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1. 发明申请

WO2007089541A2 FLUIDIC DROPLET COALESCENCE 审中-公开
标题翻译：流体滴灌技术
公开(公告)号：WO2007089541A2
公开(公告)日：2007-08-09
申请号：PCT/US2007/002063
申请日：2007-01-24
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , AHN, Keunho , CHONG, Henry , AGRESTI, Jeremy , WEITZ, David, A. , LINK, Darren, Roy
发明人： AHN, Keunho , CHONG, Henry , AGRESTI, Jeremy , WEITZ, David, A. , LINK, Darren, Roy
IPC分类号： B01F13/00 , B01J19/00
CPC分类号： B01F13/0071 , B01F13/0076 , B01J19/0093 , B01J2219/00272 , B01J2219/00828 , B01J2219/00833 , B01J2219/00835 , B01J2219/00853 , B01J2219/00889 , B01J2219/0093 , B01L3/5027 , B01L3/502784 , B01L2200/0673 , B01L2300/0867 , B01L2400/0415 , B01L2400/0487 , G01N15/1404 , G01N2015/1006
摘要： The present invention generally relates to systems and methods for the control of fluidic species and, in particular, to the coalescence of fluidic droplets. In certain instances, the systems and methods are microfluidic. In one aspect, the invention relates to systems and methods for causing two or more fluidic droplets within a channel to coalescence. The fluidic droplets may be of unequal size in certain cases. In some embodiments, a first fluidic droplet may be caused to move at a first velocity, and a second fluidic droplet may be caused to move at a second velocity different from the first velocity, for instance, substantially greater than the first velocity. The droplets may then coalesce, for example, upon application of an electric field. In the absence of an electric field, in some cases, the droplets may be unable to coalesce. In some cases, two series of fluidic droplets may coalesce, one or both series being substantially uniform. For instance, one series of droplets may have a distribution of diameters such that no more than about 5% of the droplets have a diameter greater than about 10% of the average diameter. In certain cases, one or more series of droplets may each consist essentially of a substantially uniform number of entities of a species therein (i.e., molecules, cells, particles, etc.). The fluidic droplets may be coalesced to start a reaction, and/or to stop a reaction, in some cases. For instance, a reaction may be initiated when a species in a first droplet contacts a species in a second droplet after the droplets coalesce, or a first droplet may contain an ongoing reaction and a second droplet may contain a species that inhibits the reaction. Other embodiments of the invention are directed to kits or methods for promoting the coalescence of fluidic droplets.
摘要翻译：本发明一般涉及用于控制流体物种的系统和方法，尤其涉及流体液滴聚结的系统和方法。在某些情况下，系统和方法是微流体。一方面，本发明涉及用于使通道内的两个或多个流体液滴聚结的系统和方法。在某些情况下，流体液滴的尺寸可能不相等。在一些实施例中，可以使第一流体液滴以第一速度移动，并且可以使第二流体液滴以不同于第一速度的第二速度移动，例如基本上大于第一速度。例如，当施加电场时，液滴可以聚结。在没有电场的情况下，在一些情况下，液滴可能不能聚结。在一些情况下，两系列流体液滴可以聚结，一个或两个串联基本均匀。例如，一系列液滴可以具有直径分布，使得不超过约5％的液滴具有大于平均直径的约10％的直径。在某些情况下，一个或多个液滴系列可以各自基本上由其中的物质的实质上数量相同的实体组成（即，分子，细胞，颗粒等）。在某些情况下，流体液滴可以聚结开始反应和/或停止反应。例如，当液滴聚结之后，当第一液滴中的物质接触第二液滴中的物质时，或者第一液滴可以含有正在进行的反应，并且第二液滴可以含有抑制反应的物质时，可以开始反应。本发明的其它实施方案涉及用于促进流体液滴聚结的试剂盒或方法。

2. 发明申请

WO2018005665A1 APPARATUSES, METHODS AND SYSTEMS FOR RELEVANCE SCORING IN A GRAPH DATABASE USING MULTIPLE PATHWAYS 审中-公开
标题翻译：使用多路径在图形数据库中进行相关评分的设备，方法和系统
公开(公告)号：WO2018005665A1
公开(公告)日：2018-01-04
申请号：PCT/US2017/039792
申请日：2017-06-28
申请人： THOMSON REUTERS GLOBAL RESOURCES UNLIMITED COMPANY , MULDER, Andrew T. , ROTHERMICH, Joseph, A. , CHONG, Henry
发明人： MULDER, Andrew T. , ROTHERMICH, Joseph, A. , CHONG, Henry
IPC分类号： G06F17/30
摘要： In accordance with one aspect, the present disclosure is directed to quantifying the relevance between two entities in a graph database. One way of doing this is determining the number of pathways and the length of the pathways within the graph database that connect the two entities, wherein each entity is represented as a node. In some implementations, the present disclosure identifies and quantifies the connection between a news document (e.g., a news article) and a company or other entity. For example, the connection between an online news article and a company's underlying equity instrument can be evaluated.
摘要翻译：根据一个方面，本公开涉及量化图形数据库中的两个实体之间的相关性。这样做的一种方式是确定连接两个实体的图形数据库内的路径数量和路径长度，其中每个实体都表示为一个节点。在一些实现中，本公开识别和量化新闻文档（例如新闻文章）与公司或其他实体之间的连接。例如，可以评估在线新闻文章与公司的基础权益工具之间的关系。

3. 发明申请

WO2007089541A3 FLUIDIC DROPLET COALESCENCE 审中-公开
标题翻译：流体滴灌技术
公开(公告)号：WO2007089541A3
公开(公告)日：2007-11-15
申请号：PCT/US2007002063
申请日：2007-01-24
申请人： HARVARD COLLEGE , AHN KEUNHO , CHONG HENRY , AGRESTI JEREMY , WEITZ DAVID A , LINK DARREN ROY
发明人： AHN KEUNHO , CHONG HENRY , AGRESTI JEREMY , WEITZ DAVID A , LINK DARREN ROY
IPC分类号： B01F13/00 , B01J19/00
CPC分类号： B01F13/0071 , B01F13/0076 , B01J19/0093 , B01J2219/00272 , B01J2219/00828 , B01J2219/00833 , B01J2219/00835 , B01J2219/00853 , B01J2219/00889 , B01J2219/0093 , B01L3/5027 , B01L3/502784 , B01L2200/0673 , B01L2300/0867 , B01L2400/0415 , B01L2400/0487
摘要： The present invention generally relates to methods for the control of fluidic species and, in particular, to the coalescence of fluidic droplets. In certain instances, the methods are microf luidic. In one aspect, the invention relates to methods for causing two or more fluidic droplets within a channel to coalescence. The fluidic droplets may be of unequal size in certain cases. In some embodiments, a first fluidic droplet (21) may be caused to move at a first velocity, and a second fluidic droplet (22) may be caused to move at a second velocity different from the first velocity, for instance, substantially greater than the first velocity. The droplets may then coalesce, for example, upon application of an electric field. In the absence of an electric field, in some cases, the droplets may be unable to coalesce. In some cases, two series of fluidic droplets may coalesce, one or both series being substantially uniform. For instance, one series of droplets may have a distribution of diameters such that no more than about 5% of the droplets have a diameter greater than about 10% of the average diameter. In certain cases, one or more series of droplets may each consist essentially of a substantially uniform number of entities of a species therein (i.e., molecules, cells, particles, etc.). The fluidic droplets may be coalesced to start a reaction, and/or to stop a reaction, in some cases. For instance, a reaction may be initiated when a species in a first droplet contacts a species in a second droplet after the droplets coalesce, or a first droplet may contain an ongoing reaction and a second droplet may contain a species that inhibits the reaction.
摘要翻译：本发明一般涉及用于控制流体物种的方法，尤其涉及流体液滴聚结的方法。在某些情况下，该方法是微流感。一方面，本发明涉及使通道内的两个或多个流体液滴聚结的方法。在某些情况下，流体液滴的尺寸可能不相等。在一些实施例中，可以使第一流体液滴（21）以第一速度移动，并且可以使第二流体液滴（22）以不同于第一速度的第二速度移动，例如基本上大于第一速度。例如，当施加电场时，液滴可以聚结。在没有电场的情况下，在一些情况下，液滴可能不能聚结。在一些情况下，两系列流体液滴可以聚结，一个或两个串联基本均匀。例如，一系列液滴可以具有直径分布，使得不超过约5％的液滴具有大于平均直径的约10％的直径。在某些情况下，一个或多个液滴系列可以各自基本上由基本上一致数量的物质实体（即分子，细胞，颗粒等）组成。在某些情况下，流体液滴可能被聚结起始反应，和/或停止反应。例如，当液滴聚结之后，当第一液滴中的物质接触第二液滴中的物质时，或者第一液滴可能含有正在进行的反应，并且第二液滴可以含有抑制反应的物质时，反应可以开始。

4. 发明专利

CA3134490A1 SAFETY DEVICE FOR HANDLEBAR OF ROLLING TRANSPORTATION SYSTEM 未知
公开(公告)号：CA3134490A1
公开(公告)日：2022-04-16
申请号：CA3134490
申请日：2021-10-15
申请人： CHONG HENRY
发明人： CHONG HENRY
IPC分类号： B62K21/12 , B62J27/00 , B62K21/02 , B62K21/16
摘要： A safety device is configured to prevent inadvertent rotation of a steering device (handlebar) relative to (a frame 00 a bicycle.

5. 发明专利

CA2736644A1 LIFE BIKE E-BIKE (LIFE = LIGHTWEIGHT, INTELLIGENT, FLEXIBLE, ELECTRIC) 未知
公开(公告)号：CA2736644A1
公开(公告)日：2012-10-04
申请号：CA2736644
申请日：2011-04-04
申请人： CHONG HENRY
发明人： CHONG HENRY
IPC分类号： B62M6/40

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