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1. 发明申请

WO2012093172A1 ALPHABODIES SPECIFICALLY BINDING TO CYTOKINES OR GROWTH FACTORS AND/OR CYTOKINE OR GROWTH FACTOR RECEPTORS 审中-公开
标题翻译： ALPHABODIES特异性结合细胞因子或生长因子和/或细胞因子或生长因子受体
公开(公告)号：WO2012093172A1
公开(公告)日：2012-07-12
申请号：PCT/EP2012/050193
申请日：2012-01-06
申请人： COMPLIX NV , LASTERS, Ignace , DESMET, Johan , HENDERIKX, Maria , WEHNERT, Anita , MEERSSEMAN, Geert
发明人： LASTERS, Ignace , DESMET, Johan , HENDERIKX, Maria , WEHNERT, Anita , MEERSSEMAN, Geert
IPC分类号： C07K16/24 , C07K14/00
CPC分类号： C07K14/001 , C07K16/244 , C07K16/2866 , C07K2317/33 , C07K2318/20
摘要： Alphabodies that specifically bind to cytokines or growth factor and/or their receptors, as well as polypeptides that comprise or essentially consist of such Alphabodies. Further nucleic acids encoding such Alphabodies; methods for preparing such Alphabodies and polypeptides; host cells expressing or capable of expressing such Alphabodies and polypeptides; compositions, and in particular pharmaceutical compositions, that comprise such Alphabodies, polypeptides, nucleic acids and/or host cells; and uses of such Alphabodies or polypeptides, nucleic acids, host cells and/or compositions, in particular for prophylactic, therapeutic or diagnostic purposes.
摘要翻译：与细胞因子或生长因子和/或其受体特异性结合的抗体，以及包含或基本上由此类Alphabody组成的多肽。编码这样的阿片受体的另外的核酸; 制备此类抗体和多肽的方法; 表达或能够表达此类α受体和多肽的宿主细胞; 组合物，特别是药物组合物，其包含这样的阿片受体，多肽，核酸和/或宿主细胞; 以及这些阿拉伯抗体或多肽，核酸，宿主细胞和/或组合物的用途，特别是用于预防，治疗或诊断目的。

2. 发明申请

WO2011003935A1 PARATHYROID HORMONE RELATED PROTEIN ANTAGONISTS 审中-公开
标题翻译： PARATHYROID HORMONE相关蛋白质拮抗剂
公开(公告)号：WO2011003935A1
公开(公告)日：2011-01-13
申请号：PCT/EP2010/059713
申请日：2010-07-07
申请人： COMPLIX NV , LOVERIX, Stefan , DESMET, Johan , LASTERS, Ignace , VANWETSWINKEL, Sophie , VAN GELDER, Patrick
发明人： LOVERIX, Stefan , DESMET, Johan , LASTERS, Ignace , VANWETSWINKEL, Sophie , VAN GELDER, Patrick
IPC分类号： C07K1/00 , C07K7/08 , C07K14/00
CPC分类号： C07K14/001 , C07K14/635 , C07K2318/20 , G01N33/574 , G01N2333/635
摘要： The present invention relates to PTHrP-binding single-chain 3-stranded alpha-helical coiled coil molecules, denoted 'Alphabodies', nucleic acids encoding said Aiphabodies, host cells comprising said nucleic acids, as well as pharmaceutical compositions comprising said Alphabodies, and methods for the treatment, prevention and diagnosis of cancer using said Alphabodies.
摘要翻译：本发明涉及表示为“Alphabodies”，编码所述Aiphabodies的核酸，包含所述核酸的宿主细胞以及包含所述Alphabody的药物组合物的PTHrP结合单链3-链α-螺旋卷曲螺旋分子，以及方法用于使用所述的Alphabodies来治疗，预防和诊断癌症。

3. 发明申请

WO2004058807A3 MHC CLASS I RESTRICTED T-CELL STIMULATING PEPTIDES FROM HEPATITIS B VIRUS 审中-公开
标题翻译： MHC I类限制性T细胞来自乙型肝炎病毒的刺激肽
公开(公告)号：WO2004058807A3
公开(公告)日：2004-09-30
申请号：PCT/EP0313948
申请日：2003-12-09
申请人： ALGONOMICS N V , LASTERS IGNACE , DESMET JOHAN , STEGMANN TOON , CASTELEIN BERNARD
发明人： LASTERS IGNACE , DESMET JOHAN , STEGMANN TOON , CASTELEIN BERNARD
IPC分类号： C07K14/02 , A61K38/00 , A61K39/12 , A61K39/29 , C07K7/06
CPC分类号： C07K14/005 , A61K2039/5154 , A61K2039/5256 , A61K2039/53 , A61K2039/55555 , A61K2039/57 , C12N2730/10122
摘要： The present invention related to peptides which are suitable for inducing an immune response to HBV and to the use of said peptides for the preparations of vaccines, compositions and in methods of diagnosis. Said sequences of said peptides are predicted using a method of the invention.
摘要翻译：本发明涉及适用于诱导针对HBV的免疫应答的肽以及所述肽用于制备疫苗，组合物和诊断方法的用途。使用本发明的方法预测所述肽的所述序列。

4. 发明申请

WO0133438A3 METHOD FOR GENERATING INFORMATION RELATED TO THE MOLECULAR STRUCTURE OF A BIOMOLECULE 审中-公开
标题翻译：用于产生与生物分子的分子结构相关的信息的方法
公开(公告)号：WO0133438A3
公开(公告)日：2002-03-28
申请号：PCT/EP0010921
申请日：2000-11-03
申请人： ALGONOMICS NV , DESMET JOHAN , LASTERS IGNACE , VLIEGHE DOMINIQUE , BOUTTON CARLO , STAS PHILIPPE , SPRIET JAN
发明人： DESMET JOHAN , LASTERS IGNACE , VLIEGHE DOMINIQUE , BOUTTON CARLO , STAS PHILIPPE , SPRIET JAN
IPC分类号： C07K1/00 , C40B40/06 , C40B40/10 , C40B40/12 , G06F17/50 , G06F19/16 , G06F19/00
CPC分类号： G06F19/16 , B01J2219/00689 , B01J2219/00695 , B01J2219/007 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , C07K1/00 , C07K2299/00 , C40B40/06 , C40B40/10 , C40B40/12
摘要： A method for generating information related to the molecular structure of a biomolecule, comprising the steps of: (a) receiving a three-dimensional representation of said molecular structure, comprising a first set of residue portions and a template; and (b) modifying the representation of step (a) by at least one optimization cycle. Each optimization cycle comprises the steps of: (b1) perturbing a first representation of the molecular structure by modifying the structure of one or more of the first set of residue portions; (b2) relaxing the perturbed representation by optimizing the structure of one or more of the non-perturbed residue portions of the first set with respect to the one or more perturbed residue portions; (b3) evaluating the perturbed and relaxed representation of the molecular structure by using an energetic cost function and replacing the first representation by the perturbed and relaxed representation if the latter's global energy is more optimal than that of the first representation; and the method further comprises the steps of (c) terminating the optimization process according to step (b) when a predetermined termination criterion is reached; and (d) outputting to a storage medium or to a consecutive method a data structure comprising information extracted from step (b).
摘要翻译：一种用于产生与生物分子的分子结构相关的信息的方法，包括以下步骤：（a）接收所述分子结构的三维表示，包括第一组残基部分和模板; 和（b）通过至少一个优化周期来修改步骤（a）的表示。每个优化周期包括以下步骤：（b1）通过修改第一组残留部分中的一个或多个的结构扰乱分子结构的第一表示; （b2）通过相对于一个或多个扰动残余部分优化第一组的非扰动残余部分的一个或多个的结构来放松扰动表示; （b3）通过使用能量成本函数来评估分子结构的扰动和松弛表示，并且如果后者的全局能量比第一表示更为优化，则通过扰动和轻松表示来代替第一表示; 并且所述方法还包括以下步骤：（c）当达到预定的终止标准时，终止根据步骤（b）的优化过程; 以及（d）向存储介质或连续方法输出包括从步骤（b）提取的信息的数据结构。

5. 发明申请

WO2012093013A1 ALPHABODIES SPECIFICALLY BINDING TO CLASS-I VIRAL FUSION PROTEINS AND METHODS FOR PRODUCING THE SAME 审中-公开
标题翻译：字体特殊绑定到类别的病毒融合蛋白及其生产方法
公开(公告)号：WO2012093013A1
公开(公告)日：2012-07-12
申请号：PCT/EP2011/071634
申请日：2011-12-02
申请人： COMPLIX NV , DESMET, Johan , LASTERS, Ignace , MEERSSEMAN, Geert , DEROO, Sabrina
发明人： DESMET, Johan , LASTERS, Ignace , MEERSSEMAN, Geert , DEROO, Sabrina
IPC分类号： C07K16/10 , C07K14/00
CPC分类号： C07K14/00 , C07K16/1027 , C07K16/1063 , C07K2317/76 , C07K2317/92 , C07K2318/20
摘要： Single-chain Alphabodies that comprise an alpha-helical binding region which mediates binding to a first fusion-driving region of a class- 1 viral fusion protein and which structurally mimics a second fusion - driving region of said class-1 viral fusion protein, wherein said first and second fusion - driving regions of said class-1 viral fusion protein are regions which interact to drive the fusion between a virus displaying said class- 1 viral fusion protein and a target cell.
摘要翻译：单链抗体，其包含介导与第1类病毒融合蛋白的第一融合驱动区结合并且结构上模拟所述1类病毒融合蛋白的第二融合驱动区的α螺旋结合区，其中所述1类病毒融合蛋白的第一和第二融合驱动区域是相互作用以驱动显示所述1类病毒融合蛋白的病毒与靶细胞之间的融合的区域。

6. 发明申请

WO2010066740A1 SINGLE-CHAIN ANTIPARALLEL COILED COIL PROTEINS 审中-公开
标题翻译：单链抗纤维线圈蛋白
公开(公告)号：WO2010066740A1
公开(公告)日：2010-06-17
申请号：PCT/EP2009/066640
申请日：2009-12-08
申请人： COMPLIX NV , DESMET, Johan , LASTERS, Ignace , LOVERIX, Stefan
发明人： DESMET, Johan , LASTERS, Ignace , LOVERIX, Stefan
IPC分类号： C07K1/00 , C07K7/08 , C07K14/00
CPC分类号： C07K1/1075 , C07K14/001 , C07K2318/20 , G01N33/6845
摘要： The present invention relates to single-chain proteins of the formula HRS1-L1-HRS2-L2-HRS3, wherein HRS1, HRS2 and HRS3 are heptad repeat sequences and L1 and L2 are structurally flexible linker sequences, and wherein HRS1, HRS2 and HRS3 form a thermodynamically stable triple-stranded, antiparallel, alpha-helical coiled coil structure in aqueous solution. The invention also relates to amino acid sequence variants, conditions and methods to obtain such proteins and variants, and usages thereof, especially their usage as scaffolds and as therapeutic products.
摘要翻译：本发明涉及式HRS1-L1-HRS2-L2-HRS3的单链蛋白，其中HRS1，HRS2和HRS3是七重复序列，L1和L2是结构上柔性的接头序列，其中HRS1，HRS2和HRS3形成在水溶液中的热力学稳定的三股，反向平行的α-螺旋卷曲螺旋结构。本发明还涉及获得这种蛋白质和变体的氨基酸序列变体，条件和方法，以及其用途，特别是其作为支架和用作治疗产品的用途。

7. 发明申请

WO2005118626A3 PEPTIDES FOR INDUCING A CTL AND/OR HTL RESPONSE TO HEPATITIS C VIRUS 审中-公开
标题翻译：用于诱导针对HEPATITIS C病毒的CTL和/或HTL反应的肽
公开(公告)号：WO2005118626A3
公开(公告)日：2006-07-06
申请号：PCT/EP2005052457
申请日：2005-05-30
申请人： INNOGENETICS NV , PHARMEXA INC , DEPLA ERIK , BUYSE MARIE-ANGE , LASTERS IGNACE , DESMET JOHAN , MAERTENS GEERT , BAKER DENISE , CHESNUT ROBERT W , NEWMAN MARK , SETTE ALESSANDRO , SIDNEY JOHN , SOUTHWOOD SCOTT
发明人： DEPLA ERIK , BUYSE MARIE-ANGE , LASTERS IGNACE , DESMET JOHAN , MAERTENS GEERT , BAKER DENISE , CHESNUT ROBERT W , NEWMAN MARK , SETTE ALESSANDRO , SIDNEY JOHN , SOUTHWOOD SCOTT
IPC分类号： C07K14/18 , A61K38/16 , A61K39/00 , A61K39/295 , G01N33/576
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/29 , A61K2039/55566 , A61K2039/57 , C12N2770/24222 , C12N2770/24234
摘要： The present invention is directed to peptides, and nucleic acids encoding them, derived from the Hepatitis C Virus (HCV). The peptides are those which elicit a CTL and/or HTL response in a host. The invention is also directed to compositions and vaccines for prevention and treatment of HCV infection and diagnostic methods for detection of HCV exposure in patients.
摘要翻译：本发明涉及衍生自丙型肝炎病毒（HCV）的肽和编码它们的核酸。肽是在宿主中引起CTL和/或HTL应答的肽。本发明还涉及用于预防和治疗HCV感染的组合物和疫苗以及用于检测患者中HCV暴露的诊断方法。

8. 发明申请

WO2004092207A2 RESPIRATORY SYNCYTIAL VIRUS (RSV) PEPTIDES 审中-公开
标题翻译：呼吸道同源性病毒（RSV）肽
公开(公告)号：WO2004092207A2
公开(公告)日：2004-10-28
申请号：PCT/EP2004004061
申请日：2004-04-16
申请人： ALGONOMICS N V , LASTERS IGNACE , DESMET JOHAN , STEGMANN TOON
发明人： LASTERS IGNACE , DESMET JOHAN , STEGMANN TOON
IPC分类号： A61K38/00 , A61K39/00 , C07K14/135 , G01N33/50 , G01N33/569 , A61K39/155 , C07K7/06
CPC分类号： G01N33/505 , A61K38/00 , A61K39/00 , A61K2039/53 , C07K14/005 , C12N2760/18522 , G01N33/56977 , G01N33/56983
摘要： The present invention relates to peptides which are suitable for inducing an immune response to RSV and to the use of said peptides for the preparations of vaccines, compositions and in methods of diagnosis.
摘要翻译：本发明涉及适用于诱导对RSV的免疫应答的肽以及用于制备疫苗，组合物和诊断方法的所述肽的用途。

9. 发明申请

WO2004058807A2 MHC CLASS I RESTRICTED T-CELL STIMULATING PEPTIDES FROM HEPATITIS B VIRUS 审中-公开
标题翻译： MHCⅠ类限制性T细胞刺激因子从乙型肝炎病毒
公开(公告)号：WO2004058807A2
公开(公告)日：2004-07-15
申请号：PCT/EP2003/013948
申请日：2003-12-09
申请人： ALGONOMICS N.V. , LASTERS, Ignace , DESMET, Johan , STEGMANN, Toon , CASTELEIN, Bernard
发明人： LASTERS, Ignace , DESMET, Johan , STEGMANN, Toon , CASTELEIN, Bernard
IPC分类号： C07K14/02
CPC分类号： C07K14/005 , A61K2039/5154 , A61K2039/5256 , A61K2039/53 , A61K2039/55555 , A61K2039/57 , C12N2730/10122
摘要： The present invention related to peptides which are suitable for inducing an immune response to HBV and to the use of said peptides for the preparations of vaccines, compositions and in methods of diagnosis. Said sequences of said peptides are predicted using a method of the invention.
摘要翻译：本发明涉及适用于诱导对HBV的免疫反应的肽以及所述肽用于制备疫苗，组合物和诊断方法的用途。使用本发明的方法预测所述肽的所述序列。

10. 发明申请

WO0137147A3 APPARATUS AND METHOD FOR STRUCTURE-BASED PREDICTION OF AMINO ACID SEQUENCES 审中-公开
标题翻译：用于氨基酸序列的结构预测的装置和方法
公开(公告)号：WO0137147A3
公开(公告)日：2002-07-04
申请号：PCT/EP0010923
申请日：2000-11-03
申请人： ALGONOMICS NV , DESMET JOHAN , LASTERS IGNACE , VLIEGHE DOMINIQUE , BOUTTON CARLO , STAS PHILIPPE
发明人： DESMET JOHAN , LASTERS IGNACE , VLIEGHE DOMINIQUE , BOUTTON CARLO , STAS PHILIPPE
IPC分类号： G06F19/16 , G06F17/50 , G06F19/00
CPC分类号： G06F19/16
摘要： A. Receiving a reference (3D) structure for a protein. B. Substituting into the reference structure of step (A) a pattern, whereby the said pattern consists of one or more of the moduled residue positions defined in step (A), each carrying a particular amino acid residue type in a fixed conformation, and the one or more amino acid residue types of the said pattern are replacing the corresponding amino acid residue types present in the reference structure. C. Optimizing the global conformation of the reference structure of step (A) being substituted by the pattern of step (B). D. Assessing the energetic compatibility of the pattern defined in step (B) within the context of the reference structure defined in step (A) being structurally optimized in step (C) with respect to the said pattern, by way of comparing the global energy of the substituted and optimized protein structure with the global energy of the non-substituted reference structure.
摘要翻译： A.接收蛋白质的参考（3D）结构。 B.将步骤（A）的参考结构代入模式，其中所述模式由步骤（A）中定义的一个或多个模块化残基位置组成，每个载体具有固定构象的特定氨基酸残基类型，以及所述图案的一个或多个氨基酸残基类型替换参考结构中存在的相应氨基酸残基类型。 C.优化步骤（A）的参考结构的全局构象由步骤（B）的模式代替。 D.在步骤（C）中定义的参考结构的上下文中评估步骤（B）中定义的模式的能量相容性在步骤（C）中相对于所述模式在结构上优化，通过比较全局能量的取代和优化的蛋白质结构与未取代的参考结构的全局能量。

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