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1. 发明授权

US07747301B2 Apparatus and method for non-invasive and minimally-invasive sensing of parameters relating to blood 有权
标题翻译：用于非侵入性和微创感染与血液相关参数的装置和方法
公开(公告)号：US07747301B2
公开(公告)日：2010-06-29
申请号：US11233308
申请日：2005-09-22
申请人： Xuefeng Cheng , Daniel Hwan Kim , Butrus T. Khuri-Yakub
发明人： Xuefeng Cheng , Daniel Hwan Kim , Butrus T. Khuri-Yakub
IPC分类号： A61B5/145
CPC分类号： A61B5/0059 , A61B5/0048 , A61B5/0261 , A61B5/029 , A61B5/14539 , A61B5/14542 , A61B5/14551 , A61B5/1464 , A61B5/413 , A61B5/489 , A61B8/065 , A61B8/08 , A61B8/488 , G01S15/8968
摘要： Medical diagnostic system, apparatus and methods are disclosed. Optical transmitters generate radiation-containing photons having a specific interaction with at least one target chromophore in a target structure, preferably a blood vessel such as the interior jugular vein. The optical transmitters transmit the radiation into at least a first area including a substantial portion of the target structure and into a second area not including a substantial portion of the target structure. Optical receivers detect a portion radiation scattered from at least the first area and the second area. A processor estimates oxygenation, pH or cardiac output based on the scattered radiation detected from the first area, and the scattered radiation from the second area.
摘要翻译：公开了医疗诊断系统，装置和方法。光学发射器产生具有与目标结构中的至少一个目标发色团特别相互作用的辐射含有光子，优选为诸如颈内静脉的血管。光发射机将辐射发射到包括目标结构的大部分的至少第一区域中，并进入不包括目标结构的大部分的第二区域。光接收器检测从至少第一区域和第二区域散射的部分辐射。处理器基于从第一区域检测到的散射辐射和来自第二区域的散射辐射来估计氧合，pH或心输出量。

2. 发明申请

US20100152559A1 APPARATUS AND METHOD FOR NON-INVASIVE AND MINIMALLY-INVASIVE SENSING OF PARAMETERS RELATING TO BLOOD 审中-公开
标题翻译：用于非侵入性和微量入侵感染参数相关血液的装置和方法
公开(公告)号：US20100152559A1
公开(公告)日：2010-06-17
申请号：US12563887
申请日：2009-09-21
申请人： Xuefeng Cheng , Daniel Hwan Kim , Butrus T. Khuri-Yakub
发明人： Xuefeng Cheng , Daniel Hwan Kim , Butrus T. Khuri-Yakub
IPC分类号： A61B5/1455
CPC分类号： A61B5/0059 , A61B5/0048 , A61B5/0261 , A61B5/029 , A61B5/14539 , A61B5/14542 , A61B5/14551 , A61B5/1464 , A61B5/413 , A61B5/489 , A61B8/065 , A61B8/08 , A61B8/488 , G01S15/8968
摘要： Medical diagnostic system, apparatus and methods are disclosed. Optical transmitters generate radiation-containing photons having a specific interaction with at least one target chromophore in a target structure, preferably a blood vessel such as the interior jugular vein. The optical transmitters transmit the radiation into at least a first area including a substantial portion of the target structure and into a second area not including a substantial portion of the target structure. Optical receivers detect a portion radiation scattered from at least the first area and the second area. A processor estimates oxygenation, pH or cardiac output based on the scattered radiation detected from the first area, and the scattered radiation from the second area.
摘要翻译：公开了医疗诊断系统，装置和方法。光学发射器产生具有与目标结构中的至少一个目标发色团特别相互作用的辐射含有光子，优选为诸如颈内静脉的血管。光发射机将辐射发射到包括目标结构的大部分的至少第一区域中，并进入不包括目标结构的大部分的第二区域。光接收器检测从至少第一区域和第二区域散射的部分辐射。处理器基于从第一区域检测到的散射辐射和来自第二区域的散射辐射来估计氧合，pH或心输出量。

3. 发明申请

US20100152591A1 APPARATUS AND METHOD FOR NON-INVASIVE AND MINIMALLY-INVASIVE SENSING OF PARAMETERS RELATING TO BLOOD 审中-公开
标题翻译：用于非侵入性和微量入侵感染参数相关血液的装置和方法
公开(公告)号：US20100152591A1
公开(公告)日：2010-06-17
申请号：US12618614
申请日：2009-11-13
申请人： Zengpin Yu , Butrus T. Khuri-Yakub , Xuefeng Cheng , Daniel Hwan Kim
发明人： Zengpin Yu , Butrus T. Khuri-Yakub , Xuefeng Cheng , Daniel Hwan Kim
IPC分类号： A61B5/02
CPC分类号： A61B5/14552 , A61B5/0051 , A61B5/029 , A61B5/14551 , A61B5/1459 , A61B8/00 , A61B8/12
摘要： A system and method for monitoring one or more parameters relating to blood, such as cardiac output, of a patient is provided. The system preferably includes an acoustic energy transducer unit configured and positioned to transmit acoustic energy into a target structure, preferably a blood vessel, within the patient so as to induce a measurable change, preferably a change in blood volume, within the target structure. The transducer unit can be an ultrasonic array, annular array, or groups thereof, or a single element transducer. The unit can also be a vibrator or acoustic loudspeaker. An optical transmitter transmits light into the target structure, and an optical receiver senses light scattered from within the target structure. The blood parameter can then be estimated from the sensed scattered radiation. Relative blood oxygen saturation in the blood vessel can be estimated by transmitting two wavelengths to measure oxy-hemoglobin and deoxy-hemoglobin.
摘要翻译：提供了一种用于监测与患者血液（例如心输出量）相关的一个或多个参数的系统和方法。该系统优选地包括声能换能器单元，其被配置和定位成将声能传递到患者体内的目标结构，优选血管，以便在目标结构内引起可测量的变化，优选血容量的变化。换能器单元可以是超声波阵列，环形阵列或其组，或单个元件换能器。该单元也可以是振动器或声音扬声器。光学发射器将光发射到目标结构中，并且光学接收器感测从目标结构内散射的光。然后可以从感测的散射辐射估计血液参数。可以通过传输两个波长来估计血管中的相对血氧饱和度来测量氧血红蛋白和脱氧血红蛋白。

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