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    • 4. 发明申请
    • PEPTIDES HAVING ANTI-CANCER AND ANTI-INFLAMMATORY ACTIVITY
    • 具有抗癌和抗炎活性的肽
    • WO0029009A9
    • 2001-12-13
    • PCT/US9927289
    • 1999-11-18
    • COASTSIDE BIO RESOURCESCOLLIN PETER DONALD
    • COLLIN PETER DONALD
    • A61K38/00C07K7/06A61K38/04C07K5/00C07K7/00C07K16/00C07K17/00
    • C07K7/06A61K38/00A61K2039/505
    • A pentapeptide is disclosed having the generic formula A-A-A-B-C, wherein A is a non-polar amino acid, B is a polar amino acid, and C is a charged amino acid. In a preferred embodiment the peptide has the sequence A-Pro-Pro-B-C, and in a further preferred embodiment has the sequence of leucine-proline-proline-serine-argenine. In a most preferred embodiment, the peptide comprises at least one D-amino acid. The peptide can be extracted from the epidermis of sea cucumbers. The peptides of the present invention are useful for inhibition of tumor progression and/or inflammation in a mammal by administration from 1 milligram per kilogram body weight to 5000 milligrams per kilogram body weight. The peptide can be administered in conjunction with any suitable carriers or excipients as are known those skilled in the arts via oral delivery forms, such as in capsules, drinks, powders, rectally via suppositories, or other suitable means.
    • 公开了具有通式A-A-A-B-C的五肽,其中A是非极性氨基酸,B是极性氨基酸,C是带电荷的氨基酸。 在优选的实施方案中,肽具有序列A-Pro-Pro-B-C,并且在另一个优选的实施方案中具有亮氨酸 - 脯氨酸 - 脯氨酸 - 丝氨酸 - 阿丁酸的序列。 在最优选的实施方案中,肽包含至少一个D-氨基酸。 该肽可以从海参的表皮中提取出来。 本发明的肽通过从每毫克体重1毫克施用至5000毫克/千克体重来抑制哺乳动物的肿瘤进展和/或炎症是有用的。 肽可以与本领域技术人员通过口服递送形式如胶囊,饮料,粉末,直肠栓剂或其它合适方法中已知的任何合适的载体或赋形剂一起施用。