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1. 发明申请

WO2010059000A2 METHOD AND APPARATUS FOR MANUFACTURING POLYMER PARTICLE 审中-公开
标题翻译：制造聚合物颗粒的方法和装置
公开(公告)号：WO2010059000A2
公开(公告)日：2010-05-27
申请号：PCT/KR2009006881
申请日：2009-11-23
申请人： LG CHEMICAL LTD , CHOE JAE HOON , RHEE CHANG HOUN , SEO JUNG HYUN , KIM YOO SEOK , SONG IN HYOUP , CHOI JUNG UK , SONG KWANG HO
发明人： CHOE JAE HOON , RHEE CHANG HOUN , SEO JUNG HYUN , KIM YOO SEOK , SONG IN HYOUP , CHOI JUNG UK , SONG KWANG HO
IPC分类号： B01J14/00 , B01J4/00 , C08J3/12
CPC分类号： B01J19/0093 , B01J19/243 , B01J2219/00788 , B01J2219/00889 , C08J3/12 , C08J3/126 , C08J2325/06 , C08J2333/06
摘要： The present invention relates to a method and apparatus for manufacturing polymer particles. The present invention provides an apparatus and method that enables the manufacture of polymer particles the monodispersion whereof is excellent and physical properties whereof are uniform, including the degree of crosslinking and polymerization. The present invention also enables the effective manufacture of a particle that has either a high degree of crosslinking or a core cell or core-double cell structure and exhibits superior monodispersion within a desired particle diameter. In addition, in the present invention the repeatability of said manufacturing process of polymer particles may be kept superior. In addition, the present invention provides apparatus and method that enables to effectively control the particle diameter, shape, degree of crosslinking, degree of polymerization, structure, solid concentration of the polymerization solution, etc., according to the objective.
摘要翻译：本发明涉及一种制造聚合物颗粒的方法和装置。本发明提供一种能够制造单分散性优异且其物理性质均匀的聚合物颗粒的装置和方法，包括交联度和聚合度。本发明还能够有效地制造具有高度交联度或芯体或核 - 双电池结构的颗粒，并且在所需粒径内表现出优异的单分散性。此外，在本发明中，聚合物颗粒的所述制造方法的重复性可以保持优异。此外，本发明提供了能够根据目的有效地控制粒径，形状，交联度，聚合度，结构，聚合溶液的固体浓度等的装置和方法。

2. 发明申请

WO2007139336A1 MICRO CHANNEL REACTOR SYSTEM 审中-公开
标题翻译：微通道反应器系统
公开(公告)号：WO2007139336A1
公开(公告)日：2007-12-06
申请号：PCT/KR2007/002601
申请日：2007-05-29
申请人： LG CHEM, LTD. , CHO, Jun-Yeon , CHOI, Jung-Uk , CHOE, Jae-Hoon , PARK, Kwang-Cheon , RHEE, Chang-Houn , BAE, Sun-Hyuk , SONG, Kwang-Ho
发明人： CHO, Jun-Yeon , CHOI, Jung-Uk , CHOE, Jae-Hoon , PARK, Kwang-Cheon , RHEE, Chang-Houn , BAE, Sun-Hyuk , SONG, Kwang-Ho
IPC分类号： C01B3/38
CPC分类号： C01B3/16 , B01J19/0093 , B01J2219/00783 , B01J2219/00804 , B01J2219/00835 , B01J2219/00873 , C01B2203/0283 , C01B2203/066 , C01B2203/0894 , C01B2203/1035
摘要： The present invention discloses to a channel reactor system having a first channel plate assembly in which an exothermic reaction is performed and a second channel plate assembly provided for heat-exchanging and constituted integrally with the first channel plate assembly so as to remove effectively heat, the channel reactor system comprising at least two channel units into which reaction gas and cooling fluid are separately introduced, each channel unit comprising a reaction channel plate assembly into which reaction gas is introduced and a heat-exchanging channel plate assembly into which cooling fluid is introduced; and at least one intermediate plate disposed between the upper and lower channel units, the intermediate plate supplying reaction gas and cooling fluid inflowed from the upper channel unit with new reactant and cooling fluid and supplying reaction gas and cooling fluid to the reaction channel plate assembly and the heat-exchanging channel plate assembly of the lower channel unit, respectively.
摘要翻译：本发明公开了一种通道反应器系统，其具有其中进行放热反应的第一通道板组件和设置用于热交换并与第一通道板组件一体构成的第二通道板组件，以便有效地除去热量，通道反应器系统包括至少两个通道单元，反应气体和冷却流体被单独引入到该通道单元中，每个通道单元包括反应通道板组件，反应气体被引入到其中;以及热交换通道板组件，其中引入冷却流体; 以及设置在上通道单元和下通道单元之间的至少一个中间板，中间板供应来自上通道单元的反应气体和冷却流体，其具有新的反应物和冷却流体，并将反应气体和冷却流体供应到反应通道板组件，下通道单元的热交换通道板组件。

3. 发明申请

WO2010059000A3 METHOD AND APPARATUS FOR MANUFACTURING POLYMER PARTICLE 审中-公开
公开(公告)号：WO2010059000A3
公开(公告)日：2010-09-02
申请号：PCT/KR2009006881
申请日：2009-11-23
申请人： LG CHEMICAL LTD , CHOE JAE HOON , RHEE CHANG HOUN , SEO JUNG HYUN , KIM YOO SEOK , SONG IN HYOUP , CHOI JUNG UK , SONG KWANG HO
发明人： CHOE JAE HOON , RHEE CHANG HOUN , SEO JUNG HYUN , KIM YOO SEOK , SONG IN HYOUP , CHOI JUNG UK , SONG KWANG HO
IPC分类号： B01J14/00 , B01J4/00 , C08J3/12
CPC分类号： B01J19/0093 , B01J19/243 , B01J2219/00788 , B01J2219/00889 , C08J3/12 , C08J3/126 , C08J2325/06 , C08J2333/06
摘要： The present invention relates to a method and apparatus for manufacturing polymer particles. The present invention provides an apparatus and method that enables the manufacture of polymer particles the monodispersion whereof is excellent and physical properties whereof are uniform, including the degree of crosslinking and polymerization. The present invention also enables the effective manufacture of a particle that has either a high degree of crosslinking or a core cell or core-double cell structure and exhibits superior monodispersion within a desired particle diameter. In addition, in the present invention the repeatability of said manufacturing process of polymer particles may be kept superior. In addition, the present invention provides apparatus and method that enables to effectively control the particle diameter, shape, degree of crosslinking, degree of polymerization, structure, solid concentration of the polymerization solution, etc., according to the objective.

4. 发明申请

WO2008126995A1 A PROCESS FOR PREPARING INTERMEDIATE OF DONEPEZIL 审中-公开
标题翻译：一种制备多奈哌齐中间体的方法
公开(公告)号：WO2008126995A1
公开(公告)日：2008-10-23
申请号：PCT/KR2008/001790
申请日：2008-03-31
申请人： DONG WHA PHARM. IND. CO., LTD. , OH, Yoon-Seok , LIM, Jae-Kyung , KWON, O-Jin , CHOI, Jung-Uk , SHIN, Dong-Hyuk , JUNG, Jin-Yong , RYU, Jei-Man
发明人： OH, Yoon-Seok , LIM, Jae-Kyung , KWON, O-Jin , CHOI, Jung-Uk , SHIN, Dong-Hyuk , JUNG, Jin-Yong , RYU, Jei-Man
IPC分类号： C07D211/22
CPC分类号： C07D211/32
摘要： There is provided a method for preparing a compound 2-[(E)-l-(l-benzyl-4-piperidyl)methylidene]-5,6-dimethoxy-l-indanone that is an intermediate of donepezil that has been widely known as a therapeutic agent for treating dementia. The present invention is related to the method for preparing a compound 2-[(E)-l-(l-benzyl-4-piperidyl)methylidene]-5,6-dimethoxy-l-indanone by reacting a 5,6-dimethoxy-l-indanone compound with a l-benzyl-piperidine-4-carbaldehyde compound under a basic condition as in sodium alkoxide. The method for preparing an intermediate of donepezil according to the present invention may be useful to facilitate the commercial mass- production and enhance the production yield.
摘要翻译：提供了一种制备作为多奈哌齐中间体的化合物2 - [（E）-1-（1-苄基-4-哌啶基）亚甲基] -5,6-二甲氧基-1-二氢茚酮的方法，已广为人知作为治疗痴呆的治疗剂。本发明涉及制备化合物2 - [（E）-1-（1-苄基-4-哌啶基）亚甲基] -5,6-二甲氧基-1-二氢茚酮的方法，该方法是使5,6-二甲氧基 -1-茚酮化合物与1-苄基 - 哌啶-4-甲醛化合物在碱性条件下反应，如在醇钠中。根据本发明的制备多奈哌齐中间体的方法可用于促进商业批量生产并提高产量。

5. 发明申请

WO2008010672A1 A CHEMICAL REACTOR INCLUDING HEAT EXCHANGERS 审中-公开
标题翻译：化学反应器，包括热交换器
公开(公告)号：WO2008010672A1
公开(公告)日：2008-01-24
申请号：PCT/KR2007/003483
申请日：2007-07-19
申请人： LG CHEM, LTD. , CHO, Jun-Yeon , CHOE, Jae-Hoon , PARK, Kwang-Cheon , KWAK, Gyea-Young , RHEE, Chang-Houn , BAE, Sun-Hyuk , CHOI, Jung-Uk , SONG, Kwang-Ho
发明人： CHO, Jun-Yeon , CHOE, Jae-Hoon , PARK, Kwang-Cheon , KWAK, Gyea-Young , RHEE, Chang-Houn , BAE, Sun-Hyuk , CHOI, Jung-Uk , SONG, Kwang-Ho
IPC分类号： C01B3/38
CPC分类号： C01B3/34 , C01B2203/0216 , C01B2203/0233 , C01B2203/0811 , C01B2203/1041 , C01B2203/1058 , C01B2203/1064 , C01B2203/107 , C01B2203/1076 , C01B2203/1217 , C01B2203/1235 , Y02P20/124
摘要： The present invention discloses to a chemical reactor with high heat efficiency and small volume, the chemical reaction of the present invention comprises a first unit for performing heat exchange of exothermic reaction products with exothermic reaction raw material fed for exothermic reaction; a second unit including a plate assembly for exothermic reactions and a plate assembly for endothermic reactions; and a third unit for performing heat exchange of endothermic reaction products with endothermic reaction raw material fed for endothermic reactions, the exothermic reaction raw material discharged from the first unit is fed into the plate assembly for exothermic reactions in the second unit and used in the exothermic reactions, the exothermic reaction products are fed into the first unit to pre-heat the exothermic reaction raw material, the endothermic reaction raw material discharged from the third unit is fed into the plate assembly for endothermic reactions in the second unit and used in the endothermic reactions, the endothermic reaction products are fed into the third unit to pre-heat the endothermic reaction raw material, and the first unit, the second unit and the third unit are laminately disposed.
摘要翻译：本发明公开了一种热效率高，体积小的化学反应器，本发明的化学反应包括用于进行放热反应的放热反应原料与放热反应产物进行热交换的第一单元; 包括用于放热反应的板组件和用于吸热反应的板组件的第二单元; 以及第三单元，用于进行用于吸热反应的吸热反应原料的吸热反应产物的热交换，从第一单元排出的放热反应原料在第二单元中进料到用于放热反应的板组件中，并用于放热反应中，将放热反应产物进料到第一单元中以预热放热反应原料，将从第三单元排出的吸热反应原料进料到第二单元中用于吸热反应的板组件中并用于吸热反应中，将吸热反应产物进料到第三单元中以预热吸热反应原料，并且第一单元，第二单元和第三单元层叠。

6. 发明申请

WO1998017614A1 PROCESS FOR THE CONTINUOUS PRODUCTION OF NEOPENTYL GLYCOL 审中-公开
标题翻译：连续生产NEOPYYY GLYCOL的方法
公开(公告)号：WO1998017614A1
公开(公告)日：1998-04-30
申请号：PCT/KR1997000199
申请日：1997-10-22
申请人： LG CHEMICAL LIMITED , CHOI, Jung, Uk , JUNG, Seong, Moon , LEE, Kee, Hyouk , MOON, Ji, Joong , KIM, Young, Jin , MOON, Kwang, Ik
发明人： LG CHEMICAL LIMITED
IPC分类号： C07C31/20
CPC分类号： C07C45/80 , C07C29/141 , C07C45/75 , C07C45/82 , C07C47/19 , C07C31/20
摘要： A neopentyl glycol having a purity of 98 % or more is produced continuously by a process comprising the steps of: conducting an aldol condensation of isobutyraldehyde with an aqueous formaldehyde solution containing methanol in an amount of 0.1 to 15 wt.% in the presence of a tertiary alkylamine catalyst; extracting the condensation product mixture with octanol; distilling the extract; hydrogenating the distillation product; extracting the hydrogenation product mixture with water; and subjecting the extract to distillation.
摘要翻译：通过包括以下步骤的方法连续生产纯度为98％或更高的新戊二醇：在异氰酸酯与甲醇含量为0.1至15重量％的甲醛水溶液的存在下进行醛醇缩合叔烷基胺催化剂; 用辛醇萃取缩合产物混合物; 蒸馏提取物; 使蒸馏产物氢化; 用水萃取氢化产物混合物; 并对提取物进行蒸馏。

7. 发明申请

WO2011102645A3 AN IMPROVED PROCESS FOR PREPARING TELMISARTAN 审中-公开
标题翻译：改进TELMISARTAN的改进方法
公开(公告)号：WO2011102645A3
公开(公告)日：2012-01-19
申请号：PCT/KR2011001041
申请日：2011-02-17
申请人： DONG WHA PHARM CO LTD , OH YOON-SEOK , LIM JAE-KYUNG , CHOI JUNG-UK , KWON O-JIN , LEE JUN-SANG
发明人： OH YOON-SEOK , LIM JAE-KYUNG , CHOI JUNG-UK , KWON O-JIN , LEE JUN-SANG
IPC分类号： C07D403/10 , C07D403/04 , C07D403/06
CPC分类号： C07D403/04
摘要： The present invention relates to an improved process for preparing telmisartan from 4-methyl-6-(1-methyl-1H-benzimidazole-2-yl)-2-propyl-1H-benzimidazole and 2-[4-(bromomethyl)phenyl] benzoate by using condensation reaction and hydrolysis reaction wherein the condensation reaction is performed to prepare an intermediate by using mixed solvent of dimethyl sulfoxide and isopropanol as reaction solvent using dimethyl sulfoxide of 0.5~1.5 times and isopropanol of 1.5~4.5 times on the basis of the usage of 4-methyl-6-(1-methyl-1H-benzimidazole-2-yl)-2-prophyl-1H-benzimidazole and the hydrolysis reaction is performed to cause the reaction in mixed solvent of methanol of 7~9 times and purified water of 5~7 times on the basis of the intermediate. The process for preparing telmisartan according to the present invention provides a simple preparing process for mass production and improves a manufacturing yield with high purity by eliminating an additional process for removing an inorganic salt as a byproduct due to a base used in the condensation reaction and the hydrolysis reaction.
摘要翻译：本发明涉及从4-甲基-6-（1-甲基-1H-苯并咪唑-2-基）-2-丙基-1H-苯并咪唑和2- [4-（溴甲基）苯基]苯并咪唑制备替米沙坦的改进方法，苯甲酸酯通过使用缩合反应和水解反应，其中通过使用二甲基亚砜和异丙醇的混合溶剂作为反应溶剂进行缩合反应，使用0.5〜1.5倍的二甲基亚砜和1.5〜4.5倍的异丙醇，基于使用4-甲基-6-（1-甲基-1H-苯并咪唑-2-基）-2-预防-1H-苯并咪唑并进行水解反应，使甲醇混合溶剂中的反应为7〜9次，纯化水为中间体5〜7次。根据本发明的替米沙坦制备方法提供了一种简单的批量制备方法，通过除去由于缩合反应中使用的碱作为副产物而除去无机盐的附加方法，提高了高纯度的制造产率，水解反应。

8. 发明申请

WO2007035074A1 STACK TYPE REACTOR 审中-公开
标题翻译：堆叠式反应器
公开(公告)号：WO2007035074A1
公开(公告)日：2007-03-29
申请号：PCT/KR2006/003828
申请日：2006-09-26
申请人： LG CHEM, LTD. , CHOE, Jae Hoon , CHOI, Jung Uk , KWON, Young Woon , PARK, Kwang Cheon , SEO, Jung Hyun , CHO, Jun Yeon , KIM, Yoo Seok , SONG, Kwang Ho
发明人： CHOE, Jae Hoon , CHOI, Jung Uk , KWON, Young Woon , PARK, Kwang Cheon , SEO, Jung Hyun , CHO, Jun Yeon , KIM, Yoo Seok , SONG, Kwang Ho
IPC分类号： B01F5/00
CPC分类号： B01F13/0059 , B01F5/0641 , B01J19/0093 , B01J2219/00783 , B01J2219/00835 , B01J2219/00889 , B01J2219/00984
摘要： The present invention discloses the stack type reactor which can adjust a length of channel (that is, a reaction time) according to the kind of raw substance to make raw substances be reacted with each other for a sufficient time and mix completely raw substances to maximize the reaction efficiency thereof. The stack type reactor according to the present invention comprises an upper block including at least two inlets through which different kinds of raw substances are entered and a lower channel communicated in fluid with the inlets and formed a lower surface thereof; and an unit block including an upper channel corresponding to the lower channel of the upper block and formed on an upper surface thereof, the unit block including a lower channel formed a lower surface thereof and communicated in fluid with the upper channel via a connecting flow passage penetrating therethrough. The upper block and the unit block are coupled with each other to form a flow passage acting as a flow path of the raw substances by corresponding to the lower channel of the upper block and the upper channel of the first unit block.
摘要翻译：本发明公开了可以根据原料种类调整通道长度（即反应时间）的堆叠式反应器，使原料相互反应足够的时间，并将完全原料混合最大化其反应效率。根据本发明的堆叠式反应器包括：上部块，其包括至少两个入口，通过该入口进入不同种类的原料，下部通道与入口连通并形成其下表面; 以及单元块，其包括与上部块的下部通道相对应并形成在其上表面上的上部通道，该单位块包括形成下表面的下通道，并且其下表面经由连接流动通道与上通道流体连通穿透其中。上块和单元块彼此联接以形成用作原料的流动路径的流动通道，其对应于上块的下通道和第一单元块的上通道。

9. 发明申请

WO2011102645A2 AN IMPROVED PROCESS FOR PREPARING TELMISARTAN 审中-公开
标题翻译：改进TELMISARTAN的改进方法
公开(公告)号：WO2011102645A2
公开(公告)日：2011-08-25
申请号：PCT/KR2011/001041
申请日：2011-02-17
申请人： DONG WHA PHARM. CO., LTD. , OH, Yoon-Seok , LIM, Jae-Kyung , CHOI, Jung-Uk , KWON, O-Jin , LEE, Jun-Sang
发明人： OH, Yoon-Seok , LIM, Jae-Kyung , CHOI, Jung-Uk , KWON, O-Jin , LEE, Jun-Sang
IPC分类号： C07D403/10 , C07D403/04 , C07D403/06
CPC分类号： C07D403/04
摘要： The present invention relates to an improved process for preparing telmisartan from 4-methyl-6-(1-methyl-1 H -benzimidazole-2-yl)-2-propyl-1 H -benzimidazole and 2-[4-(bromomethyl)phenyl] benzoate by using condensation reaction and hydrolysis reaction wherein the condensation reaction is performed to prepare an intermediate by using mixed solvent of dimethyl sulfoxide and isopropanol as reaction solvent using dimethyl sulfoxide of 0.5~1.5 times and isopropanol of 1.5~4.5 times on the basis of the usage of 4-methyl-6-(1-methyl-1 H -benzimidazole-2-yl)-2-prophyl-1 H -benzimidazole and the hydrolysis reaction is performed to cause the reaction in mixed solvent of methanol of 7~9 times and purified water of 5~7 times on the basis of the intermediate. The process for preparing telmisartan according to the present invention provides a simple preparing process for mass production and improves a manufacturing yield with high purity by eliminating an additional process for removing an inorganic salt as a byproduct due to a base used in the condensation reaction and the hydrolysis reaction.
摘要翻译：本发明涉及从4-甲基-6-（1-甲基-1H-苯并咪唑-2-基）-2-丙基-1H-苯并咪唑和2- [4-（溴甲基）苯基]苯并咪唑制备替米沙坦的改进方法，苯甲酸酯通过使用缩合反应和水解反应，其中通过使用二甲基亚砜和异丙醇的混合溶剂作为反应溶剂进行缩合反应，使用0.5〜1.5倍的二甲基亚砜和1.5〜4.5倍的异丙醇，基于使用4-甲基-6-（1-甲基-1H-苯并咪唑-2-基）-2-预防-1H-苯并咪唑并进行水解反应，使甲醇混合溶剂中的反应为7〜9次，纯化水为中间体5〜7次。根据本发明的替米沙坦制备方法提供了一种简单的批量制备方法，通过除去由于缩合反应中使用的碱作为副产物而除去无机盐的附加方法，提高了高纯度的制造产率，水解反应。

10. 发明申请

WO2006129974A1 METHOD FOR PREPARING ADHESIVE ACRYLIC ESTER POLYMER SYRUP 审中-公开
标题翻译：制备丙烯酸酯聚合物SYRUP的方法
公开(公告)号：WO2006129974A1
公开(公告)日：2006-12-07
申请号：PCT/KR2006/002104
申请日：2006-06-01
申请人： LG CHEM, LTD. , PARK, Jong-suh , CHOI, Sun-Hyuk , CHOI, Jung-uk
发明人： PARK, Jong-suh , CHOI, Sun-Hyuk , CHOI, Jung-uk
IPC分类号： C08F2/02
CPC分类号： C09J133/06 , C08F2/02
摘要： The present invention relates to a method for preparing an acrylic ester polymer syrup by bulk polymerization, and more particularly, to a method for preparing an acrylic ester polymer syrup, which comprises the steps of: supplying a monomer solution and an initiator solution to a monomer solution reservoir and an initiator solution reservoir, respectively; supplying the monomer solution and the initiator solution to a complete-mixing type continuous reactor, while maintaining the dissolved oxygen in the monomer solution reservoir and the initiator solution reservoir at 0.0001 to 3 ppm, separately or after mixing prior to the supply; and performing bulk polymerization continuously while maintaining the solution mixture supplied to the continuous reactor at 70 to 150 0C and 1 to 10 atm, with a mean residence time of 30 to 240 minutes. In accordance with the present invention, an acrylic ester polymer syrup can be obtained with a degree of polymerization of 20 to 70 % at a low polymerization temperature, even with a small amount of initiator. Productivity can be improved by reducing reaction time with the use of an initiator having a short half-life and polymerization can be performed very stably and continuously without gelation.
摘要翻译：本发明涉及通过本体聚合制备丙烯酸酯聚合物浆料的方法，更具体地说，涉及一种制备丙烯酸酯聚合物浆料的方法，其包括以下步骤：向单体供应单体溶液和引发剂溶液溶液储层和引发剂溶液储层; 将单体溶液和引发剂溶液供应到完全混合型连续反应器，同时将单体溶液储存器和引发剂溶液储存器中的溶解氧分别维持在0.0001至3ppm，或在供给之前混合; 并连续进行本体聚合，同时将提供给连续反应器的溶液混合物保持在70〜150℃和1〜10atm，平均停留时间为30〜240分钟。根据本发明，即使使用少量的引发剂，也可以在低聚合温度下聚合度为20〜70％的丙烯酸酯聚合物糖浆。通过使用半衰期短的引发剂减少反应时间可以提高生产率，聚合可以非常稳定和连续地进行而没有凝胶化。

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