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1. 发明授权

US09604075B2 Method for the operation of a radiotherapy system and a radiotherapy system 有权
公开(公告)号：US09604075B2
公开(公告)日：2017-03-28
申请号：US13684463
申请日：2012-11-23
申请人： Christian Scholz
发明人： Christian Scholz
IPC分类号： A61N5/10
CPC分类号： A61N5/1031 , A61N5/1047
摘要： A method for calculating local part radiation doses in a radiotherapy system for applying a total radiation dose in a target volume with several beams is provided. The method includes determining at least one first control plane for controlling the dosing of the beams, determining at least one second control plane for controlling the positioning of the beams, and allocating beams to the first and second control planes. The method also includes, for at least one side of a first control plane, calculating in isolation of the corresponding local part radiation doses of all the beams allocated to the first control plane.

2. 发明授权

US08790659B2 SlpA as a tool for recombinant protein and enzyme technology 有权
标题翻译： SlpA作为重组蛋白和酶技术的工具
公开(公告)号：US08790659B2
公开(公告)日：2014-07-29
申请号：US13569353
申请日：2012-08-08
申请人： Christian Scholz , Elke Faatz , Urban Schmitt , Peter Schaarschmidt
发明人： Christian Scholz , Elke Faatz , Urban Schmitt , Peter Schaarschmidt
IPC分类号： A61K39/245
CPC分类号： C12N15/62 , C12N9/90 , G01N33/536 , G01N33/54393 , Y02A50/57
摘要： Disclosed are a recombinant DNA molecule encoding a fusion protein comprising a SlpA chaperone and a target polypeptide wherein human FK506 binding proteins (FKBPs) are excluded as target polypeptides, a corresponding expression vector encoding said fusion protein as well as host cells transformed with said expression vector. Also disclosed are a method for producing the fusion protein, a recombinantly produced fusion protein comprising a SlpA chaperone and a target polypeptide. A further aspect of the invention is the use of the recombinantly produced fusion protein, and a reagent kit containing a recombinantly produced fusion protein comprising a SlpA chaperone and a target polypeptide.
摘要翻译：公开了编码包含SlpA伴侣和靶多肽的融合蛋白的重组DNA分子，其中人FK506结合蛋白（FKBP）被排除为靶多肽，编码所述融合蛋白的相应表达载体以及用所述表达载体转化的宿主细胞。还公开了产生融合蛋白的方法，重组产生的包含SlpA伴侣和靶多肽的融合蛋白。本发明的另一方面是使用重组产生的融合蛋白，以及含有重组产生的包含SlpA伴侣和靶多肽的融合蛋白的试剂盒。

3. 发明授权

US08541518B2 Semi continuous operational method for producing copolymers 有权
标题翻译：用于生产共聚物的半连续操作方法
公开(公告)号：US08541518B2
公开(公告)日：2013-09-24
申请号：US12920143
申请日：2009-02-10
申请人： Gerhard Albrecht , Klaus Lorenz , Christian Scholz , Petra Wagner
发明人： Gerhard Albrecht , Klaus Lorenz , Christian Scholz , Petra Wagner
IPC分类号： C08F2/04 , C08F224/00 , C08F2/10 , C04B28/28
CPC分类号： C08F220/04 , C08F220/26
摘要： A process for the preparation of a copolymer in a semicontinuous mode of operation in a polymerization apparatus containing a polymerization reactor connected to a metering device, in each case acid monomer being initially introduced into the metering device and polyether macromonomer and water into the polymerization reactor, acid monomer being metered from the metering device into the polymerization reactor, the metering of the acid monomer into the polymerization reactor being effected in such a way that first a polymerization pH is established in the aqueous medium and then, until the conversion of 70 mol % of the polyether macromonomer initially introduced into the polymerization reactor, acid monomer is passed into the polymerization reactor in an amount per unit time such that the pH in the aqueous medium deviates by not more than ±0.3 from the initially established polymerization pH.
摘要翻译：在含有连接到计量装置的聚合反应器的聚合装置中制备半连续操作模式的共聚物的方法，每种情况下，酸性单体最初引入计量装置和聚醚大分子单体和水进入聚合反应器，酸性单体从计量装置计量到聚合反应器中，酸性单体计量到聚合反应器中的方式是首先在水性介质中建立聚合pH，然后直到70mol％的最初引入聚合反应器的聚醚大分子单体，酸单体以每单位时间的量进入聚合反应器，使得水介质中的pH从最初建立的聚合pH偏离不大于±0.3。

4. 发明授权

US08536251B2 Copolymer containing acid building blocks and various types of polyether building blocks 有权
标题翻译：含有酸性结构单元和各种聚醚结构单元的共聚物
公开(公告)号：US08536251B2
公开(公告)日：2013-09-17
申请号：US13132990
申请日：2009-11-25
申请人： Silke Flakus , Klaus Lorenz , Helmut Mack , Christian Scholz , Petra Wagner , Barbara Wimmer , Angelika Hartl , Martin Winklbauer , Manfred Bichler
发明人： Silke Flakus , Klaus Lorenz , Helmut Mack , Christian Scholz , Petra Wagner , Barbara Wimmer , Angelika Hartl , Martin Winklbauer , Manfred Bichler
IPC分类号： C04B24/26 , C08L53/00 , C08L39/04 , C08L27/04 , C08L29/00 , C08K5/00 , C08F16/12 , C08F220/12 , C08F12/30 , C08F30/02
CPC分类号： C08F216/1416 , C04B24/2605 , C04B24/2647 , C04B24/267 , C04B28/02 , C04B28/04 , C04B2103/30 , C04B2103/408 , C08F220/06 , C04B14/06
摘要： The invention relates to a copolymer comprising i) 3 to 40 mol % of an isoprenolpolyether derivative structural unit α ii) 3 to 40 mol % of a vinyloxypolyether derivative structural unit β and iii) 35 to 93 mol % of an acid structural unit γ, the structural units of the copolymer which belong to the vinyloxypolyether derivative structural unit β having longer side chains than the structural units which belong to the isoprenolpolyether derivative structural unit α.
摘要翻译：本发明涉及一种共聚物，其包含i）3至40mol％的异戊二烯聚醚衍生物结构单元αii）3至40mol％的乙烯氧基聚醚衍生物结构单元β和iii）35至93mol％的酸性结构单元γ，属于乙烯氧基聚醚醚衍生物结构单元β的共聚物的结构单元具有比属于异戊二烯聚醚衍生物结构单元α的结构单元更长的侧链。

5. 发明申请

US20130079579A1 DEVICE AND METHOD FOR RADIATION DOSIMETRY 有权
标题翻译：用于辐射测量的装置和方法
公开(公告)号：US20130079579A1
公开(公告)日：2013-03-28
申请号：US13627734
申请日：2012-09-26
申请人： Mark Hastenteufel , Iwan Kawrakow , Christian Scholz
发明人： Mark Hastenteufel , Iwan Kawrakow , Christian Scholz
IPC分类号： A61N5/10
CPC分类号： A61N5/10 , A61N5/1031 , A61N5/1065 , A61N2005/1061 , A61N2005/1074 , A61N2005/1087
摘要： A method and a device for regulating a therapeutic beam directed at an object are provided. The method includes displaying at least one multidimensional image data record encompassing at least one target area of the object. The method also includes determining the treatment beam dosage directed at the at lest one target area, and recording and optionally visualizing an isoline or isosurface dependent on the treatment beam dosage in the at least one multidimensional image data record. The method includes adjusting the isoline or isosurface such that the isoline or isosurface approximates a contour of the target area as closely as possible or corresponds to the contour, and regulating the treatment beam dosage by evaluation of the adjusted isoline or isosurface.
摘要翻译：提供了一种用于调节针对物体的治疗束的方法和装置。该方法包括显示包含对象的至少一个目标区域的至少一个多维图像数据记录。该方法还包括确定针对最少一个目标区域的治疗束剂量，以及取决于至少一个多维图像数据记录中的治疗束剂量的记录和任选地显现等值线或等值面。该方法包括调整等值线或等值面，使得等值线或等值面近似于目标区域的轮廓尽可能接近或对应于轮廓，并且通过评估调整的等值线或等值面来调节治疗束的剂量。

6. 发明授权

US07604935B2 Soluble rubella E1 envelope protein variants 有权
标题翻译：可溶性风疹E1包膜蛋白变体
公开(公告)号：US07604935B2
公开(公告)日：2009-10-20
申请号：US11584887
申请日：2006-10-23
申请人： Barbara Upmeier , Ralf Bollhagen , Alfred Engel , Elke Faatz , Peter Schaarschmidt , Christian Scholz , Toralf Zarnt
发明人： Barbara Upmeier , Ralf Bollhagen , Alfred Engel , Elke Faatz , Peter Schaarschmidt , Christian Scholz , Toralf Zarnt
IPC分类号： C12Q1/70 , C12N7/01 , A61K39/20
CPC分类号： C07K14/005 , C07K2319/35 , C12N2770/36222 , Y10S530/826
摘要： A soluble rubella E1 antigen variant is disclosed that comprises amino acids 334-409 of the native rubella E1 peptide, but lacks the C-terminal end and at least the transmembrane region and the anchor segment as well as at least the amino acids 143 to 164. Also described is a recombinant DNA molecule encoding the rubella E1 antigen variants which are recombinantly expressed as a chaperone fusion protein, refolded into a soluble and immunoreactive conformation, and further used for the serological detection of anti-rubella antibodies. In addition, also disclosed is a method for the detection, determination and quantification of anti-rubella antibodies of IgG and/or IgM subclass in a sample wherein the rubella E1 antigen is used as a capture reagent and/or binding partner for the antibodies.
摘要翻译：公开了可溶性风疹E1抗原变体，其包含天然风疹E1肽的氨基酸334-409，但缺少C末端和至少跨膜区和锚定区以及至少氨基酸143至164 还描述了编码风疹E1抗原变体的重组DNA分子，其被重组表达为伴侣融合蛋白，重折叠成可溶性和免疫反应性构象，并进一步用于抗风疹抗体的血清学检测。此外，还公开了用于检测，测定和定量样品中IgG和/或IgM亚类的抗风疹抗体的方法，其中所述风疹E1抗原用作抗体的捕获试剂和/或结合配偶体。

7. 发明授权

US07278628B2 Device for the dosing of gaseous and/or vaporous matters 失效
标题翻译：用于计量气态和/或蒸气物质的装置
公开(公告)号：US07278628B2
公开(公告)日：2007-10-09
申请号：US10503561
申请日：2003-01-30
申请人： Christian Scholz
发明人： Christian Scholz
IPC分类号： B01F3/04
CPC分类号： A61L9/125 , Y10S261/88
摘要： Apparatus for dosing gaseous and/or vaporous substances An apparatus for dosing gaseous and/or vaporous substances, in particular for generating varying scents, includes a multitude of packaged storage containers (1) from which different gases and/or vapors are driven out by a carrier medium. On their inlet sides, the storage containers are connected to a common carrier medium manifold (13) via a shut-off device (4) assigned to each storage container that can be actuated, and on their outlet sides to a joint homogenization chamber (8). Both the carrier medium manifold and the homogenization chamber are connected to a carrier medium source using a regulating valve (5, 9). Check valves (6, 7) are integrated in the gas passages to the storage container and from the storage container to the homogenization chamber. A dosing apparatus designed based on this principle is characterized by low space requirements and materially separate volume flows that can be exactly timed and dosed.
摘要翻译：用于计量气态和/或蒸气物质的装置用于给气体和/或蒸气物质进行投配，特别是用于产生不同气味的装置包括多个包装的储存容器（1），不同的气体和/或蒸汽从其中被载体介质。在其入口侧，储存容器通过分配给可以被致动的每个储存容器的切断装置（4）连接到共同的载体介质歧管（13），并且在它们的出口侧连接到接头均化室（8 ）。载体介质歧管和均质室都使用调节阀（5,9）连接到载体介质源。止回阀（6,7）集成在储存容器和从储存容器到匀浆室的气体通道中。基于该原理设计的计量装置的特征在于具有低空间要求和能够精确定时和计量的物质上独立的体积流量。

8. 发明申请

US20060247402A1 Cement additive 有权
标题翻译：水泥添加剂
公开(公告)号：US20060247402A1
公开(公告)日：2006-11-02
申请号：US10551268
申请日：2004-03-05
申请人： Toshimi Matsumoto , Sven Asmus , Gerhard Albrecht , Klaus Lorenz , Petra Wagner , Christian Scholz
发明人： Toshimi Matsumoto , Sven Asmus , Gerhard Albrecht , Klaus Lorenz , Petra Wagner , Christian Scholz
IPC分类号： C08F224/00
CPC分类号： C04B24/2647 , C04B24/267 , C04B24/2688 , C04B40/0039 , C04B2111/34 , C04B24/06 , C04B24/121 , C04B24/122 , C04B24/18 , C04B24/32 , C04B24/38 , C04B38/10 , C04B2103/10 , C04B2103/20 , C04B2103/304 , C04B2103/44 , C04B2103/50 , C04B2103/61
摘要： The present invention concerns a cement additive containing copolymers comprising one or more constitutional units represented by formula A: (A) R1 is hydrogen, an alkyl group having 1 to 4 carbon atoms, an alkenyl group having 1 to 4 carbon atoms or an aryl group having 6 to 9 carbon atoms; R2 is hydrogen or an alkyl group having 1 to 9 carbon atoms, an alkenyl group having 1 to 9 carbon atoms or an aryl group having 6 to 9 carbon atoms; T is alkylene (including straight-chain and branched alkylene) having 1 to 4 carbon atoms or arylene having 6 to 9 carbon atoms; n is 0 or 1; S1 and S2 are, independently of one another, —OCkH2k— or —OCH2CHR3—, with the proviso that k is 2 or 3, R3 is an alkyl group having 1 to 9 carbon atoms, an aryl group having 6 to 9 carbon atoms; and 6
摘要翻译：本发明涉及包含一种或多种由式A表示的结构单元的共聚物的水泥添加剂：（A）R 1是氢，具有1至4个碳原子的烷基，具有1个至4个碳原子或具有6至9个碳原子的芳基; R2是氢或碳原子数1〜9的烷基，碳原子数1〜9的烯基或碳原子数6〜9的芳基。 T是具有1至4个碳原子的亚烷基（包括直链和支链亚烷基）或具有6至9个碳原子的亚芳基; n为0或1; S 1和S 2 2彼此独立地是-OC 2 k H 2 - 或-OCH 3，其中k为2或3，R3为碳原子数1〜9的烷基，碳原子数为6〜9的芳基。和6 <_M 1 + m 2 <_ 25。

9. 发明授权

US07094884B2 Soluble complexes of amylod β peptide and peptidyl prolyl isomerase chaperone and methods of making and using them 有权
标题翻译：淀粉状β肽和肽基脯氨酰异构酶伴侣的可溶性复合物及其制备和使用方法
公开(公告)号：US07094884B2
公开(公告)日：2006-08-22
申请号：US10443654
申请日：2003-05-22
申请人： Christian Scholz , Elke Faatz , Peter Schaarschmidt
发明人： Christian Scholz , Elke Faatz , Peter Schaarschmidt
IPC分类号： A61K38/24 , C07K14/00
CPC分类号： G01N33/56988 , A61K39/00 , A61K47/64 , C07K14/005 , C07K2319/00 , C12N9/90 , C12N2740/16122 , G01N33/54306 , G01N33/56911 , G01N33/56983 , G01N2333/005 , G01N2333/16 , G01N2333/195 , G01N2469/20 , G01N2800/2821 , Y02A50/472
摘要： The present invention relates to the diagnosis of Alzheimer's Disease. It especially teaches the production of a soluble Aβ-chaperone complex and the advantageous use of such chaperone-Aβ complex, especially in the detection of Aβ in an immunoassay, as well as its use as an immunogen.
摘要翻译：本发明涉及阿尔茨海默病的诊断。它特别教导了可溶性的Abeta-伴侣复合物的生产和这种伴侣 - Aβ复合物的有利使用，特别是在免疫测定中检测Abeta以及其作为免疫原的用途。

10. 发明申请

US20060143449A1 Security-translator 审中-公开
标题翻译：安全翻译
公开(公告)号：US20060143449A1
公开(公告)日：2006-06-29
申请号：US11285282
申请日：2005-11-23
申请人： Martin Groger , Markus Fohrenck , Christian Scholz
发明人： Martin Groger , Markus Fohrenck , Christian Scholz
IPC分类号： H04L9/00
CPC分类号： H04L63/0227 , H04L63/105 , H04L69/40
摘要： A security translator (STL) that serves for connecting a data network (N2) pertaining to a lower security level to a data network (N1) pertaining to a higher security level examines its own integrity at definite intervals in order to ascertain malfunctions and, where appropriate, to trigger a transition to the secure failure state. The secure failure state consists in the connection from the data network with a lower security level to the data network with a higher security level being interrupted. This is obtained by means of a watchdog circuit (WD1, WD2) which keeps the connection (CTN) between the data network (N2) with a lower security level and the data network (N1) with a higher security level closed as long as it receives regular signs of life and which automatically interrupts the connection if it receives no sign of life over a predetermined period.
摘要翻译：用于将属于较低安全级别的数据网络（N 2）连接到属于较高安全级别的数据网络（N 1）的安全转换器（STL）以确定的间隔检查其自己的完整性以便确定故障，并且在适当情况下，触发转移到安全故障状态。安全故障状态包括从具有较低安全级别的数据网络到具有较高安全级别中断的数据网络的连接。这是通过看门狗电路（WD 1，WD 2）获得的，它将数据网络（N 2）与较低安全级别之间的连接（CTN）与安全级别较高的数据网络（N 1）保持只要它接收到正常的生命迹象，并且如果在预定时段内没有收到生命迹象，则自动中断连接。

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