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1. 发明授权

US5654321A 2-chloro-3-arylamino-1,4-naphthoquinone derivatives, process for preparation thereof and use thereof as an agent for inhibiting platelet aggregation 失效
标题翻译： 2-氯-3-芳基氨基-1,4-萘醌衍生物，其制备方法及其作为抑制血小板凝聚剂的用途
公开(公告)号：US5654321A
公开(公告)日：1997-08-05
申请号：US593887
申请日：1996-01-30
申请人： Chang-Kiu Moon , Chung-Kyu Ryu
发明人： Chang-Kiu Moon , Chung-Kyu Ryu
IPC分类号： C07C255/58 , C07D213/74 , C07D213/02 , A61K31/44
CPC分类号： C07D213/74 , C07C255/58 , C07C2102/10
摘要： The present invention relates to a novel 2-chloro-3-arylamino-1,4-naphthoquinone derivative represented by the following formula (I), which has a potent inhibitory activity against platelet aggregation: ##STR1## in which X represents nitrogen (N) or carbon (C) atom andR represents cyano, orR can further represent alkyl, carboxyl or acyl when X represents nitrogen (N) atom,and to a process for preparing thereof and to a pharmaceutical composition for inhibiting blood coagulation which comprises the compound of formula (I) as an active ingredient.
摘要翻译：本发明涉及对下列式（I）表示的新颖的2-氯-3-芳基氨基-1,4-萘醌衍生物，其具有对血小板聚集的有效抑制活性：其中X表示氮（N）或碳（C）原子，R代表氰基，当X代表氮（N）原子时，R可进一步代表烷基，羧基或酰基，以及其制备方法和用于抑制血液凝固的药物组合物其包含式（I）化合物作为活性成分。

2. 发明授权

US4918099A Drug, preparation and use thereof 失效
标题翻译：药物，制剂及其用途
公开(公告)号：US4918099A
公开(公告)日：1990-04-17
申请号：US844325
申请日：1986-03-26
申请人： Chang-Kiu Moon
发明人： Chang-Kiu Moon
IPC分类号： A61K31/35 , A61K31/365 , A61K36/00 , A61K36/48 , C07D311/94 , C07D493/04
CPC分类号： C07D311/94 , A61K31/35 , A61K31/365 , A61K36/48 , Y10S514/822 , Y10S514/833 , Y10S514/866 , Y10S514/884
摘要： A novel drug comprises as active ingredient an extract extractable from plant material of plants belonging to the genus Caesalpinia, one or several components of this extract and/or one or several substances present in this extract or derived therefrom but prepared synthetically.These substances are in particular benz(b)indeno(2.1-d)pyran derivatives, including brazilin, brazilein, hematoxylin and/or hematein. The drug is especially suited for treatment of a patient suffering from micro-circulatory disorders, diabetes mellitus, increased blood sugar values, increasing blood platelet aggregation, increased blood viscosity, decreased eryhtrocyte deformability, disorders of the lysosomal enzyme activity and/or suffering from disorders of the prostaglandin metabolism, especially increasing thromboxane A.sub.2 activity.
摘要翻译：一种新药包含作为活性成分的可从属于凯撒刺属的植物的植物材料提取的提取物，该提取物的一种或多种组分和/或该提取物中存在的一种或多种物质，或由其衍生而来，但合成制备。这些物质特别是苯并（b）茚并（2.1-d）吡喃衍生物，包括巴西，巴西林，苏木精和/或hematein。该药物特别适用于治疗患有微循环障碍，糖尿病，血糖值升高，血小板聚集增加，血液粘度升高，红细胞变形能力降低，溶酶体酶活性紊乱和/或患有疾病的患者的前列腺素代谢，特别是增加血栓素A2活性。

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