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1. 发明专利

IE860848L DRUG EXTRACTED FROM PLANT MATERIAL 未知
公开(公告)号：IE860848L
公开(公告)日：1986-09-29
申请号：IE84886
申请日：1986-03-27
申请人： CHANG KIU MOON
IPC分类号： A61K31/35 , A61K35/78

2. 发明专利

IL78329D0 DRUG COMPRISING A PLANT EXTRACT OR ITS COMPONENTS AND PREPARATION THEREOF 未知
公开(公告)号：IL78329D0
公开(公告)日：1986-07-31
申请号：IL7832986
申请日：1986-03-30
申请人： CHANG KIU MOON
IPC分类号： A61K20060101 , A61K

3. 发明专利

GR860828B METHOD FOR PREPARING A MEDICAMENT 未知
公开(公告)号：GR860828B
公开(公告)日：1986-07-28
申请号：GR860100828
申请日：1986-03-28
申请人： CHANG KIU MOON DR
发明人： MOON DE CHANG-KIU
IPC分类号： A61K20060101 , A61K31/35 , A61K31/365 , A61K33/00 , A61K36/00 , A61K36/48 , C07D20060101 , C07D311/00 , C07D311/94 , C07D493/04 , C07G99/00
摘要： A novel drug comprises as active ingredient an extract extractable from plant material of plants belonging to the genus Caesalpinia, one or several components of this extract and/or one or several substances present in this extract or derived therefrom but prepared synthetically. These substances are in particular benz(b)indeno(2.1-d)pyran derivatives, including brazilin, brazilein, hematoxylin and/or hematein. The drug is especially suited for treatment of a patient suffering from micro-circulatory disorders, diabetes mellitus, increased blood sugar values, increasing blood platelet aggregation, increased blood viscosity, decreased eryhtrocyte deformability, disorders of the lysosomal enzyme activity and/or suffering from disorders of the prostaglandin metabolism, especially increasing thromboxane A2 activity.

4. 发明专利

NZ215678A DRUG CONTAINING EXTRACTS FROM PLANTS OF CAESALPINIA SPECIES 未知
公开(公告)号：NZ215678A
公开(公告)日：1988-11-29
申请号：NZ21567886
申请日：1986-04-02
申请人： CHANG KIU MOON DR
发明人： DR CHANG-KIU MOON
IPC分类号： A61K20060101 , A61K31/35 , A61K31/365 , A61K33/00 , A61K36/00 , A61K36/48 , C07D20060101 , C07D311/00 , C07D311/94 , C07D493/04 , C07G99/00 , A61K35/78
摘要： A novel drug comprises as active ingredient an extract extractable from plant material of plants belonging to the genus Caesalpinia, one or several components of this extract and/or one or several substances present in this extract or derived therefrom but prepared synthetically. These substances are in particular benz(b)indeno(2.1-d)pyran derivatives, including brazilin, brazilein, hematoxylin and/or hematein. The drug is especially suited for treatment of a patient suffering from micro-circulatory disorders, diabetes mellitus, increased blood sugar values, increasing blood platelet aggregation, increased blood viscosity, decreased eryhtrocyte deformability, disorders of the lysosomal enzyme activity and/or suffering from disorders of the prostaglandin metabolism, especially increasing thromboxane A2 activity.

5. 发明授权

US4918099A Drug, preparation and use thereof 失效
标题翻译：药物，制剂及其用途
公开(公告)号：US4918099A
公开(公告)日：1990-04-17
申请号：US844325
申请日：1986-03-26
申请人： Chang-Kiu Moon
发明人： Chang-Kiu Moon
IPC分类号： A61K31/35 , A61K31/365 , A61K36/00 , A61K36/48 , C07D311/94 , C07D493/04
CPC分类号： C07D311/94 , A61K31/35 , A61K31/365 , A61K36/48 , Y10S514/822 , Y10S514/833 , Y10S514/866 , Y10S514/884
摘要： A novel drug comprises as active ingredient an extract extractable from plant material of plants belonging to the genus Caesalpinia, one or several components of this extract and/or one or several substances present in this extract or derived therefrom but prepared synthetically.These substances are in particular benz(b)indeno(2.1-d)pyran derivatives, including brazilin, brazilein, hematoxylin and/or hematein. The drug is especially suited for treatment of a patient suffering from micro-circulatory disorders, diabetes mellitus, increased blood sugar values, increasing blood platelet aggregation, increased blood viscosity, decreased eryhtrocyte deformability, disorders of the lysosomal enzyme activity and/or suffering from disorders of the prostaglandin metabolism, especially increasing thromboxane A.sub.2 activity.
摘要翻译：一种新药包含作为活性成分的可从属于凯撒刺属的植物的植物材料提取的提取物，该提取物的一种或多种组分和/或该提取物中存在的一种或多种物质，或由其衍生而来，但合成制备。这些物质特别是苯并（b）茚并（2.1-d）吡喃衍生物，包括巴西，巴西林，苏木精和/或hematein。该药物特别适用于治疗患有微循环障碍，糖尿病，血糖值升高，血小板聚集增加，血液粘度升高，红细胞变形能力降低，溶酶体酶活性紊乱和/或患有疾病的患者的前列腺素代谢，特别是增加血栓素A2活性。

6. 发明授权

US6030993A 2-hydroxypropionic acid derivative and its manufacturing method 失效
标题翻译： 2-羟基丙酸衍生物及其制备方法
公开(公告)号：US6030993A
公开(公告)日：2000-02-29
申请号：US214388
申请日：1999-05-04
申请人： Sang Sup Jew , Suk Ku Kang , Deuk Joon Kim , Won Ki Kim , Hwa Jung Kim , Chang Kiu Moon , Jeong Hill Park , Young Ger Suh , Bong Jin Lee , Jee Woo Lee , Ki Hwa Jung , Moon Woo Chun , Hoon Huh , Eung Seok Lee , Hyung Ook Kim , Eun Kyung Kim , Sung Jin Kim , Jae Hoon Cheong , Kwang Ho Ko , Bak Kwang Kim
发明人： Sang Sup Jew , Suk Ku Kang , Deuk Joon Kim , Won Ki Kim , Hwa Jung Kim , Chang Kiu Moon , Jeong Hill Park , Young Ger Suh , Bong Jin Lee , Jee Woo Lee , Ki Hwa Jung , Moon Woo Chun , Hoon Huh , Eung Seok Lee , Hyung Ook Kim , Eun Kyung Kim , Sung Jin Kim , Jae Hoon Cheong , Kwang Ho Ko , Bak Kwang Kim
IPC分类号： A61K31/23 , A61K31/341 , A61K31/381 , A61K31/415 , A61K31/426 , A61P3/10 , C07C67/31 , C07C69/708 , C07C69/712 , C07D231/12 , C07D277/20 , C07D277/24 , C07D277/32 , C07D307/42 , C07D333/16 , C07D333/26 , C07D333/32 , C07D521/00 , A61K31/215
CPC分类号： C07D231/12 , C07C69/708 , C07D233/56 , C07D249/08 , C07D307/42 , C07D333/16 , C07D333/26 , C07D333/32
摘要： This invention relates to a novel 2-hydroxypropionic acid derivative and its manufacturing method. Based on its mechanism to inhibit the CPT I, 2-hydroxypropionic acid derivative of this invention has blood glucose lowering effects so that the derivative may be effectively used as an antidiabetic agent having remarkable antidiabetic activity and fewer side effects.
摘要翻译： PCT No.PCT / KR97 / 00133 Sec。 371日期1999年5月4日 102（e）日期1999年5月4日PCT提交1997年7月2日PCT公布。公开号WO98 / 00389 日本1998年1月8日本发明涉及新型2-羟基丙酸衍生物及其制造方法。基于抑制CPT I的机制，本发明的2-羟基丙酸衍生物具有降血糖作用，因此该衍生物可有效地用作具有显着抗糖尿病活性和较少副作用的抗糖尿病药。

7. 发明授权

US6013666A Oxirane carboxylic acid derivative and its manufacturing method 失效
标题翻译：环氧乙烷羧酸衍生物及其制备方法
公开(公告)号：US6013666A
公开(公告)日：2000-01-11
申请号：US214389
申请日：1999-05-11
申请人： Sang Sup Jew , Suk Ku Kang , Deuk Joon Kim , Won Ki Kim , Hwa Jung Kim , Chang Kiu Moon , Jeong Hill Park , Young Ger Suh , Bong Jin Lee , Jee Woo Lee , Ki Hwa Jung , Moon Woo Chun , Hoon Huh , Eung Seok Lee , Hyung Ook Kim , Eun Kyung Kim , Sung Jin Kim , Jae Hoon Cheong , Kwang Ho Ko , Bak Kwang Kim
发明人： Sang Sup Jew , Suk Ku Kang , Deuk Joon Kim , Won Ki Kim , Hwa Jung Kim , Chang Kiu Moon , Jeong Hill Park , Young Ger Suh , Bong Jin Lee , Jee Woo Lee , Ki Hwa Jung , Moon Woo Chun , Hoon Huh , Eung Seok Lee , Hyung Ook Kim , Eun Kyung Kim , Sung Jin Kim , Jae Hoon Cheong , Kwang Ho Ko , Bak Kwang Kim
IPC分类号： C07D303/48 , C07D405/06 , C07D405/12 , C07D407/12 , C07D409/12 , A61K31/335 , A61K31/38 , C07D241/02 , C07D307/02 , C07D401/00
CPC分类号： C07D405/12 , C07D303/48 , C07D407/12 , C07D409/12
摘要： This invention relates to a novel oxirane carboxylic acid derivative and thereof manufacturing method. Based on thereof mechanism to inhibit the CPT I, oxirane carboxylic acid derivative of this invention has blood glucose lowering effects so that the derivative may be effectively used as an antidiabetic agent having remarkable antidiabetic activity and less side effects.
摘要翻译： PCT No.PCT / KR97 / 00132 Sec。 371日期1999年5月11日 102（e）1999年5月11日PCT 1997年7月2日PCT公布。出版物WO98 / 0042200 日本1998年1月8日本发明涉及一种新型的环氧乙烷羧酸衍生物及其制造方法。基于抑制CPT I的机制，本发明的环氧乙烷羧酸衍生物具有降血糖作用，使得该衍生物可有效用作具有显着抗糖尿病活性和较少副作用的抗糖尿病药。

8. 发明授权

US5654321A 2-chloro-3-arylamino-1,4-naphthoquinone derivatives, process for preparation thereof and use thereof as an agent for inhibiting platelet aggregation 失效
标题翻译： 2-氯-3-芳基氨基-1,4-萘醌衍生物，其制备方法及其作为抑制血小板凝聚剂的用途
公开(公告)号：US5654321A
公开(公告)日：1997-08-05
申请号：US593887
申请日：1996-01-30
申请人： Chang-Kiu Moon , Chung-Kyu Ryu
发明人： Chang-Kiu Moon , Chung-Kyu Ryu
IPC分类号： C07C255/58 , C07D213/74 , C07D213/02 , A61K31/44
CPC分类号： C07D213/74 , C07C255/58 , C07C2102/10
摘要： The present invention relates to a novel 2-chloro-3-arylamino-1,4-naphthoquinone derivative represented by the following formula (I), which has a potent inhibitory activity against platelet aggregation: ##STR1## in which X represents nitrogen (N) or carbon (C) atom andR represents cyano, orR can further represent alkyl, carboxyl or acyl when X represents nitrogen (N) atom,and to a process for preparing thereof and to a pharmaceutical composition for inhibiting blood coagulation which comprises the compound of formula (I) as an active ingredient.
摘要翻译：本发明涉及对下列式（I）表示的新颖的2-氯-3-芳基氨基-1,4-萘醌衍生物，其具有对血小板聚集的有效抑制活性：其中X表示氮（N）或碳（C）原子，R代表氰基，当X代表氮（N）原子时，R可进一步代表烷基，羧基或酰基，以及其制备方法和用于抑制血液凝固的药物组合物其包含式（I）化合物作为活性成分。

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