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1. 发明授权

US07803828B2 Functionally selective alpha2C adrenoreceptor agonists 有权
标题翻译：功能选择性α2C肾上腺素受体激动剂
公开(公告)号：US07803828B2
公开(公告)日：2010-09-28
申请号：US11508458
申请日：2006-08-23
申请人： Kevin D. McCormick , Christopher W. Boyce , Robert G. Aslanian , Neng-Yang Shih , Salem Fevrier , Pietro Mangiaracina , Chia-Yu Huang , Bo Liang , Rong-Qiang Liu , Huagang Lu
发明人： Kevin D. McCormick , Christopher W. Boyce , Robert G. Aslanian , Neng-Yang Shih , Salem Fevrier , Pietro Mangiaracina , Chia-Yu Huang , Bo Liang , Rong-Qiang Liu , Huagang Lu
IPC分类号： A01N43/50 , C07D233/00
CPC分类号： C07D403/02 , C07D401/06 , C07D403/06
摘要： In its many embodiments, the present invention provides a novel class of indolines as inhibitors of α2C adrenergic receptor agonists, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more conditions associated with the α2C adrenergic receptors using such compounds or pharmaceutical compositions.
摘要翻译：在其许多实施方案中，本发明提供了作为α2C肾上腺素能受体激动剂抑制剂的新一类中和体，制备此类化合物的方法，含有一种或多种此类化合物的药物组合物，制备包含一种或多种此类化合物的药物制剂的方法，以及使用这些化合物或药物组合物治疗，预防，抑制或改善与α2C肾上腺素能受体相关的一种或多种病症的方法。

2. 发明申请

US20080039439A1 Alpha2C adrenoreceptor agonists 失效
标题翻译： α2C肾上腺素受体激动剂
公开(公告)号：US20080039439A1
公开(公告)日：2008-02-14
申请号：US11705673
申请日：2007-02-13
申请人： Kevin McCormick , Christopher Boyce , Neng-Yang Shih , Chia-Yu Huang , Robert Aslanian , Salem Fevrier , Bo Liang , Rong-qiang Liu , Ruiyan Liu , Pietro Mangiaracina , Manuel de Lera Ruiz , Younong Yu , Lisa Guise-Zawacki , Junying Zheng
发明人： Kevin McCormick , Christopher Boyce , Neng-Yang Shih , Chia-Yu Huang , Robert Aslanian , Salem Fevrier , Bo Liang , Rong-qiang Liu , Ruiyan Liu , Pietro Mangiaracina , Manuel de Lera Ruiz , Younong Yu , Lisa Guise-Zawacki , Junying Zheng
IPC分类号： A61K31/535 , A61K31/502 , A61K31/54 , A61K31/553 , A61P1/00 , A61P25/00 , A61P37/00 , A61P9/00 , C07D241/36 , C07D279/06 , C07D498/04 , C12N5/06
CPC分类号： C07D413/14 , C07D241/36 , C07D279/06 , C07D403/06 , C07D413/06 , C07D417/06 , C07D417/14 , C07D471/04 , C07D498/04
摘要： In its many embodiments, the present invention relates to a novel class of phenylmorpholine and phenylthiomorpholine compounds useful as α2C adrenergic receptor agonists, pharmaceutical compositions containing the compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the α2C adrenergic receptor agonists using such compounds or pharmaceutical compositions.
摘要翻译：在其许多实施方案中，本发明涉及可用作α2C肾上腺素能受体激动剂的新型苯基吗啉和苯硫基吗啉化合物，含有该化合物的药物组合物，以及治疗，预防，抑制或改善一种或多种与 α2C肾上腺素能受体激动剂，使用这些化合物或药物组合物。

3. 发明授权

US08845500B2 Resistance adjustable rotational exerciser 有权
标题翻译：电阻可调旋转锻炼器
公开(公告)号：US08845500B2
公开(公告)日：2014-09-30
申请号：US13435921
申请日：2012-03-30
申请人： Chia-Yu Huang
发明人： Chia-Yu Huang
IPC分类号： A63B21/02
CPC分类号： A63B21/0608 , A63B21/00069 , A63B21/015 , A63B21/0724 , A63B21/4035 , A63B21/4049 , A63B23/03525 , A63B23/03541 , A63B2244/102
摘要： A resistance adjustable rotational exerciser includes a body, two rotary members and an adjustment device. The body has two outer rings with a connection plate connected therebetween. The two rotary members are rotatably connected to the outer rings and each have a handle. The adjustment device has front and rear plates respectively connected to the front and rear sides of the connection plate. The front and rear plates have resistance strips. Springs are located between the connection plate and the front and rear plates. A knob is located at the front plate and connected to connection rods connected between the front and rear plates. The user holds the handles to operate the exerciser in different directions to exercise the muscles and joints. By operation of the knob, the distance between the front and rear plates is adjusted to obtain desired resistance.
摘要翻译：电阻可调节旋转锻炼器包括主体，两个旋转构件和调节装置。主体具有两个连接在其间的连接板的外圈。两个旋转构件可旋转地连接到外圈并且每个具有把手。调节装置具有分别连接到连接板的前侧和后侧的前板和后板。前后板有电阻条。弹簧位于连接板和前后板之间。一个旋钮位于前板，并连接到连接在前板和后板之间的连接杆。用户握住手柄以在不同方向操作锻炼者以锻炼肌肉和关节。通过旋钮的操作，调整前板和后板之间的距离以获得所需的阻力。

4. 发明授权

US08513232B2 Substituted spirocyclic piperidine derivatives as histamine-3 (H3) receptor ligands 失效
标题翻译：取代的螺环哌啶衍生物作为组胺-3（H3）受体配体
公开(公告)号：US08513232B2
公开(公告)日：2013-08-20
申请号：US12846100
申请日：2010-07-29
申请人： Edward R. Bacon , Nadine C. Becknell , Reddeppa reddy Dandu , Lisa Guise-Zawacki , Tao Guo , Chia-yu Huang , Robert L. Hudkins , Babu G. Sundar , Ming Tao , Minglang Wu , Allison L. Zulli
发明人： Edward R. Bacon , Nadine C. Becknell , Reddeppa reddy Dandu , Lisa Guise-Zawacki , Tao Guo , Chia-yu Huang , Robert L. Hudkins , Babu G. Sundar , Ming Tao , Minglang Wu , Allison L. Zulli
IPC分类号： C07D491/10 , C07D401/14 , C07D471/10 , A61K31/397 , A61K31/438 , A61K31/506 , A61P11/00 , A61P1/00 , A61P25/00 , A61P29/00
CPC分类号： C07D491/10
摘要： The present invention provides compounds of Formula (I): their use as H3 antagonists/inverse agonists, processes for their preparation, and pharmaceuticals compositions thereof.
摘要翻译：本发明提供式（I）化合物：其用作H3拮抗剂/反向激动剂，其制备方法及其药物组合物。

5. 发明申请

US20110071131A1 Substituted Spirocyclic Piperidine Derivatives as Histamine-3 (H3) Receptor Ligands 失效
标题翻译：取代的螺环哌啶衍生物作为组胺-3（H3）受体配体
公开(公告)号：US20110071131A1
公开(公告)日：2011-03-24
申请号：US12846100
申请日：2010-07-29
申请人： Edward R. Bacon , Nadine C. Becknell , Reddeppa reddy Dandu , Lisa Guise-Zawacki , Tao Guo , Chia-yu Huang , Robert L. Hudkins , Babu G. Sundar , Ming Tao , Minglang Wu , Allison L. Zulli
发明人： Edward R. Bacon , Nadine C. Becknell , Reddeppa reddy Dandu , Lisa Guise-Zawacki , Tao Guo , Chia-yu Huang , Robert L. Hudkins , Babu G. Sundar , Ming Tao , Minglang Wu , Allison L. Zulli
IPC分类号： A61K31/397 , C07D471/10 , A61K31/438 , C07D413/14 , A61K31/5377 , C07D401/14 , A61K31/506 , A61P25/00 , A61P1/00 , A61P11/00 , A61P9/00 , A61P29/00
CPC分类号： C07D491/10
摘要： The present invention provides compounds of Formula (I): their use as H3 antagonists/inverse agonists, processes for their preparation, and pharmaceuticals compositions thereof.
摘要翻译：本发明提供式（I）化合物：其用作H3拮抗剂/反向激动剂，其制备方法及其药物组合物。

6. 发明授权

US07342016B2 Farnesyl protein transferase inhibitors as antitumor agents 失效
标题翻译：法呢基蛋白转移酶抑制剂作为抗肿瘤剂
公开(公告)号：US07342016B2
公开(公告)日：2008-03-11
申请号：US10325896
申请日：2002-12-19
申请人： Hugh Y. Zhu , F. George Njoroge , Alan B. Cooper , Timothy J. Guzi , Dinanath F. Rane , Keith P. Minor , Ronald J. Doll , Viyyoor M. Girijavallabhan , Bama Santhanam , Patrick A. Pinto , Bancha Vibulbhan , Kartik M. Keertikar , Carmen S. Alvarez , John J. Baldwin , Ge Li , Chia-Yu Huang , Ray A. James , James J-S Wang , Jagdish A. Desai
发明人： Hugh Y. Zhu , F. George Njoroge , Alan B. Cooper , Timothy J. Guzi , Dinanath F. Rane , Keith P. Minor , Ronald J. Doll , Viyyoor M. Girijavallabhan , Bama Santhanam , Patrick A. Pinto , Bancha Vibulbhan , Kartik M. Keertikar , Carmen S. Alvarez , John J. Baldwin , Ge Li , Chia-Yu Huang , Ray A. James , James J-S Wang , Jagdish A. Desai
IPC分类号： A61K31/497 , A61K31/44 , C07D401/14 , C07D221/06
CPC分类号： C07D231/12 , C07D221/16 , C07D233/56 , C07D249/08 , C07D401/04 , C07D401/06 , C07D401/14
摘要： Disclosed are novel tricyclic compounds represented by the formula (1.0): and a pharmaceutically acceptable salt or solvate thereof. The compounds are useful for inhibiting farnesyl protein transferase. Also disclosed are pharmaceutical compositions comprising compounds of formula 1.0. Also disclosed are methods of treating cancer using the compounds of formula 1.0.
摘要翻译：公开了由式（1.0）表示的新型三环化合物及其药学上可接受的盐或溶剂化物。该化合物可用于抑制法呢基蛋白转移酶。还公开了包含式1.0化合物的药物组合物。还公开了使用式1.0化合物治疗癌症的方法。

7. 发明申请

US20080027100A1 Functionally selective alpha2C adrenoreceptor agonists 失效
标题翻译：功能选择性α2C肾上腺素受体激动剂
公开(公告)号：US20080027100A1
公开(公告)日：2008-01-31
申请号：US11705683
申请日：2007-02-13
申请人： Kevin McCormick , Christopher Boyce , Neng-Yang Shih , Chia-Yu Huang , Robert Aslanian , Jianhua Chao , Salem Fevrier , Bo Liang , Huagang Lu , Pietro Mangiaracina , Rong-Qiang Liu , Younong Yu
发明人： Kevin McCormick , Christopher Boyce , Neng-Yang Shih , Chia-Yu Huang , Robert Aslanian , Jianhua Chao , Salem Fevrier , Bo Liang , Huagang Lu , Pietro Mangiaracina , Rong-Qiang Liu , Younong Yu
IPC分类号： A61K31/4178 , A61K31/4709 , A61P1/12 , A61P13/00 , A61P25/00 , A61P25/06 , A61P25/18 , A61P25/24 , A61P27/14 , A61P37/00 , A61P9/00 , C07D215/00 , C07D403/06 , C12N5/00
CPC分类号： C07D403/02 , C07D401/14 , C07D403/06 , C07D405/14 , C07D407/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： In its many embodiments, the present invention provides a novel class of indolines as inhibitors of α2C adrenergic receptor agonists, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more conditions associated with the α2C adrenergic receptors using such compounds or pharmaceutical compositions.
摘要翻译：在其许多实施方案中，本发明提供了作为α2C肾上腺素能受体激动剂抑制剂的新一类中和体，制备此类化合物的方法，含有一种或多种此类化合物的药物组合物，制备包含一种或多种此类化合物的药物制剂的方法，以及使用这些化合物或药物组合物治疗，预防，抑制或改善与α2C肾上腺素能受体相关的一种或多种病症的方法。

8. 发明申请

US20070299211A1 Ambient temperature rapid self-polymerization compositions of high cross-linked or linear type beta-amino-ester alternative co-polymers and their applications 审中-公开
标题翻译：高温交联或直链型β-氨基酯替代共聚物的环境温度快速自聚合组合物及其应用
公开(公告)号：US20070299211A1
公开(公告)日：2007-12-27
申请号：US11478676
申请日：2006-07-03
申请人： Po-Cheng Chen , Shih-Chieh Wang , Chia-Yu Huang , Kan-Nan Chen
发明人： Po-Cheng Chen , Shih-Chieh Wang , Chia-Yu Huang , Kan-Nan Chen
IPC分类号： C08F120/02
CPC分类号： C08G73/02 , C08L79/02
摘要： Self-polymerization of mono-aziridine (or azetidine) and multi-aziridine (or azetidine) containing compounds with vinyl group containing organic acid, such as acrylic acid (AA), 2-methylenesuccinic acid, 2,3-dimethylenesuccinic acid and etc, at ambient temperature results in the new type of cross-linked and linear type copolymers, respectively.The polymerization of multi-functional aziridine (or azetidine) containing compounds with vinyl group containing organic acid results in the formation of high cross-linked polymers. The self-polymerization takes place at ambient temperature and the resultants, cross-linked polymeric networked materials, are solvent insoluble and potential for adhesive, composite matrix and other applications. These insoluble materials are hydrolyzed in an acidic or basic condition to form the water soluble β-amino acids.A linear poly(β-aminoester) is obtained from the self-polymerization of vinyl group containing organic acid with mono-aziridine (or azetidine) containing compound at ambient temperature. poly(β-aminoester) is applicable for gene transfer, controlled drug release and other applications. This self-polymerization process offers a convenient route for preparing poly(β-aminoesters).
摘要翻译：含有丙烯酸（AA），2-甲基琥珀酸，2,3-二甲基琥珀酸等有机酸的含有乙烯基的单氮杂环丁烷（或氮杂环丁烷）和多氮丙啶（或氮杂环丁烷）在环境温度下分别导致了新型的交联和线型共聚物。含有含乙烯基的有机酸的含多官能氮丙啶（或氮杂环丁烷）化合物的聚合导致形成高交联聚合物。自聚合在环境温度下进行，并且所得的交联聚合物网络材料是溶剂不溶性的，并且具有粘合剂，复合基质和其它应用的潜力。这些不溶物质在酸性或碱性条件下水解以形成水溶性β-氨基酸。由含乙烯基的有机酸与单氮丙啶（或氮杂环丁烷）化合物在环境温度下的自聚合得到线性聚（β-氨基酯）。聚（β-氨基酯）适用于基因转移，受控药物释放和其他应用。这种自聚合方法提供了制备聚（β-氨基酯）的方便途径。

9. 发明授权

US06432959B1 Inhibitors of farnesyl-protein transferase 失效
标题翻译：法呢基蛋白转移酶抑制剂
公开(公告)号：US06432959B1
公开(公告)日：2002-08-13
申请号：US09469465
申请日：1999-12-22
申请人： Alan B. Cooper , Ronald J. Doll , Johan A. Ferreira , Ashit Ganguly , Viyyoor M. Girijavallabhan , Arthur G. Taveras , Jianping Chao , John J. Baldwin , Chia-Yu Huang , Ge Li
发明人： Alan B. Cooper , Ronald J. Doll , Johan A. Ferreira , Ashit Ganguly , Viyyoor M. Girijavallabhan , Arthur G. Taveras , Jianping Chao , John J. Baldwin , Chia-Yu Huang , Ge Li
IPC分类号： A61K31496
CPC分类号： C07D401/14 , C07D403/12 , C07D417/14
摘要： Novel compounds and pharmaceutical compositions are disclosed which are inhibitors of the enzyme, farnesyl protein transferase. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering the novel aminooxyamide compound to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammals such as a human.
摘要翻译：公开了新的化合物和药物组合物，其是酶的法呢基蛋白转移酶的抑制剂。还公开了抑制Ras功能并因此抑制细胞异常生长的方法。该方法包括将新的氨氧基酰胺化合物施用于生物系统。特别地，该方法抑制哺乳动物如人的细胞的异常生长。

10. 发明申请

US20130260969A1 RESISTANCE ADJUSTABLE ROTATIONAL EXERCISER 有权
标题翻译：电阻可调式旋转练习器
公开(公告)号：US20130260969A1
公开(公告)日：2013-10-03
申请号：US13435921
申请日：2012-03-30
申请人： Chia-Yu Huang
发明人： Chia-Yu Huang
IPC分类号： A63B21/02
CPC分类号： A63B21/0608 , A63B21/00069 , A63B21/015 , A63B21/0724 , A63B21/4035 , A63B21/4049 , A63B23/03525 , A63B23/03541 , A63B2244/102
摘要： A resistance adjustable rotational exerciser includes a body, two rotary members and an adjustment device. The body has two outer rings with a connection plate connected therebetween. The two rotary members are rotatably connected to the outer rings and each have a handle. The adjustment device has front and rear plates respectively connected to the front and rear sides of the connection plate. The front and rear plates have resistance strips. Springs are located between the connection plate and the front and rear plates. A knob is located at the front plate and connected to connection rods connected between the front and rear plates. The user holds the handles to operate the exerciser in different directions to exercise the muscles and joints. By operation of the knob, the distance between the front and rear plates is adjusted to obtain desired resistance.
摘要翻译：电阻可调节旋转锻炼器包括主体，两个旋转构件和调节装置。主体具有两个连接在其间的连接板的外圈。两个旋转构件可旋转地连接到外圈并且每个具有把手。调节装置具有分别连接到连接板的前侧和后侧的前板和后板。前后板有电阻条。弹簧位于连接板和前后板之间。一个旋钮位于前板，并连接到连接在前板和后板之间的连接杆。用户握住手柄以在不同方向操作锻炼者以锻炼肌肉和关节。通过旋钮的操作，调整前板和后板之间的距离以获得所需的阻力。

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