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1. 发明申请

WO2012106723A1 POLYPHENOL PRODUCTION BY VACCINIUM MYRTILLUS CELL CULTURES 审中-公开
标题翻译：多环芳烃生产由真菌微生物细胞培养
公开(公告)号：WO2012106723A1
公开(公告)日：2012-08-09
申请号：PCT/US2012/024008
申请日：2012-02-06
申请人： DIANAPLANTSCIENCES, INC. , YOON, Sung-Yong , LALL, Sonia
发明人： YOON, Sung-Yong , LALL, Sonia
IPC分类号： A01N65/00 , A61K36/45
CPC分类号： C12N5/04 , A61K36/45
摘要： Cell cultures of Vaccinium myrtillus configured to grow in suspension culture in a liquid medium. The cells are derived from one or more V. myrtillus plant parts, such as an edible plant part (e.g., a leaf part or a berry part) or a stem part. The cells are adapted to grow to a high density is a relatively short period of time (e.g., about 7 days). In addition, the cells are adapted to produce high concentrations of polyphenols and/or procyanidins and essentially no anthocyanin. Methods for production of polyphenols and/or procyanidins from Vaccinium myrtillus cells grown in suspension culture are disclosed.
摘要翻译：酿酒酵母的细胞培养物配置为在液体培养基中悬浮培养中生长。细胞衍生自一种或多种V.myrtillus植物部分，例如可食用植物部分（例如叶部分或浆果部分）或茎部分。适于生长至高密度的细胞是相当短的时间段（例如约7天）。此外，细胞适于产生高浓度的多酚和/或原花青素，并且基本上不含花青素。公开了在悬浮培养物中生长的来自牛痘霉菌细胞的多酚和/或原花青素的生产方法。

2. 发明专利

BRPI0922484A2 Cultura de célula de planta para produção de produtos naturais com contaminação de glucosinolato reduzida 未知
公开(公告)号：BRPI0922484A2
公开(公告)日：2015-08-11
申请号：BRPI0922484
申请日：2009-12-17
申请人： DIANAPLANTSCIENCES INC
发明人： MATHEWS HELENA V , YOON YONG , VENKATRAMESH MYLAVARAPU
IPC分类号： C12N5/04 , A01H5/00 , C12N5/02

3. 发明申请

US20160208299A1 PRODUCTION OF ISOQUINOLINE ALKALOIDS AND FLAVONOIDS IN PLANT CELL CULTURES OF GOLDENSEAL (HYDRASTIS CANADENSIS) 审中-公开
标题翻译：在金黄植物细胞培养物（HYDRASTIS CANADENSIS）中生产异喹啉碱和黄酮类化合物
公开(公告)号：US20160208299A1
公开(公告)日：2016-07-21
申请号：US14996411
申请日：2016-01-15
申请人： DIANAPLANTSCIENCES INC.
发明人： Raymond E.B. Ketchum , Colby G. Caldwell , Sung-Yong H. Yoon
IPC分类号： C12P17/12 , A61K36/71
CPC分类号： C12P17/12 , A01H4/001 , A01H5/02 , A61K36/71 , C12P17/188
摘要： Natural product preparations of isoquinoline alkaloids are obtained from plant callus cells of goldenseal, Hydrastis canadensis, grown in suspension cell culture. The natural product preparations can be extracted from the cells and/or obtained from the culture medium in which the cells are grown. Accordingly, callus cell lines can be selected to grow in suspension culture, produce desirable levels and/or ratios of isoquinoline alkaloids, and/or release the isoquinoline alkaloids into the liquid medium. The level and/or ratio of certain isoquinoline alkaloids, such as hydrastine and/or berberine produced by the cells and/or released into the medium can be different than those found in native plants or plant parts (e.g., rhizomes) from which the cells were derived. For instance, cell lines can be selected to increase the production and/or ratio of hydrastine to berberine, or vice versa.
摘要翻译：异喹啉生物碱的天然产物制剂是从悬浮细胞培养物中生长的金缕梅，加拿大葫芦科植物愈伤组织细胞获得的。天然产物制剂可以从细胞中提取和/或从其中培养细胞的培养基获得。因此，可以选择愈伤组织细胞系在悬浮培养中生长，产生异喹啉生物碱的所需水平和/或比例，和/或将异喹啉生物碱释放到液体培养基中。由细胞产生的和/或释放到培养基中的某些异喹啉生物碱（例如氢化天竺葵碱和/或小檗碱）的水平和/或比例可以不同于天然植物或植物部分（例如，根状茎）中发现的那些，被派生。例如，可以选择细胞系以增加hydrastine与小檗碱的产生和/或比例，反之亦然。

4. 发明申请

US20150004142A1 INCORPORATION OF CULTURED BILBERRY CELLS IN COSMETICS, DIETARY SUPPLEMENTS, AND/OR FUNCTIONAL FOODS 审中-公开
标题翻译：在化妆品，膳食补充品和/或功能性食品中培养的白蛋白细胞的合成
公开(公告)号：US20150004142A1
公开(公告)日：2015-01-01
申请号：US14316495
申请日：2014-06-26
申请人： DianaPlantSciences, Inc.
发明人： Colby G. Caldwell , Sung-Yong H. Yoon
IPC分类号： A61K36/45 , A23L1/30
CPC分类号： A61K36/45 , A23L33/105 , A61K8/498 , A61K8/602 , A61K8/97 , A61K2800/30 , A61K2800/522 , A61Q19/08
摘要： Compositions include cultured bilberry cells or extracts thereof mixed with a cosmetic component or a food component to yield cosmetics, dietary supplements, and/or functional foods. The cultured bilberry cells or extracts can have high levels of polyphenols with little or no anthocyanins. The polyphenol fraction from the cultured bilberry cells is unique compared to the polyphenol fraction from the tissues of a traditional bilberry plant. The cultured cells have high levels of natural flavonols, flavan-3-ols and procyanidins, but are notably lacking in anthocyanins and chlorogenic acid.
摘要翻译：组合物包括与化妆品组分或食品组分混合的培养的越桔细胞或其提取物，以产生化妆品，膳食补充剂和/或功能性食品。培养的越桔细胞或提取物可以具有高水平的多酚，几乎没有或没有花青素。来自培养的越桔细胞的多酚部分与来自传统越桔植物的组织的多酚部分相比是独特的。培养的细胞具有高水平的天然黄酮醇，黄烷-3-醇和原花青素，但是明显缺乏花青素和绿原酸。

5. 发明专利

BRPI0925058A2 Métodos para criar variação de cor antocianinas produzidas por cultura de células 未知
公开(公告)号：BRPI0925058A2
公开(公告)日：2015-07-21
申请号：BRPI0925058
申请日：2009-05-04
申请人： DIANAPLANTSCIENCES INC
发明人： MATHEWS HELENA V , YOON SUNG-YONG
IPC分类号： A01H4/00 , C12N5/04

6. 发明专利

BRPI0925040A2 Produção e extração de procianidinas a partir da cultura celular de plantas 未知
公开(公告)号：BRPI0925040A2
公开(公告)日：2015-07-21
申请号：BRPI0925040
申请日：2009-05-04
申请人： DIANAPLANTSCIENCES INC
发明人： VENKATRAMESH MYLAVARAPU , WAGNER D RY , LALL SONIA , LEJARD FREDERIC , YOON SUNG-YONG
IPC分类号： C12N5/04

7. 发明申请

US20160002686A1 PLANT CELL CULTURE FOR PRODUCTION OF NATURAL PRODUCTS WITH REDUCED FLUCOSINOLATE CONTAMINATION 审中-公开
标题翻译：用于生产具有降低的氟橡胶污染的天然产物的植物细胞培养物
公开(公告)号：US20160002686A1
公开(公告)日：2016-01-07
申请号：US14840258
申请日：2015-08-31
申请人： DIANAPLANTSCIENCES, INC.
发明人： Helena V. Matthews , Sung-Yong Yoon , Mylavarapu Venkatramesh
IPC分类号： C12P17/06 , C12N5/04
CPC分类号： C12P17/06 , A01H4/00 , C12N5/04
摘要： Disclosed are methods for obtaining a natural product preparation with reduced glucosinolate contamination from a plant of Brassicaceae. The methods can include cultivating a plant callus from a plant capable of producing a desired natural product, selecting a callus with reduced glucosinolate production, and cultivating the selected callus in a liquid medium. The method can also include recovering the natural product from the culture. Also disclosed are methods for obtaining cabbage anthocyanin with reduced glucosinolate contamination. The methods can include cultivating a red cabbage plant callus with reduced glucosinolate production in a liquid medium to obtain a suspension culture and cultivating the suspension culture in a medium lacking a nitrogen source. The method can also include recovering the anthocyanin with reduced glucosinolate contamination from the culture. Finally, several specific low-glucosinolate cell lines are described.
摘要翻译：本发明公开了一种从甘蓝科植物获得具有降低的硫代葡萄糖苷污染的天然产物制剂的方法。所述方法可以包括从能够产生所需天然产物的植物培养植物愈伤组织，选择具有降低的硫代葡萄糖苷产生的愈伤组织，以及在液体培养基中培养所选择的愈伤组织。该方法还可以包括从培养物中回收天然产物。还公开了获得具有降低的硫代葡萄糖苷污染的甘蓝花青素的方法。该方法可以包括在液体培养基中培养具有降低的硫代葡萄糖苷产量的红甘蓝植物愈伤组织以获得悬浮培养物，并在不含氮源的培养基中培养悬浮培养物。该方法还可以包括从培养物中降低芥子油苷污染来回收花青素。最后，描述了几种特异性低硫代葡萄糖苷酸细胞系。

8. 发明授权

US09206452B2 Plant cell culture for production of natural products with reduced glucosinolate contamination 有权
标题翻译：用于生产具有降低的硫代葡萄糖苷污染的天然产物的植物细胞培养物
公开(公告)号：US09206452B2
公开(公告)日：2015-12-08
申请号：US14062452
申请日：2013-10-24
申请人： DIANAPLANTSCIENCES, INC.
发明人： Helena V. Mathews , Sung-Yong Yoon , Mylavarapu Venkatramesh
IPC分类号： C12N5/00 , C12P17/06 , A01H4/00
CPC分类号： C12P17/06 , A01H4/00 , C12N5/04
摘要： Disclosed are methods for obtaining a natural product preparation with reduced glucosinolate contamination from a plant of Brassicaceae. The methods can include cultivating a plant callus from a plant capable of producing a desired natural product, selecting a callus with reduced glucosinolate production, and cultivating the selected callus in a liquid medium. The method can also include recovering the natural product from the culture. Also disclosed are methods for obtaining cabbage anthocyanin with reduced glucosinolate contamination. The methods can include cultivating a red cabbage plant callus with reduced glucosinolate production in a liquid medium to obtain a suspension culture and cultivating the suspension culture in a medium lacking a nitrogen source. The method can also include recovering the anthocyanin with reduced glucosinolate contamination from the culture. Finally, several specific low-glucosinolate cell lines are described.
摘要翻译：本发明公开了一种从甘蓝科植物获得具有降低的硫代葡萄糖苷污染的天然产物制剂的方法。所述方法可以包括从能够产生所需天然产物的植物培养植物愈伤组织，选择具有降低的硫代葡萄糖苷产生的愈伤组织，以及在液体培养基中培养所选择的愈伤组织。该方法还可以包括从培养物中回收天然产物。还公开了获得具有降低的硫代葡萄糖苷污染的甘蓝花青素的方法。该方法可以包括在液体培养基中培养具有降低的硫代葡萄糖苷产量的红甘蓝植物愈伤组织以获得悬浮培养物，并在不含氮源的培养基中培养悬浮培养物。该方法还可以包括从培养物中降低芥子油苷污染来回收花青素。最后，描述了几种特异性低硫代葡萄糖苷酸细胞系。

9. 发明申请

US20140051135A1 PLANT CELL CULTURE FOR PRODUCTION OF NATURAL PRODUCTS WITH REDUCED GLUCOSINOLATE CONTAMINATION 有权
标题翻译：用于生产具有降低的葡萄糖苷酸盐污染的天然产品的植物细胞培养物
公开(公告)号：US20140051135A1
公开(公告)日：2014-02-20
申请号：US14062452
申请日：2013-10-24
申请人： DIANAPLANTSCIENCES, INC.
发明人： Helena V. Mathews , Sung-Yong Yoon , Mylavarapu Venkatramesh
IPC分类号： C12P17/06
CPC分类号： C12P17/06 , A01H4/00 , C12N5/04
摘要： Disclosed are methods for obtaining a natural product preparation with reduced glucosinolate contamination from a plant of Brassicaceae. The methods can include cultivating a plant callus from a plant capable of producing a desired natural product, selecting a callus with reduced glucosinolate production, and cultivating the selected callus in a liquid medium. The method can also include recovering the natural product from the culture. Also disclosed are methods for obtaining cabbage anthocyanin with reduced glucosinolate contamination. The methods can include cultivating a red cabbage plant callus with reduced glucosinolate production in a liquid medium to obtain a suspension culture and cultivating the suspension culture in a medium lacking a nitrogen source. The method can also include recovering the anthocyanin with reduced glucosinolate contamination from the culture. Finally, several specific low-glucosinolate cell lines are described.
摘要翻译：本发明公开了一种从甘蓝科植物获得具有降低的硫代葡萄糖苷污染的天然产物制剂的方法。所述方法可以包括从能够产生所需天然产物的植物培养植物愈伤组织，选择具有降低的硫代葡萄糖苷产生的愈伤组织，以及在液体培养基中培养所选择的愈伤组织。该方法还可以包括从培养物中回收天然产物。还公开了获得具有降低的硫代葡萄糖苷污染的甘蓝花青素的方法。该方法可以包括在液体培养基中培养具有降低的硫代葡萄糖苷产量的红甘蓝植物愈伤组织以获得悬浮培养物，并在不含氮源的培养基中培养悬浮培养物。该方法还可以包括从培养物中降低芥子油苷污染来回收花青素。最后，描述了几种特异性低硫代葡萄糖苷酸细胞系。

10. 发明申请

WO2012047817A1 PRODUCTION AND EXTRACTION OF PROCYANIDINS FROM PLANT CELLS CULTURES 审中-公开
标题翻译：从植物细胞生产和提取方法文化
公开(公告)号：WO2012047817A1
公开(公告)日：2012-04-12
申请号：PCT/US2011/054648
申请日：2011-10-03
申请人： DIANAPLANTSCIENCES, INC. , YOON, Sung-Yong , PARK, Young, Chul , MCDONALD, Amy , DUBOIS, Camille, Pierre , LALL, Sonia
发明人： YOON, Sung-Yong , PARK, Young, Chul , MCDONALD, Amy , DUBOIS, Camille, Pierre , LALL, Sonia
IPC分类号： A23G1/04
CPC分类号： A23L1/3002 , A01H4/001 , A01H5/08 , A01H5/12 , A23L33/105 , A23L33/115 , A61K36/185 , C07D311/62 , C12N5/0025 , C12N5/04
摘要： A method of preparing cocoa oligomeric procyanidins from cocoa cell cultures grown in the presence of monosaccharide can increase production of procyanidins as follows: culturing cells sufficient to result in production of cocoa oligomeric procyanidins at a first rate; and introducing a monosaccharide to the cells sufficient for inducing the cells to produce the cocoa oligomeric procyanidins at a second rate that his higher than the first rate. The method can further include extracting the cocoa oligomeric procyanidins from the cells, and such extracting can occur between 1 day to 21 days after introduction of the monosaccharide. Optionally, the monosaccharide can be introduced in an amount about 0.5% to about to about 20% by volume of the culture medium. The monosaccharide can be glucose, sucrose, fructose, or the like. The monosaccharide can be introduced during or after a last phase of an exponential growth state.
摘要翻译：从单糖存在下生长的可可细胞培养物制备可可低聚原花青素的方法可以增加原花青素的产生，如下所述：培养足以产生可可低聚原花青素的细胞以一率; 以及将细胞引入足以诱导细胞以高于第一速率的第二速率产生可可低聚原花青素的细胞。该方法可以进一步包括从细胞中提取可可低聚原花青素，并且这种提取可以在引入单糖后1天至21天之间发生。任选地，单糖可以以培养基的体积的约0.5％至约20％的量引入。单糖可以是葡萄糖，蔗糖，果糖等。单糖可以在指数生长状态的最后阶段期间或之后引入。

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