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    • 6. 发明申请
    • TWO-DIMENSIONAL FLUID SEPARATION WITH FIRST SEPARATION UNIT FEEDING TO HIGH-PRESSURE END OF SECOND SEPARATION UNIT
    • 具有第二分离单元高压端的第一分离单元的二维流体分离
    • WO2012175111A1
    • 2012-12-27
    • PCT/EP2011/060263
    • 2011-06-20
    • AGILENT TECHNOLOGIES, INC.WITT, Klaus
    • WITT, Klaus
    • G01N30/32G01N30/46
    • G01N30/463G01N30/32G01N30/465G01N2030/322
    • A sample separation apparatus (200) for separating a fluidic sample, wherein the sample separation apparatus (200) comprises a first fluid drive (202) configured for conducting the fluidic sample to be separated through a first separation unit (204), a second fluid drive (206) configured for conducting the separated fluidic sample through a second separation unit (208) downstream of the first separation unit (204), a flow coupler (210) having two fluid inlet terminals (212, 214) and a fluid outlet terminal (216), the fluid outlet terminal (216) being fluidically connectable to the second separation unit (208), and a fluidic valve (218) having fluidic interfaces (222, 224, 226, 228) with the first fluid drive (202), with the second fluid drive (206) and with the two fluid inlet terminals (212, 214) of the flow coupler (210), wherein the fluidic valve (218) is switchable for performing the separation of the fluidic sample so that the first fluid drive (202), the second fluid drive (206) and the flow coupler (210) are in fluid communication with one another in each switching state of the fluidic valve (218).
    • 一种用于分离流体样品的样品分离装置(200),其中样品分离装置(200)包括第一流体驱动器(202),其构造成用于将待分离的流体样品通过第一分离单元(204),第二流体 驱动器(206),其构造成用于通过第一分离单元(204)下游的第二分离单元(208)来导引分离的流体样品;流动耦合器(210),其具有两个流体入口端子(212,214)和流体出口端子 (216),流体出口端子(216)可流体连接到第二分离单元(208),以及具有与第一流体驱动器(202)的流体界面(222,224,226,228)的流体阀(218) 与第二流体驱动器(206)和流动联接器(210)的两个流体入口端子(212,214)连通,其中流体阀门(218)可切换以执行流体样品的分离,使得第一 流体驱动器(202),第二流体驱动器(206) 并且流动联接器(210)在流体阀(218)的每个切换状态下彼此流体连通。
    • 8. 发明申请
    • ELECTROPHORETIC SEPARATION IN A MOVING FLUID
    • 移动流体中的电泳分离
    • WO2006021465A1
    • 2006-03-02
    • PCT/EP2005/051092
    • 2005-03-10
    • AGILENT TECHNOLOGIES, INC.HEID, Christian A.WITT, Klaus
    • HEID, Christian A.WITT, Klaus
    • G01N27/447
    • G01N27/44769G01N27/44795
    • A device for electrophoretic separation and purification of positively and negatively charged compounds (8, 9) and neutral compounds (10) in a hydraulically motivated analyte solution is provided, using a radial or axial electrical field which is generated inside a flow chamber (2) which has preferably a cylindrical geometry. Hydraulic flow forces and electrical forces act upon the analyte solution resulting in deflection (13) of the charged and neutral compounds (8, 9, 10) of the analyte solution, the deflection being a function of the electrical field and of the hydraulic forces being applied on the analyte solution and of the charge of the compound, respectively its iso-electric point, both depending of the pH-value of the solution, which can be predetermined, therefore causing the separation. A method for separation and purification of positively and negatively charged compounds (8, 9) and neutral compounds (10) is performed by this device.
    • 使用在流动室(2)内部产生的径向或轴向电场,提供在水力驱动的分析物溶液中电泳分离和纯化带正电和带负电荷的化合物(8,9)和中性化合物(10)的装置, 其优选地具有圆柱形几何形状。 液压流动力和电力作用在分析物溶液上,导致分析物溶液的带电和中性化合物(8,9,10)的偏转(13),该偏转是电场和液压力的函数 分别施加在分析物溶液和化合物的电荷上,其等电点,均取决于可以预定的溶液的pH值,因此导致分离。 通过该装置进行带正电和带负电荷的化合物(8,9)和中性化合物(10)的分离和纯化方法。
    • 10. 发明申请
    • FLUIDIC VALVE WITH SELECTIVELY SWITCHABLE STORAGE PATHS
    • 具有选择性切换储物阀的流体阀
    • WO2014000778A1
    • 2014-01-03
    • PCT/EP2012/062394
    • 2012-06-26
    • AGILENT TECHNOLOGIES, INC.WITT, KlausCHOIKHET, Konstantin
    • WITT, KlausCHOIKHET, Konstantin
    • G01N30/20B01D15/18G01N30/46
    • G01N30/80B01D15/1871G01N27/447G01N30/06G01N30/20G01N30/461G01N30/6039G01N2030/208
    • A sample separation apparatus (100, 200) for separating a fluidic sample (104), the sample separation apparatus (100, 200) comprising: a first separation unit (102) for separating the fluidic sample (104); a first fluid drive (106) configured for generating a fluid flow for conducting the fluidic sample (104) to be separated through the first separation unit (102); a second separation unit (110), arranged downstream of the first separation unit (102), for further separating the fluidic sample (104) after treatment by the first separation unit (102); a second fluid drive (112) configured for generating a fluid flow for conducting the fluidic sample (104) or at least parts thereof, after treatment by the first separation unit (102), through the second separation unit (110); a fluidic valve (114) having a first inlet (116) fluidically coupled to one of the first fluid drive (106) and the second fluid drive (112); the fluidic valve (114) having a second inlet (118) fluidically coupled to the other of the first fluid drive (106) and the second fluid drive (112); the fluidic valve (114) comprising at least two different sets (131, 133) of storage paths, wherein each set of storage paths comprises a first storage path (128); and wherein the first storage path (128) of a first set (131) of said at least two sets of storage paths has a first volume and the first storage path (132) of a second set (133) of said at least two sets of storage paths has a second volume different from the first volume; the fluidic valve (114) being configured for selectively switching one set of said least two sets of storage paths to the first inlet (116) and the second inlet (118).
    • 1.一种用于分离流体样品(104)的样品分离装置(100,200),所述样品分离装置(100,200)包括:用于分离流体样品(104)的第一分离单元(102) 第一流体驱动器(106),其被配置用于产生用于传导待通过所述第一分离单元(102)分离的所述流体样品(104)的流体流; 布置在第一分离单元(102)的下游的第二分离单元(110),用于在通过第一分离单元(102)处理之后进一步分离流体样品(104); 第二流体驱动器(112),被配置为在通过第一分离单元(102)处理之后通过第二分离单元(110)产生用于传导流体样品(104)或其至少部分的流体流; 流体阀(114)具有流体耦合到第一流体驱动器(106)和第二流体驱动器(112)之一的第一入口(116); 流体阀(114)具有与第一流体驱动器(106)和第二流体驱动器(112)中的另一个流体连接的第二入口(118)。 所述流体阀(114)包括至少两个不同的存储路径组(131,133),其中每组存储路径包括第一存储路径(128); 并且其中所述至少两组存储路径中的第一组(131)的第一存储路径(128)具有第一卷,并且所述至少两个集合的第二集合(133)的第一存储路径(132) 的存储路径具有与第一卷不同的第二卷; 所述流体阀(114)构造成用于选择性地将一组所述至少两组存储路径切换到所述第一入口(116)和所述第二入口(118)。