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1. 发明申请

WO2009014615A2 AMPHIPATHIC ALPHA-HELICAL PEPTIDE COMPOSITIONS AS ANTIVIRAL AGENTS 审中-公开
标题翻译： AMPHIPATHIC ALPHA-HELICAL PEPTIDE COMPOSITION AS ANTIVIRAL AGENTS
公开(公告)号：WO2009014615A2
公开(公告)日：2009-01-29
申请号：PCT/US2008/008627
申请日：2008-07-14
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , GLENN, Jeffrey, S. , CHO, Nam-Joon , FRANK, Curtis, W. , CHEONG, Kwang, Ho
发明人： GLENN, Jeffrey, S. , CHO, Nam-Joon , FRANK, Curtis, W. , CHEONG, Kwang, Ho
CPC分类号： A61K38/162 , A01N37/46 , A61L2/0082 , A61L29/08 , A61L29/16 , A61L31/08 , A61L31/16 , A61L2300/25 , A61L2300/408
摘要： The invention features methods and compositions that exploit the ability of amphipathic alpha-helical (AH) peptides to cause disruption of lipid-containing vesicles, such as enveloped viruses, in a size-dependent manner.
摘要翻译：本发明的特征在于利用两亲性α-螺旋（AH）肽以大小依赖的方式引起含脂质囊泡如包膜病毒破坏的能力的方法和组合物。

2. 发明申请

WO2008044807A2 AIR CONDITIONER AND CONTROLLING METHOD FOR THE SAME 审中-公开
标题翻译：空调器及其控制方法
公开(公告)号：WO2008044807A2
公开(公告)日：2008-04-17
申请号：PCT/KR2006004807
申请日：2006-11-15
申请人： LG ELECTRONICS INC , SONG CHI WOO , CHO NAM JOON , CHUNG BAIK YOUNG , CHANG SE DONG
发明人： SONG CHI WOO , CHO NAM JOON , CHUNG BAIK YOUNG , CHANG SE DONG
IPC分类号： F25B43/02
CPC分类号： F25B31/004 , F25B13/00 , F25B2313/0253 , F25B2400/075 , F25B2600/021 , F25B2600/2501 , F25B2600/2519 , F25B2700/03 , Y02B30/741
摘要： The present invention relates to an air conditioner and a method for controlling the same for stable operation of a cycle. For this, present invention provides an air conditioner including a plurality of compressors operated continuously for continuous qclic operation, oil separators for separating oil from refrigerant from the compressors and supplying the oil to the compressors again, and an oil distributor for selective supply of the oil from the oil separators to some of the plurality of compressors.
摘要翻译：空调机及其控制方法技术领域本发明涉及一种空调机及其控制方法，用于使循环的稳定运行。为此，本发明提供一种空调机，其包括连续运行的多台压缩机，用于连续运行的油压分离器，用于从压缩机中分离出制冷剂的油分，并再次向压缩机供油;以及油分配器，用于选择性地供给油从油分离器到多个压缩机中的一些。

3. 发明申请

WO2011062368A3 DRIVING BODY ACCELERATION DEVICE USING ELASTICITY 审中-公开
公开(公告)号：WO2011062368A3
公开(公告)日：2011-05-26
申请号：PCT/KR2010/006848
申请日：2010-10-07
申请人： CHO, Nam Joon
发明人： CHO, Nam Joon
IPC分类号： F16H3/44 , F16H3/00
摘要： A driving body acceleration device using elasticity includes an input gear, a carrier connected to the input gear, planetary gears mounted to the carrier such that each of the planetary gears is rotated about a hinge shaft, a sun gear threadedly engaged with the planetary gears while being surrounded by the planetary gears, an output shaft coupled to the center of the sun gear, a cam having a cam groove, and acceleration units, each of which has one end coupled to a corresponding one of the hinge shafts and the other end coupled to the cam groove, and each of which rotates a corresponding one of the hinge shafts such that each of the planetary gears is rotated, when the revolution angle at one end of each of the acceleration units is different from that at the other end of each of the acceleration units.

4. 发明申请

WO2011062368A2 DRIVING BODY ACCELERATION DEVICE USING ELASTICITY 审中-公开
标题翻译：使用弹性驱动身体加速装置
公开(公告)号：WO2011062368A2
公开(公告)日：2011-05-26
申请号：PCT/KR2010006848
申请日：2010-10-07
申请人： CHO NAM JOON
发明人： CHO NAM JOON
IPC分类号： F16H3/44 , F16H3/00
CPC分类号： F16H3/74
摘要： A driving body acceleration device using elasticity includes an input gear, a carrier connected to the input gear, planetary gears mounted to the carrier such that each of the planetary gears is rotated about a hinge shaft, a sun gear threadedly engaged with the planetary gears while being surrounded by the planetary gears, an output shaft coupled to the center of the sun gear, a cam having a cam groove, and acceleration units, each of which has one end coupled to a corresponding one of the hinge shafts and the other end coupled to the cam groove, and each of which rotates a corresponding one of the hinge shafts such that each of the planetary gears is rotated, when the revolution angle at one end of each of the acceleration units is different from that at the other end of each of the acceleration units.
摘要翻译：使用弹性的驱动体加速装置包括输入齿轮，连接到输入齿轮的行星架，安装在载体上的行星齿轮，使得每个行星齿轮围绕铰链轴转动，太阳齿轮与行星齿轮螺纹接合，同时被行星齿轮围绕的输出轴，耦合到太阳齿轮的中心的输出轴，具有凸轮槽的凸轮和加速单元，每个加速单元的一端联接到对应的一个铰链轴，另一端连接并且当每个加速单元的一端的旋转角度与每个加速度单元的另一端处的旋转角度不同时，每个行星齿轮都旋转相应的一个铰链轴，的加速单位。

5. 发明申请

WO2009148541A1 PIP-2 INHIBITION-BASED ANTIVIRAL AND ANTI-HYPERLIPIDEMIC THERAPIES 审中-公开
标题翻译： PIP-2基于抑制的抗病毒和抗高血压治疗
公开(公告)号：WO2009148541A1
公开(公告)日：2009-12-10
申请号：PCT/US2009/003271
申请日：2009-05-29
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , GLENN, Jeffrey, S. , CHO, Nam-Joon , PANG, Phillip, S. , LEE, Choongho
发明人： GLENN, Jeffrey, S. , CHO, Nam-Joon , PANG, Phillip, S. , LEE, Choongho
IPC分类号： A61K39/42
CPC分类号： G01N33/92 , A61K31/7036 , A61K45/06 , C12Q1/18
摘要： Interaction of a specific viral domain with phosphatidylinositol 4,5-bisphosphate (PIP 2) is shown to mediate viral replication. Basic Amino Acid PIP-2 Pincer (BAAPP) domains are described herein, including, without limitation, NS5A protein of HCV, NS4B protein of HCV, poliovirus, and rhinovirus.
摘要翻译：特异性病毒结构域与磷脂酰肌醇4,5-二磷酸酯（PIP 2）的相互作用显示可介导病毒复制。本文描述了碱性氨基酸PIP-2蒎烯（BAAPP）结构域，包括但不限于HCV的NS5A蛋白，HCV的NS4B蛋白，脊髓灰质炎病毒和鼻病毒。

6. 发明申请

WO2009014615A3 AMPHIPATHIC ALPHA-HELICAL PEPTIDE COMPOSITIONS AS ANTIVIRAL AGENTS 审中-公开
标题翻译： AMPHIPATHIC ALPHA-HELICAL PEPTIDE COMPOSITION AS ANTIVIRAL AGENTS
公开(公告)号：WO2009014615A3
公开(公告)日：2009-12-03
申请号：PCT/US2008008627
申请日：2008-07-14
申请人： UNIV LELAND STANFORD JUNIOR , GLENN JEFFREY S , CHO NAM-JOON , FRANK CURTIS W , CHEONG KWANG HO
发明人： GLENN JEFFREY S , CHO NAM-JOON , FRANK CURTIS W , CHEONG KWANG HO
IPC分类号： A61K38/16 , A61L2/16 , A61L31/10
CPC分类号： A61K38/162 , A01N37/46 , A61L2/0082 , A61L29/08 , A61L29/16 , A61L31/08 , A61L31/16 , A61L2300/25 , A61L2300/408
摘要： The invention features methods and compositions that exploit the ability of amphipathic alpha-helical (AH) peptides to cause disruption of lipid-contaming vesicles, such as enveloped viruses, in a size-dependent manner. In a preferred embodiment, the AH peptides have an aminoacid sequence of the N-terminal amphipathic alpha-helix of the hepatitis C virus (HCV) nonstructural protein NS5A.
摘要翻译：本发明的特征在于利用两亲性α-螺旋（AH）肽以大小依赖的方式引起脂质连续囊泡如包膜病毒破坏的能力的方法和组合物。在优选的实施方案中，AH肽具有丙型肝炎病毒（HCV）非结构蛋白NS5A的N-末端两亲性α-螺旋的氨基酸序列。

7. 发明申请

WO2006110350A2 METHOD OF FABRICATING LIPID BILAYER MEMBRANES ON SOLID SUPPORTS 审中-公开
标题翻译：在固体支撑物上制备脂质双层膜的方法
公开(公告)号：WO2006110350A2
公开(公告)日：2006-10-19
申请号：PCT/US2006/012085
申请日：2006-03-29
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , CHO, Nam-Joon , FRANK, Curtis, W.
发明人： CHO, Nam-Joon , FRANK, Curtis, W.
IPC分类号： C12M3/00
CPC分类号： G01N33/533 , B82Y5/00 , G01N33/554 , Y10T428/31678
摘要： The present invention provides a method of producing a planar lipid bilayer on a solid support. With this method, a solution of lipid vesicles is first deposited on the solid support. Next, the lipid vesicles are destabilized by adding an amphipathic peptide solution to the lipid vesicle solution. This destabilization leads to production of a planar lipid bilayer on the solid support. The present invention also provides a supported planar lipid bilayer, where the planar lipid bilayer is made of naturally occurring lipids and the solid support is made of unmodified gold or titanium oxide. Preferably, the supported planar lipid bilayer is continuous. The planar lipid bilayer may be made of any naturally occurring lipid or mixture of lipids, including but not limited to phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phosphatidylinositol, cardiolipin, cholesterol, and sphingomyelin.
摘要翻译：本发明提供了一种在固体支持物上制备平面脂双层的方法。使用该方法，首先将脂质囊泡溶液沉积在固体支持物上。接下来，通过向脂质囊泡溶液中加入两亲肽溶液使脂质囊泡不稳定。这种不稳定性导致在固体支持物上产生平面脂双层。本发明还提供了一种支撑的平面脂质双层，其中平面脂质双层由天然存在的脂质制成，并且固体支持物由未改性的金或氧化钛制成。优选地，支撑的平面脂质双层是连续的。平面脂质双层可以由任何天然存在的脂质或脂质混合物制成，包括但不限于磷脂酰胆碱，磷脂酰乙醇胺，磷脂酰丝氨酸，磷脂酰肌醇，心磷脂，胆固醇和鞘磷脂。

8. 发明申请

WO2010039195A3 SCREENING FOR INHIBITORS OF HCV AMPHIPATHIC HELIX (AH) FUNCTION 审中-公开
标题翻译：筛选HCV双价体螺旋（AH）功能抑制剂
公开(公告)号：WO2010039195A3
公开(公告)日：2010-05-27
申请号：PCT/US2009005306
申请日：2009-09-23
申请人： UNIV LELAND STANFORD JUNIOR , GLENN JEFFREY S , CHO NAM-JOON , YANG WENJIN
发明人： GLENN JEFFREY S , CHO NAM-JOON , YANG WENJIN
IPC分类号： G01N33/68 , G01N33/92
CPC分类号： C07K14/005 , C12N2770/24222
摘要： Screening methods are provided for identifying pharmacologic inhibitors of HCV amphipathic helix (AH) function, which inhibitors are useful in the prevention and treatment of HCV infection. Also provided are compounds useful in the inhibition of viral replication. The methods of the invention are based on the unexpected discovery that the presence of an AH, e.g. an AH of an HCV polypeptide, causes an increase in the apparent diameter of the vesicles. The methods of the invention provide for addition of AH peptides to lipid vesicles, for example in a high-throughput format; which addition may be performed in the absence or presence of a candidate pharmacologic agent. The change in apparent vesicle size is measured, and compared to control samples. An increase in vesicle size or aggregation is indicative of AH function being present; and a lack of increase is indicative that the AH function is absent or has been inhibited by a test agent.
摘要翻译：筛选方法用于鉴定HCV两亲性螺旋（AH）功能的药理学抑制剂，该抑制剂可用于预防和治疗HCV感染。还提供了用于抑制病毒复制的化合物。本发明的方法基于意想不到的发现，即AH的存在，例如， HCV多肽的AH引起囊泡表观直径的增加。本发明的方法例如以高通量形式向脂质囊泡中添加AH肽; 该添加可以在不存在或存在候选药剂的情况下进行。测量表观囊泡大小的变化，并与对照样品比较。囊泡大小或聚集的增加表明存在AH功能; 并且缺乏增加表明AH功能不存在或已被测试药剂抑制。

9. 发明申请

WO2010039195A2 SCREENING FOR INHIBITORS OF HCV AMPHIPATHIC HELIX (AH) FUNCTION 审中-公开
标题翻译：筛选HCV雄性HELIX（AH）功能的抑制剂
公开(公告)号：WO2010039195A2
公开(公告)日：2010-04-08
申请号：PCT/US2009/005306
申请日：2009-09-23
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , GLENN, Jeffrey S. , CHO, Nam-Joon , YANG, Wenjin
发明人： GLENN, Jeffrey S. , CHO, Nam-Joon , YANG, Wenjin
IPC分类号： C12Q1/70
CPC分类号： C07K14/005 , C12N2770/24222
摘要： Screening methods are provided for identifying pharmacologic inhibitors of HCV amphipathic helix (AH) function, which inhibitors are useful in the prevention and treatment of HCV infection. Also provided are compounds useful in the inhibition of viral replication. The methods of the invention are based on the unexpected discovery that the presence of an AH, e.g. an AH of an HCV polypeptide, causes an increase in the apparent diameter of the vesicles. The methods of the invention provide for addition of AH peptides to lipid vesicles, for example in a high-throughput format; which addition may be performed in the absence or presence of a candidate pharmacologic agent. The change in apparent vesicle size is measured, and compared to control samples. An increase in vesicle size or aggregation is indicative of AH function being present; and a lack of increase is indicative that the AH function is absent or has been inhibited by a test agent.
摘要翻译：提供筛选方法用于鉴定HCV两亲性螺旋（AH）功能的药理学抑制剂，该抑制剂可用于预防和治疗HCV感染。还提供了可用于抑制病毒复制的化合物。本发明的方法基于意想不到的发现，即AH的存在，例如， HCV多肽的AH引起囊泡表观直径的增加。本发明的方法提供了将AH肽添加到脂质囊泡中，例如以高通量形式加入; 该添加可以在不存在或存在候选药理剂的情况下进行。测量明显囊泡大小的变化，并与对照样品进行比较。囊泡大小或聚集的增加表明存在AH功能; 并且缺乏增加表明AH功能不存在或已被测试者抑制。

10. 发明申请

WO2008044807A3 AIR CONDITIONER AND CONTROLLING METHOD FOR THE SAME 审中-公开
公开(公告)号：WO2008044807A3
公开(公告)日：2008-04-17
申请号：PCT/KR2006/004807
申请日：2006-11-15
申请人： LG ELECTRONICS INC. , SONG, Chi Woo , CHO, Nam Joon , CHUNG, Baik Young , CHANG, Se Dong
发明人： SONG, Chi Woo , CHO, Nam Joon , CHUNG, Baik Young , CHANG, Se Dong
IPC分类号： F24F11/02 , F25B31/00
摘要： The present invention relates to an air conditioner and a method for controlling the same for stable operation of a cycle. For this, present invention provides an air conditioner including a plurality of compressors (83, 84) operated continuously for continuous cyclic operation, oil separators (85, 86) for separating oil from refrigerant from the compressors (83, 84) and supplying the oil to the compressors (83, 84) again, and an oil distributor (510, 530, 550) for selective supply of the oil from the oil separators (85, 86) to some of the plurality of compressors (83,84).

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