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1. 发明专利

TW569008B 一種多功光電生物醫學晶片檢測儀有权
简体标题：一种多功光电生物医学芯片检测仪
公开(公告)号：TW569008B
公开(公告)日：2004-01-01
申请号：TW090110689
申请日：2001-05-04
申请人：李世光 LEE, CHIH KUNG , 薛順成 SHUEN-CHEN SHIUE , 李舒昇 LEE, SHU SHENG , 吳俊彥 WU, JIUN YAN , 林啓萬 CHII-WANN LIN , 林世明 SHIMING LIN
发明人：李世光 LEE, CHIH KUNG , 薛順成 SHUEN-CHEN SHIUE , 李舒昇 LEE, SHU SHENG , 吳俊彥 WU, JIUN YAN , 李世光 LEE, CHIH KUNG , 林啓萬 CHII-WANN LIN , 林世明 SHIMING LIN
IPC分类号： G01N , G02B
摘要：本案係為一種即時且多功之光電檢測系統裝置，其不僅可應用於生物醫學晶片生化檢測，且可應用於晶片複製量產之生產檢測，此多功系統架構主要整合四項先進光電檢測原理之子系統架構，並共享部分光路與元件設計，只需要切換部分元件即可具備包括橢偏儀(ellipsometer)、都卜勒測速及干涉儀(Laser Doppler vibrometer/interferometer，LDVI)、可測量振幅及相位之表面電漿共振儀(surface plasmon resonance for amplitude and phase detection，SPR)、相移干涉顯微鏡(phase shifting interference microscope)、光子穿隧顯微鏡(photon tunneling microscope)、光學同調斷層掃描儀(optical coherence tomography，OCT)、共焦掃描顯微鏡(confocal scanning microscope)、及影像顯微鏡等功能，其以創新的光學機構及訊號處理的方法可達成先除螢光反應外所有生物醫學相關的光電檢測。
简体摘要：本案系为一种实时且多功之光电检测系统设备，其不仅可应用于生物医学芯片生化检测，且可应用于芯片复制量产之生产检测，此多功系统架构主要集成四项雪铁龙光电检测原理之子系统架构，并共享部分光路与组件设计，只需要切换部分组件即可具备包括椭偏仪(ellipsometer)、都卜勒测速及干涉仪(Laser Doppler vibrometer/interferometer，LDVI)、可测量振幅及相位之表面等离子共振仪(surface plasmon resonance for amplitude and phase detection，SPR)、相移干涉显微镜(phase shifting interference microscope)、光子穿隧显微镜(photon tunneling microscope)、光学同调断层扫描仪(optical coherence tomography，OCT)、共焦扫描显微镜(confocal scanning microscope)、及影像显微镜等功能，其以创新的光学机构及信号处理的方法可达成先除萤光反应外所有生物医学相关的光电检测。

2. 发明授权

US08498696B2 Health monitoring device and human electric signal processing method 有权
标题翻译：健康监测装置和人体电信号处理方法
公开(公告)号：US08498696B2
公开(公告)日：2013-07-30
申请号：US12796634
申请日：2010-06-08
申请人： Jia-Yush Yen , Fan-Che Yen , Chih-Kung Lee , Chii-Wann Lin , Kuang-Chong Wu , Ching-En Tseng
发明人： Jia-Yush Yen , Fan-Che Yen , Chih-Kung Lee , Chii-Wann Lin , Kuang-Chong Wu , Ching-En Tseng
IPC分类号： A61B5/04
CPC分类号： A61B5/04525 , A61B5/04017 , A61B5/726
摘要： A health monitoring device is provided and includes a detecting unit for detecting a first electric signal from a human body and a processing unit for performing the following steps: receiving the first electric signal; performing wavelet transform on the first electric signal, to filter frequency bands thereof which include undesired noises, and then perform a reverse wavelet transform to obtain a second electric signal; combining frequency bands of the first electric signal which include primary characteristics and then perform a reverse wavelet transform on the combined frequency bands to obtain a fourth electric signal; and comparing the fourth electric signal with a plurality of electric signal patterns of a database to determine whether the fourth electric signal is an electric signal for healthiness.
摘要翻译：本发明提供一种健康监测装置，其特征在于，包括：检测来自人体的第一电信号的检测部;以及执行以下步骤的处理部：接收所述第一电信号; 对第一电信号执行小波变换，对包括不期望的噪声的频带进行滤波，然后执行反向小波变换以获得第二电信号; 组合包括主要特征的第一电信号的频带，然后对组合的频带执行反向小波变换，以获得第四电信号; 以及将第四电信号与数据库的多个电信号模式进行比较，以确定第四电信号是否是用于健康的电信号。

3. 发明申请

US20110120547A1 Photoelectric device 审中-公开
标题翻译：光电器件
公开(公告)号：US20110120547A1
公开(公告)日：2011-05-26
申请号：US12657091
申请日：2010-01-13
申请人： Chii-Wann Lin , Chien-Sheng Liu
发明人： Chii-Wann Lin , Chien-Sheng Liu
IPC分类号： H01L31/00
CPC分类号： H01L31/035218 , H01L31/055 , Y02E10/52
摘要： The present invention provides a photoelectric device, including a photoelectric semiconductor thin film having a light facing surface and a back light surface; and a photoelectric converter having a medium and photoelectric converting particles mounted on the medium, wherein the photoelectric converter is disposed at an outer side of the light facing surface of the photoelectric semiconductor film for absorbing and converting solar energy so as to enhance photoelectric conversion efficacy. The photoelectric converter absorbs the wavelength that the photoelectric semiconductor thin film cannot absorb, and emits the frequency band that the photoelectric semiconductor thin film can absorb. Thus, the photoelectric device of the present invention decreases the interference of light absorption, increases the light emission, eliminates the wastes of incident light, and increases the photoelectric conversion efficacy. Hence, the fabrication method of the solar cell is simplified, and the cost is decreased in the present invention.
摘要翻译：本发明提供一种光电器件，包括具有面向光的表面和背光表面的光电半导体薄膜; 以及光电转换器，其具有安装在介质上的介质和光电转换粒子，其中所述光电转换器设置在所述光电半导体膜的面向光的表面的外侧，用于吸收和转换太阳能，以便增强光电转换效能。光电转换器吸收光电半导体薄膜不能吸收的波长，并发射光电半导体薄膜可以吸收的频带。因此，本发明的光电装置降低了光吸收的干扰，增加了发光，消除了入射光的浪费，提高了光电转换效率。因此，简化了太阳能电池的制造方法，在本发明中成本降低。

4. 发明申请

US20100274101A1 WIRELESS MONITORING BIO-DIAGNOSIS SYSTEM 审中-公开
标题翻译：无线监控生物诊断系统
公开(公告)号：US20100274101A1
公开(公告)日：2010-10-28
申请号：US12556675
申请日：2009-09-10
申请人： Chii-Wann Lin , Kuang-Chong Wu , Chih-Kung Lee , Shi-Ming Lin , Shih-Yuan Lee , Fu-Shan Jaw , Chern-Lin Chen , U Lei , Long-Sun Huang , Shey-Shi Lu , Phone Lin , Jia-Yush Yen , Yao-Joe Yang , Lung-Jieh Yang , Wen-Pin Shih , Nan-Fu Chiu
发明人： Chii-Wann Lin , Kuang-Chong Wu , Chih-Kung Lee , Shi-Ming Lin , Shih-Yuan Lee , Fu-Shan Jaw , Chern-Lin Chen , U Lei , Long-Sun Huang , Shey-Shi Lu , Phone Lin , Jia-Yush Yen , Yao-Joe Yang , Lung-Jieh Yang , Wen-Pin Shih , Nan-Fu Chiu
IPC分类号： A61B5/00
CPC分类号： C12Q1/26 , A61B5/0031 , A61B5/024 , A61B5/14532 , A61B5/14546 , A61B5/1459 , A61B2562/12 , C12Q1/006 , C12Q1/32 , G01N33/6893 , G01N2800/32
摘要： A MEMS wireless monitoring bio-diagnosis system includes an implantable biosensor system chip, a surface transmitter and an external monitor center. The implantable biosensor system chip contains a biosensor for a cardio-vascular indicator and a wireless transmitter to deliver detected bio-signal data. With the MEMS wireless monitoring bio-diagnosis system, the bio-signal data can be monitored effectively and transmitted to a remote medical unit.
摘要翻译： MEMS无线监测生物诊断系统包括可植入生物传感器系统芯片，表面发射器和外部监视器中心。可植入生物传感器系统芯片包含用于心血管指示器的生物传感器和用于传送检测到的生物信号数据的无线发射器。利用MEMS无线监控生物诊断系统，生物信号数据可以被有效地监控并传输到远程医疗单元。

5. 发明申请

US20090161110A1 METHOD FOR IMPROVING SURFACE PLASMON RESONANCE BY USING CONDUCTING METAL OXIDE AS ADHESIVE LAYER 有权
标题翻译：通过使用导电金属氧化物作为粘合层改善表面等离子体共振的方法
公开(公告)号：US20090161110A1
公开(公告)日：2009-06-25
申请号：US12048238
申请日：2008-03-14
申请人： CHII-WANN LIN , NAN-FU CHIU , WEI-YI FENG , CHIA-CHEN CHANG , KUO-CHUAN HO , CHIH-KUNG LEE , KUANG-CHONG WU
发明人： CHII-WANN LIN , NAN-FU CHIU , WEI-YI FENG , CHIA-CHEN CHANG , KUO-CHUAN HO , CHIH-KUNG LEE , KUANG-CHONG WU
IPC分类号： G01N21/55
CPC分类号： G01N21/553
摘要： Surface plasmon resonance (SPR) sensing technique which provides high specificity and accuracy has been an important method for molecular sensing technology. In the past, in order to affix 45 nm gold film onto glass or silicon substrate, several nanometers of chromium (Cr) or titanium (Ti) has been used as adhesive layer for the attachment of Au film. However, the existence of Cr or Ti thin film deteriorates the performance of SPR sensor due to their characteristic optical absorption. Our experimental results have confirmed the uses of conducting metal oxide, specifically, ITO and Zinc Oxide (ZnO) can be used to replace Cr or Ti for better performance in terms of SPR resonant properties (resonant angle and HMBW) and sensitivity enhancement for 3 to 15 times than traditional ones. It would contribute significantly to the SPR applications in both biosensors and gas sensors.
摘要翻译：提供高特异性和准确度的表面等离子体共振（SPR）感测技术已成为分子感测技术的重要方法。在过去，为了将45nm金膜贴在玻璃或硅衬底上，已经使用几纳米的铬（Cr）或钛（Ti）作为用于附着Au膜的粘合剂层。然而，Cr或Ti薄膜的存在由于其特征性光吸收而使SPR传感器的性能劣化。我们的实验结果证实了导电金属氧化物的用途，特别是ITO和氧化锌（ZnO）可以用于替代Cr或Ti，以获得更好的SPR谐振特性（谐振角和HMBW）性能，灵敏度提高为3〜比传统的15倍。这将有助于生物传感器和气体传感器中的SPR应用。

6. 发明申请

US20090073420A1 Optical waveguide surface plasmon resonance sensor 失效
标题翻译：光波导表面等离子体共振传感器
公开(公告)号：US20090073420A1
公开(公告)日：2009-03-19
申请号：US12076203
申请日：2008-03-14
申请人： Chii-Wann Lin , Jheng-Long Lee , Rong-Huay Juang , Shi-Ming Lin , Chih-Kung Lee , Rea-Min Chu , Ching-Ho Wang , Jim-Min Fang , Tsung-Liang Chuang
发明人： Chii-Wann Lin , Jheng-Long Lee , Rong-Huay Juang , Shi-Ming Lin , Chih-Kung Lee , Rea-Min Chu , Ching-Ho Wang , Jim-Min Fang , Tsung-Liang Chuang
IPC分类号： G01N21/00
CPC分类号： G01N21/553
摘要： An optical waveguide SPR sensor is adapted for differential measurement. The optical waveguide SPR sensor includes a base, a bottom layer, and at least one set of optical waveguide layers. The set of the optical waveguide layers includes a measuring optical waveguide channel and a reference optical waveguide channel. The measuring optical waveguide channel includes an SPR sensing film layer. The measuring optical waveguide channel and the reference optical waveguide channel are independently configured and substantially parallel one to another. The bottom layer has a refractive index higher than a refractive index of the optical waveguide layer.
摘要翻译：光波导SPR传感器适用于差分测量。光波导SPR传感器包括基底，底层以及至少一组光波导层。该组光波导层包括测量光波导通道和参考光波导通道。测量光波导通道包括SPR感测膜层。测量光波导通道和参考光波导通道独立地构造并基本上彼此平行。底层的折射率高于光波导层的折射率。

7. 发明申请

US20090015840A1 MINIATURE SURFACE PLASMON RESONANCE SENSOR CHIP 审中-公开
标题翻译：微型表面等离子体共振传感器芯片
公开(公告)号：US20090015840A1
公开(公告)日：2009-01-15
申请号：US11849573
申请日：2007-09-04
申请人： Chii-Wann Lin , Chih-Kung Lee , Tz-Bin Wang , Chi-Shen Tuan , Yueh-Yuan Fang
发明人： Chii-Wann Lin , Chih-Kung Lee , Tz-Bin Wang , Chi-Shen Tuan , Yueh-Yuan Fang
IPC分类号： G01N21/55
CPC分类号： G01N21/553
摘要： The present invention provides a miniature surface plasmon resonance sensor chip that produces a plane light source with an organic optoelectronic material by an electro-luminescence method and excites a surface plasmon resonance wave to observe a signal variation at the surface of a sensor chip caused by the combining condition of surface bio-molecules and provide a more accurate miniature sensor in conformity with micro-channel.
摘要翻译：本发明提供一种微型表面等离子体共振传感器芯片，其通过电致发光法产生具有有机光电子材料的平面光源，并且激发表面等离子体共振波，以观察由传感器芯片的表面引起的信号变化结合表面生物分子的条件，并提供符合微通道的更精确的微型传感器。

8. 发明申请

US20070229836A1 Organic Luminescent Surface Plasmon Resonance Sensor 审中-公开
标题翻译：有机发光表面等离子体共振传感器
公开(公告)号：US20070229836A1
公开(公告)日：2007-10-04
申请号：US11278638
申请日：2006-04-04
申请人： Chii-Wann Lin , Nan-Fu Chiu , Jiun-Haw Lee , Lung-Jieh Yang , Yao-Joe Yang , Chih-Kung Lee
发明人： Chii-Wann Lin , Nan-Fu Chiu , Jiun-Haw Lee , Lung-Jieh Yang , Yao-Joe Yang , Chih-Kung Lee
IPC分类号： G01N21/55
CPC分类号： G01N21/553 , G01N21/554 , G01N2201/0628
摘要： One embodiment of the present invention is a sensor for analyzing an analyte that includes: (a) an sensing element that is adapted to interface with the analyte; (b) an organic luminescent element that is adapted to excite surface plasmon resonance on the sensing element; and (c) a detector that is adapted to detect signals from the sensing element.
摘要翻译：本发明的一个实施例是用于分析分析物的传感器，其包括：（a）适于与分析物相接触的感测元件; （b）适于在感测元件上激发表面等离子体共振的有机发光元件; 和（c）适于检测来自感测元件的信号的检测器。

9. 发明授权

US07197196B2 Miniature surface plasmon resonance waveguide device with sinusoidal curvature compensation 有权
标题翻译：具有正弦曲率补偿的微型表面等离子体共振波导装置
公开(公告)号：US07197196B2
公开(公告)日：2007-03-27
申请号：US10994777
申请日：2004-11-22
申请人： Chii-Wann Lin , Cheng-Lung Lee , Way-Seen Wang , Chih Kung Lee
发明人： Chii-Wann Lin , Cheng-Lung Lee , Way-Seen Wang , Chih Kung Lee
IPC分类号： G02B6/26 , G01N21/55
CPC分类号： G01N21/553
摘要： The present invention is in related to a miniature surface plasmon resonance waveguide device with sinusoidal curvature compensation and at least comprises: a substract, a waveguide structure, a sensing film layer and a cover layer, wherein the waveguide structure is configured with the function of sinusoidal curvature compensation and installed above the substract, further that, the waveguide structure includes a light input port and a light output port; the sensing film layer is on a special region of the waveguide structure, the special region is a sensing region; the cover layer is upper than the substract and has an opening. By means of the optimal curve figure of the sinusoidal curvature compensation, attenuation of light energy can be minimized while in propagation, and allows the input and output of the light on the same side of the device.
摘要翻译：本发明涉及具有正弦曲率补偿的微型表面等离子体共振波导装置，并且至少包括：减法器，波导结构，感测膜层和覆盖层，其中波导结构被配置为具有正弦曲线曲率补偿并安装在减法器上方，此外，波导结构包括光输入端口和光输出端口; 感光膜层位于波导结构的特殊区域，特殊区域为感应区域; 覆盖层高于该底部并且具有开口。通过正弦曲率补偿的最佳曲线图，在传播过程中光能的衰减可以最小化，并允许光在设备同一侧的输入和输出。

10. 发明申请

US20060146332A1 Linear wave guide type surface plasmon resonance microsensor 审中-公开
标题翻译：线性波导型表面等离子共振微传感器
公开(公告)号：US20060146332A1
公开(公告)日：2006-07-06
申请号：US11082882
申请日：2005-03-18
申请人： Chii-Wann Lin , Cheng-Lung Lee , Chih Lee , Way-Seen Wang
发明人： Chii-Wann Lin , Cheng-Lung Lee , Chih Lee , Way-Seen Wang
IPC分类号： G01N21/55
CPC分类号： G01N21/553 , G01N21/7703
摘要： An improved linear wave guide type surface plasmon resonance (SPR) microsensor, particularly a microsensor employing a dual-opening multi-channel design, adopts a cross differential comparison to enhance the performance of the microsensor and uses a surface plated metal thin film to provide a wavelength absorption according to a SPR characteristic and match with an appropriate sized micro-channel to give a highly sensitive high-flux measurement. The invention applied in a water solution sample comprises: a substrate; a bottom layer contacting a surface of the substrate; at least one wave guide layer contacting the bottom layer and the other surface of the substrate; at least two SPR sensing areas on a surface opposite to the contact surface of the wave guide layer and the bottom layer; at least two SPR sensing film layers on a surface opposite to the contact surface of the two PRS sensing areas and the wave guide layer.
摘要翻译：改进的线性波导型表面等离子体共振（SPR）微传感器，特别是使用双开口多通道设计的微传感器，采用交叉差分比较来增强微传感器的性能，并使用表面电镀金属薄膜来提供根据SPR特性的波长吸收，并与适当尺寸的微通道匹配，以产生高灵敏度的高通量测量。本发明应用于水溶液样品中包括：基底; 底层与基板的表面接触; 至少一个波导层与基底的底层和另一个表面接触; 在与波导层和底层的接触表面相对的表面上的至少两个SPR感测区域; 在与两个PRS感测区域的接触表面相对的表面上的至少两个SPR感测膜层和波导层。

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