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1. 发明申请

US20110082292A1 HIGH-PURITY LARGE-SCALE PREPARATION OF STANNSOPORFIN 有权
标题翻译： STANNSOPORFIN的高纯度大规模制备
公开(公告)号：US20110082292A1
公开(公告)日：2011-04-07
申请号：US12968651
申请日：2010-12-15
申请人： George S. DRUMMOND , Robert CAROSELLI , Keith A. COOKE , Daniel LEVIN , David G. ROE , Christopher P. BOUCHER
发明人： George S. DRUMMOND , Robert CAROSELLI , Keith A. COOKE , Daniel LEVIN , David G. ROE , Christopher P. BOUCHER
IPC分类号： C07D487/22
CPC分类号： C07F7/2284 , A61K9/0019 , A61K31/555 , C07D487/22 , C07F7/003
摘要： Large scale (bulk) compositions comprising high-purity stannsoporfin are disclosed, as well as methods of synthesizing such compositions.
摘要翻译：公开了包含高纯度固体锡的大规模（本体）组合物，以及合成这些组合物的方法。

2. 发明申请

US20080125585A1 HIGH-PURITY LARGE-SCALE PREPARATION OF STANNSOPORFIN 有权
标题翻译： STANNSOPORFIN的高纯度大规模制备
公开(公告)号：US20080125585A1
公开(公告)日：2008-05-29
申请号：US11867559
申请日：2007-10-04
申请人： George S. DRUMMOND , Robert Caroselli , Keith A. Cooke , Daniel Levin , David G. Roe , Christopher P. Boucher
发明人： George S. DRUMMOND , Robert Caroselli , Keith A. Cooke , Daniel Levin , David G. Roe , Christopher P. Boucher
IPC分类号： C07D487/22
CPC分类号： C07F7/2284 , A61K9/0019 , A61K31/555 , C07D487/22 , C07F7/003
摘要： Large scale (bulk) compositions comprising high-purity stannsoporfin are disclosed, as well as methods of synthesizing such compositions.
摘要翻译：公开了包含高纯度固体锡的大规模（本体）组合物，以及合成这些组合物的方法。

3. 发明授权

US08530458B2 High-purity large-scale preparation of stannsoporfin 有权
公开(公告)号：US08530458B2
公开(公告)日：2013-09-10
申请号：US12968651
申请日：2010-12-15
申请人： George S. Drummond , Robert Caroselli , Keith A. Cooke , Daniel Levin , David G. Roe , Christopher P. Boucher
发明人： George S. Drummond , Robert Caroselli , Keith A. Cooke , Daniel Levin , David G. Roe , Christopher P. Boucher
IPC分类号： A01N55/02 , C07D487/22 , C07B47/00
CPC分类号： C07F7/2284 , A61K9/0019 , A61K31/555 , C07D487/22 , C07F7/003
摘要： Large scale (bulk) compositions comprising high-purity stannsoporfin are disclosed, as well as methods of synthesizing such compositions.

4. 发明授权

US07960371B2 High-purity large-scale preparation of stannsoporfin 有权
标题翻译：高纯度大规模制备锡兰
公开(公告)号：US07960371B2
公开(公告)日：2011-06-14
申请号：US11867559
申请日：2007-10-04
申请人： George S. Drummond , Robert Caroselli , Keith A. Cooke , Daniel Levin , David G. Roe , Christopher P. Boucher
发明人： George S. Drummond , Robert Caroselli , Keith A. Cooke , Daniel Levin , David G. Roe , Christopher P. Boucher
IPC分类号： C07B47/00 , C07D487/22 , A01N55/02
CPC分类号： C07F7/2284 , A61K9/0019 , A61K31/555 , C07D487/22 , C07F7/003
摘要： Large scale (bulk) compositions comprising high-purity stannsoporfin are disclosed, as well as methods of synthesizing such compositions.
摘要翻译：公开了包含高纯度固体锡的大规模（本体）组合物，以及合成这些组合物的方法。

5. 发明授权

US07777028B2 Preparation of metal mesoporphyrin compounds 有权
标题翻译：金属中卟啉化合物的制备
公开(公告)号：US07777028B2
公开(公告)日：2010-08-17
申请号：US11957317
申请日：2007-12-14
申请人： Robert A. Vukovich , Benjamin Levinson , George S. Drummond , Robert Caroselli , Kazimierz G. Antczak , Christopher P. Boucher , Richard Mortimer , Daniel Levin , Keith A. Cooke
发明人： Robert A. Vukovich , Benjamin Levinson , George S. Drummond , Robert Caroselli , Kazimierz G. Antczak , Christopher P. Boucher , Richard Mortimer , Daniel Levin , Keith A. Cooke
IPC分类号： C07B47/00
CPC分类号： C07D487/22 , C07F7/003 , C07F15/025
摘要： A method of preparing metal mesoporphyrin halide compounds is described. The metal mesoporphyrin halide compound may be formed by forming a novel mesoporphyrin IX intermediate compound and then converting the mesoporphyrin IX intermediate to the metal mesoporphyrin halide through metal insertion. The novel intermediate compound may be formed by a catalytic hydrogenation of hemin in acid and subsequent recovery.
摘要翻译：描述了制备金属中卟啉卤化物的方法。金属中卟啉卤化物可以通过形成新的中卟啉IX中间体化合物形成，然后通过金属插入将中卟啉IX中间体转化成金属中卟啉卤化物。新型中间体化合物可以通过氢氧化锂在酸中的催化氢化和随后的回收形成。

6. 发明授权

US08735574B2 Methods for synthesizing metal mesoporphyrins 有权
标题翻译：合成金属中卟啉的方法
公开(公告)号：US08735574B2
公开(公告)日：2014-05-27
申请号：US13435868
申请日：2012-03-30
申请人： Christopher P. Boucher , David Roe
发明人： Christopher P. Boucher , David Roe
IPC分类号： C07D487/22
CPC分类号： C07F7/2284 , C07D487/22
摘要： Embodiments describe methods of synthesizing metal mesoporphyrin compounds. In embodiments, a metal mesoporphyrin compound may be formed by hemin transmetallation and subsequent hydrogenation of the tin protoporphyrin IX to form a metal mesoporphyrin. In other embodiments, a method of synthesizing a metal mesoporphyrin compound comprises forming a protoporphyrin methyl ester from hemin and converting the protoporphyrin methyl ester intermediate to a metal mesoporphyrin compound through metal insertion and hydrogenation. In other embodiments, a metal mesoporphyrin compound may be formed from hemin by a hydrogen-free hydrogenation method to form a mesoporphyrin IX intermediate followed by metal insertion and hydrogenation. In embodiments, a method of synthesizing a metal mesoporphyrin compound comprises forming a mesoporphyrin IX dihydrochloride intermediate compound and converting the mesoporphyrin IX intermediate to a metal mesoporphyrin compound through metal insertion. In embodiments, a metal mesoporphyrin compound may be formed directly from hemin without isolation of any intermediates.
摘要翻译：实施方案描述了合成金属中卟啉化合物的方法。在实施方案中，金属中卟啉化合物可以通过血红素转移金属化和随后的锡原卟啉IX的氢化形成金属中卟啉来形成。在其它实施方案中，合成金属中卟啉化合物的方法包括由血红素形成原卟啉甲酯，并通过金属插入和氢化将原卟啉甲酯中间体转化成金属中卟啉化合物。在其它实施方案中，金属中卟啉化合物可以由氢氧化钠通过无氢氢化方法形成中卟啉IX中间体，接着进行金属插入和氢化。在实施方案中，合成金属中卟啉化合物的方法包括形成中卟啉IX二盐酸盐中间体化合物，并通过金属插入将中卟啉IX中间体转化为金属中卟啉化合物。在实施方案中，金属中卟啉化合物可直接由血红素形成，而不分离任何中间体。

7. 发明申请

US20120253033A1 METHODS FOR SYNTHESIZING METAL MESOPORPHYRINS 有权
标题翻译：用于合成金属间苯二酚的方法
公开(公告)号：US20120253033A1
公开(公告)日：2012-10-04
申请号：US13435868
申请日：2012-03-30
申请人： Christopher P. BOUCHER , David ROE
发明人： Christopher P. BOUCHER , David ROE
IPC分类号： C07D487/22
CPC分类号： C07F7/2284 , C07D487/22
摘要： Embodiments describe methods of synthesizing metal mesoporphyrin compounds. In embodiments, a metal mesoporphyrin compound may be formed by hemin transmetallation and subsequent hydrogenation of the tin protoporphyrin IX to form a metal mesoporphyrin. In other embodiments, a method of synthesizing a metal mesoporphyrin compound comprises forming a protoporphyrin methyl ester from hemin and converting the protoporphyrin methyl ester intermediate to a metal mesoporphyrin compound through metal insertion and hydrogenation. In other embodiments, a metal mesoporphyrin compound may be formed from hemin by a hydrogen-free hydrogenation method to form a mesoporphyrin IX intermediate followed by metal insertion and hydrogenation. In embodiments, a method of synthesizing a metal mesoporphyrin compound comprises forming a mesoporphyrin IX dihydrochloride intermediate compound and converting the mesoporphyrin IX intermediate to a metal mesoporphyrin compound through metal insertion. In embodiments, a metal mesoporphyrin compound may be formed directly from hemin without isolation of any intermediates.
摘要翻译：实施方案描述了合成金属中卟啉化合物的方法。在实施方案中，金属中卟啉化合物可以通过血红素转移金属化和随后的锡原卟啉IX的氢化形成金属中卟啉来形成。在其它实施方案中，合成金属中卟啉化合物的方法包括由血红素形成原卟啉甲酯，并通过金属插入和氢化将原卟啉甲酯中间体转化成金属中卟啉化合物。在其它实施方案中，金属中卟啉化合物可以由氢氧化钠通过无氢氢化方法形成中卟啉IX中间体，接着进行金属插入和氢化。在实施方案中，合成金属中卟啉化合物的方法包括形成中卟啉IX二盐酸盐中间体化合物，并通过金属插入将中卟啉IX中间体转化为金属中卟啉化合物。在实施方案中，金属中卟啉化合物可直接由血红素形成，而不分离任何中间体。

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