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1. 发明申请

US20080215088A1 Systems, Methods, and compositions for achieving closure of suture sites 失效
标题翻译：用于实现缝合部位闭合的系统，方法和组合物
公开(公告)号：US20080215088A1
公开(公告)日：2008-09-04
申请号：US12079049
申请日：2008-03-24
申请人： Olexander Hnojewyj , Bruce Addis , Daniel Browne , David Cheung
发明人： Olexander Hnojewyj , Bruce Addis , Daniel Browne , David Cheung
IPC分类号： A61B17/08
CPC分类号： A61B17/0057 , A61B17/00491 , A61B2017/00004 , A61B2017/00495 , A61B2017/00637 , A61B2017/0065 , A61B2017/00654 , A61B2017/00663
摘要： Systems and methods employ functional instruments to close incisions and wounds using a suture knot in combination with a biocompatible material composition. The systems and methods are well suited for use, for example, at a vascular puncture site following a vascular access procedure.
摘要翻译：系统和方法使用功能性仪器来使用缝线结与生物相容性材料组合物闭合切口和伤口。该系统和方法非常适用于例如血管通路手术后的血管穿刺部位。

2. 发明授权

US07351249B2 Systems, methods, and compositions for achieving closure of suture sites 有权
标题翻译：用于实现缝合部位闭合的系统，方法和组合物
公开(公告)号：US07351249B2
公开(公告)日：2008-04-01
申请号：US10212472
申请日：2002-08-05
申请人： Olexander Hnojewyj , Bruce Addis , Daniel Browne , David Cheung
发明人： Olexander Hnojewyj , Bruce Addis , Daniel Browne , David Cheung
IPC分类号： A61B17/08
CPC分类号： A61B17/0057 , A61B17/00491 , A61B2017/00004 , A61B2017/00495 , A61B2017/00637 , A61B2017/0065 , A61B2017/00654 , A61B2017/00663
摘要： Systems and methods employ functional instruments to close incisions and wounds using a suture knot in combination with a biocompatible material composition. The systems and methods are well suited for use, for example, at a vascular puncture site following a vascular access procedure.
摘要翻译：系统和方法使用功能性仪器来使用缝线结与生物相容性材料组合物闭合切口和伤口。该系统和方法非常适用于例如血管通路手术后的血管穿刺部位。

3. 发明申请

US20220347275A1 Methods and Compositions for Treating Skin Conditions Associated With Vascular Hyper-reactivity 有权
公开(公告)号：US20220347275A1
公开(公告)日：2022-11-03
申请号：US16984036
申请日：2020-08-03
申请人： Connie Ho , Alice Du , Daniel Browne
发明人： Connie Ho , Alice Du , Daniel Browne
IPC分类号： A61K38/48 , A61K9/00 , A61K47/64 , A61K31/4164 , A61K47/34
摘要： The present invention provides a methods and compositions for treating a patient having a skin condition characterized by vascular hyper-reactivity, such as chronic or episodic flushing or blushing, and/or rosacea. The method comprises applying a topical composition to affected areas of the patient's skin. The topical composition comprises an effective amount of a botulinum neurotoxin for decreasing vasodilation in cutaneous microvasculature, and a carrier for effectively transporting the botulinum toxin to the cutaneous microvasculature. The invention thereby provides a safe, effective, comfortable, and/or convenient manner of treating vascular hyper-reactivity in skin.

4. 发明授权

US08667284B2 Detection of invalid escrow keys 有权
标题翻译：检测无效代管钥匙
公开(公告)号：US08667284B2
公开(公告)日：2014-03-04
申请号：US13350360
申请日：2012-01-13
申请人： Venkataramann Renganathan , Brian Thomas Carver , Daniel Browne Jump , David Charles LeBlanc , Samuel Ira Weiss
发明人： Venkataramann Renganathan , Brian Thomas Carver , Daniel Browne Jump , David Charles LeBlanc , Samuel Ira Weiss
IPC分类号： G06F7/04
CPC分类号： H04L9/0894 , G06F21/64 , H04L9/3242 , H04L9/3263
摘要： A secure hash, such as a Hash-based Message Authentication Code (“HMAC”), is generated using a piece of secret information (e.g., a secret key) and a piece of public information specific to each escrow key (e.g., a certificate hash or public key). Using the secret key ensures that escrow key validation data can only be generated by knowing the secret key, which prevents an attacker from generating the appropriate escrow key validation data. Using the certificate hash as the public data ties each escrow key validation data to a particular certificate, thereby preventing the attacker from simply copying the validation data from another escrow key. Any escrow key that is found to be invalid may be removed from the file container and a system audit log may be generated so that a company, individual, or other entity can be aware of the possible attempt at a security breach.
摘要翻译：使用秘密信息（例如，秘密密钥）和每个暂存密钥专用的一条公共信息（例如，证书（例如，证书））生成诸如基于哈希的消息认证码（“HMAC”）的安全散列散列或公钥）。使用秘密密钥确保托管密钥验证数据只能通过知道密钥生成，从而防止攻击者生成适当的托管密钥验证数据。使用证书哈希作为公共数据将每个托管密钥验证数据与特定证书相关联，从而防止攻击者简单地从另一个托管密钥复制验证数据。发现无效的任何托管密钥可能会从文件容器中删除，并且可能会生成系统审核日志，以便公司，个人或其他实体可以意识到安全漏洞可能的尝试。

5. 发明申请

US20130185557A1 Detection of Invalid Escrow Keys 有权
标题翻译：检测无效的托管键
公开(公告)号：US20130185557A1
公开(公告)日：2013-07-18
申请号：US13350360
申请日：2012-01-13
申请人： Venkataramann Renganathan , Brian Thomas Carver , Daniel Browne Jump , David Charles LeBlanc , Samuel Ira Weiss
发明人： Venkataramann Renganathan , Brian Thomas Carver , Daniel Browne Jump , David Charles LeBlanc , Samuel Ira Weiss
IPC分类号： H04L9/30
CPC分类号： H04L9/0894 , G06F21/64 , H04L9/3242 , H04L9/3263
摘要： A secure hash, such as a Hash-based Message Authentication Code (“HMAC”), is generated using a piece of secret information (e.g., a secret key) and a piece of public information specific to each escrow key (e.g., a certificate hash or public key). Using the secret key ensures that escrow key validation data can only be generated by knowing the secret key, which prevents an attacker from generating the appropriate escrow key validation data. Using the certificate hash as the public data ties each escrow key validation data to a particular certificate, thereby preventing the attacker from simply copying the validation data from another escrow key. Any escrow key that is found to be invalid may be removed from the file container and a system audit log may be generated so that a company, individual, or other entity can be aware of the possible attempt at a security breach.
摘要翻译：使用秘密信息（例如，秘密密钥）和每个暂存密钥专用的一条公共信息（例如，证书（例如，证书））生成诸如基于哈希的消息认证码（“HMAC”）的安全散列散列或公钥）。使用秘密密钥确保托管密钥验证数据只能通过知道密钥生成，从而防止攻击者生成适当的托管密钥验证数据。使用证书哈希作为公共数据将每个托管密钥验证数据与特定证书相关联，从而防止攻击者简单地从另一个托管密钥复制验证数据。发现无效的任何托管密钥可能会从文件容器中删除，并且可能会生成系统审核日志，以便公司，个人或其他实体可以意识到安全漏洞可能的尝试。

6. 发明授权

US08409249B2 Systems, methods, and compositions for achieving closure of suture sites 失效
公开(公告)号：US08409249B2
公开(公告)日：2013-04-02
申请号：US12079049
申请日：2008-03-24
申请人： Olexander Hnojewyj , Bruce Addis , Daniel Browne , David Cheung
发明人： Olexander Hnojewyj , Bruce Addis , Daniel Browne , David Cheung
IPC分类号： A61B17/08
CPC分类号： A61B17/0057 , A61B17/00491 , A61B2017/00004 , A61B2017/00495 , A61B2017/00637 , A61B2017/0065 , A61B2017/00654 , A61B2017/00663
摘要： Systems and methods employ functional instruments to close incisions and wounds using a suture knot in combination with a biocompatible material composition. The systems and methods are well suited for use, for example, at a vascular puncture site following a vascular access procedure.

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