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1. 发明授权

US07777028B2 Preparation of metal mesoporphyrin compounds 有权
标题翻译：金属中卟啉化合物的制备
公开(公告)号：US07777028B2
公开(公告)日：2010-08-17
申请号：US11957317
申请日：2007-12-14
申请人： Robert A. Vukovich , Benjamin Levinson , George S. Drummond , Robert Caroselli , Kazimierz G. Antczak , Christopher P. Boucher , Richard Mortimer , Daniel Levin , Keith A. Cooke
发明人： Robert A. Vukovich , Benjamin Levinson , George S. Drummond , Robert Caroselli , Kazimierz G. Antczak , Christopher P. Boucher , Richard Mortimer , Daniel Levin , Keith A. Cooke
IPC分类号： C07B47/00
CPC分类号： C07D487/22 , C07F7/003 , C07F15/025
摘要： A method of preparing metal mesoporphyrin halide compounds is described. The metal mesoporphyrin halide compound may be formed by forming a novel mesoporphyrin IX intermediate compound and then converting the mesoporphyrin IX intermediate to the metal mesoporphyrin halide through metal insertion. The novel intermediate compound may be formed by a catalytic hydrogenation of hemin in acid and subsequent recovery.
摘要翻译：描述了制备金属中卟啉卤化物的方法。金属中卟啉卤化物可以通过形成新的中卟啉IX中间体化合物形成，然后通过金属插入将中卟啉IX中间体转化成金属中卟啉卤化物。新型中间体化合物可以通过氢氧化锂在酸中的催化氢化和随后的回收形成。

2. 发明申请

US20080125585A1 HIGH-PURITY LARGE-SCALE PREPARATION OF STANNSOPORFIN 有权
标题翻译： STANNSOPORFIN的高纯度大规模制备
公开(公告)号：US20080125585A1
公开(公告)日：2008-05-29
申请号：US11867559
申请日：2007-10-04
申请人： George S. DRUMMOND , Robert Caroselli , Keith A. Cooke , Daniel Levin , David G. Roe , Christopher P. Boucher
发明人： George S. DRUMMOND , Robert Caroselli , Keith A. Cooke , Daniel Levin , David G. Roe , Christopher P. Boucher
IPC分类号： C07D487/22
CPC分类号： C07F7/2284 , A61K9/0019 , A61K31/555 , C07D487/22 , C07F7/003
摘要： Large scale (bulk) compositions comprising high-purity stannsoporfin are disclosed, as well as methods of synthesizing such compositions.
摘要翻译：公开了包含高纯度固体锡的大规模（本体）组合物，以及合成这些组合物的方法。

3. 发明授权

US08530458B2 High-purity large-scale preparation of stannsoporfin 有权
公开(公告)号：US08530458B2
公开(公告)日：2013-09-10
申请号：US12968651
申请日：2010-12-15
申请人： George S. Drummond , Robert Caroselli , Keith A. Cooke , Daniel Levin , David G. Roe , Christopher P. Boucher
发明人： George S. Drummond , Robert Caroselli , Keith A. Cooke , Daniel Levin , David G. Roe , Christopher P. Boucher
IPC分类号： A01N55/02 , C07D487/22 , C07B47/00
CPC分类号： C07F7/2284 , A61K9/0019 , A61K31/555 , C07D487/22 , C07F7/003
摘要： Large scale (bulk) compositions comprising high-purity stannsoporfin are disclosed, as well as methods of synthesizing such compositions.

4. 发明授权

US07960371B2 High-purity large-scale preparation of stannsoporfin 有权
标题翻译：高纯度大规模制备锡兰
公开(公告)号：US07960371B2
公开(公告)日：2011-06-14
申请号：US11867559
申请日：2007-10-04
申请人： George S. Drummond , Robert Caroselli , Keith A. Cooke , Daniel Levin , David G. Roe , Christopher P. Boucher
发明人： George S. Drummond , Robert Caroselli , Keith A. Cooke , Daniel Levin , David G. Roe , Christopher P. Boucher
IPC分类号： C07B47/00 , C07D487/22 , A01N55/02
CPC分类号： C07F7/2284 , A61K9/0019 , A61K31/555 , C07D487/22 , C07F7/003
摘要： Large scale (bulk) compositions comprising high-purity stannsoporfin are disclosed, as well as methods of synthesizing such compositions.
摘要翻译：公开了包含高纯度固体锡的大规模（本体）组合物，以及合成这些组合物的方法。

5. 发明授权

US09101313B2 System and method for improving a performance estimation of an operator of a vehicle 有权
标题翻译：用于改善车辆操作者的性能估计的系统和方法
公开(公告)号：US09101313B2
公开(公告)日：2015-08-11
申请号：US13601844
申请日：2012-08-31
申请人： Daniel Levin , Lena Westervall , Gustav Markkula , Peter Kronberg , Trent Victor
发明人： Daniel Levin , Lena Westervall , Gustav Markkula , Peter Kronberg , Trent Victor
IPC分类号： A61B5/18 , G08B21/06 , B60W40/09 , B60W40/08
CPC分类号： A61B5/18 , B60W40/09 , B60W2040/0872 , B60W2540/10 , B60W2540/18 , B60W2550/308 , G08B21/06
摘要： System for improving a performance estimation of an operator of a vehicle, comprising a first module implementing a first method for estimating a performance state of vehicle operation, a second module implementing a second method for estimating at least one of a physiological and behavioral state of the operator, a device for sharing an estimated state between one of the first and the second module and the other one of the first and the second module, wherein the implemented estimation method of one of the first and the second module is adjusted based on the state of the other one of the first and the second module, thereby improving the estimation of at least one of the performance state of vehicle operation and the physiological and/or behavioral state of the operator.
摘要翻译：用于改善车辆操作者的性能估计的系统，包括实现用于估计车辆操作的性能状态的第一方法的第一模块，实现用于估计车辆操作的生理和行为状态中的至少一个的第二方法的第二模块操作者，用于在第一和第二模块之一和第一和第二模块中的一个模块之间共享估计状态的装置，其中基于状态来调整第一模块和第二模块之一的所实现的估计方法的第一模块和第二模块中的另一个模块，从而改进对车辆操作的性能状态和操作者的生理和/或行为状态中的至少一个的估计。

6. 发明授权

US08965037B2 Visual input of vehicle operator 有权
标题翻译：车载操作员视觉输入
公开(公告)号：US08965037B2
公开(公告)日：2015-02-24
申请号：US13601789
申请日：2012-08-31
申请人： Daniel Levin , Gustav Markkula
发明人： Daniel Levin , Gustav Markkula
IPC分类号： G06T7/00 , B60W50/14 , B60K28/06 , A61B3/113 , A61B5/18 , G06F3/01
CPC分类号： B60K28/066 , A61B3/113 , A61B5/18 , G06F3/013 , G06K9/00604 , G06K9/00845
摘要： The present invention relates to a method for determining a vehicle operator's visual input of an object in the operator's surroundings, which method comprises receiving an object position signal indicative of the position of at least one object, receiving an operator motion input signal indicative of operator physiological data comprising information relating to body motion of the operator, estimating an operator eye-gaze direction, and determining a visual input quality value representative of level of visual input of the at least one object received by the operator, based on the object position signal and the estimated operator eye-gaze direction.
摘要翻译：本发明涉及一种用于确定车辆操作员在操作员周围环境中的物体的视觉输入的方法，该方法包括：接收表示至少一个物体的位置的物体位置信号，接收指示操作者生理学的操作者运动输入信号数据，其包括与操作者的身体运动有关的信息，估计操作者的眼睛注视方向，以及基于对象位置信号确定代表操作者接收的至少一个对象的视觉输入的水平的视觉输入质量值，以及估计操作者眼睛注视方向。

7. 发明授权

US08916545B2 Pharmaceutical compositions comprising POH derivatives 有权
标题翻译：包含POH衍生物的药物组合物
公开(公告)号：US08916545B2
公开(公告)日：2014-12-23
申请号：US13566731
申请日：2012-08-03
申请人： Thomas Chen , Daniel Levin , Satish Pupalli
发明人： Thomas Chen , Daniel Levin , Satish Pupalli
IPC分类号： A61K47/48 , C07D207/26 , C07D487/04 , A61N5/10 , A61K45/06 , A61K31/415 , C07D231/12
CPC分类号： C07C33/14 , A61K9/0043 , A61K31/045 , A61K31/4015 , A61K31/415 , A61K31/4188 , A61K31/495 , A61K45/06 , A61K47/54 , A61K47/542 , A61K47/543 , A61N5/10 , C07B59/00 , C07B2200/05 , C07C2601/16 , C07D207/26 , C07D231/12 , C07D487/04
摘要： The present invention provides for a derivative of monoterpene or sesquiterpene, such as a perillyl alcohol derivative. For example, the perillyl alcohol derivative may be a perillyl alcohol carbamate. The perillyl alcohol derivative may be perillyl alcohol conjugated with a therapeutic agent such as a chemotherapeutic agent. The present invention also provides for a method of treating a disease such as cancer, comprising the step of delivering to a patient a therapeutically effective amount of a derivative of monoterpene (or sesquiterpene). The route of administration may vary, and can include, inhalation, intranasal, oral, transdermal, intravenous, subcutaneous or intramuscular injection.
摘要翻译：本发明提供单萜或倍半萜衍生物，例如芳香醇衍生物。例如，紫苏醇衍生物可以是芳族醇氨基甲酸酯。紫苏醇衍生物可以是与治疗剂如化学治疗剂缀合的紫苏醇。本发明还提供了治疗诸如癌症的疾病的方法，其包括向患者递送治疗有效量的单萜（或倍半萜烯）衍生物的步骤。给药途径可以变化，并且可以包括吸入，鼻内，口服，透皮，静脉内，皮下或肌内注射。

8. 发明申请

US20130331422A1 METHODS AND DEVICES FOR USING ISOPERILLY ALCOHOL 有权
标题翻译：使用异丙醇的方法和装置
公开(公告)号：US20130331422A1
公开(公告)日：2013-12-12
申请号：US13993910
申请日：2011-12-16
申请人： Thomas Chen , Daniel Levin , Satish Puppali , Daniel Anthony Dickman
发明人： Thomas Chen , Daniel Levin , Satish Puppali , Daniel Anthony Dickman
IPC分类号： A61K31/045 , A61K31/4015 , A61K31/4188 , A61K45/06 , A61K31/415
CPC分类号： A61K31/045 , A61K31/05 , A61K31/165 , A61K31/325 , A61K31/4015 , A61K31/415 , A61K31/4188 , A61K45/06 , A61K47/54 , A61K47/55 , A61N5/10 , C07B2200/07 , C07C271/22 , C07D207/26 , C07D231/12 , C07D487/04 , A61K2300/00
摘要： The present invention provides for a method of treating a disease such as cancer, comprising the step of administering to a patient a therapeutically effective amount of an isomer or analog of monoterpene or sesquiterpene (or its derivative), such as an isoperillyl alcohol. The present invention also provides for a method of treating a disease comprising the step of administering to a patient a therapeutically effective amount of a derivative of an isomer or analog of monoterpene or sesquiterpene, such as an isoperillyl alcohol carbamate. The derivative may be an isoperillyl alcohol conjugated with a therapeutic agent such as a chemotherapeutic agent. The route of administration may vary, including inhalation, intranasal, oral, transdermal, intravenous, subcutaneous or intramuscular injection.
摘要翻译：本发明提供了治疗诸如癌症的疾病的方法，包括向患者施用治疗有效量的单萜烯或倍半萜烯（或其衍生物）的异构体或类似物，例如异环戊醇。本发明还提供了治疗疾病的方法，其包括向患者施用治疗有效量的单萜或倍半萜的异构体或类似物的衍生物，例如异哌环醇氨基甲酸酯的步骤。衍生物可以是与治疗剂如化学治疗剂缀合的异环戊醇。给药途径可以变化，包括吸入，鼻内，口服，透皮，静脉内，皮下或肌内注射。

9. 发明授权

US08524944B2 Process for the preparation of sodium gamma-hydroxybutyrate 有权
标题翻译： γ-羟基丁酸钠的制备方法
公开(公告)号：US08524944B2
公开(公告)日：2013-09-03
申请号：US12988026
申请日：2009-04-15
申请人： Daniel Levin , James Luchi
发明人： Daniel Levin , James Luchi
IPC分类号： C07C59/01
CPC分类号： C07D307/04
摘要： The present invention is directed to a process for the preparation of the saponification products of lactones, preferably three- to eight-membered lactones. The present invention is also directed to a process for the preparation of compounds having general formula (I): wherein M is selected from the group consisting of cationic species, preferably metal cations (even more preferably Na), from a compound having the formula (II): comprising reacting a compound having formula (II) with a suitable hydroxide salt (M-OH) (III) such as, preferably, sodium hydroxide, in an aqueous medium. The reaction preferably utilizes a continuous process method for the substantial consumption of reagent and continuous, semi-continuous, and/or batch-wise processing for final consumption of reagent.
摘要翻译：本发明涉及制备内酯，优选三至八元内酯的皂化产物的方法。本发明还涉及制备具有通式（I）的化合物的方法：其中M选自具有式（I）的化合物的阳离子种类，优选金属阳离子（甚至更优选Na） II）：包括在水性介质中使具有式（II）的化合物与合适的氢氧化物盐（M-OH）（III），例如优选氢氧化钠反应。该反应优选利用连续的方法来大量消耗试剂和连续，半连续和/或分批处理以最终消耗试剂。

10. 发明申请

US20110245494A1 PROCESSES AND INTERMEDIATES FOR MAKING SWEET TASTE ENHANCERS 有权
标题翻译：制作甜味剂增强剂的方法和中间体
公开(公告)号：US20110245494A1
公开(公告)日：2011-10-06
申请号：US13056843
申请日：2009-07-29
申请人： Catherine Tachdjian , Donald S. Karanewsky , Xiao-Qing Tang , Qing Chen , Peter Leeming , Tayyab Rashid , Daniel Levin
发明人： Catherine Tachdjian , Donald S. Karanewsky , Xiao-Qing Tang , Qing Chen , Peter Leeming , Tayyab Rashid , Daniel Levin
IPC分类号： C07D285/16 , C07C255/60 , C07C381/00 , C07C237/44 , C07C229/40 , C07C231/06 , C07C231/02 , C07C253/30 , C07C255/58
CPC分类号： C07D285/16 , C01B21/096 , C07C231/02 , C07C231/14 , C07C235/20 , C07C237/44 , C07C253/30 , C07C255/54 , C07C255/57 , C07C255/59 , C07C303/40 , C07C307/10
摘要： The present invention includes methods/processes and intermediates for preparing compounds having structural Formula (I): wherein X is alkyl, substituted alkyl, alkenyl, substituted alkenyl, heteroalkyl, substituted heteroalkyl, heteroalkenyl, or substituted heteroalkenyl.
摘要翻译：本发明包括用于制备具有结构式（I）的化合物的方法/方法和中间体：其中X是烷基，取代的烷基，烯基，取代的烯基，杂烷基，取代的杂烷基，杂烯基或取代的杂烯基。

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