C07F17/00 , C12N13/00 , A61K2300/00
摘要： Methods and apparatuses are provided for inactivation of pathogens in fluids containing blood products. Preferred methods include the steps of adding an effective, nontoxic amount of a photosensitizer such as riboflavin to the blood product and exposing the fluid to light having a peak wavelength.
摘要翻译：提供了用于在含有血液制品的流体中灭活病原体的方法和装置。优选的方法包括以下步骤：向血液制品中加入有效无毒量的光敏剂如核黄素并使流体暴露于具有峰值波长的光。

3. 发明申请

US20050283059A1 Fetal oximetry system and sensor 有权
标题翻译：胎儿血氧饱和度测定系统和传感器
公开(公告)号：US20050283059A1
公开(公告)日：2005-12-22
申请号：US10957430
申请日：2004-10-01
申请人： Vijay Iyer , Robert Johnson , Johannes Buschmann , Reinhold Falkowski , Christopher Cutler , William Wallace , Steven Smith , Daniel McGraw , Nick Tu , Clifford Montagnoli , Trent Banks
发明人： Vijay Iyer , Robert Johnson , Johannes Buschmann , Reinhold Falkowski , Christopher Cutler , William Wallace , Steven Smith , Daniel McGraw , Nick Tu , Clifford Montagnoli , Trent Banks
IPC分类号： A61B5/145 , A61B5/00 , A61B5/1455 , A61B5/1464
CPC分类号： A61B5/1464 , A61B5/14542 , A61B5/6848 , A61B5/6882
摘要： An optical measuring device having multiple optical paths between one or more light emitters and one or more light detectors and/or providing at least two sets of wavelength of light along at least one path, with a final measurement being produced as a combination of measurements of the sets of wavelengths of light taken along one or more of the optical paths. Features that contribute to increased safety and ease of use include providing (1) a receiving cavity in a proximal end of an insertion rod that holds a free end of a circuit connector to keep it from becoming tangled or snagged, (2) a mechanism to keep the sensor within an introducer tube during storage and insertion and to expose a portion of the sensor only when the sensor is applied to the unborn baby, (3) a tab on the insertion rod to prevent the circuit connector from becoming tangled or snagged within the introducer tube, (4) a rotating feature whereby if a torque applied on the sensor exceeds a first predetermined amount, the sensor rotates, and a disengaging feature whereby the sensor detaches from insertion rod if a pull-off force exceeds a second predetermined amount, the rotating and disengaging features being independent of one another, (5) a circuit connector that includes at least one of the following features: (a) a stiffening member provided at the proximal end to minimize bending, (b) a shielding layer, and (c) at least one slit to increase the flexibility of the circuit connector, and (6) an interface that includes an identification element that is detected by an external circuit only if the circuit connector is connected to the interface. The present invention also pertains to a method of manufacturing a needle that is used in an invasive sensor, and preferably for fetal monitoring, that provides features not heretofore available in conventional sensors.
摘要翻译：一种光学测量装置，其在一个或多个光发射器与一个或多个光检测器之间具有多个光路，和/或沿着至少一个路径提供至少两组波长的光，其最终的测量是作为沿着一个或多个光路取得的光的波长组。有助于提高安全性和使用易用性的特征包括提供（1）在插入杆的近端中的容纳腔，其保持电路连接器的自由端以防止缠绕或阻塞，（2）机构在储存和插入过程中将传感器保持在导引管内，并且只有当传感器应用于未出生的婴儿时才能暴露传感器的一部分，（3）插入杆上的突片，以防止电路连接器缠结或阻塞导引管，（4）旋转特征，如果施加在传感器上的扭矩超过第一预定量，则传感器旋转，并且如果脱离力超过第二预定量，则传感器脱离插入杆的脱离特征，所述旋转和分离特征彼此独立;（5）电路连接器，其包括以下特征中的至少一个：（a）加强构件，其设置在所述近端处的迷你微孔弯曲，（b）屏蔽层，和（c）至少一个狭缝，以增加电路连接器的灵活性;以及（6）包括识别元件的界面，只有当电路连接器连接到接口。本发明还涉及一种制造针头的方法，所述针头用于侵入式传感器，并且优选地用于胎儿监测，其提供以前在常规传感器中可用的特征。

4. 发明申请

US20050211628A1 Method and apparatus for enhancing filter bed performance 失效
公开(公告)号：US20050211628A1
公开(公告)日：2005-09-29
申请号：US11126433
申请日：2005-05-10
申请人： Dennis Chilcote , Michael Gratz , Robert Clifford , John Mills , Gregory Vineretsky , Daniel McGraw , Alan Dunn , Bobby Dabbs , Karie Mars
发明人： Dennis Chilcote , Michael Gratz , Robert Clifford , John Mills , Gregory Vineretsky , Daniel McGraw , Alan Dunn , Bobby Dabbs , Karie Mars
IPC分类号： B01D24/22 , C02F3/04
CPC分类号： B01D24/22 , B01D24/46
摘要： In a vessel containing a filter bed and containing a mixed liquor containing suspended solids, a system disturbs/dislodges a sludge mat that settles on the filter bed. Thus, the system controls the sludge mat on the filter bed that otherwise may blind the filter bed and significantly reduce or stop process liquid flow into and through the filter bed. The system helps maintain effective vessel effluent flowrates with reduced requirements for filter bed backwashing or other filter bed maintenance. The system includes a sludge mat dislodging member that moves along the filter bed surface, preferably on but substantially not inside the filter bed, to disrupt/dislodge the sludge mat and/or prevent formation of the sludge mat. Preferably, the dislodging member is carried inside the vessel on a moving arm or arms that rotate in a plane parallel to the filter bed surface. The preferred sludge mat dislodging member(s) hang from the rotating arm(s) to slide along the top of the filter bed through the sludge mat. The sludge mat control methods and apparatus preferably are used during normal operation of the reactor/vessel, without requiring shutdown or interruption of the process. The methods and apparatus may be effective in sludge blanket microbial remediation reactors that require high flowrates of liquid effluent due to low residence times in a given vessel.

5. 发明申请

US20050112021A1 Reduction of Contaminants In Blood and Blood Products Using Photosensitizers and Peak Wavelengths of Light 审中-公开
标题翻译：使用光敏剂减少血液和血液中的污染物和光的峰值波长
公开(公告)号：US20050112021A1
公开(公告)日：2005-05-26
申请号：US10904361
申请日：2004-11-05
申请人： Dennis HLAVINKA , Raymond GOODRICH , Laura GOODRICH , Daniel MCGRAW
发明人： Dennis HLAVINKA , Raymond GOODRICH , Laura GOODRICH , Daniel MCGRAW
IPC分类号： A61K31/00 , A61K31/28 , A61K31/555 , A61K31/60 , A61K31/603 , A61K31/695 , A61K31/7048 , A61K31/7135 , A61K33/00 , A61K33/14 , A61K33/32 , A61K35/18 , A61K41/00 , A61K45/06 , A61K47/48 , A61L2/00 , A61L2/08 , A61L2/10 , A61L2/24 , A61L2/26 , A61M1/36 , C07F11/00 , C07F13/00 , C07F15/02 , C07F17/00 , C12N13/00
CPC分类号： A61L2/24 , A61K31/00 , A61K31/28 , A61K31/555 , A61K31/60 , A61K31/603 , A61K31/695 , A61K31/7048 , A61K31/7135 , A61K33/00 , A61K33/14 , A61K33/32 , A61K35/18 , A61K41/0019 , A61K41/0057 , A61K41/0071 , A61K45/06 , A61K47/52 , A61L2/0011 , A61L2/0047 , A61L2/0076 , A61L2/0088 , A61L2/08 , A61L2/10 , A61L2/26 , A61L2202/14 , A61L2202/22 , A61M1/3681 , A61M1/3683 , C07F11/005 , C07F13/005 , C07F15/02 , C07F17/00 , C12N13/00 , A61K2300/00
摘要： Methods and apparatuses are provided for inactivation of pathogens in fluids containing blood products. Preferred methods include the steps of adding an effective, non-toxic amount of a photosensitizer such as riboflavin to the blood product and exposing the fluid to light having a peak wavelength.
摘要翻译：提供了用于在含有血液制品的流体中灭活病原体的方法和装置。优选的方法包括将有效的无毒量的光敏剂如核黄素添加到血液制品中并将流体暴露于具有峰值波长的光的步骤。

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