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1. 发明专利

IL248607B Methods and compositions for immunization against virus 未知
公开(公告)号：IL248607B
公开(公告)日：2023-01-01
申请号：IL24860716
申请日：2016-10-30
申请人： ACAD SINICA , CHI HUEY WONG , JUINE RUEY CHEN , CHE MA , CHENG CHI WANG
发明人： CHI-HUEY WONG , JUINE-RUEY CHEN , CHE MA , CHENG-CHI WANG
IPC分类号： A61K39/12 , A61K39/21 , A61K39/29 , A61P31/12 , A61P31/14 , A61P31/18 , C07K16/10
摘要： Immunogenic compositions comprising partially glycosylated viral glycoproteins for use as vaccines against viruses are provided. Vaccines formulated using mono-, di-, or tri-glycosylated viral surface glycoproteins and polypeptides provide potent and broad protection against viruses, even across strains. Pharmaceutical compositions comprising monoglycosylated hemagglutinin polypeptides and vaccines generated therefrom and methods of their use for prophylaxis or treatment of viral infections are disclosed. Methods and compositions are disclosed for influenza virus HA, NA and M2, RSV proteins F, G and SH, Dengue virus glycoproteins M or E, hepatitis C virus glycoprotein E1 or E2 and HIV glycoproteins gp120 and gp41.

2. 发明专利

IL258728D0 Vaccines with higher carbohydrate antigen density and novel saponin adjuvant 未知
公开(公告)号：IL258728D0
公开(公告)日：2018-06-28
申请号：IL25872818
申请日：2018-04-16
申请人： CHENG CHI WANG , OBI PHARMA INC , WEI HAN LEE , NAN HSUAN WANG , CHUNG HAO CHANG , YIH HUANG HSIEH , CHENG DER TONY YU , YU HSIN LIN , I JU CHEN , YU CHEN LIN
发明人： CHENG-CHI WANG , WEI HAN LEE , NAN-HSUAN WANG , CHUNG-HAO CHANG , YIH-HUANG HSIEH , CHENG DER TONY YU , YU-HSIN LIN , I-JU CHEN , YU-CHEN LIN
IPC分类号： A61K20060101
摘要： The present invention provides saponin adjuvants, which are useful in vaccines against carbohydrate antigens.

3. 发明专利

IL239785A Vaccines with higher carbohydrate antigen density and comprising a saponin adjuvant 未知
公开(公告)号：IL239785A
公开(公告)日：2018-05-31
申请号：IL23978515
申请日：2015-07-05
申请人： CHENG CHI WANG , OBI PHARMA INC , WEI HAN LEE , NAN HSUAN WANG , CHUNG HAO CHANG , YIH HUANG HSIEH , CHENG DER TONY YU , YU HSIN LIN , I JU CHEN , YU CHEN LIN
发明人： CHENG-CHI WANG , WEI HAN LEE , NAN-HSUAN WANG , CHUNG-HAO CHANG , YIH-HUANG HSIEH , CHENG DER TONY YU , YU-HSIN LIN , I-JU CHEN , YU-CHEN LIN
IPC分类号： A61K20060101 , A61P20060101 , C07H20060101
摘要： The present invention provides saponin adjuvants, which are useful in vaccines against carbohydrate antigens.

4. 发明专利

IL215430A Immunogenic compositions and vaccines for immunization against viruses and use thereof 未知
公开(公告)号：IL215430A
公开(公告)日：2016-11-30
申请号：IL21543011
申请日：2011-09-27
申请人： ACADEMIA SINICA , CHI-HUEY WONG , JUINE-RUEY CHEN , CHE MA , CHENG-CHI WANG
发明人： CHI-HUEY WONG , JUINE-RUEY CHEN , CHE MA , CHENG-CHI WANG
IPC分类号： A61K20060101
摘要： Immunogenic compositions comprising partially glycosylated viral glycoproteins for use as vaccines against viruses are provided. Vaccines formulated using mono-, di-, or tri-glycosylated viral surface glycoproteins and polypeptides provide potent and broad protection against viruses, even across strains. Pharmaceutical compositions comprising monoglycosylated hemagglutinin polypeptides and vaccines generated therefrom and methods of their use for prophylaxis or treatment of viral infections are disclosed. Methods and compositions are disclosed for influenza virus HA, NA and M2, RSV proteins F, G and SH, Dengue virus glycoproteins M or E, hepatitis C virus glycoprotein E1 or E2 and HIV glycoproteins gp120 and gp41.

5. 发明专利

IL248607D0 Methods and compositions for immunization against virus 未知
公开(公告)号：IL248607D0
公开(公告)日：2016-12-29
申请号：IL24860716
申请日：2016-10-30
申请人： ACADEMIA SINICA , CHI-HUEY WONG , JUINE-RUEY CHEN , CHE MA , CHENG-CHI WANG
发明人： CHI-HUEY WONG , JUINE-RUEY CHEN , CHE MA , CHENG-CHI WANG
IPC分类号： A61K20060101
摘要： Immunogenic compositions comprising partially glycosylated viral glycoproteins for use as vaccines against viruses are provided. Vaccines formulated using mono-, di-, or tri-glycosylated viral surface glycoproteins and polypeptides provide potent and broad protection against viruses, even across strains. Pharmaceutical compositions comprising monoglycosylated hemagglutinin polypeptides and vaccines generated therefrom and methods of their use for prophylaxis or treatment of viral infections are disclosed. Methods and compositions are disclosed for influenza virus HA, NA and M2, RSV proteins F, G and SH, Dengue virus glycoproteins M or E, hepatitis C virus glycoprotein E1 or E2 and HIV glycoproteins gp120 and gp41.

6. 发明专利

IL215430D0 METHODS AND COMPOSITIONS FOR IMMUNIZATION AGAINST VIRUS 未知
公开(公告)号：IL215430D0
公开(公告)日：2011-12-29
申请号：IL21543011
申请日：2011-09-27
申请人： ACADEMIA SINICA , CHI HUEY WONG , JUINE RUEY CHEN , CHE MA , CHENG CHI WANG
IPC分类号： A61K20060101
摘要： Immunogenic compositions comprising partially glycosylated viral glycoproteins for use as vaccines against viruses are provided. Vaccines formulated using mono-, di-, or tri-glycosylated viral surface glycoproteins and polypeptides provide potent and broad protection against viruses, even across strains. Pharmaceutical compositions comprising monoglycosylated hemagglutinin polypeptides and vaccines generated therefrom and methods of their use for prophylaxis or treatment of viral infections are disclosed. Methods and compositions are disclosed for influenza virus HA, NA and M2, RSV proteins F, G and SH, Dengue virus glycoproteins M or E, hepatitis C virus glycoprotein E1 or E2 and HIV glycoproteins gp120 and gp41.

7. 发明专利

IL258728A Vaccines with higher carbohydrate antigen density and novel saponin adjuvant 未知
公开(公告)号：IL258728A
公开(公告)日：2019-07-31
申请号：IL25872818
申请日：2018-04-16
申请人： CHENG CHI WANG , OBI PHARMA INC , WEI HAN LEE , NAN HSUAN WANG , CHUNG HAO CHANG , YIH HUANG HSIEH , CHENG DER TONY YU , YU HSIN LIN , I JU CHEN , YU CHEN LIN
发明人： CHENG-CHI WANG , WEI HAN LEE , NAN-HSUAN WANG , CHUNG-HAO CHANG , YIH-HUANG HSIEH , CHENG DER TONY YU , YU-HSIN LIN , I-JU CHEN , YU-CHEN LIN
IPC分类号： A61K39/00 , A61K39/39 , C07H15/24
摘要： The present invention provides saponin adjuvants, which are useful in vaccines against carbohydrate antigens.

8. 发明专利

IL239785D0 Vaccines with higher carbohydrate antigen density and novel saponin adjuvant 未知
公开(公告)号：IL239785D0
公开(公告)日：2015-08-31
申请号：IL23978515
申请日：2015-07-05
申请人： CHENG CHI WANG , OBI PHARMA INC , WEI HAN LEE , NAN HSUAN WANG , CHUNG HAO CHANG , YIH HUANG HSIEH , CHENG DER TONY YU , YU HSIN LIN , I JU CHEN , YU CHEN LIN
IPC分类号： C07H20060101
摘要： The present invention provides saponin adjuvants, which are useful in vaccines against carbohydrate antigens.

9. 发明授权

US08741311B2 Methods and compositions for immunization against virus 有权
标题翻译：针对病毒免疫的方法和组合物
公开(公告)号：US08741311B2
公开(公告)日：2014-06-03
申请号：US12748265
申请日：2010-03-26
申请人： Chi-Huey Wong , Che Ma , Cheng-Chi Wang , Juine-Ruey Chen
发明人： Chi-Huey Wong , Che Ma , Cheng-Chi Wang , Juine-Ruey Chen
IPC分类号： A61K39/145
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/55505 , C07K16/1018 , C07K2317/76 , C12N7/00 , C12N2740/11034 , C12N2740/16034 , C12N2760/16122 , C12N2760/16134 , C12N2760/16171 , C12N2770/24134 , Y02A50/386
摘要： Immunogenic compositions comprising partially glycosylated viral glycoproteins for use as vaccines against viruses are provided. Vaccines formulated using mono-, di-, or tri-glycosylated viral surface glycoproteins and polypeptides provide potent and broad protection against viruses, even across strains. Pharmaceutical compositions comprising monoglycosylated hemagglutinin polypeptides and vaccines generated therefrom and methods of their use for prophylaxis or treatment of viral infections are disclosed. Methods and compositions are disclosed for influenza virus HA, NA and M2, RSV proteins F, G and SH, Dengue virus glycoproteins M or E, hepatitis C virus glycoprotein E1 or E2 and HIV glycoproteins gp120 and gp41.
摘要翻译：提供了包含部分糖基化的病毒糖蛋白的免疫原性组合物，其用作抗病毒疫苗。使用单糖，二糖或三糖基化的病毒表面糖蛋白和多肽配制的疫苗甚至可以跨毒株提供有效和广泛的防病毒保护。公开了包含单糖基化血凝素多肽和由其产生的疫苗的药物组合物及其用于预防或治疗病毒感染的方法。公开了用于流感病毒HA，NA和M2，RSV蛋白F，G和SH，登革病毒糖蛋白M或E，丙型肝炎病毒糖蛋白E1或E2和HIV糖蛋白gp120和gp41的方法和组合物。

10. 发明授权

US08139175B2 Thin film transistor, thin film transistor substrate, and methods for manufacturing the same 有权
标题翻译：薄膜晶体管，薄膜晶体管基板及其制造方法
公开(公告)号：US08139175B2
公开(公告)日：2012-03-20
申请号：US12197416
申请日：2008-08-25
申请人： Chin-Lung Ting , Cheng-Chi Wang
发明人： Chin-Lung Ting , Cheng-Chi Wang
IPC分类号： G02F1/136
CPC分类号： H01L29/78696 , H01L29/66757 , H01L29/78606 , H01L29/78675
摘要： A thin film transistor includes a channel layer of a specific shape, a thermal gradient inducer body, a gate insulating film, a gate electrode and an interlayer insulating film, a source electrode and a drain electrode. The channel layer is formed on a substrate. The channel layer has a nucleation region and a crystal end. The thermal gradient inducer body partially circumscribes the channel layer. The gate insulating film is formed on the substrate, and the channel layer is at least partially covered with the gate insulating film. The gate electrode is formed on the gate insulating film. The interlayer insulating film is formed on the gate insulating film, and the gate electrode is at least partially covered with the interlayer insulating film. The source electrode and the drain electrode are formed on the interlayer insulating film, passed through the gate insulating film and the interlayer insulating film, and electrically connected to the channel layer.
摘要翻译：薄膜晶体管包括特定形状的沟道层，热梯度诱导体，栅极绝缘膜，栅电极和层间绝缘膜，源电极和漏电极。沟道层形成在基板上。沟道层具有成核区域和晶体端部。热梯度诱导体主体部分地界定通道层。栅极绝缘膜形成在基板上，沟道层至少部分地被栅极绝缘膜覆盖。栅电极形成在栅极绝缘膜上。层间绝缘膜形成在栅极绝缘膜上，并且栅电极至少部分被层间绝缘膜覆盖。源电极和漏极形成在层间绝缘膜上，通过栅极绝缘膜和层间绝缘膜，并与沟道层电连接。

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