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1. 发明申请

US20110306507A1 METHOD AND TOOLS FOR PROGNOSIS OF CANCER IN HER2+PARTIENTS 审中-公开
标题翻译：在HER2 +部分中预防癌症的方法和工具
公开(公告)号：US20110306507A1
公开(公告)日：2011-12-15
申请号：US12733575
申请日：2008-09-05
申请人： Christos Sotiriou , Benjamin Haibe-Kains , Christine Desmedt
发明人： Christos Sotiriou , Benjamin Haibe-Kains , Christine Desmedt
IPC分类号： C40B30/04 , C40B40/10 , C07K14/47 , C07K16/40 , C07K16/18 , C40B60/12 , C12N9/64 , C40B40/08 , C07H21/00
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/118
摘要： A gene or protein set includes at least 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, and possibly 40, 45, 50, 55, 60, 65 genes or proteins, antibodies or hypervariable portion thereof directed against the proteins encoded by these genes.
摘要翻译：基因或蛋白质组包括至少1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21， 22,23,24,25,26,27,28,29,30,31,32,33,34,35，以及可能的40,45,50,55,60,65基因或蛋白质，抗体或其高变区针对这些基因编码的蛋白质。

2. 发明授权

US08580496B2 Method and kit for the detection of genes associated with PIK3CA mutation and involved in PI3K/AKT pathway activation in the ER-postitive and HER2-positive subtypes with clinical implications 失效
标题翻译：用于检测与PIK3CA突变相关的基因并参与具有临床意义的ER- postitive和HER2阳性亚型中的PI3K / AKT通路激活的方法和试剂盒
公开(公告)号：US08580496B2
公开(公告)日：2013-11-12
申请号：US12860638
申请日：2010-08-20
申请人： Christos Sotiriou , Sherene Loi , Grant McArthur , Benjamin Haibe-Kains
发明人： Christos Sotiriou , Sherene Loi , Grant McArthur , Benjamin Haibe-Kains
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/6837 , C12Q2600/106 , C12Q2600/112 , C12Q2600/156 , C12Q2600/158
摘要： A method to determine the clinical outcome of breast tumor affecting a patient if treated with an antitumoral agent against breast tumor. The method includes the step of assaying a sample of a breast tumor from the patient for an expression level of selected genes, by contacting mRNA sequences from the cells of this breast tumor with a set of more than 3 nucleotide sequences related to human mutated PIK3CA.
摘要翻译：如果用抗肿瘤剂对乳腺肿瘤治疗，则确定影响患者的乳腺肿瘤的临床结果的方法。该方法包括通过使来自该乳腺肿瘤的细胞的mRNA序列与与人突变的PIK3CA相关的多于3个核苷酸序列的一组接触，从患者中检测乳腺肿瘤的样品以获得所选择的基因的表达水平。

3. 发明申请

US20120071346A1 GENE-BASED ALGORITHMIC CANCER PROGNOSIS 审中-公开
标题翻译：基于基因的算法癌症预防
公开(公告)号：US20120071346A1
公开(公告)日：2012-03-22
申请号：US13306590
申请日：2011-11-29
申请人： Christos SOTIRIOU , Mauro Delorenzi , Martine Piccart , Virginie Durbecq
发明人： Christos SOTIRIOU , Mauro Delorenzi , Martine Piccart , Virginie Durbecq
IPC分类号： C40B30/04 , C40B60/12 , C12M1/40 , C12Q1/68 , C40B40/06
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , G01N33/574
摘要： The present invention is related to the methods and systems for prognosis determination in tumor samples, by measuring gene expression in a tumor sample and applying a gene-expression grade index (GGI) or a relapse score (RS) to yield a number c risk score.
摘要翻译：本发明涉及通过测量肿瘤样品中的基因表达和应用基因表达等级指数（GGI）或复发评分（RS）以产生数量c风险评分的肿瘤样品中预后测定的方法和系统。

4. 发明申请

US20130296328A1 EPIGENETIC PORTRAITS OF HUMAN BREAST CANCERS 审中-公开
标题翻译：人类乳腺癌的原发性渊源
公开(公告)号：US20130296328A1
公开(公告)日：2013-11-07
申请号：US13980809
申请日：2012-01-20
申请人： François Fuks , Sarah Dedeurwaerder , Christos Sotiriou , Christine Desmedt
发明人： François Fuks , Sarah Dedeurwaerder , Christos Sotiriou , Christine Desmedt
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/154
摘要： The present invention provides new target gene regions for use in prediction, prognosis, diagnosis and therapy of breast cancer, based on the differential methylation profile of said targets in samples from subjects with breast cancer and healthy subjects.
摘要翻译：基于乳腺癌和健康受试者的样品中所述靶标的差异甲基化谱，本发明提供了用于乳腺癌预测，预后，诊断和治疗的新的靶基因区域。

5. 发明申请

US20060190852A1 Asynchronous, multi-rail, asymmetric-phase, static digital logic with completion detection and method for designing the same 审中-公开
公开(公告)号：US20060190852A1
公开(公告)日：2006-08-24
申请号：US11283070
申请日：2005-11-21
申请人： Christos Sotiriou
发明人： Christos Sotiriou
IPC分类号： G06F17/50
CPC分类号： G06F17/5059 , A45C5/14 , A45C2003/007 , G06F7/00
摘要： A method of converting a Boolean logic circuit into an asynchronous multi-rail circuit is provided. A Boolean logic circuit is converted into a first multi-rail circuit using at least Shannon's expansion. The first multi-rail circuit is technology mapped into a second multi-rail circuit. Completion detection circuitry is added which receives the primary outputs of the second multi-rail circuit.

6. 发明申请

US20120065084A1 METHODS AND TOOLS FOR PREDICTING THE EFFICIENCY OF ANTHRACYCLINES IN CANCER 审中-公开
标题翻译：用于预测癌症中ANTHRACYCLINES的效率的方法和工具
公开(公告)号：US20120065084A1
公开(公告)日：2012-03-15
申请号：US13264726
申请日：2010-04-16
申请人： Christos Sotiriou , Christine Desmedt
发明人： Christos Sotiriou , Christine Desmedt
IPC分类号： C40B30/00 , C40B40/06 , C07H15/252 , C40B40/08
CPC分类号： C12Q1/6809 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158
摘要： A gene set, kit and method predict the efficiency of anthracyclines-based treatment of breast cancer.
摘要翻译：基因组，试剂盒和方法预测基于蒽环类药物治疗乳腺癌的效率。

7. 发明申请

US20110038862A1 METHOD AND KIT FOR THE DETECTION OF GENES ASSOCIATED WITH PIK3CA MUTATION AND INVOLVED IN PI3K/AKT PATHWAY ACTIVATION IN THE ER-POSTITIVE AND HER2-POSITIVE SUBTYPES WITH CLINICAL IMPLICATIONS 失效
标题翻译：检测与PIK3CA突变相关基因并参与PI3K / AKT途径激活在具有临床意义的ER阳性和HER2阳性亚型中的基因的方法和试剂盒
公开(公告)号：US20110038862A1
公开(公告)日：2011-02-17
申请号：US12860638
申请日：2010-08-20
申请人： CHRISTOS SOTIRIOU , SHERENE LOI , GRANT MCARTHUR , BENJAMIN HAIBE-KAINS
发明人： CHRISTOS SOTIRIOU , SHERENE LOI , GRANT MCARTHUR , BENJAMIN HAIBE-KAINS
IPC分类号： A61K39/395 , C12Q1/68 , A61K31/4535 , A61P35/00 , A61K31/436 , A61K31/138 , A61K31/565
CPC分类号： C12Q1/6886 , C12Q1/6837 , C12Q2600/106 , C12Q2600/112 , C12Q2600/156 , C12Q2600/158
摘要： A method to determine the clinical outcome of breast tumour affecting a patient if treated with an antitumoural agent against breast tumour. The method includes the step of assaying a sample of a breast tumour from the patient for an expression level of selected genes, by contacting mRNA sequences from the cells of this breast tumour with a set of more than 3 nucleotide sequences related to human mutated PIK3CA.
摘要翻译：如果用针对乳腺肿瘤的抗肿瘤药物治疗，则确定影响患者的乳腺肿瘤的临床结果的方法。该方法包括通过使来自该乳腺肿瘤的细胞的mRNA序列与与人突变的PIK3CA相关的多于3个核苷酸序列的一组接触，从患者中检测乳腺肿瘤的样品以获得所选择的基因的表达水平。

8. 发明申请

US20100298160A1 METHOD AND TOOLS FOR PROGNOSIS OF CANCER IN ER-PATIENTS 审中-公开
标题翻译： ER患者癌症预防方法与工具
公开(公告)号：US20100298160A1
公开(公告)日：2010-11-25
申请号：US12733574
申请日：2008-09-05
申请人： Christos Sotiriou , Benjamin Haibe-Kains , Christine Desmedt
发明人： Christos Sotiriou , Benjamin Haibe-Kains , Christine Desmedt
IPC分类号： C40B30/04 , C40B40/08 , C40B40/10
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/118
摘要： A gene or protein set includes at least 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 55, 60, 65, 70, 75, 80, 85, 90, 95 possibly 100, 105, 110 genes or proteins or the entire set or antibodies (or hypervariable portion thereof) directed against the proteins encoded by these genes.
摘要翻译：基因或蛋白质组包括至少1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21， 22，23，24，25，26，27，28，29，30，31，32，33，34，35，36，37，38，39，40，41，42，43，44，45，46， 47,48,49,50,55,60,65,70,75,80,85,90,95可能为100,105,110个基因或蛋白质，或针对蛋白质的整个组或抗体（或其高变区部分）由这些基因编码。

9. 发明申请

US20080275652A1 GENE-BASED ALGORITHMIC CANCER PROGNOSIS 审中-公开
标题翻译：基于基因的算法癌症预防
公开(公告)号：US20080275652A1
公开(公告)日：2008-11-06
申请号：US11929043
申请日：2007-10-30
申请人： Christos SOTIRIOU , Mauro DELORENZI , Martine PICCART , Virginie DURBECQ
发明人： Christos SOTIRIOU , Mauro DELORENZI , Martine PICCART , Virginie DURBECQ
IPC分类号： G06F19/00 , C40B40/08 , C40B60/12 , C40B30/00
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , G01N33/574
摘要： Gene-Based Algorithmic Cancer Prognosis relates to methods and systems for prognosis determination in tumor samples. The methods and systems measure gene expression in a tumor sample and applying a gene-expression grade index (GGI) or a relapse score (RS) to yield a number c risk score.
摘要翻译：基于基因的算法癌症预后与肿瘤样本中预后测定的方法和系统有关。方法和系统测量肿瘤样本中的基因表达，并应用基因表达分级指数（GGI）或复发评分（RS）以产生数量c风险评分。

10. 发明申请

US20060217919A1 System and method of determining the speed of digital application specific integrated circuits 有权
标题翻译：确定数字专用集成电路速度的系统和方法
公开(公告)号：US20060217919A1
公开(公告)日：2006-09-28
申请号：US11330350
申请日：2006-01-12
申请人： Christos Sotiriou
发明人： Christos Sotiriou
IPC分类号： G06F19/00
CPC分类号： G01R31/31703 , G01R31/3016 , G01R31/31708 , G01R31/31725
摘要： According to an embodiment of the invention, a system for identifying when a running speed of an integrated circuit is within an applied clock speed is provided. A monotonic circuit is configured to receive input data and transmit output data. A completion detection circuit is configured to generate a completion detection signal for the monotonic circuit. A comparator is configured to compare at least the completion detection signal and a clock signal, and configured to emit an error signal if the clock signal arrives before the completion detection signal. A synchronous circuit element is configured to receive at least a portion of the output data and configured to be clock driven by the clock signal. The error signal represents that the clock speed is faster than an operating speed of the monotonic circuit.
摘要翻译：根据本发明的实施例，提供了一种用于识别集成电路的运行速度何时处于施加的时钟速度内的系统。单调电路被配置为接收输入数据并发送输出数据。完成检测电路被配置为产生用于单调电路的完成检测信号。比较器被配置为至少比较完成检测信号和时钟信号，并且如果时钟信号在完成检测信号之前到达则被配置为发出错误信号。同步电路元件被配置为接收输出数据的至少一部分并被配置为由时钟信号驱动时钟。误差信号表示时钟速度比单调电路的运行速度快。

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