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1. 发明申请

WO2006053588A1 SUPPLY ARRANGEMENT WITH SUPPLY RESERVOIR ELEMENT AND FLUIDIC DEVICE 审中-公开
标题翻译：供应储备元件和流体装置的供应安排
公开(公告)号：WO2006053588A1
公开(公告)日：2006-05-26
申请号：PCT/EP2004/052985
申请日：2004-11-17
申请人： AGILENT TECHNOLOGIES, INC. , PRECKEL, Tobias , ZIMMERMANN, Hans-Peter , CHOIKHET, Konstantin
发明人： PRECKEL, Tobias , ZIMMERMANN, Hans-Peter , CHOIKHET, Konstantin
IPC分类号： B01L3/00 , B01F15/02 , B01F11/00
CPC分类号： B01L3/502715 , B01F5/0683 , B01F5/0689 , B01F11/0045 , B01F11/0071 , B01F15/0205 , B01F15/0212 , B01L3/502738 , B01L3/505 , B01L2200/0642 , B01L2400/0481 , B01L2400/0638
摘要： A supply arrangement is provided, comprising a supply reservoir element (1) having a reservoir unit being prefilled with liquid reagents, and a fluidic device (2) which comprises a reception device to receive the liquid reagents from the reservoir unit. Both of which are permanently coupled in the arrangement or in a supply kit (15,15'), which holds the supply arrangement within a holding fixture (10). The reception device or the reservoir unit comprise a puncturing element (5,5') inside the supply arrangement to cause a fluid flow from the reservoir unit to the reception device. Furthermore, methods are provided to supply fluidic devices by use of the supply arrangement or supply kits (15,15').
摘要翻译：提供了一种供应装置，其包括具有预充满液体试剂的储存器单元的供应储存器元件（1）和包括从储存器单元接收液体试剂的接收装置的流体装置（2）。这两者都在该装置中永久耦合，或者在供给装置（15,15'）中，其将供给装置保持在保持夹具（10）内。接收装置或贮存器单元包括在供应装置内部的穿刺元件（5,5'），以使流体从贮存器单元流到接收装置。此外，提供了通过使用供应装置或供应工具包（15,15'）来供应流体装置的方法。

2. 发明申请

WO2013083187A1 CALIBRATION PROCEDURE FOR FLUIDIC SENSORS 审中-公开
标题翻译：流体传感器校准程序
公开(公告)号：WO2013083187A1
公开(公告)日：2013-06-13
申请号：PCT/EP2011/071970
申请日：2011-12-06
申请人： AGILENT TECHNOLOGIES, INC. , EFFELSBERG, Uwe , BEK, Fritz , CHOIKHET, Konstantin
发明人： EFFELSBERG, Uwe , BEK, Fritz , CHOIKHET, Konstantin
IPC分类号： G01F25/00 , G01N30/28
CPC分类号： G01F25/0015 , G01F25/0007 , G01N30/32 , G01N30/34 , G01N2030/324
摘要： A method of calibrating at least one flow sensor (82, 84, 86) of a fluid handling system (10) for handling a fluid, wherein the method comprises conducting a fluid through a fluidic conduit (88), being in fluid communication with the at least one flow sensor (82, 84, 86), in accordance with a predefined fluid conduction protocol, and determining calibration data for calibrating the at least one flow sensor (82, 84, 86) based on an analysis of a course of flow sensor data (606) measured by the at least one flow sensor (82, 84, 86) when applying the predefined fluid conduction protocol.
摘要翻译：校准用于处理流体的流体处理系统（10）的至少一个流量传感器（82,84,86）的方法，其中所述方法包括通过流体导管（88）导入流体，所述流体导管与所述流体传感器至少一个流量传感器（82,84,86），根据预定的流体传导协议，以及基于流程的分析确定用于校准所述至少一个流量传感器（82,84,86）的校准数据当应用所述预定义的流体传导协议时由所述至少一个流量传感器（82,84,86）测量的传感器数据（606）。

3. 发明申请

WO2014000778A1 FLUIDIC VALVE WITH SELECTIVELY SWITCHABLE STORAGE PATHS 审中-公开
标题翻译：具有选择性切换储物阀的流体阀
公开(公告)号：WO2014000778A1
公开(公告)日：2014-01-03
申请号：PCT/EP2012/062394
申请日：2012-06-26
申请人： AGILENT TECHNOLOGIES, INC. , WITT, Klaus , CHOIKHET, Konstantin
发明人： WITT, Klaus , CHOIKHET, Konstantin
IPC分类号： G01N30/20 , B01D15/18 , G01N30/46
CPC分类号： G01N30/80 , B01D15/1871 , G01N27/447 , G01N30/06 , G01N30/20 , G01N30/461 , G01N30/6039 , G01N2030/208
摘要： A sample separation apparatus (100, 200) for separating a fluidic sample (104), the sample separation apparatus (100, 200) comprising: a first separation unit (102) for separating the fluidic sample (104); a first fluid drive (106) configured for generating a fluid flow for conducting the fluidic sample (104) to be separated through the first separation unit (102); a second separation unit (110), arranged downstream of the first separation unit (102), for further separating the fluidic sample (104) after treatment by the first separation unit (102); a second fluid drive (112) configured for generating a fluid flow for conducting the fluidic sample (104) or at least parts thereof, after treatment by the first separation unit (102), through the second separation unit (110); a fluidic valve (114) having a first inlet (116) fluidically coupled to one of the first fluid drive (106) and the second fluid drive (112); the fluidic valve (114) having a second inlet (118) fluidically coupled to the other of the first fluid drive (106) and the second fluid drive (112); the fluidic valve (114) comprising at least two different sets (131, 133) of storage paths, wherein each set of storage paths comprises a first storage path (128); and wherein the first storage path (128) of a first set (131) of said at least two sets of storage paths has a first volume and the first storage path (132) of a second set (133) of said at least two sets of storage paths has a second volume different from the first volume; the fluidic valve (114) being configured for selectively switching one set of said least two sets of storage paths to the first inlet (116) and the second inlet (118).
摘要翻译： 1.一种用于分离流体样品（104）的样品分离装置（100,200），所述样品分离装置（100,200）包括：用于分离流体样品（104）的第一分离单元（102）第一流体驱动器（106），其被配置用于产生用于传导待通过所述第一分离单元（102）分离的所述流体样品（104）的流体流; 布置在第一分离单元（102）的下游的第二分离单元（110），用于在通过第一分离单元（102）处理之后进一步分离流体样品（104）; 第二流体驱动器（112），被配置为在通过第一分离单元（102）处理之后通过第二分离单元（110）产生用于传导流体样品（104）或其至少部分的流体流; 流体阀（114）具有流体耦合到第一流体驱动器（106）和第二流体驱动器（112）之一的第一入口（116）; 流体阀（114）具有与第一流体驱动器（106）和第二流体驱动器（112）中的另一个流体连接的第二入口（118）。所述流体阀（114）包括至少两个不同的存储路径组（131,133），其中每组存储路径包括第一存储路径（128）; 并且其中所述至少两组存储路径中的第一组（131）的第一存储路径（128）具有第一卷，并且所述至少两个集合的第二集合（133）的第一存储路径（132）的存储路径具有与第一卷不同的第二卷; 所述流体阀（114）构造成用于选择性地将一组所述至少两组存储路径切换到所述第一入口（116）和所述第二入口（118）。

4. 发明申请

WO2010124741A1 DETERMINING FLUID COMPRESSIBILITY WHILE DELIVERING FLUID 审中-公开
标题翻译：确定流体中流体的可压缩性
公开(公告)号：WO2010124741A1
公开(公告)日：2010-11-04
申请号：PCT/EP2009/055306
申请日：2009-04-30
申请人： AGILENT TECHNOLOGIES, INC. , CHOIKHET, Konstantin , HERZOG, Philip , WITT, Klaus
发明人： CHOIKHET, Konstantin , HERZOG, Philip , WITT, Klaus
IPC分类号： F04B11/00 , F04B49/12 , F16F15/023 , F16F15/027 , G01L7/16 , G01N11/00 , G01N19/00 , G01N30/34 , G01N30/32
CPC分类号： G01N30/34 , F04B11/0075 , G01N2030/326
摘要： A method for determining compressibility of a fluid is described. The method comprises starting at a first value of pressure and compressing a first volume of the fluid to a first compressed volume at a second value of pressure, starting at the first value of pressure and compressing a second volume of the fluid to a second compressed volume at the second value of pressure, determining a first volumetric difference corresponding to a difference between the second volume and the first volume, determining a second volumetric difference corresponding to a difference between the second compressed volume and the first compressed volume, and determining a value of compressibility of the fluid from a ratio derived from the second volumetric difference and the first volumetric difference.
摘要翻译：描述了一种用于确定流体的可压缩性的方法。该方法包括以第一压力值开始，并以第一压力值从第一压力值将第一体积的流体压缩至第一压缩体积，并将第二体积的流体压缩至第二压缩体积在所述第二压力值下，确定对应于所述第二容积和所述第一容积之间的差的第一体积差，确定对应于所述第二压缩体积和所述第一压缩体积之间的差的第二体积差，以及确定来自第二体积差和第一体积差的比率的流体的压缩性。

5. 发明申请

WO2009121410A1 FLUIDIC DEVICE WITH PLANAR COUPLING MEMBER 审中-公开
标题翻译：具有平面耦合构件的流体装置
公开(公告)号：WO2009121410A1
公开(公告)日：2009-10-08
申请号：PCT/EP2008/053985
申请日：2008-04-03
申请人： AGILENT TECHNOLOGIES, INC. , BAEUERLE, Martin , MUELLER, Jochen , CHOIKHET, Konstantin , WITT, Klaus
发明人： BAEUERLE, Martin , MUELLER, Jochen , CHOIKHET, Konstantin , WITT, Klaus
IPC分类号： B01L3/00
CPC分类号： G01N30/6004 , B01J2219/00804 , B01J2219/0081 , B01L3/502707 , B01L3/502715 , B01L3/565 , B01L3/567 , B01L2200/025 , B01L2200/027 , B01L2300/0887 , B01L2400/0622 , G01N30/6095 , Y10T137/0491 , Y10T137/86863
摘要： A fluidic device (300, 304) for providing fluidic connections is described. The fluidic device (300, 304) comprises a fluid conduit and a planar coupling member (301, 305) with a fluid port (303, 307), the fluid port (303, 307) being fluidically connected with the fluid conduit. A contour (302, 306) of the planar coupling member is in a predefined relationship with the fluid port's position.
摘要翻译：描述了用于提供流体连接的流体装置（300,304）。流体装置（300,304）包括流体导管和具有流体端口（303,307）的平面耦合构件（301,305），流体端口（303,307）与流体导管流体连接。平面联接构件的轮廓（302,306）与流体端口的位置成预定关系。

6. 发明申请

WO2006056236A1 MICROFLUIDIC ARRANGEMENT WITH COUPLING DEVICE HAVING A SELECTABLE OPTICAL DETECTION PORTION 审中-公开
标题翻译：具有可选择光学检测部分的耦合器件的微流动装置
公开(公告)号：WO2006056236A1
公开(公告)日：2006-06-01
申请号：PCT/EP2004/053104
申请日：2004-11-25
申请人： AGILENT TECHNOLOGIES, INC. , ZIMMERMANN, Hans-Peter , CHOIKHET, Konstantin , PRECKEL, Tobias
发明人： ZIMMERMANN, Hans-Peter , CHOIKHET, Konstantin , PRECKEL, Tobias
IPC分类号： B01L3/00
CPC分类号： G01N21/05 , B01L3/502715 , B01L3/502738 , B01L2300/0654 , B01L2300/0816 , B01L2300/0874 , B01L2400/0644 , F16K99/0001 , F16K99/0013 , F16K2099/0084 , G01N2021/0346 , Y10T137/8242 , Y10T137/8326
摘要： A fluidic arrangement for an improved optical detection for a microfluidic device is provided, having a channel adapted to conduct a fluid, and a coupling device (1) having at least two coupling channels, one of which selectable for optical detection without interrupting processes running in the other channel(s). The coupling device is coupled with the fluidic device (2), so that the fluid flows from a channel of the fluidic device (2) into one of the coupling channels. The coupling channel having an optical detection portion (6) is part of a detection lane adapted to detect the fluid flowing therethrough, while the fluid flowing through the coupling channel without an optical detection portion is not influenced by the detecting activity. A vertical axis (a-a) permits turning of the coupling device (1) whereas the microfluidic device (2) is statically arranged. Turning leads to alternation of optical detection lane and an idle lane, enabling to detect the fluid of another lane. A method for performing optical detection of fluids processed in a fluidic device comprising one or multiple channels by use of the fluidic arrangement.
摘要翻译：提供了一种用于微流体装置的改进的光学检测的流体装置，其具有适于传导流体的通道和具有至少两个耦合通道的耦合装置（1），其中一个可选择用于光学检测而不中断在其他频道。联接装置与流体装置（2）联接，使得流体从流体装置（2）的通道流入耦合通道中的一个。具有光学检测部分（6）的耦合通道是适于检测流过其中的流体的检测通道的一部分，而没有光学检测部分流过耦合通道的流体不受检测活动的影响。垂直轴（a-a）允许联接装置（1）的转动，而微流体装置（2）是静态布置的。转向导致光学检测通道和空闲通道的交替，使得能够检测另一个通道的流体。一种用于在流体装置中处理的流体进行光学检测的方法，该流体装置包括使用流体装置的一个或多个通道。

7. 发明申请

WO2013167193A1 TWO-DIMENSIONAL FLUID SEPARATION WITH CONTROLLED PRESSURE 审中-公开
标题翻译：具有控制压力的二维流体分离
公开(公告)号：WO2013167193A1
公开(公告)日：2013-11-14
申请号：PCT/EP2012/058695
申请日：2012-05-10
申请人： AGILENT TECHNOLOGIES, INC. , WITT, Klaus , CHOIKHET, Konstantin
发明人： WITT, Klaus , CHOIKHET, Konstantin
IPC分类号： G01N30/32 , G01N30/46
CPC分类号： B01D15/18 , G01N27/44704 , G01N30/32 , G01N30/34 , G01N30/463 , G01N30/465 , G01N30/6095 , G01N30/72 , G01N2030/322 , G01N2030/328
摘要： A sample separation apparatus (200) for separating a fluidic sample, the sample separation apparatus (200) comprising a first separation unit (204) for separating the fluidic sample, a first fluid drive (202) configured for conducting the fluidic sample to be separated through the first separation unit (204), a second separation unit (208), arranged downstream of the first separation unit (204), for further separating the fluidic sample after treatment by the first separation unit (204), a second fluid drive (206) configured for at least partially conducting the fluidic sample, after treatment by the first separation unit (204), through the second separation unit (208), and a fluidic valve (218) having fluidic interfaces (222, 224, 226, 228) fluidically coupled to the first fluid drive (202) and the second fluid drive (206) and being switchable for performing the separation of the fluidic sample, wherein the sample separation apparatus (200) is configured for adjusting a pressure at a predefined position to a predefined value, wherein the predefined position is in a fluidic path between an outlet (270) of the first separation unit (204) and an inlet (272) of the second separation unit (208) or in fluid communication with this fluidic path.
摘要翻译： 1.一种用于分离流体样品的样品分离装置（200），所述样品分离装置（200）包括用于分离流体样品的第一分离单元（204），被配置用于传导待分离的流体样品的第一流体驱动器通过第一分离单元（204），布置在第一分离单元（204）下游的第二分离单元（208），用于在第一分离单元（204）处理之后进一步分离流体样品，第二流体驱动器 206），其被配置为在通过所述第一分离单元（204）经过所述第二分离单元（208）处理之后至少部分地导电所述流体样品;以及流体阀（218），其具有流体界面（222,224,226,228））流体耦合到所述第一流体驱动器（202）和所述第二流体驱动器（206）并且可切换以执行所述流体样品的分离，其中所述样品分离装置（200）构造成用于调节所述流体样品预定位置到预定值，其中预定位置处于第一分离单元（204）的出口（270）和第二分离单元（208）的入口（272）之间的流体路径中，或者与该流体连通流体路径

8. 发明申请

WO2013013717A2 PACKET-WISE PROPORTIONING FOLLOWED BY IMMEDIATE LONGITUDINAL MIXING 审中-公开
标题翻译：随着纵向混合的分组比例增加
公开(公告)号：WO2013013717A2
公开(公告)日：2013-01-31
申请号：PCT/EP2011062956
申请日：2011-07-27
申请人： AGILENT TECHNOLOGIES INC , WITT KLAUS , CHOIKHET KONSTANTIN , HAERTL HANS-GEORG
发明人： WITT KLAUS , CHOIKHET KONSTANTIN , HAERTL HANS-GEORG
CPC分类号： F17D3/01 , G05D11/133 , Y10T137/2499
摘要： A fluid supply system (150) adapted for metering two or more fluids in controlled proportions and for supplying a resultant mixture, the fluid supply system (150) comprising a plurality of solvent supply lines (104 to 107), each fluidically connected with a fluid source (100 to 103) providing a respective fluid, a pumping unit (110) comprising a reciprocating element (115) adapted for intaking fluid supplied at an inlet of the pumping unit (110) and for supplying the pressurized fluid at an outlet of the pumping unit (110), wherein the pumping unit (110) is adapted for taking in fluids from selected solvent supply lines (104 to 107) and for supplying a pressurized mixture of the fluids at its outlet, a proportioning valve (108) interposed between the solvent supply lines (104 to 107) and the inlet of the pumping unit (110), the proportioning valve (108) adapted for modulating solvent composition by sequentially coupling selected ones of the solvent supply lines (104 to 107) with the inlet of the pumping unit (110), and a longitudinal mixing unit (152) adapted for mixing longitudinally subsequent sections of the fluids so as to modify their succession in flow direction.
摘要翻译：一种流体供应系统（150），其适于以受控比例计量两种或多种流体并用于供应所得混合物，所述流体供应系统（150）包括多个溶剂供应管线（104至107），每个流体连接有流体源（100至103）提供相应的流体;泵送单元（110），包括适于吸入在泵送单元（110）的入口处供应的流体的往复运动元件（115），并用于在加压流体的出口泵送单元（110），其中所述泵送单元（110）适于从选定的溶剂供应管线（104至107）吸入流体并且用于在其出口处供应流体的加压混合物，位于其间的比例阀（108）溶剂供应管线（104至107）和泵送单元（110）的入口，比例阀（108）适于通过将选定的溶剂供应管线（104至107）中的选定溶剂供应管线（104至107）与入口泵送单元（110）的纵向混合单元（152）和适于混合流体纵向后续部分的纵向混合单元（152），以便改变它们在流动方向上的连续性。

9. 发明申请

WO2010015279A1 SYNCHRONIZATION OF SUPPLY FLOW PATHS 审中-公开
标题翻译：供应流程同步
公开(公告)号：WO2010015279A1
公开(公告)日：2010-02-11
申请号：PCT/EP2008/060387
申请日：2008-08-07
申请人： AGILENT TECHNOLOGIES, INC. , WITT, Klaus , CHOIKHET, Konstantin
发明人： WITT, Klaus , CHOIKHET, Konstantin
IPC分类号： F04B11/00 , F04B13/02
CPC分类号： F04B11/0058 , F04B13/02 , F04B2203/0204 , Y10T137/0318 , Y10T137/86131
摘要： A solvent supply system for supplying a composite solvent is described. The solvent supply system comprises a first supply flow path with a first pump unit, the first supply flow path being adapted for supplying a flow of a first solvent to a mixing unit, the first pump unit operating periodically, and a second supply flow path with a second pump unit, the second supply flow path being adapted for supplying a flow of a second solvent to the mixing unit, the second pump unit operating periodically. The mixing unit is adapted for mixing the first and the second solvent and for supplying a composite solvent. The solvent supply system further comprises a control unit adapted for controlling operation of the first and the second pump unit, the control unit being adapted to prevent at least one of a predefined phase relation and a predefined frequency relation between the first pump unit and the second pump unit.
摘要翻译：描述了用于供应复合溶剂的溶剂供应系统。所述溶剂供应系统包括具有第一泵单元的第一供应流动路径，所述第一供应流动路径适于将第一溶剂的流供应到混合单元，所述第一泵单元周期性地运行，以及第二供给流路，第二泵单元，所述第二供应流路适于将第二溶剂的流供应到所述混合单元，所述第二泵单元周期性地运行。混合单元适于混合第一和第二溶剂并供应复合溶剂。所述溶剂供应系统还包括适于控制所述第一和第二泵单元的操作的控制单元，所述控制单元适于防止所述第一泵单元和所述第二泵单元之间的预定相位关系和预定频率关系中的至少一个泵单元。

10. 发明申请

WO2006103133A1 COMPENSATING TEMPERATURE-INDUCED ERRORS DURING PISTON MOVEMENT 审中-公开
标题翻译：在活塞运动期间补偿温度诱导的误差
公开(公告)号：WO2006103133A1
公开(公告)日：2006-10-05
申请号：PCT/EP2006/050709
申请日：2006-02-06
申请人： AGILENT TECHNOLOGIES, INC. , WITT, Klaus , CHOIKHET, Konstantin , BIERBAUM, Alexander
发明人： WITT, Klaus , CHOIKHET, Konstantin , BIERBAUM, Alexander
IPC分类号： G01N30/32
CPC分类号： G01N30/32 , G01N30/34 , G01N2030/324 , G01N2030/326
摘要： A method for controlling movement of a piston in a metering device is described. The method comprises supplying a fluid by actuating the metering device's piston, wherein compression or expansion of the fluid causes corresponding temperature variations . The method further comprises superposing a corrective movement onto the piston movement, with the corrective movement at least partly compensating for at least one of thermal expansion and contraction of the fluid induced by the temperature variations . In one embodiment, the corrective movement imposed onto the piston movement comprises two components: a reduction (74) of the compression jump (73) , and a subsequent increase (75) of the piston's forward displacement rate (71) during a period (76) of time (72) .
摘要翻译：描述了一种用于控制计量装置中活塞运动的方法。该方法包括通过致动计量装置的活塞来供应流体，其中流体的压缩或膨胀引起相应的温度变化。该方法还包括将校正运动叠加到活塞运动上，校正运动至少部分地补偿由温度变化引起的流体的热膨胀和收缩中的至少一种。在一个实施例中，施加到活塞运动上的校正运动包括两个部件：压缩跳跃（73）的减小（74）和在一段时间内的活塞向前移位速率（71）的随后增加（75））的时间（72）。

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