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1. 发明申请

WO2005019236A1 NOVEL SULFENAMIDE OXIDES 审中-公开
标题翻译：新型SULFENAMIDE氧化物
公开(公告)号：WO2005019236A1
公开(公告)日：2005-03-03
申请号：PCT/AU2004/001110
申请日：2004-08-20
申请人： GRIFFITH UNIVERSITY , VON ITZSTEIN, Laurence Mark , DAVIS, Christopher Bonner , THOMSON, Robin Joy
发明人： VON ITZSTEIN, Laurence Mark , DAVIS, Christopher Bonner , THOMSON, Robin Joy
IPC分类号： C07H15/14
CPC分类号： C07H15/14 , A61K31/70
摘要： Sulfenamide oxide compounds of general formula (I) are disclosed wherein A, R 1 , R 2 , X 1 , X 1 ’, X 2 , X 2 ’, X 3 , X 3 ’, X 4 , X 4 ’, X 5 and X 5 ’ define a variety of variables and wherein q is 0 or 1 and p is 1 or 2. The compounds disclosed in the examples are galactofuranosyl and glucofuranosyl sulfenamide oxide compounds wherein the variable A is oxygen. Methods of synthesis of compounds of general formula (I), pharmaceutical compositions containing them and methods of using them to treat patients suffering a microbial infection are also disclosed.
摘要翻译：公开了通式（I）的亚磺酰胺氧化物，其中A，R1，R2，X1，X1'，X2，X2'，X3，X3'，X4，X4'，X5和X5'定义了各种变量，其中q 是0或1，p是1或2.实施例中公开的化合物是其中变量A是氧的半乳糖呋喃糖基和葡糖呋喃糖基次磺酰胺氧化物。还公开了通式（I）的化合物，含有它们的药物组合物和使用它们治疗患有微生物感染的患者的方法。

2. 发明申请

WO2005019237A1 NOVEL SULFENAMIDES 审中-公开
标题翻译：新浪SULFENAMIDES
公开(公告)号：WO2005019237A1
公开(公告)日：2005-03-03
申请号：PCT/AU2004/001115
申请日：2004-08-20
申请人： GRIFFITH UNIVERSITY , VON ITZSTEIN, Laurence Mark , DAVIS, Christopher Bonner , THOMSON, Robin Joy , HARTNELL, Regan David , MADGE, Paul David Orr
发明人： VON ITZSTEIN, Laurence Mark , DAVIS, Christopher Bonner , THOMSON, Robin Joy , HARTNELL, Regan David , MADGE, Paul David Orr
IPC分类号： C07H15/14
CPC分类号： C07H15/14 , A61K31/70
摘要： Sulfenamide compounds of general formula (I) are disclosed wherein A, R 1, R 2 , X 1 , X 1 ’, X 2 , X 2 ’, X 3 , X 3 ’, X 4 , X 4 ’, X 5 and X 5 ’ define a variety of variables and q is 0 or 1. The compounds of the examples are galactofuranosyl and arabinofuranosyl compounds wherein the variable A is oxygen. Methods for the synthesis of compounds of general formula (I), pharmaceutical compositions them and methods of using them to treat patients suffering a microbial infection are also disclosed.
摘要翻译：公开了通式（I）的亚磺酰胺化合物，其中A，R1，R2，X1，X1'，X2，X2'，X3，X3'，X4，X4'，X5和X5'定义各种变量，q为0 实例的化合物是半乳糖呋喃糖基和阿拉伯呋喃糖基化合物，其中变量A是氧。还公开了合成通式（I）的化合物的方法，药物组合物及其用于治疗患有微生物感染的患者的方法。

3. 发明申请

WO03097657A9 AN ANTIMICROBIAL AGENT 审中-公开
标题翻译：抗菌药物
公开(公告)号：WO03097657A9
公开(公告)日：2004-03-11
申请号：PCT/AU0300620
申请日：2003-05-22
申请人： UNIV GRIFFITH , VON ITZSTEIN LAURENCE MARK , DAVIS CHRISTOPHER BONNER , THOMSON ROBIN JOY
发明人： VON ITZSTEIN LAURENCE MARK , DAVIS CHRISTOPHER BONNER , THOMSON ROBIN JOY
IPC分类号： A61K31/7004 , A61K31/7028 , A61P31/04 , C07H5/10 , C07H15/14 , C07H15/18
CPC分类号： C07H5/10 , A61K31/7004 , C07H15/14 , C07H15/18
摘要： The present invention relates to novel thioglycosides of D-galactofuranose that have an antimicrobial action, methods for their synthesis, pharmaceutical compositions containing them and methods for the treatment of patients suffering microbial infection.
摘要翻译：本发明涉及具有抗微生物作用的D-半乳糖呋喃糖的新型硫代糖苷，其合成方法，含有它们的药物组合物和用于治疗患有微生物感染的患者的方法。

4. 发明申请

WO2003097657A1 AN ANTIMICROBIAL AGENT 审中-公开
标题翻译：抗菌药物
公开(公告)号：WO2003097657A1
公开(公告)日：2003-11-27
申请号：PCT/AU2003/000620
申请日：2003-05-22
申请人： GRIFFITH UNIVERSITY , VON ITZSTEIN, Laurence, Mark , DAVIS, Christopher, Bonner , THOMSON, Robin, Joy
发明人： VON ITZSTEIN, Laurence, Mark , DAVIS, Christopher, Bonner , THOMSON, Robin, Joy
IPC分类号： C07H15/14
CPC分类号： C07H5/10 , A61K31/7004 , C07H15/14 , C07H15/18
摘要： The present invention relates to novel thioglycosides of D-galactofuranose that have an antimicrobial action, methods for their synthesis, pharmaceutical compositions containing them and methods for the treatment of patients suffering microbial infection.
摘要翻译：本发明涉及具有抗微生物作用的D-半乳糖呋喃糖的新型硫代糖苷，其合成方法，含有它们的药物组合物和用于治疗患有微生物感染的患者的方法。

5. 发明申请

WO2003070715A1 AN ANTIMICROBIAL AGENT 审中-公开
标题翻译：抗菌药物
公开(公告)号：WO2003070715A1
公开(公告)日：2003-08-28
申请号：PCT/AU2003/000222
申请日：2003-02-21
申请人： GRIFFITH UNIVERSITY , MONASH UNIVERSITY , VON ITZSTEIN, Laurence, Mark , COPPEL, Ross, Leon , DAVIS, Christopher, Bonner , THOMSON, Robin, Joy , OWEN, David, James
发明人： VON ITZSTEIN, Laurence, Mark , COPPEL, Ross, Leon , DAVIS, Christopher, Bonner , THOMSON, Robin, Joy , OWEN, David, James
IPC分类号： C07D307/20
CPC分类号： A61K31/341 , C07D307/20
摘要： A compound of general formula (I): wherein R1 and R2 may be the same or different and are selected from the group consisting of hydrogen, optionally substituted C4-30 alkyl and optionally substituted C4-30 alkenyl, provided that R1 and R2 may not both be hydrogen, or R1 and R2 together with the nitrogen atom from which they depend form a saturated or unsaturated, optionally substituted heterocyclic group which may include additional heteroatoms selected from the group consisting of O, N and S, or R1 and R2 together with the nitrogen atom from which they depend form an optionally substituted lactam moiety; X1 is selected from the group consisting of OR3, SR3, NR3R'3, hydrogen, halogen, CN, C(O)NR3R'3, C(O)OR3, OSO3R3, OPO3R3, NNR3R'3, SNR3R'3, NHSR3, SSR3 and substituted alkyl; X2 is selected from the group consisting of OR4, SR4, NR4R'4, hydrogen, halogen, CN, C(O)NR4R'4, C(O)OR4, OSO3R4, OPO3R4, NNR4R'4, SNR4R'4, NHSR4, SSR4 and substituted alkyl; X3 is selected from the group consisting of OR5, SR5, NR5R'5, hydrogen, halogen, CN, C(O)NR5R'5, C(O)OR5, OSO3R5, OPO3R5R'5, NNR5R'5, SNR5R'5, NHSR5, SSR5 and substituted alkyl; X4 is selected from the group consisting of OR6, SR6, NR6R'6, hydrogen, halogen, CN, C(O)NR6R'6, C(O)OR6, OSO3R6, OPO3R6R'6, NNR6R'6, SNR6R'6, NHSR6, SSR6 and substituted alkyl; R3, R'3, R4, R'4, R5, R'5, R6 and R'6 are the same or different and are selected from the group consisting of hydrogen, optionally substituted alkyl, optionally substituted aralkyl, optionally substituted aryl, optionally substituted acyl and a carbohydrate moiety; or a pharmaceutically acceptable salt thereof.
摘要翻译：通式I的化合物：其中R 1和R 2可以相同或不同，并且选自氢，任选取代的C 4-30烷基和任选取代的C 4-30烯基，条件是R 1和R 2不能均为氢或R1和R2与它们所依赖的氮原子一起形成饱和或不饱和的任选取代的杂环基，其可以包括另外的选自O，N和S的杂原子，或者R 1和R 2与氮它们所依赖的原子形成任选取代的内酰胺部分X1选自OR3，SR3，NR3R'3，氢，卤素，CN，CONR3R'3，COOR3，OSO3R3，OPO3R3，NNR3R'3，SNR3R'3 ，NHSR 3，SSR 3和取代的烷基X 2选自OR4，SR4，NR4R'4，氢，卤素，CN，CONR4R'4，COOR4，OSO3R4，OPO3R4，NNR4R4，SNR4R'4，NHSR4，SSR4 并且取代的烷基X 3选自OR 5，S R5，NR5R'5，氢，卤素，CN，CONR5R'5，COOR5，OSO3R5，OPO3R5R'5，NNR5R'5，SNR5R'5，NHSR5，SSR5和取代的烷基X4选自OR6，SR6， NR6R'6，氢，卤素，CN，CONR6R'6，COOR6，OSO3R6，OPO3R6R'6，NNR6R'6，SNR6R'6，NHSR6，SSR6和取代的烷基R3，R'3，R4，R'4，R5， R'5，R 6和R 6相同或不同，并且选自氢，任选取代的烷基，任选取代的芳烷基，任选取代的芳基，任选取代的酰基和碳水化合物部分或其药学上可接受的盐。

6. 发明申请

WO2006037185A1 NOVEL SULFENAMIDES AND SULFENAMIDE OXIDES 审中-公开
标题翻译：新型SULFENAMIDES和SULFENAMIDE OXIDES
公开(公告)号：WO2006037185A1
公开(公告)日：2006-04-13
申请号：PCT/AU2005/001548
申请日：2005-10-07
申请人： GRIFFITH UNIVERSITY , MONASH UNIVERSITY , VON ITZSTEIN, Laurence, Mark , COPPEL, Ross, Leon , DAVIS, Christopher, Bonner , THOMSON, Robyn, Joy , HARTNELL, Regan, David , OWEN, David, James
发明人： VON ITZSTEIN, Laurence, Mark , COPPEL, Ross, Leon , DAVIS, Christopher, Bonner , THOMSON, Robyn, Joy , HARTNELL, Regan, David , OWEN, David, James
IPC分类号： C07H15/14 , A61K31/70 , A61P31/04
CPC分类号： C07H15/14
摘要： A compound of the general formula (I): wherein R 1 , R 2 , X 1 , X 1 ', X 2 , X 2 ', X 3 , X 3 ', X 4 , X 4 ' and X 5 define various substituents and p is 0, 1 or 2. The invention also relates to use of the compounds as anti-microbial agents.
摘要翻译：通式（I）的化合物：其中R 1，R 2，X 1，X 1， '，X 2，X 2，X 3，X 3，X 4， X 4，X 5和X 5定义各种取代基，p为0,1或2.本发明还涉及该化合物作为抗微生物剂的用途。

7. 发明授权

US09192419B2 Zero-profile interbody spacer and coupled plate assembly 有权
标题翻译：零剖面体间隔板和联接板组件
公开(公告)号：US09192419B2
公开(公告)日：2015-11-24
申请号：US12613866
申请日：2009-11-06
申请人： William P. McDonough , William L. Strausbaugh , Christopher Bonner , Thomas Pepe , Ralph Meili , Markus Hunziker , Michael Jeger , Thomas Kueenzi , David Koch , Rainer Ponzer , Joern Richter , Roger Berger
发明人： William P. McDonough , William L. Strausbaugh , Christopher Bonner , Thomas Pepe , Ralph Meili , Markus Hunziker , Michael Jeger , Thomas Kueenzi , David Koch , Rainer Ponzer , Joern Richter , Roger Berger
IPC分类号： A61F2/44 , A61B17/88 , A61B17/80 , A61F2/46 , A61B17/17 , A61B17/86 , A61F2/30
CPC分类号： A61F2/4455 , A61B17/1728 , A61B17/1757 , A61B17/8033 , A61B17/8042 , A61B17/8052 , A61B17/8057 , A61B17/86 , A61B17/88 , A61F2/30965 , A61F2/4465 , A61F2/4611 , A61F2002/30387 , A61F2002/305 , A61F2002/30504 , A61F2002/30505 , A61F2002/30507 , A61F2002/30517 , A61F2002/30576 , A61F2002/30604 , A61F2002/30787 , A61F2002/30794 , A61F2002/30841 , A61F2002/4475 , A61F2002/448 , A61F2002/4615 , A61F2220/0016 , A61F2220/0025 , A61F2230/0034 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00131 , A61F2310/00407 , A61F2310/00796
摘要： An implant for insertion into a disc space between vertebrae, wherein the implant includes a spacer portion, a plate portion coupled to the spacer portion, two bone fixation elements for engaging the vertebrae and a retention mechanism for preventing the bone fixation elements from postoperatively backing-out of the plate portion. The retention mechanism may be in the form of a spring biased snapper element that is biased into communication with the bone fixation elements so that once the bone fixation element advances past the snapper element, the snapper element is biased back to its initial position in which the snapper element interfaces with the bone fixation elements. Alternatively, the retention mechanism may be in the form of a propeller rotatable between a first position in which the bone fixation elements are insertable to a second position where the bone fixation elements are prevented from backing-out.
摘要翻译：一种用于插入到椎骨之间的椎间盘空间中的植入物，其中所述植入物包括间隔部分，联接到所述间隔部分的板部分，用于接合所述椎骨的两个骨固定元件和用于防止骨固定元件从术后背衬的保持机构，从板部分出来。保持机构可以是弹簧偏压的鲷鱼元件的形式，其被偏压成与骨固定元件连通，使得一旦骨固定元件前进超过鲷鱼元件，鲷鱼元件被偏压回到其初始位置，其中鲷鱼元素与骨固定元件接合。或者，保持机构可以是在第一位置和第二位置之间可旋转的螺旋桨的形式，其中骨固定元件可插入第二位置，在第二位置防止骨固定元件脱离。

8. 发明申请

US20100145460A1 ZERO-PROFILE INTERBODY SPACER AND COUPLED PLATE ASSEMBLY 审中-公开
标题翻译： ZERO-PROFILE INTERBODY SPACER和联轴板组件
公开(公告)号：US20100145460A1
公开(公告)日：2010-06-10
申请号：US12614082
申请日：2009-11-06
申请人： William P. McDonough , William L. Strausbaugh , Christopher Bonner , Thomas Pepe , Ralph Meili , Markus Hunziker , Michael Jeger , Thomas Kueenzi , David Koch , Rainer Ponzer , Joern Richter , Roger Berger
发明人： William P. McDonough , William L. Strausbaugh , Christopher Bonner , Thomas Pepe , Ralph Meili , Markus Hunziker , Michael Jeger , Thomas Kueenzi , David Koch , Rainer Ponzer , Joern Richter , Roger Berger
IPC分类号： A61F2/44
CPC分类号： A61F2/4455 , A61B17/1728 , A61B17/1757 , A61B17/8033 , A61B17/8042 , A61B17/8052 , A61B17/8057 , A61B17/86 , A61B17/88 , A61F2/30965 , A61F2/4465 , A61F2/4611 , A61F2002/30387 , A61F2002/305 , A61F2002/30504 , A61F2002/30505 , A61F2002/30507 , A61F2002/30517 , A61F2002/30576 , A61F2002/30604 , A61F2002/30787 , A61F2002/30794 , A61F2002/30841 , A61F2002/4475 , A61F2002/448 , A61F2002/4615 , A61F2220/0016 , A61F2220/0025 , A61F2230/0034 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00131 , A61F2310/00407 , A61F2310/00796
摘要： An implant for insertion into the disc space between vertebrae. The implant including a spacer portion, a plate portion coupled to the spacer portion, a plurality of bone fixation elements for engaging the vertebrae and a retention mechanism for preventing the bone fixation elements from postoperatively uncoupling from the implant.
摘要翻译：用于插入椎间盘间隙的植入物。所述植入物包括间隔部分，联接到间隔部分的板部分，用于接合椎骨的多个骨固定元件和用于防止骨固定元件从植入物中脱离的固定机构。

9. 发明申请

US20050033202A1 Mechanically activated objects for treatment of degenerative retinal disease 审中-公开
标题翻译：机械活化物体治疗退行性视网膜疾病
公开(公告)号：US20050033202A1
公开(公告)日：2005-02-10
申请号：US10822437
申请日：2004-04-12
申请人： Alan Chow , George McLean , Vincent Chow , Jay Cech , Christopher Bonner , Vladimir Gelfandbein
发明人： Alan Chow , George McLean , Vincent Chow , Jay Cech , Christopher Bonner , Vladimir Gelfandbein
IPC分类号： A61H1/00 , A61H5/00 , A61N1/05 , A61N1/36 , A61N2/06 , A61N2/12
CPC分类号： A61N1/36046 , A61H5/00 , A61N1/0543 , A61N2/06 , A61N2/12
摘要： Mechanically activated objects or devices for use in treating degenerative retinal diseases are provided. Such devices apply mechanical forces to tissues of an eye to effectuate treatment and are configured for chronic implantation (thereby applying chronic stimulation/irritation) in or on the eye. The devices may be configured for contact with a retina of the eye, preferably positioned in a subretinal space. Various embodiments comprise a moving member configured for chronic contact with at least a portion of the eye, which moving member is activated by an actuator. In some embodiments, the actuator may be distally located relative to the moving member. Alternatively, the moving member may be supported by a body member that, optionally, also supports the actuator.
摘要翻译：提供用于治疗退行性视网膜疾病的机械活化物体或装置。这样的装置将机械力施加到眼睛的组织以实现治疗，并且被配置为在眼睛中或眼睛上进行慢性植入（从而施加慢性刺激/刺激）。所述装置可以被配置为与眼睛的视网膜接触，优选地定位在视网膜下空间中。各种实施例包括构造成用于与眼睛的至少一部分慢性接触的移动构件，该移动构件由致动器致动。在一些实施例中，致动器可以相对于移动构件向远侧定位。或者，移动构件可以由主体构件支撑，其可选地还支撑致动器。

10. 发明授权

US09078771B2 Trial implant assembly 有权
标题翻译：试验植入组件
公开(公告)号：US09078771B2
公开(公告)日：2015-07-14
申请号：US12760679
申请日：2010-04-15
申请人： Marc Reichen , David Chow , K. Daniel Riew , Kurt Schmura , Christopher Bonner , David Gerber
发明人： Marc Reichen , David Chow , K. Daniel Riew , Kurt Schmura , Christopher Bonner , David Gerber
IPC分类号： A61F2/44 , A61F2/46 , A61F2/30
CPC分类号： A61F2/4684 , A61F2/442 , A61F2/4611 , A61F2002/30553 , A61F2250/0008
摘要： A trial implant assembly is provided that includes a threaded shaft having exterior threading adjacent a distal end and a trial implant that includes a trial base having an interiorly threaded through hole couplable to the distal end of the shaft and a trial head having a superior endplate and an inferior endplate and a support connecting the superior endplate to the inferior endplate. A variety of visualization windows are provided through the trial implant as well as a variety of mechanically adjustable stops to prevent over insertion of the trial head within the intervertebral disc space.
摘要翻译：提供了一种试验植入组件，其包括具有邻近远端的外螺纹的螺纹轴和包括具有可连接到所述轴的远端的内螺纹通孔的试验基座的试验植入物，以及具有上终板的试验头，连接下端板和下端板的下端板和支撑件。通过试验植入物提供各种可视化窗口以及各种可机械调节的止动件，以防止试验头在椎间盘空间内过度插入。

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