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1. 发明申请

US20080107636A1 Induction of and Maintenance of Nucleic Acid Damage in Pathogens Using Riboflavin and Light 有权
标题翻译：使用核黄素和光诱导和维持病原体中的核酸损伤
公开(公告)号：US20080107636A1
公开(公告)日：2008-05-08
申请号：US11932629
申请日：2007-10-31
申请人： Raymond GOODRICH , Shawn KEIL
发明人： Raymond GOODRICH , Shawn KEIL
IPC分类号： A01N1/02 , A01N63/00
CPC分类号： A01N43/90 , A61K41/0019 , A61L2/0011 , A61L2/0082 , A61L2/0088 , A61L2/08 , A61L2/084 , A61L2/10 , A61L2202/22 , A61M1/0213 , A61M1/3681 , A61M1/3683 , A61M1/3693 , A61M2205/123 , A01N25/00 , A01N2300/00
摘要： A process for damaging and maintaining damage to the nucleic acids of pathogens such as white blood cells, bacteria and viruses which may be contained in blood or blood components. This process comprises adding to the blood or blood component containing pathogens an effective amount of riboflavin, and exposing the fluid to light of an appropriate wavelength to damage the nucleic acid of the pathogen and to substantially maintain the damage to the pathogenic nucleic acids to allow for subsequent transfusion into a recipient.
摘要翻译：一种损害和维护可能包含在血液或血液成分中的病原体核酸如白细胞，细菌和病毒的损害的过程。该方法包括向含有病原体的血液或血液成分中加入有效量的核黄素，并将该液体暴露于适当波长的光以损害病原体的核酸，并且基本维持致病性核酸的损伤，以允许随后输血到接受者。

2. 发明申请

US20070216368A1 Cell balancing system 审中-公开
标题翻译：电池平衡系统
公开(公告)号：US20070216368A1
公开(公告)日：2007-09-20
申请号：US10779324
申请日：2004-02-13
申请人： Lance Chandler , Raymond Goodrich , David Sorlien
发明人： Lance Chandler , Raymond Goodrich , David Sorlien
IPC分类号： H02J7/00
CPC分类号： H02J7/0016
摘要： Referring to FIG. 1, a cell balancing system of the present invention is shown and generally designated 100. System 100 includes a number of battery cells 102 in electrical communication with a safety circuit 104. In a preferred embodiment, the safety circuit 104 is included in an application specific semiconductor (ASIC) and provides an input/output channel 106 that includes, for example, Vbat(+), Clock, Data, Return, and Vbat(−) signals for use by a device which incorporates the battery. It is to be appreciated that I/O channel 106 may be of any type, generic or proprietary, and may have any number of communication protocols as is known in the art.
摘要翻译：参考图在图1中，示出了本发明的电池平衡系统，并且总体上标示为100。系统100包括与安全电路104电连通的多个电池单元102。在优选实施例中，安全电路104被包括在特定应用的半导体（ASIC）中，并且提供输入/输出通道106，其包括例如Vbat（+），时钟，数据，返回和Vbat（ - ）信号供包含电池的设备使用。应当理解，I / O通道106可以是任何类型的，通用的或专有的，并且可以具有本领域已知的任何数量的通信协议。

3. 发明申请

US20070212379A1 Preparation of Vaccines Using Photosensitizers and Light 审中-公开
标题翻译：使用光敏剂和光制备疫苗
公开(公告)号：US20070212379A1
公开(公告)日：2007-09-13
申请号：US11626607
申请日：2007-01-24
申请人： Raymond GOODRICH
发明人： Raymond GOODRICH
IPC分类号： A61K39/00 , C12N13/00
CPC分类号： C12N7/00 , A61K39/00 , A61K39/0011 , A61K39/12 , A61K39/21 , A61K2039/5152 , A61K2039/521 , A61K2039/5252 , C12N2700/00 , C12N2740/16034 , C12N2740/16063
摘要： Methods are provided for treating a vaccine containing infectious particles which may be viral, bacterial, and/or cellular in nature. Preferred methods include the steps of adding an effective, non-toxic amount of an endogenous photosensitizer to the fluid and exposing the fluid to photoradiation sufficient to inactivate the infectious particles but not enough to damage the antigenic characteristics of the infectious particles.
摘要翻译：提供了用于治疗含有感染性颗粒的疫苗的方法，所述感染性颗粒本质上可以是病毒，细菌和/或细胞。优选的方法包括以下步骤：将有效的无毒量的内源性光敏剂添加到流体中，并使流体暴露于足以灭活感染性颗粒但不足以损害感染性颗粒的抗原特征的光照射。

4. 发明申请

US20070009377A1 Methods for Reducing Pathogens in Biological Samples 审中-公开
标题翻译：减少生物样品中病原体的方法
公开(公告)号：US20070009377A1
公开(公告)日：2007-01-11
申请号：US11428669
申请日：2006-07-05
申请人： Raymond Goodrich , Cynthia Scott
发明人： Raymond Goodrich , Cynthia Scott
IPC分类号： A01N1/02 , A61L2/10
CPC分类号： A61L2/0011 , A61L2/0082 , A61L2/0088 , A61M1/3681 , A61M1/3683 , A61M2205/053
摘要： This invention provides methods, devices and device components for treating biological samples with electromagnetic radiation. The methods, devices and device components of the present invention are capable of providing well characterized, uniform and reproducible net radiant energies and/or radiant powers to biological samples undergoing processing. In addition, the present methods, devices and device components are capable of delivering electromagnetic radiation to biological samples having a distribution of wavelengths selected to provide enhanced pathogen reduction, while minimizing photoinduced damage to components comprising therapeutic and/or reinfusion agents.
摘要翻译：本发明提供了用电磁辐射处理生物样品的方法，装置和装置组件。本发明的方法，装置和装置组件能够为经历加工的生物样品提供良好的表征，均匀和可再现的净辐射能和/或辐射功率。此外，本发明的方法，装置和装置组件能够将具有波长分布的电磁辐射递送到生物样品，所述波长选择为提供增强的病原体减少，同时使对包含治疗和/或再灌注剂的组分的光诱导损伤最小化。

5. 发明申请

US20050112021A1 Reduction of Contaminants In Blood and Blood Products Using Photosensitizers and Peak Wavelengths of Light 审中-公开
标题翻译：使用光敏剂减少血液和血液中的污染物和光的峰值波长
公开(公告)号：US20050112021A1
公开(公告)日：2005-05-26
申请号：US10904361
申请日：2004-11-05
申请人： Dennis HLAVINKA , Raymond GOODRICH , Laura GOODRICH , Daniel MCGRAW
发明人： Dennis HLAVINKA , Raymond GOODRICH , Laura GOODRICH , Daniel MCGRAW
IPC分类号： A61K31/00 , A61K31/28 , A61K31/555 , A61K31/60 , A61K31/603 , A61K31/695 , A61K31/7048 , A61K31/7135 , A61K33/00 , A61K33/14 , A61K33/32 , A61K35/18 , A61K41/00 , A61K45/06 , A61K47/48 , A61L2/00 , A61L2/08 , A61L2/10 , A61L2/24 , A61L2/26 , A61M1/36 , C07F11/00 , C07F13/00 , C07F15/02 , C07F17/00 , C12N13/00
CPC分类号： A61L2/24 , A61K31/00 , A61K31/28 , A61K31/555 , A61K31/60 , A61K31/603 , A61K31/695 , A61K31/7048 , A61K31/7135 , A61K33/00 , A61K33/14 , A61K33/32 , A61K35/18 , A61K41/0019 , A61K41/0057 , A61K41/0071 , A61K45/06 , A61K47/52 , A61L2/0011 , A61L2/0047 , A61L2/0076 , A61L2/0088 , A61L2/08 , A61L2/10 , A61L2/26 , A61L2202/14 , A61L2202/22 , A61M1/3681 , A61M1/3683 , C07F11/005 , C07F13/005 , C07F15/02 , C07F17/00 , C12N13/00 , A61K2300/00
摘要： Methods and apparatuses are provided for inactivation of pathogens in fluids containing blood products. Preferred methods include the steps of adding an effective, non-toxic amount of a photosensitizer such as riboflavin to the blood product and exposing the fluid to light having a peak wavelength.
摘要翻译：提供了用于在含有血液制品的流体中灭活病原体的方法和装置。优选的方法包括将有效的无毒量的光敏剂如核黄素添加到血液制品中并将流体暴露于具有峰值波长的光的步骤。

6. 发明申请

US20070098697A1 Preventing Transfusion Related Complications in a Recipient of a Blood Transfusion 有权
标题翻译：预防输血的输血相关并发症
公开(公告)号：US20070098697A1
公开(公告)日：2007-05-03
申请号：US11469186
申请日：2006-08-31
申请人： Raymond Goodrich , Junzhi Li
发明人： Raymond Goodrich , Junzhi Li
IPC分类号： A61K35/14 , A61K31/525
CPC分类号： A61K35/14 , A01N1/0215 , A01N1/0226 , A61K31/525 , A61K35/19 , A61K41/0023 , A61K2300/00
摘要： This invention is directed toward a process for reducing transfusion related complications in a recipient of an allogeneic blood transfusion by adding to the blood to be transfused a photosensitizer comprising riboflavin, irradiating the blood and riboflavin with light, transfusing the irradiated blood into a recipient, and reducing a transfusion related complication by the recipient to cells in the donor blood. The invention is also directed towards a process for preventing rejection of a donor organ by a recipient comprising the steps of transfusing the recipient of the donor organ with treated platelets; and transplanting the donor organ into the recipient.
摘要翻译：本发明涉及一种减少异体输血接受者输血相关并发症的方法，该方法是向输注血液中加入含有核黄素的光敏剂，用光照射血液和核黄素，将照射的血液输入接受者，以及将接受者的输血相关并发症减少到供体血液中的细胞。本发明还涉及一种用于防止接受者排出供体器官的方法，包括以下步骤：将经过处理的血小板输入供体器官的受体; 并将供体器官移植到受体中。

7. 发明授权

US5043261A Lyophilized and reconstituted red blood cell and hemosome compositions 失效
标题翻译：冻干和重建的红细胞和血红素组成
公开(公告)号：US5043261A
公开(公告)日：1991-08-27
申请号：US360386
申请日：1989-06-02
申请人： Raymond Goodrich , Christine Williams
发明人： Raymond Goodrich , Christine Williams
IPC分类号： A61K35/18
CPC分类号： A61K35/18
摘要： A process and medium are disclosed for the lyophilization of red blood cells which comprises the use of solutions including monosaccharide hexoses and pentoses, and biocompatible polymers to permit the reconstitution of viable red blood cells.
摘要翻译：公开了用于冻干红细胞的方法和培养基，其包括使用包括单糖己糖和戊糖的溶液以及生物相容性聚合物，以允许重建可行的红细胞。

8. 发明申请

US20070267999A1 Multi-chemistry chargers 审中-公开
标题翻译：多化学充电器
公开(公告)号：US20070267999A1
公开(公告)日：2007-11-22
申请号：US10778893
申请日：2004-02-13
申请人： Don Buckley , Lance Chandler , Raymond Goodrich
发明人： Don Buckley , Lance Chandler , Raymond Goodrich
IPC分类号： H02J7/00
CPC分类号： H02J7/0004
摘要： A multi-chemistry charger system includes a charger in electrical connection with an analysis station, a battery port formed with a receiver cup sized to receive and establish electrical connection with battery pack. Charger also is in electrical communication with a network system having network components, such as remote computer or lab equipment, and an external programming center, such as a reprogrammable databank or a remotely located databank capable supplying current, updated battery information and charging characteristics. A wireless interface is also in communication with charger to provide a wireless link to other devices, or to retrieve programming or related data from outside data sources.
摘要翻译：多化学充电器系统包括与分析站电连接的充电器，形成有接收杯的电池端口，其尺寸适于接收和建立与电池组的电连接。充电器还与具有诸如远程计算机或实验室设备的网络组件的网络系统以及诸如可编程数据库或能够提供电流，更新的电池信息和充电特性的远程位置的数据库之类的外部编程中心进行电气通信。无线接口还与充电器通信以提供到其他设备的无线链路，或从外部数据源检索节目或相关数据。

9. 发明申请

US20070148630A1 Removal of Adenine During a Pathogen Reduction Process in Whole Blood or Red Blood Cells by Dilution 审中-公开
标题翻译：通过稀释在全血或红细胞的病原体减少过程中去除腺嘌呤
公开(公告)号：US20070148630A1
公开(公告)日：2007-06-28
申请号：US11624487
申请日：2007-01-18
申请人： Raymond Goodrich , Suzann Doane
发明人： Raymond Goodrich , Suzann Doane
IPC分类号： A01N1/02 , C12N5/08
CPC分类号： A61L2/084 , A01N1/0205 , A01N1/0215 , A01N1/0294 , A01N43/90 , A61K35/18 , A61K41/0019 , A61L2/0005 , A61L2/0011 , A61L2/0082 , A61L2/0088 , A61L2/08 , A61L2/10 , A61L2/16 , A61L2202/22
摘要： The methods of this invention involve preventing the formation of a complex between adenine and riboflavin by reducing the amount of adenine in a solution containing blood or blood components to be pathogen reduced.
摘要翻译：本发明的方法涉及通过减少含有血液或血液成分的溶液中的腺嘌呤的量减少而防止腺嘌呤和核黄素之间的复合物的形成。

10. 发明申请

US20090155419A1 Microwavable Food Products 有权
标题翻译：微波炉食品
公开(公告)号：US20090155419A1
公开(公告)日：2009-06-18
申请号：US12265545
申请日：2008-11-05
申请人： Renee Gan , Gary Smith , Ya-yu Pai , Keith Forneck , Christine Louise Kwiat , Megan N. Raymond Goodrich , Arthur C. Teasdale
发明人： Renee Gan , Gary Smith , Ya-yu Pai , Keith Forneck , Christine Louise Kwiat , Megan N. Raymond Goodrich , Arthur C. Teasdale
IPC分类号： B65D81/34 , A21D13/00
CPC分类号： A21D17/006 , A21D2/183 , A21D2/188 , A21D8/042 , A21D10/02 , A21D13/32 , A21D15/00 , A21D15/02 , B65D81/3453 , B65D2581/3405 , B65D2581/3494
摘要： The packaging system includes a first food product sealed within an inner wrapper, a second food product positioned within a tray and spacing the first food product from the tray, and an outer wrapper sealing the first food product, sealed within the inner wrapper, the second food product and the tray therein. A shield is disposed on the tray and is in contact with more than one surface of the second food product. Prior to microwave heating, the inner and outer wrapper are removed.
摘要翻译：包装系统包括密封在内包装内的第一食品，定位在托盘内并将第一食品与托盘间隔开的第二食品，以及密封第一食品的外包装，密封在内包装内，第二食品食品和托盘。屏蔽件设置在托盘上并与第二食品的多于一个的表面接触。在微波加热之前，内外包装被去除。

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