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1. 发明申请

WO2006063181A1 MULTIFUNCTIONAL MEDICAL ARTICLES 审中-公开
标题翻译：多功能医学文章
公开(公告)号：WO2006063181A1
公开(公告)日：2006-06-15
申请号：PCT/US2005/044504
申请日：2005-12-06
申请人： SURMODICS, INC. , CHINN, Joseph, A. , STUCKE, Sean, M. , CHUDZIK, Stephen, J.
发明人： CHINN, Joseph, A. , STUCKE, Sean, M. , CHUDZIK, Stephen, J.
IPC分类号： A61M25/00 , A61L29/16
CPC分类号： A61L29/085 , A61L27/34 , A61L31/10 , A61L33/0011
摘要： The invention provides medical articles that include more than one biocompatibility-promoting function. In one aspect, the invention provides a medical articles that include a polymeric matrix including more than one biocompatible agent, wherein each biocompatible agent is provided at a distinct portion of the medical article surface. Methods of making medical articles, as well as methods of using the same, are also described.
摘要翻译：本发明提供包括多于一种生物相容性促进功能的医疗制品。在一个方面，本发明提供了包括包含多于一种生物相容剂的聚合物基质的医疗制品，其中每个生物相容性试剂提供在医疗用品表面的不同部分。还描述了制造医疗用品的方法及其使用方法。

2. 发明申请

WO2006050110A2 PRO-FIBROTIC COATINGS 审中-公开
标题翻译： PRO-FIBROTIC涂料
公开(公告)号：WO2006050110A2
公开(公告)日：2006-05-11
申请号：PCT/US2005/038959
申请日：2005-10-28
申请人： SURMODICS, INC. , CHINN, Joseph, A. , CHUDZIK, Stephen, J. , STUCKE, Sean, M.
发明人： CHINN, Joseph, A. , CHUDZIK, Stephen, J. , STUCKE, Sean, M.
IPC分类号： A61L33/12 , A61L15/32
CPC分类号： A61L31/10 , A61L27/34 , A61L33/0029 , A61L33/122 , C08L89/06
摘要： Pro-fibrotic coatings for medical articles are described that include a pro-fibrotic polymer such as collagen. The pro-fibrotic coatings can also include a thromboresistant polymer. The coatings can be formed by activation of photoreactive groups pendent or independent of the coating materials.
摘要翻译：描述了用于医疗制品的原纤维化涂层，其包括前纤维化聚合物如胶原蛋白。前纤维化涂层还可以包括抗血栓性聚合物。涂层可以通过活化侧基或独立于涂层材料的光反应性基团形成。

3. 发明申请

WO2005115490A3 NATURAL BIODEGRADABLE POLYSACCHARIDE COATINGS FOR MEICAL ARTICLES 审中-公开
标题翻译：天然生物可降解的多糖涂层用于医学文章
公开(公告)号：WO2005115490A3
公开(公告)日：2006-02-09
申请号：PCT/US2005018452
申请日：2005-05-25
申请人： SURMODICS INC , HEYER TONI M , SWAN DALE G , CHUDZIK STEPHEN J , CHINN JOSEPH A , CHAPPA RALPH A
发明人： HEYER TONI M , SWAN DALE G , CHUDZIK STEPHEN J , CHINN JOSEPH A , CHAPPA RALPH A
IPC分类号： A61L2/00 , A61L27/00 , A61L27/34 , A61L33/00 , B05D3/00
CPC分类号： A61L27/34 , A61L33/0029 , C08L33/06
摘要： Polymeric coatings that include coupled biomolecules are formed on the surface of articles, such as medical devices. A coated layer that includes a synthetic polymer including a reactive group is formed on a surface and then a biomolecule is attached to the reactive group. The synthetic polymer can be an acrylate polymer or an amine-containing polymer having pendent photoreactive groups.
摘要翻译：包括偶联的生物分子的聚合物涂层形成在诸如医疗装置的制品的表面上。在表面上形成包括含有反应性基团的合成聚合物的涂层，然后将生物分子连接到反应性基团上。合成聚合物可以是具有侧基光反应性基团的丙烯酸酯聚合物或含胺聚合物。

4. 发明申请

WO2005113034A1 NATURAL BIODEGRADABLE POLYSACCHARIDES COATINGS FOR MEDICAL ARTICLES 审中-公开
标题翻译：天然生物可降解多糖类药物涂料
公开(公告)号：WO2005113034A1
公开(公告)日：2005-12-01
申请号：PCT/US2005/016604
申请日：2005-05-12
申请人： SURMODICS, INC. , CHUDZIK, Stephen, J. , CHINN, Joseph, A. , SWAN, Dale, G. , BURKSTRAND, Michael, J.
发明人： CHUDZIK, Stephen, J. , CHINN, Joseph, A. , SWAN, Dale, G. , BURKSTRAND, Michael, J.
IPC分类号： A61L27/34
CPC分类号： A61L31/16 , A61F2210/0004 , A61F2310/00389 , A61L27/34 , A61L27/54 , A61L31/10 , A61L2300/232 , A61L2300/252 , A61L2300/258 , A61L2300/406 , A61L2300/416 , A61L2300/418 , A61L2300/622 , C08L5/00
摘要： Biodegradable coatings that include natural biodegradable polysaccharides are described. The coating is formed from a plurality of natural biodegradable polysaccharides having pendent coupling groups.
摘要翻译：描述了包括天然可生物降解多糖的可生物降解涂层。涂层由具有侧联偶合基团的多种天然可生物降解多糖形成。

5. 发明申请

WO2006091675A3 IMPLANTABLE MEDICAL ARTICLES HAVING LAMININ COATINGS AND METHODS OF USE 审中-公开
标题翻译：具有层压涂层的可植入医疗用品及其使用方法
公开(公告)号：WO2006091675A3
公开(公告)日：2007-06-14
申请号：PCT/US2006006294
申请日：2006-02-23
申请人： SURMODICS INC , WILLIAMS STUART K , BABCOCK DAVID E , CHINN JOSEPH A , CLAPPER DAVID L
发明人： WILLIAMS STUART K , BABCOCK DAVID E , CHINN JOSEPH A , CLAPPER DAVID L
IPC分类号： A61L27/22 , A61L27/16 , A61L27/24 , A61L27/26 , A61L27/34 , A61L27/56 , A61L29/08 , A61L31/10 , C08H1/00 , C08L27/18 , C08L89/00
CPC分类号： A61K38/39 , A61K38/10 , A61L27/34 , A61L27/54 , A61L29/085 , A61L31/10 , A61L2300/25 , A61L2300/254 , A61L2300/606 , C08L89/00 , C08L89/06
摘要： Laminin-containing coatings for the surfaces of implantable medical devices are disclosed. The coatings promote the formation of vessels in association with the coated surfaces with minimal fibrotic resonse.
摘要翻译：公开了用于可植入医疗装置的表面的含层粘蛋白的涂层。涂层促进与涂层表面相关联的血管的形成，同时具有最小的纤维化反应。

6. 发明申请

WO2007035886A1 NATURAL BIODEGRADABLE MATRICES AND USES THEREOF 审中-公开
标题翻译：自然生物可降解矩阵及其用途
公开(公告)号：WO2007035886A1
公开(公告)日：2007-03-29
申请号：PCT/US2006/036861
申请日：2006-09-21
申请人： SURMODICS, INC. , CHUDZIK, Stephen, J. , BURKSTRAND, Michael, J. , SWAN, Dale, G. , CHINN, Joseph, A.
发明人： CHUDZIK, Stephen, J. , BURKSTRAND, Michael, J. , SWAN, Dale, G. , CHINN, Joseph, A.
IPC分类号： A61L31/04 , A61L31/14 , A61L31/16 , A61L31/10
CPC分类号： A61L27/20 , A61K9/0024 , A61K9/0051 , A61K9/2027 , A61K9/205 , A61K47/34 , A61L27/34 , A61L27/54 , A61L27/58 , A61L29/085 , A61L29/16 , A61L31/042 , A61L31/10 , A61L31/16 , A61L2300/232 , A61L2300/252 , A61L2300/258 , A61L2300/604 , A61L2300/606 , A61L2420/02 , B05D1/36 , B05D7/52 , C08B31/006 , C08B31/04 , C08B33/02 , C08B33/04 , C08L3/02 , C08L3/12 , C09D103/02 , C09D103/18
摘要： Matrices formed from a natural biodegradable material and that exhibit surface degradation in the presence of an enzyme are described. Matrices including a bioactive agent can be implanted or formed in a subject for release of the bioactive agent upon degradation of the matrix. The matrix can be provided in various forms, including coatings for implantable devices, implants, and in-situ formed matrices. The matrix can also be in the form of a medical device having a structure that is used to treat a medical condition.
摘要翻译：描述了由天然可生物降解材料形成并在酶存在下显示表面降解的基质。包括生物活性剂的基质可以在受试者中植入或形成，以在基质降解时释放生物活性剂。基质可以以各种形式提供，包括用于可植入装置的涂层，植入物和原位形成的基质。该基质还可以是具有用于治疗医疗状况的结构的医疗装置的形式。

7. 发明申请

WO2005115490A2 METHODS AND REAGENTS FOR PREPARING BIOMOLECULE-CONTAINING COATINGS 审中-公开
标题翻译：制备生物分子涂料的方法和试剂
公开(公告)号：WO2005115490A2
公开(公告)日：2005-12-08
申请号：PCT/US2005/018452
申请日：2005-05-25
申请人： SURMODICS, INC. , HEYER, Toni, M. , SWAN, Dale, G. , CHUDZIK, Stephen, J. , CHINN, Joseph, A. , CHAPPA, Ralph, A.
发明人： HEYER, Toni, M. , SWAN, Dale, G. , CHUDZIK, Stephen, J. , CHINN, Joseph, A. , CHAPPA, Ralph, A.
IPC分类号： A61L27/00
CPC分类号： A61L27/34 , A61L33/0029 , C08L33/06
摘要： Polymeric coatings that include coupled biomolecules are formed on the surface of articles, such as medical devices. A coated layer that includes a synthetic polymer including a reactive group is formed on a surface and then a biomolecule is attached to the reactive group. The synthetic polymer can be an acrylate polymer or an amine-containing polymer having pendent photoreactive groups.
摘要翻译：包括偶联的生物分子的聚合物涂层形成在诸如医疗装置的制品的表面上。在表面上形成包括含有反应性基团的合成聚合物的涂层，然后将生物分子连接到反应性基团上。合成聚合物可以是具有侧基光反应性基团的丙烯酸酯聚合物或含胺聚合物。

8. 发明申请

WO2008002852A3 CROSSLINKABLE MACROMERS 审中-公开
标题翻译：可交换MACROMERS
公开(公告)号：WO2008002852A3
公开(公告)日：2009-04-30
申请号：PCT/US2007071978
申请日：2007-06-25
申请人： SURMODICS INC , CHUDZIK STEPHEN J , CHINN JOSEPH A
发明人： CHUDZIK STEPHEN J , CHINN JOSEPH A
IPC分类号： A61L27/34 , A61L27/16 , A61L27/54 , A61L29/04 , A61L29/08 , A61L29/16 , A61L31/04 , A61L31/10 , A61L31/16 , C08J3/24
CPC分类号： A61L27/34 , A61L29/085 , A61L31/10 , Y10S623/92 , Y10S623/926
摘要： A crosslinkable macromer system and related methods of preparing the system and using the system in the form of a crosslinked matrix between a tissue site and an implant article such as a tissue implant or on the porous surface of a prosthetic device. The macromer system includes two or more polymer-pendent polymerizable groups and one or more multifunctional initiator groups. The polymerizable groups and the initiator group(s), when polymer-pendent, can be pendent on the same or different polymeric backbones. The macromer system provides advantages over the use of polymerizable macromers and separate, low molecular weight initiators, including advantages with respect to such properties as nontoxicity, efficiency, and solubility. A macromer system of the invention can be used as an interface between the tissue site and implant article in a manner sufficient to permit tissue growth through the crosslinked matrix and between the tissue site and implant. In a preferred embodiment, polymers with pendent polymerizable groups, for use in the macromer system, are prepared by reacting a polysaccharide polymer with a reactive moiety in an organic, polar solvent such as formamide.
摘要翻译：一种可交联的大分子单体系统和相关的制备该系统的方法以及在组织部位和植入物制品例如组织植入物或假体装置的多孔表面之间使用交联基质形式的系统。大分子单体体系包括两个或多个聚合物侧基可聚合基团和一个或多个多官能引发剂基团。当聚合物侧链可聚合基团和引发剂基团可以悬挂在相同或不同的聚合物主链上。大分子单体体系提供优于使用可聚合的大分子单体和分离的低分子量引发剂，包括关于无毒性，效率和溶解性等性质的优点。本发明的大分子单体系统可以以足以允许组织生长通过交联基质和组织部位和植入物之间的方式用作组织部位和植入物之间的界面。在优选的实施方案中，用于大分子单体体系中的具有侧链可聚合基团的聚合物通过使多糖聚合物与有机极性溶剂如甲酰胺中的反应性部分反应来制备。

9. 发明申请

WO2006091675A2 IMPLANTABLE MEDICAL ARTICLES HAVING LAMININ COATINGS AND METHODS OF USE 审中-公开
标题翻译：具有层压涂层的可植入医疗用品及其使用方法
公开(公告)号：WO2006091675A2
公开(公告)日：2006-08-31
申请号：PCT/US2006/006294
申请日：2006-02-23
申请人： SURMODICS, INC. , WILLIAMS, Stuart, K. , BABCOCK, David, E. , CHINN, Joseph, A. , CLAPPER, David, L.
发明人： WILLIAMS, Stuart, K. , BABCOCK, David, E. , CHINN, Joseph, A. , CLAPPER, David, L.
CPC分类号： A61K38/39 , A61K38/10 , A61L27/34 , A61L27/54 , A61L29/085 , A61L31/10 , A61L2300/25 , A61L2300/254 , A61L2300/606 , C08L89/00 , C08L89/06
摘要： Laminin-containing coatings for the surfaces of implantable medical devices are disclosed. The coatings promote the formation of vessels in association with the coated surfaces with minimal fibrotic resonse.
摘要翻译：公开了用于可植入医疗装置的表面的含层粘蛋白的涂层。涂层促进与涂层表面相关联的血管的形成，具有最小的纤维化反应。

10. 发明申请

WO2008008253A2 IMPLANTABLE MEDICAL ARTICLES HAVING PRO-HEALING COATINGS 审中-公开
标题翻译：具有护理涂层的可植入医疗用品
公开(公告)号：WO2008008253A2
公开(公告)日：2008-01-17
申请号：PCT/US2007/015469
申请日：2007-07-03
申请人： SURMODICS, INC. , WILLIAMS, Stuart, K. , BABCOCK, David, E. , CHINN, Joseph, A. , CLAPPER, David, L.
发明人： WILLIAMS, Stuart, K. , BABCOCK, David, E. , CHINN, Joseph, A. , CLAPPER, David, L.
IPC分类号： A61F2/00 , A61L31/08 , A61L31/10
CPC分类号： A61L29/085 , A61F2/91 , A61L27/34 , A61L31/10 , A61L33/0029 , A61L33/122 , A61L33/128 , A61L2420/08 , C08L89/00 , C08L89/06
摘要： Coatings including adhesion factors for the surfaces of implantable medical articles are disclosed. The coatings are used to improve the function of the device by promoting a pro-healing response following implantation. The coatings can modulate endothelialization of the article surface to reduce the risk of adverse tissue responses that may reduce the functionality of the device.
摘要翻译：公开了包括可植入医疗制品表面的粘附因子的涂层。涂层用于通过促进植入后的预愈合反应来改善装置的功能。涂层可以调节制品表面的内皮化，以减少可能降低装置功能的不利组织反应的风险。

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