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1. 发明申请

WO1991011908A1 METHOD FOR PREPARING AND DELIVERING FEED FOR ANIMALS, PARTICULARLY PIGLETS 审中-公开
标题翻译：用于动物饲料和饲料的方法，特别是饲料
公开(公告)号：WO1991011908A1
公开(公告)日：1991-08-22
申请号：PCT/FR1991000096
申请日：1991-02-08
申请人： SEDIA S.A.R.L. , COLAS, Pierre , GUILLOU, Michel , COROLLER, Yvon
发明人： SEDIA S.A.R.L.
IPC分类号： A01K05/02
CPC分类号： A01K5/0216
摘要： A method and an installation for preparing and delivering feedstuffs for animals, particularly piglets. The method involves (a) preparing in a mixer (20) a predetermined quantity of a mixture containing a dry feedstuff and a diluting liquid with a predetermined concentration of the dry feedstuff; (b) delivering along a single duct (37) to the trough (9a, 9b, 9c) of each of the pens a quantity of the mixture obtained in (a), at a single concentration, dependent on the final amount of feedstuff to be prepared for each trough (9); and finally (c) diluting the mixture delivered in (b), in each trough (9), with the diluting liquid in order to obtain the final quantity of feedstuff having a predetermined concentration for each trough. This dilution is carried out by delivering the diluting liquid along the same duct (37) as used in (b) to deliver the mixture prepared in (a).
摘要翻译：一种用于为动物，特别是仔猪制备和输送饲料的方法和装置。该方法包括（a）在混合器（20）中制备预定量的含有预定浓度的干饲料的干饲料和稀释液的混合物; （b）沿着单个管道（37）将单个管道（37）输送到每个笔的槽（9a，9b，9c），一批量的混合物以单一浓度取决于最终的饲料量，准备每个槽（9）; 最后（c）用稀释液稀释（b）中每个槽（9）中输送的混合物，以获得每个槽具有预定浓度的最终饲料量。通过沿（b）中使用的相同管道（37）递送稀释液体以递送（a）中制备的混合物来进行该稀释。

2. 发明申请

WO2007135565A3 ANTI-PROLIFERATIVE COMPOUNDS DERIVING FROM A 3-ARYL-COUMARINE OR 3-ARYL-QUINOLIN-2-ONE AND USES THEREOF 审中-公开
标题翻译：来自3-氨基 - 鸟嘌呤或3-亚氨基 - 喹啉-2-酮的抗增生化合物及其用途
公开(公告)号：WO2007135565A3
公开(公告)日：2008-04-03
申请号：PCT/IB2007002179
申请日：2007-05-22
申请人： APTANOMICS , SCHAPIRA MATTHIEU , LAMIGEON CYRILLE , GUTMANN MATHIEU , BARTHELAIX AUDREY , HUGO NICOLAS , COLAS PIERRE
发明人： SCHAPIRA MATTHIEU , LAMIGEON CYRILLE , GUTMANN MATHIEU , BARTHELAIX AUDREY , HUGO NICOLAS , COLAS PIERRE
IPC分类号： C07D309/38 , A61K31/352 , A61K31/4704 , C07D215/22 , C07D405/12 , C07D407/12
CPC分类号： C07D215/22 , C07D309/38 , C07D405/12 , C07D407/12
摘要： The present invention is directed to molecules deriving from a 3-aryl-coumarine or 3-aryl-quinolin- 2-one and having potent anti-proliferative and/ or cytotoxic activity, especially against tumoral cells. The present invention also concerns the uses of these molecules in therapeutic application, for the treatment of different cancers. The invention also discloses the use of said compound for the manufacture of a medicament for treating cancer. The invention also concerns a process for inhibiting cell proliferation comprising contacting said cells with a compound of the invention.
摘要翻译：本发明涉及衍生自3-芳基 - 香豆素或3-芳基 - 喹啉-2-酮的分子，并且具有有效的抗增殖和/或细胞毒活性，特别是抗肿瘤细胞。本发明还涉及这些分子在治疗应用中用于治疗不同癌症的用途。本发明还公开了所述化合物在制备用于治疗癌症的药物中的用途。本发明还涉及抑制细胞增殖的方法，包括使所述细胞与本发明的化合物接触。

3. 发明申请

WO2007135565A2 ANTI-PROLIFERATIVE COMPOUNDS DERIVING FROM A 3-ARYL-COUMARINE OR 3-ARYL-QUINOLIN-2-ONE AND USES THEREOF 审中-公开
标题翻译：来自3-氨基 - 鸟嘌呤或3-亚氨基 - 喹啉-2-酮的抗增生化合物及其用途
公开(公告)号：WO2007135565A2
公开(公告)日：2007-11-29
申请号：PCT/IB2007/002179
申请日：2007-05-22
申请人： APTANOMICS , SCHAPIRA, Matthieu , LAMIGEON, Cyrille , GUTMANN, Mathieu , BARTHELAIX, Audrey , HUGO, Nicolas , COLAS, Pierre
发明人： SCHAPIRA, Matthieu , LAMIGEON, Cyrille , GUTMANN, Mathieu , BARTHELAIX, Audrey , HUGO, Nicolas , COLAS, Pierre
IPC分类号： C07D309/38 , C07D215/22 , C07D405/12 , C07D407/12 , A61K31/4704 , A61K31/352
CPC分类号： C07D215/22 , C07D309/38 , C07D405/12 , C07D407/12
摘要： The present invention is directed to molecules deriving from a 3-aryl-coumarine or 3-aryl-quinolin- 2-one and having potent anti-proliferative and/ or cytotoxic activity, especially against tumoral cells. The present invention also concerns the uses of these molecules in therapeutic application, for the treatment of different cancers. The invention also discloses the use of said compound for the manufacture of a medicament for treating cancer. The invention also concerns a process for inhibiting cell proliferation comprising contacting said cells with a compound of the invention.
摘要翻译：本发明涉及衍生自3-芳基 - 香豆素或3-芳基 - 喹啉-2-酮的分子，并且具有有效的抗增殖和/或细胞毒活性，特别是抗肿瘤细胞。本发明还涉及这些分子在治疗应用中用于治疗不同癌症的用途。本发明还公开了所述化合物在制备用于治疗癌症的药物中的用途。本发明还涉及抑制细胞增殖的方法，包括使所述细胞与本发明的化合物接触。

4. 发明申请

WO2003022298A3 UTILISATION D'UNE PROTEINE DE LA FAMILLE DES CRMPS POUR LE TRAITEMENT DES MALADIES LIEES AU SYSTEME IMMUNITAIRE 审中-公开
公开(公告)号：WO2003022298A3
公开(公告)日：2003-03-20
申请号：PCT/FR2002/003056
申请日：2002-09-09
申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , GIRAUDON, Pascale , BELIN, Marie-Françoise , MALCUS, Christophe , COLAS, Pierre , ANTOINE, Jean-Christophe , HONNORAT, Jérôme
发明人： GIRAUDON, Pascale , BELIN, Marie-Françoise , MALCUS, Christophe , COLAS, Pierre , ANTOINE, Jean-Christophe , HONNORAT, Jérôme
IPC分类号： A61K38/17
摘要： La présente invention concerne l'utilisation d'au moins une protéine de la famille CRMPs, fragment polypeptidique ou dérivé biologiquement actif de celle-ci, d'une séquence ou fragment de séquence nucléotidique codant pour ladite protéine, d'une séquence anti-sens capable de s'hybrider spécifiquement avec une séquence nucléotidiquement codant pour ladite protéine ou un anticorps dirigé contre ladite protéine pour la fabrication d'un médicament destiné à traiter les maladies liées à un dysfonctionnement du système immunitaire.Elle vise également une méthode de diagnostic d'une pathologie auto-immune consistant à mesurer l'expression d'une protéine CRMP dans les lymphocytes.

5. 发明申请

WO2003022298A2 UTILISATION D'UNE PROTEINE DE LA FAMILLE DES CRMPS POUR LE TRAITEMENT DES MALADIES LIEES AU SYSTEME IMMUNITAIRE 审中-公开
标题翻译：用于治疗与免疫系统相关的疾病的CRMP家族的蛋白质的使用
公开(公告)号：WO2003022298A2
公开(公告)日：2003-03-20
申请号：PCT/FR2002/003056
申请日：2002-09-09
申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , GIRAUDON, Pascale , BELIN, Marie-Françoise , MALCUS, Christophe , COLAS, Pierre , ANTOINE, Jean-Christophe , HONNORAT, Jérôme
发明人： GIRAUDON, Pascale , BELIN, Marie-Françoise , MALCUS, Christophe , COLAS, Pierre , ANTOINE, Jean-Christophe , HONNORAT, Jérôme
IPC分类号： A61K38/17
CPC分类号： C07K14/47 , C12N1/00
摘要： La présente invention concerne l'utilisation d'au moins une protéine de la famille CRMPs, fragment polypeptidique ou dérivé biologiquement actif de celle-ci, d'une séquence ou fragment de séquence nucléotidique codant pour ladite protéine, d'une séquence anti-sens capable de s'hybrider spécifiquement avec une séquence nucléotidiquement codant pour ladite protéine ou un anticorps dirigé contre ladite protéine pour la fabrication d'un médicament destiné à traiter les maladies liées à un dysfonctionnement du système immunitaire.Elle vise également une méthode de diagnostic d'une pathologie auto-immune consistant à mesurer l'expression d'une protéine CRMP dans les lymphocytes.
摘要翻译：本发明涉及使用至少一种CRMP家族的蛋白质，多肽片段或其活性生物衍生物，编码所述蛋白质的核苷酸序列或序列片段，能够与具有核苷酸序列的序列特异性杂交的反义序列，所述蛋白质的类型编码或针对所述蛋白质的抗体，用于产生用于治疗与免疫系统的功能障碍有关的疾病的药物。本发明还涉及诊断自身免疫病理学的方法，其包括测量淋巴细胞中CRMP蛋白的表达。

6. 发明申请

WO2009043942A1 NEW POLYPEPTIDES AND USES THEREOF IN CANCER THERAPY 审中-公开
标题翻译：新的多肽及其在癌症治疗中的应用
公开(公告)号：WO2009043942A1
公开(公告)日：2009-04-09
申请号：PCT/EP2008/063359
申请日：2008-10-06
申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , APTANOMICS , GARRIDO, Carmen , COLAS, Pierre , BICKLE, Marc , SCHMITT, Elise , REROLE, Anne-Laure
发明人： GARRIDO, Carmen , COLAS, Pierre , BICKLE, Marc , SCHMITT, Elise , REROLE, Anne-Laure
IPC分类号： C07K7/08 , C12N15/10
CPC分类号： C07K7/06 , A61K38/00 , C07K7/08
摘要： The present invention concerns a polypeptide comprising (i) an amino acid sequence from less than 15 amino acids in length, which has the ability to bind to the ATPase domain of HSP70, wherein said amino acid sequence is selected in the group comprising SEQ ID NO: 9, SEQ ID NO: 18 and SEQ ID NO: 19, and derivatives thereof; a nucleic acid coding therefore; a vector comprising said nucleic acid sequence; a host cell genetically engineered with said nucleic 4 or with said vector; a pharmaceutical composition comprising said polypeptide, said nucleic acid, or said nucleic acid vector; use of said polypeptide, said nucleic acid sequence, said vector, or said composition for treating cancer in a subject; a method for screening candidate compounds capable of modulating the intracellular interaction between HSP70 and said polypeptide; and a method for detecting HSP70 in a biological sample.
摘要翻译：本发明涉及一种多肽，其包含（i）长度小于15个氨基酸的氨基酸序列，其具有结合HSP70的ATP酶结构域的能力，其中所述氨基酸序列选自SEQ ID NO ：9，SEQ ID NO：18和SEQ ID NO：19及其衍生物; 因此编码核酸; 包含所述核酸序列的载体; 用所述核酸4或与所述载体进行遗传工程改造的宿主细胞; 包含所述多肽，所述核酸或所述核酸载体的药物组合物; 使用所述多肽，所述核酸序列，所述载体或所述组合物治疗受试者的癌症; 用于筛选能够调节HSP70与所述多肽之间的细胞内相互作用的候选化合物的方法; 以及用于检测生物样品中HSP70的方法。

7. 发明申请

WO1996025352A1 TREE-STRUCTURE LIVESTOCK FEED-CONVEYING SYSTEM AND VALVE, AND METHOD FOR CONTROLLING SAME 审中-公开
标题翻译：树结构饲料输送系统和阀门及其控制方法
公开(公告)号：WO1996025352A1
公开(公告)日：1996-08-22
申请号：PCT/FR1996000242
申请日：1996-02-14
申请人： SEDIA , COLAS, Pierre , GUILLOU, Michel
发明人： SEDIA
IPC分类号： B65G53/56
CPC分类号： B65G53/56
摘要： A design for multichannel systems for conveying a product by means of a carrier fluid is described, as well as means used in such systems, particularly switching valves for said product. The object of the invention is to provide a type of valve that is compatible with a tree-structure distribution system while minimising the likelihood of degradation of the conveyed product and reducing the manufacturing and maintenance costs of said system. The switching valve of the invention is of a type that has an inlet side comprising an inlet (51), and an outlet side comprising at least two outlets (52-54), said valve including a plug (47) moveable in a valve body (40) and capable of adopting at least as many positions as there are valve outlets. The valve plug (47) has a through bore (44) for selectively connecting the inlet with the outlet corresponding to the current position of the plug (47), wherein the valve is characterized in that the inlet of the bore extending through the plug is provided with means for attaching an upstream pipe (51) and in that said inlet side of the valve has an elongated passage (43) extending through the valve body and providing a clearance area for the displacement of the end of the upstream pipe (51) during changes in valve position. The invention has application chiefly, but not exclusively, to granulated feed distribution systems in fish breeding farms.
摘要翻译：描述了用于通过载体流体输送产品的多通道系统的设计，以及在这种系统中使用的装置，特别是用于所述产品的切换阀。本发明的目的是提供一种与树形结构分配系统兼容的类型的阀，同时最小化所传送的产品的劣化的可能性并降低所述系统的制造和维护成本。本发明的切换阀是具有入口侧的类型，其具有入口（51），出口侧包括至少两个出口（52-54），所述阀包括可在阀体中移动的塞子（47）（40），并且能够采用与阀出口至少相同的位置。阀塞（47）具有通孔（44），用于选择性地将入口与出口相对应地连接到插塞（47）的当前位置，其中阀的特征在于延伸穿过插塞的孔的入口是设置有用于附接上游管道（51）的装置，并且所述阀的所述入口侧具有延伸穿过所述阀体的细长通道（43），并且为所述上游管道（51）的端部的位移提供间隙区域，在阀位变化时。本发明主要应用于但不限于鱼类饲养场中的颗粒饲料分配系统。

8. 发明申请

WO2008064907A1 POLYPEPTIDES HAVING MODULATORY EFFECTS ON CELLS 审中-公开
标题翻译：具有细胞调节作用的多聚体
公开(公告)号：WO2008064907A1
公开(公告)日：2008-06-05
申请号：PCT/EP2007/010422
申请日：2007-11-30
申请人： ECOLE NORMALE SUPERIEURE DE LYON , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , APTANOMICS , COLAS, Pierre , DE CHASSEY, Benoît , MIKAELIAN, Ivan, Jacques , RUDKIN, Brian, B.
发明人： COLAS, Pierre , DE CHASSEY, Benoît , MIKAELIAN, Ivan, Jacques , RUDKIN, Brian, B.
IPC分类号： A61K38/00 , C07K7/00
CPC分类号： C12N9/0036 , A61K38/00 , C07K7/08 , C07K2319/00 , C12N9/16
摘要： The present invention relates to peptides and polypeptides having the sequence SAVTFAVCAL or variants thereof, capable of binding to Calcineurin and/or to NS5A-TP2 and to their use in therapy, as well as to nucleic acid sequences and vectors encoding these peptides and polypeptides, and to cells comprising said polypeptides, nucleic acid sequences or vectors. The invention further relates to the use of the peptides, polypeptides or their derivatives to bring about phenotypic changes in mammalian cells, particularly to up-regulate calcineurin activity. The invention finally relates to a method for intracellular identification of substances which bind to calcineurin and which modulate the physiological effects of calcineurin.
摘要翻译：本发明涉及能够结合钙调神经磷酸酶和/或NS5A-TP2的序列SAVTFAVCAL或其变体的肽和多肽及其在治疗中的用途，以及编码这些肽和多肽的核酸序列和载体，以及包含所述多肽，核酸序列或载体的细胞。本发明还涉及肽，多肽或其衍生物在哺乳动物细胞中引起表型变化的用途，特别是上调钙调神经磷酸酶活性。本发明最终涉及一种细胞内鉴定与钙调神经磷酸酶结合并调节钙调神经磷酸酶的生理作用的物质的方法。

9. 发明申请

WO2005095645A1 SEQUENTIAL INTRACELLULAR SCREENING METHOD 审中-公开
标题翻译：序贯细胞筛选方法
公开(公告)号：WO2005095645A1
公开(公告)日：2005-10-13
申请号：PCT/EP2005/003989
申请日：2005-04-01
申请人： APTANOMICS , BICKLE, Marc , BORIE, Christophe , COLAS, Pierre
发明人： BICKLE, Marc , BORIE, Christophe , COLAS, Pierre
IPC分类号： C12Q1/68
CPC分类号： G01N33/56961 , C12N15/1055 , C12Q1/6897 , G01N2500/02 , C12Q2565/201
摘要： The present invention relates to an intracellular screening method for detecting exogenous candidate compounds C capable of modulating the intracellular interaction between two peptidic binding partners A and B, or of creating such an interaction, said intracellular interaction being responsible for a given specific phenotype, wherein in a first step, the candidate compound C is allowed to contact the binding partner A, inside a cell, in the absence of the partner B, in a second step, the partner B is then made availave for binding to partner A, and in a third step, the phenotype of said cell is detected. The invention also relates to an Intracellular screening method for detecting exogenous candidate compounds C capable of modulating the intracellular interaction between two peptidic binding partners A and B and being incapable of modulating the interaction between peptidic binding partners A' and B', said intracellular interactions being responsible for given specific cellular phenotypes, wherein said method is also based on the sequential exposure of the candidate compound to each one of the binding partners.
摘要翻译：本发明涉及用于检测能够调节两个肽结合配偶体A和B之间的细胞内相互作用或产生这种相互作用的外源性候选化合物C的细胞内筛选方法，所述细胞内相互作用负责给定的特定表型，其中在在第二步骤中，允许候选化合物C在不存在伴侣B的情况下与细胞内的结合配偶体A接触，然后使伴侣B可用于绑定到伴侣A，并且在第三步，检测所述细胞的表型。本发明还涉及用于检测能够调节两个肽结合配偶体A和B之间的细胞内相互作用并且不能调节肽结合配偶体A'和B'之间的相互作用的外源性候选化合物C的细胞内筛选方法，所述细胞内相互作用是负责给定的特定细胞表型，其中所述方法还基于候选化合物对每个结合伴侣的顺序暴露。

10. 发明申请

WO02055108A9 TARGETED MODIFICATION OF INTRACELLULAR COMPOUNDS 审中-公开
标题翻译：细胞内化合物的目标修饰
公开(公告)号：WO02055108A9
公开(公告)日：2003-05-15
申请号：PCT/EP0114199
申请日：2001-11-13
申请人： CENTRE NAT RECH SCIENT , MASSACHUSETTS GEN HOSPITAL , MOLECULAR SCIENCES INST , COLAS PIERRE , BRENT ROGER , COHEN BARAK A
发明人： COLAS PIERRE , BRENT ROGER , COHEN BARAK A
IPC分类号： G01N33/50 , A61K31/7052 , A61K38/00 , A61K47/48 , A61K48/00 , A61P1/02 , A61P3/00 , A61P9/10 , A61P17/00 , A61P21/00 , A61P25/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P35/00 , A61P37/02 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , G01N33/15
CPC分类号： A61K47/6425
摘要： Process for specifically modulating the properties of an intracellular target molecule T, and/or of a cellular component C which interacts directly or indirectly in a cell with T, said process comprising: introducing into a cell a chimeric molecule, a so-called "targeted effector", comprising: a recognition moiety R, comprising a peptide V having a length of five to sixty amino acids, preferably ten to forty amino acids, conformationally constrained by covalent linking to a platform, said recognition moiety R having the capacity to specifically interact, within the cell, with a site on an intracellular target molecule T, the interaction with T occurring with an affinity A>1 2 1 2 d M, and the properties of T and/or of C are specifically modulated by the effector moiety E.
摘要翻译：用于特异性调节细胞内靶分子T和/或细胞组分C的性质的方法，所述细胞组分C与细胞与T直接或间接相互作用，所述方法包括：向细胞中引入嵌合分子，即所谓的“靶向效应物“，包括：识别部分R，其包含长度为五至六十个氨基酸，优选十至四十个氨基酸的肽V，其通过与平台共价连接而构象约束，所述识别部分R具有特异性相互作用的能力在细胞内具有细胞内靶分子T上的位点，与T发生亲和力A> 1的相互作用。和与所述识别部分R共价连接的效应子部分，E是分子或其部分，其具有对至少一个分子M产生作用的初始能力，并且当其与R共价连接时，获得对细胞内靶分子T发挥作用的能力; 其中靶向效应物与T的相互作用具有第二亲和力A> 2 <，亲和力A> 1或亲和力A> 2 d <小于1×10 -8 -8 M， T和/或C的特性由效应部分E特异性调节。

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