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1. 发明申请

WO2010124042A3 MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF 审中-公开
标题翻译： 5-HT受体的调节剂及其使用方法
公开(公告)号：WO2010124042A3
公开(公告)日：2011-02-03
申请号：PCT/US2010031974
申请日：2010-04-22
申请人： ABBOTT LAB , ABBOTT GMBH & CO KG , WANG YING , BREWER JASON T , AKRITOPOULOU-ZANZE IRINI , DJURIC STEVAN W , POHLKI FRAUKE , BRAJE WILFRIED , RELO ANA-LUCIA
发明人： WANG YING , BREWER JASON T , AKRITOPOULOU-ZANZE IRINI , DJURIC STEVAN W , POHLKI FRAUKE , BRAJE WILFRIED , RELO ANA-LUCIA
IPC分类号： C07D498/04 , A61K31/4985 , A61K31/551 , A61K31/553 , A61P25/00 , C07D471/04 , C07D471/14 , C07D487/04 , C07D491/04
CPC分类号： C07D498/04 , C07D471/04 , C07D471/14 , C07D487/04 , C07D491/04
摘要： The present application relates to 1,2,3,4,4a,5,6,7-octahydropyrazino[1,2-a][1,4]benzodiazepine, 1,2,3,4,4a,5,6,7-octahydropyrazino[1,2-a][1,5]benzodiazepine, 2,3,4,4a,5,6,7,11b-octahydro-1H-pyrido[3,4-d][2]benzazepine, 1,2,3,4,4a,5,6,7-octahydropyrazino[1,2-a][1]benzazepine, 1,2,3,4,4a,5-hexahydro-7H-pyrazino[1,2-a][4,1]benzoxazepine, and 2,3,4,4a,5,6-hexahydro-1H-pyrazino[2,1-d][1,5]benzoxazepine, and 5,6,7,7a,8,9,10,11-octahydropyrazino[1,2-d]pyrido[3,2-b][1,4]diazepine derivatives of formula (I) wherein R1, R2, R3, R4, R5, R6, X1, X2, X3, X4, Y1, Y2, and Y3 are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.
摘要翻译：本申请涉及1,2,3,4,4a，5,6,7-八氢吡嗪并[1,2-a] [1,4]苯并二氮杂，1,2,3,4,4a， 7-八氢吡嗪并[1,2-a] [1,5]苯并二氮杂，2,3,4,4a，5,6,7,11b-八氢-1H-吡啶并[3,4-d] [2]苯并氮杂， 1,2,3,4,4a，5,6,7-八氢吡嗪并[1,2-a] [1]苯并氮杂，1,2,3,4,4a，5-六氢-7H-吡嗪并[1,2 -a] [4,1]苯并氧氮杂和2,3,4,4a，5,6-六氢-1H-吡嗪并[2,1-d] [1,5]苯并氧氮杂和5,6,7,7a ，其中R 1，R 2，R 3，R 4，R 5，R 6，R 6，R 5，R 6， X1，X2，X3，X4，Y1，Y2和Y3如说明书中所定义。本申请还涉及包含这些化合物的组合物，以及使用这些化合物和组合物治疗疾病状况的方法，以及鉴定这些化合物的方法。

2. 发明申请

WO2010124042A2 MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF 审中-公开
标题翻译： 5-HT受体的调节剂及其使用方法
公开(公告)号：WO2010124042A2
公开(公告)日：2010-10-28
申请号：PCT/US2010/031974
申请日：2010-04-22
申请人： ABBOTT LABORATORIES , ABBOTT GMBH & CO. KG , WANG, Ying , BREWER, Jason, T. , AKRITOPOULOU-ZANZE, Irini , DJURIC, Stevan, W. , POHLKI, Frauke , BRAJE, Wilfried , RELO, Ana-Lucia
发明人： WANG, Ying , BREWER, Jason, T. , AKRITOPOULOU-ZANZE, Irini , DJURIC, Stevan, W. , POHLKI, Frauke , BRAJE, Wilfried , RELO, Ana-Lucia
IPC分类号： C07D498/04
CPC分类号： C07D498/04 , C07D471/04 , C07D471/14 , C07D487/04 , C07D491/04
摘要： The present application relates to 1,2,3,4,4a,5,6,7-octahydropyrazino[1,2- a ][1,4]benzodiazepine, 1,2,3,4,4a,5,6,7-octahydropyrazino[1,2- a ][1,5]benzodiazepine, 2,3,4,4a,5,6,7,11b-octahydro-1 H -pyrido[3,4- d ][2]benzazepine, 1,2,3,4,4a,5,6,7-octahydropyrazino[1,2- a ][1]benzazepine, 1,2,3,4,4a,5-hexahydro-7 H -pyrazino[1,2- a ][4,1]benzoxazepine, and 2,3,4,4a,5,6-hexahydro-1 H -pyrazino[2,1- d ][1,5]benzoxazepine, and 5,6,7,7a,8,9,10,11-octahydropyrazino[1,2- d ]pyrido[3,2- b ][1,4]diazepine derivatives of formula (I) wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , X 1 , X 2 , X 3 , X 4 , Y 1 , Y 2 , and Y 3 are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.
摘要翻译：本申请涉及1,2,3,4,4a，5,6,7-八氢吡嗪并[1,2-a] [1,4]苯并二氮杂，1,2,3,4,4a， 7-八氢吡嗪并[1,2-a] [1,5]苯并二氮杂，2,3,4,4a，5,6,7,11b-八氢-1H-吡啶并[3,4-d] [2]苯并氮杂， 1,2,3,4,4a，5,6,7-八氢吡嗪并[1,2-a] [1]苯并氮杂，1,2,3,4,4a，5-六氢-7H-吡嗪并[1,2 -a] [4,1]苯并氧氮杂和2,3,4,4a，5,6-六氢-1H-吡嗪并[2,1-d] [1,5]苯并氧氮杂和5,6,7,7a ，其中R 1，R 2，R 3，R 4，R 5，R 6，R 6，R 5，R 6， X1，X2，X3，X4，Y1，Y2和Y3如说明书中所定义。本申请还涉及包含这些化合物的组合物，以及使用这些化合物和组合物治疗疾病状况的方法，以及鉴定这些化合物的方法。

3. 发明申请

WO2006124813A2 SUBSTITUTED 7, 8-DIHYDRO-1H-PYRIMIDO[4,5-B] [1,4] DIAZEPIN-4-AMINES ARE NOVEL KINASE INHIBITORS 审中-公开
标题翻译：取代的7,8-二氢-1H-吡咯并[4,5-B] [1,4]二氮杂-4-胺是新型激酶抑制剂
公开(公告)号：WO2006124813A2
公开(公告)日：2006-11-23
申请号：PCT/US2006018796
申请日：2006-05-16
申请人： ABBOTT LAB , GRACIAS VIJAYA J , ABAD-ZAPATERO CELERINO , DJURIC STEVAN W , JI ZHIQIN , MICHAELIDES MICHAEL R , STEWART KENT D , ZANZE IRINI
发明人： GRACIAS VIJAYA J , ABAD-ZAPATERO CELERINO , DJURIC STEVAN W , JI ZHIQIN , MICHAELIDES MICHAEL R , STEWART KENT D , ZANZE IRINI
CPC分类号： C07D487/04
摘要： Compounds having the Formula (I) are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
摘要翻译：具有式（I）的化合物可用于抑制蛋白酪氨酸激酶。本发明还公开了制备化合物的方法，含有该化合物的组合物和使用该化合物的处理方法。

4. 发明申请

WO2011146089A1 MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF 审中-公开
标题翻译： 5-HT受体的调节剂及其使用方法
公开(公告)号：WO2011146089A1
公开(公告)日：2011-11-24
申请号：PCT/US2010/057454
申请日：2010-11-19
申请人： ABBOTT LABORATORIES , AKRITOPOULOU-ZANZE, Irini , BRAJE, Wilfried , DJURIC, Stevan W. , WILSON, Noel S. , TURNER, Sean C. , KRUGER, Albert W. , RELO, Ana-Lucia , SHEKHAR, Shashank , WELCH, Dennie S. , ZHAO, Hongyu , GANDARILLA, Jorge , GASIECKI, Alan F. , LI, Huanqiu , THOMPSON, Christina M. , ZHANG, Min , ABBOTT GMBH & CO. KG
发明人： AKRITOPOULOU-ZANZE, Irini , BRAJE, Wilfried , DJURIC, Stevan W. , WILSON, Noel S. , TURNER, Sean C. , KRUGER, Albert W. , RELO, Ana-Lucia , SHEKHAR, Shashank , WELCH, Dennie S. , ZHAO, Hongyu , GANDARILLA, Jorge , GASIECKI, Alan F. , LI, Huanqiu , THOMPSON, Christina M. , ZHANG, Min
IPC分类号： A01N43/00 , A01N43/46 , A61K31/55
CPC分类号： C07D487/04 , C07D491/04 , C07D495/04 , C07D513/04
摘要： The present application relates to aryl- and heteroaryl-fused decahydropyrroloazepine, octahydrooxepinopyrrole, octahydropyrrolothiazepine dioxide, decahydrocyclohepta[ c ]pyrrole, and octahydrocyclohepta[ c ]pyrrole derivatives of formula (I) wherein R 1 , R 2 , R 3 , R 4 , R 5 , A, Y 1 , Y 2 , and Y 3 are as defined in the specification. The present application also relates to compositions comprising such compounds, processes for making such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.
摘要翻译：本申请涉及式（I）的芳基 - 和杂芳基 - 稠合十氢吡咯并氮平，二氢八氢化吡咯并噻吩，十氢环庚三烯并[c]吡咯和八氢环庚三烯并[c]吡咯衍生物，其中R1，R2，R3，R4，R5，A，Y1 ，Y2和Y3如说明书中所定义。本申请还涉及包含这些化合物的组合物，制备这些化合物的方法，以及使用这些化合物和组合物治疗疾病状况的方法，以及鉴定这些化合物的方法。

5. 发明申请

WO2008154241A1 5-HETEROARYL SUBSTITUTED INDAZOLES AS KINASE INHIBITORS 审中-公开
标题翻译：作为激酶抑制剂的5-HETEROARYL取代的吲哚美辛
公开(公告)号：WO2008154241A1
公开(公告)日：2008-12-18
申请号：PCT/US2008/065727
申请日：2008-06-04
申请人： ABBOTT LABORATORIES , AKRITOPOULOU-ZANZE, Irini , WAKEFIELD, Brian D , MACK, Helmut , TURNER, Sean C , GASIECKI, Alan F , GRACIAS, Vijaya J , SARRIS, Kathy , KALVIN, Douglas M , MICHMERHUIZEN, Melissa J , SHUAI, Qi , PATEL, Jyoti R , BAKKER, Margaretha , TEUSCH, Nicole , JOHNSON, Eric T , KOVAR, Peter J , DJURIC, Stevan W , LONG, Andrew J , VASUDEVAN, Anil , HOBSON, Adrian , ST. JOHN MOORE, Nigel , WANG, Lu , GEORGE, Dawn , LI, Biqin , FRANK, Kristine
发明人： AKRITOPOULOU-ZANZE, Irini , WAKEFIELD, Brian D , MACK, Helmut , TURNER, Sean C , GASIECKI, Alan F , GRACIAS, Vijaya J , SARRIS, Kathy , KALVIN, Douglas M , MICHMERHUIZEN, Melissa J , SHUAI, Qi , PATEL, Jyoti R , BAKKER, Margaretha , TEUSCH, Nicole , JOHNSON, Eric T , KOVAR, Peter J , DJURIC, Stevan W , LONG, Andrew J , VASUDEVAN, Anil , HOBSON, Adrian , ST. JOHN MOORE, Nigel , WANG, Lu , GEORGE, Dawn , LI, Biqin , FRANK, Kristine
IPC分类号： C07D403/04 , C07D413/04 , C07D417/04
CPC分类号： C07D403/04 , C07D413/04 , C07D417/04
摘要： The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein A, R 1 , R 2 , R 3 and m, are defined in the description. The present invention relates also to methods of making said compounds, and compositions containing said compounds which are useful for inhibiting kinases such as Glycogen Synthase kinase 3 (GSK-3), Rho kinase (ROCK), Janus Kinases (JAK), AKT, PAK4, PLK, CK2, KDR, MK2, JNK1, aurora, pim 1 and nek 2.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐，其中A，R 1，R 2，R 3和m在说明书中定义。本发明还涉及制备所述化合物的方法和含有所述化合物的组合物，其可用于抑制激酶如糖原合酶激酶3（GSK-3），Rho激酶（ROCK），Janus激酶（JAK），AKT，PAK4 ，PLK，CK2，KDR，MK2，JNK1，极光，pim1和nek2。

6. 发明申请

WO1997024117A1 SUBSTITUTED (ARYL, HETEROARYL, ARYLMETHYL OR HETEROARYLMETHYL) HYDROXAMIC ACID COMPOUNDS 审中-公开
标题翻译：取代（芳基，杂芳基，芳基甲基或甲氧基）乙氧基化合物
公开(公告)号：WO1997024117A1
公开(公告)日：1997-07-10
申请号：PCT/US1997000264
申请日：1997-01-02
申请人： RHONE-POULENC RORER PHARMACEUTICALS INC. , GRONEBERG, Robert, D. , NEUENSCHWANDER, Kent, W. , DJURIC, Stevan, W. , MCGEEHAN, Gerard, M. , BURNS, Christopher, J. , CONDON, Steven, M. , MORRISSETTE, Matthew, M. , SALVINO, Joseph, M. , SCOTESE, Anthony, C. , ULLRICH, John, W.
发明人： RHONE-POULENC RORER PHARMACEUTICALS INC.
IPC分类号： A61K31/19
CPC分类号： C07D209/48 , C07C259/06 , C07C317/44 , C07C323/60 , C07C2601/08 , C07D215/14 , C07D317/56 , C07D317/62
摘要： This invention is directed to compounds of formula (I), wherein the variables are as described herein. Compounds within the scope of the present invention possess useful properties, more particularly pharmaceutical properties. They are especially useful for inhibiting the production or physiological effects of TNF in the treatment of a patient suffering from a disease state associated with a physiologically detrimental excess of tumor necrosis factor (TNF). Compounds within the scope of the present invention also inhibit cyclic AMP phosphodiesterase, and are useful in treating a disease state associated with pathological conditions that are modulated by inhibiting cyclic AMP phosphodiesterase, such disease states including inflammatory and autoimmune diseases, in particular type IV cyclic AMP phosphodiesterase. Compounds within the scope of the present invention may also inhibit an MMP, and are useful in treating a disease state associated with pathological conditions that are modulated by inhibiting MMPs, such disease states involve tissue breakdown and those associated with a physiologically detrimental excess of TNF. The present invention is therefore also directed to the pharmaceutical use of the compounds, pharmaceutical compositions containing the compounds, intermediates leading thereto and methods for the preparation of the compounds and their intermediates.
摘要翻译：本发明涉及式（I）的化合物，其中变量如本文所述。本发明范围内的化合物具有有用的性质，更具体地说是药物性质。它们特别可用于抑制TNF治疗患有与生理有害过量的肿瘤坏死因子（TNF）相关的疾病状态的患者的生产或生理作用。本发明范围内的化合物还抑制环AMP磷酸二酯酶，并且可用于治疗与通过抑制环AMP磷酸二酯酶调节的病理状况相关的疾病状态，所述疾病状态包括炎性和自身免疫性疾病，特别是IV型环AMP 磷酸二酯酶。本发明范围内的化合物还可以抑制MMP，并且可用于治疗与通过抑制MMP调节的病理状况相关的疾病状态，这种疾病状态涉及组织分解以及与生理上有害的过量TNF相关的疾病状态。因此，本发明还涉及化合物的药物用途，含有这些化合物的药物组合物，导致其的中间体以及制备化合物及其中间体的方法。

7. 发明申请

WO2011133182A1 MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF 审中-公开
标题翻译： 5-HT受体的调节剂及其使用方法
公开(公告)号：WO2011133182A1
公开(公告)日：2011-10-27
申请号：PCT/US2010/053530
申请日：2010-10-21
申请人： ABBOTT LABORATORIES , WANG, Ying , BREWER, Jason, T. , AKRITOPOULOU-ZANZE, Irini , DJURIC, Stevan, W. , POHLKI, Frauke , BRAJE, Wilfried , RELO, Ana-Lucia
发明人： WANG, Ying , BREWER, Jason, T. , AKRITOPOULOU-ZANZE, Irini , DJURIC, Stevan, W. , POHLKI, Frauke , BRAJE, Wilfried , RELO, Ana-Lucia
IPC分类号： C07D487/04 , C07D498/04 , C07D471/04 , C07D471/14 , A61K31/4985 , A61K31/551 , A61K31/553 , A61P25/28 , A61P3/04 , A61P3/10
CPC分类号： C07D487/04 , C07D471/04 , C07D471/14 , C07D487/14 , C07D491/04 , C07D498/04 , Y02E60/321
摘要： The present application relates to 1,2,3,4)4a,5,6,7-octahydropyraziπo[1,2- α][1,4]benzodiazepine, 1,2,3,4,4a,5,6,7-octahydropyrazino[1)2- a ][1,5]benzodiazepine, 2,3,4,4a,5,6,7,11b-octahydro-1 H -pyrido[3,4- d (][2]benzazepine, 1,2,3,4,4a,5,6,7- octahydropyrazino[1,2- a ][1]benzazepine, 1,2,3,4,4a,5-hexahydro-7 H -pyrazino[1,2- α][4,1]benzoxazepine, and 2,3,4,4a,5,6-hexahydro-1 H -pyrazino[2,1- d ][1,5]benzoxazepine, and 5,6,7,7a,8,9,10,11-octahydropyrazino[1,2- d ]pyrido[3,2-6][1,4]diazepine derivatives of formula (I) wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , X 1 , X 2 , X 3 , X 4 , Y 1 , Y 2 , and Y 3 are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.
摘要翻译：本申请涉及1,2,3,4）4a，5,6,7-八氢吡嗪并[1,2-a] [1,4]苯并二氮杂，1,2,3,4,4a， 7-八氢吡嗪并[1] 2-a] [1,5]苯并二氮杂，2,3,4,4a，5,6,7,11b-八氢-1H-吡啶并[3,4-d（R），1,2,3,4,4a，5,6,7-八氢吡嗪并[1,2-a] [1]苯并氮杂，1,2,3,4,4a，5-六氢-7H-吡嗪并[ 2 a] [4,1]苯并氧氮杂和2,3,4,4a，5,6-六氢-1H-吡嗪并[2,1-d] [1,5]苯并氧氮杂， 7a，8,9,10,11-八氢吡嗪并[1,2-d]吡啶并[3,2-b] [1,4]二氮杂衍生物其中R1，R2，R3，R4，R5，R6 X1，X2，X3，X4，Y1，Y2和Y3如本说明书中所定义，本申请还涉及包含这些化合物的组合物，以及使用这些化合物和组合物治疗疾病状况的方法，化合物。

8. 发明申请

WO2010135560A1 MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF 审中-公开
标题翻译： 5-HT受体的调节剂及其使用方法
公开(公告)号：WO2010135560A1
公开(公告)日：2010-11-25
申请号：PCT/US2010/035626
申请日：2010-05-20
申请人： ABBOTT LABORATORIES , AKRITOPOULOU-ZANZE, Irini , BRAJE, Wilfried , DJURIC, Stevan, W. , WILSON, Noel, S. , TURNER, Sean, C. , KRUGER, Albert, W. , RELO, Ana-Lucia , SHEKHAR, Shashank , WELCH, Dennie, S. , ZHAO, Hongyu , GANDARILLA, Jorge , GASIECKI, Alan, F. , LI, Huanqiu , THOMPSON, Christina, M. , ZHANG, Min
发明人： AKRITOPOULOU-ZANZE, Irini , BRAJE, Wilfried , DJURIC, Stevan, W. , WILSON, Noel, S. , TURNER, Sean, C. , KRUGER, Albert, W. , RELO, Ana-Lucia , SHEKHAR, Shashank , WELCH, Dennie, S. , ZHAO, Hongyu , GANDARILLA, Jorge , GASIECKI, Alan, F. , LI, Huanqiu , THOMPSON, Christina, M. , ZHANG, Min
IPC分类号： C07D487/04 , C07D491/04 , C07D495/04 , A61P25/00 , A61K31/551 , A61K31/554 , A61K31/553
CPC分类号： C07D513/04 , C07D487/04 , C07D491/04 , C07D491/044 , C07D495/04 , C07D495/16
摘要： The present application relates to aryl- and heteroaryl-fused decahydropyrroloazepine, octahydrooxepinopyrrole, octahydropyrrolothiazepine dioxide, decahydrocyclohepta[ c ]pyrrole, and octahydrocyclohepta[ c ]pyrrole derivatives of formula (I), wherein R 1 , R 2 , R 3 , R 4 , R 5 , A, Y 1 , Y 2 , and Y 3 are as defined in the specification. The present application also relates to compositions comprising such compounds, processes for making such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.
摘要翻译：本申请涉及式（I）的芳基 - 和杂芳基 - 稠合十氢吡咯并氮平，八氢恶庚英吡咯，八氢吡咯并噻吩二恶烷，十氢环庚三烯并[c]吡咯和八氢环庚三烯并[c]吡咯衍生物，其中R1，R2，R3，R4，R5， Y1，Y2和Y3如说明书中所定义。本申请还涉及包含这些化合物的组合物，制备此类化合物的方法，以及使用这些化合物和组合物治疗疾病状况的方法，以及鉴定这些化合物的方法。

9. 发明申请

WO2007140233A1 INHIBITORS OF POLO-LIKE KINASES 审中-公开
标题翻译： POLO-LIKE KINASES的抑制剂
公开(公告)号：WO2007140233A1
公开(公告)日：2007-12-06
申请号：PCT/US2007/069630
申请日：2007-05-24
申请人： ABBOTT LABORATORIES , DIEBOLD, Robert B. , DJURIC, Stevan W. , GIRANDA, Vincent L , HEXAMER, Laura , LIN, Nan-horng , MIYASHIRO, Julie M. , PENNING, Thomas D. , PRZYTULINSKA, Magdalena , SOWIN, Thomas , SULLIVAN, Gerard , TAO, Zhi-fu , TONG, Yunsong , VASUDEVAN, Anil , WANG, Le , WOODS, Keith W. , XIA, Zhiren , ZHANG, Henry Q.
发明人： DIEBOLD, Robert B. , DJURIC, Stevan W. , GIRANDA, Vincent L , HEXAMER, Laura , LIN, Nan-horng , MIYASHIRO, Julie M. , PENNING, Thomas D. , PRZYTULINSKA, Magdalena , SOWIN, Thomas , SULLIVAN, Gerard , TAO, Zhi-fu , TONG, Yunsong , VASUDEVAN, Anil , WANG, Le , WOODS, Keith W. , XIA, Zhiren , ZHANG, Henry Q.
IPC分类号： C07C225/20 , C07D249/14 , C07D277/64 , C07D285/06 , C07D333/20 , A61P35/00 , A61K31/132 , A61K31/505
CPC分类号： C07D249/14 , C07C225/20 , C07C2601/02 , C07C2601/04 , C07D277/64 , C07D285/06 , C07D333/20
摘要： Compounds that inhibit Plk1, compositions containing the compounds and methods of treating diseases using the compounds are disclosed.
摘要翻译：公开了抑制Plk1的化合物，含有该化合物的组合物和使用该化合物治疗疾病的方法。

10. 发明申请

WO2006124813A3 SUBSTITUTED 7, 8-DIHYDRO-1H-PYRIMIDO [4,5-B] [1,4] DIAZEPIN-4-AMINES AS?KINASE INHIBITORS 审中-公开
公开(公告)号：WO2006124813A3
公开(公告)日：2006-11-23
申请号：PCT/US2006/018796
申请日：2006-05-16
申请人： ABBOTT LABORATORIES , GRACIAS, Vijaya, J. , ABAD-ZAPATERO, Celerino , DJURIC, Stevan, W. , JI, Zhiqin , MICHAELIDES, Michael, R. , STEWART, Kent, D. , ZANZE, Irini
发明人： GRACIAS, Vijaya, J. , ABAD-ZAPATERO, Celerino , DJURIC, Stevan, W. , JI, Zhiqin , MICHAELIDES, Michael, R. , STEWART, Kent, D. , ZANZE, Irini
IPC分类号： C07D487/04 , A61K31/551 , A61P35/00
摘要： Compounds having the Formula (I) are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

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