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1. 发明专利

JPS5294265A MULTIIFUNCTION FOLDING CHAIR 失效
公开(公告)号：JPS5294265A
公开(公告)日：1977-08-08
申请号：JP861977
申请日：1977-01-26
申请人： CHEN HELEN HO CHIU , CHEN DAVID WAN CHING
发明人： CHEN HELEN HO-CHIU , CHEN DAVID WAN-CHING
IPC分类号： A47C4/28 , A47C4/24 , A47C13/00 , A63F3/00

2. 发明专利

CA2582093A1 BODY ELONGATOR 未知
公开(公告)号：CA2582093A1
公开(公告)日：2008-04-24
申请号：CA2582093
申请日：2007-02-15
申请人： CHEN HELEN , LEE JAY
发明人： CHEN HELEN , LEE JAY
IPC分类号： A61H1/02
摘要： A body elongator includes a container in which a heel elongator and a calf stretcher are fixed. The heel elongator has a leg support slide selectively movable for a predetermined distance by a driving mechanism for elongating a user's heels secured to the leg support slide. The calf stretcher has a toe bar supported between and by two carrier posts. The carrier posts, along with th e toe bar, can be rotated from a horizontal position to a vertical position wi th respect to the frame body. When the user's toes are leaned tightly against the toe bar, with heels secured to the leg support slide, making the feet plantar flexion along the movement direction of the leg support slide, the Achilles tendon and the calf muscles groups can be stretched when the leg support slide is driven to move into the container.

3. 发明专利

DE2701049A1 未知
公开(公告)号：DE2701049A1
公开(公告)日：1977-07-28
申请号：DE2701049
申请日：1977-01-12
申请人： CHEN HELEN HO CHIU
发明人： CHEN HELEN HO-CHIU
IPC分类号： A47C4/28 , A47C4/24 , A47C13/00 , A63F3/00 , A47C4/26

4. 发明专利

CA2582093C BODY ELONGATOR 未知
公开(公告)号：CA2582093C
公开(公告)日：2009-07-21
申请号：CA2582093
申请日：2007-02-15
申请人： CHEN HELEN , LEE JAY
发明人： CHEN HELEN , LEE JAY
IPC分类号： A61H1/02
摘要： A body elongator includes a container in which a heel elongator and a calf stretcher are fixed. The heel elongator has a leg support slide selectively movable for a predetermined distance by a driving mechanism for elongating a user's heels secured to the leg support slide. The calf stretcher has a toe bar supported between and by two carrier posts. The carrier posts, along with th e toe bar, can be rotated from a horizontal position to a vertical position wi th respect to the frame body. When the user's toes are leaned tightly against the toe bar, with heels secured to the leg support slide, making the feet plantar flexion along the movement direction of the leg support slide, the Achilles tendon and the calf muscles groups can be stretched when the leg support slide is driven to move into the container.

5. 发明申请

WO2020117626A1 4-AMINO OR 4-ALKOXY-SUBSTITUTED ARYL SULFONAMIDE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS 审中-公开
公开(公告)号：WO2020117626A1
公开(公告)日：2020-06-11
申请号：PCT/US2019/063909
申请日：2019-12-02
申请人： MERCK SHARP & DOHME CORP. , BUNGARD, Christopher J. , CHEN, Helen Y. , COX, Jason M. , GUO, Liangqin , KELLY, Michael J. III , KIM, Ronald M. , LAYTON, Mark E. , LIU, Hong , LIU, Jian , PATEL, Mehul F. , PERKINS, James J. , WANG, Deping , WON, Walter , YU, Younong , ZHANG, Ting
发明人： BUNGARD, Christopher J. , CHEN, Helen Y. , COX, Jason M. , GUO, Liangqin , KELLY, Michael J. III , KIM, Ronald M. , LAYTON, Mark E. , LIU, Hong , LIU, Jian , PATEL, Mehul F. , PERKINS, James J. , WANG, Deping , WON, Walter , YU, Younong , ZHANG, Ting
IPC分类号： C07D495/04 , C12Q1/26
摘要： Disclosed are compounds of Formula (I), Formula (II), or a salt thereof: Formula (I) Formula (II) which compounds have properties for inhibiting Nav 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula (I), Formula (II) or their salts, and methods of treating pain disorders, cough, and itch using the same.

6. 发明申请

WO2016022742A1 ANTIDIABETIC BICYCLIC COMPOUNDS 审中-公开
标题翻译：抗生素双胶体化合物
公开(公告)号：WO2016022742A1
公开(公告)日：2016-02-11
申请号：PCT/US2015/043903
申请日：2015-08-06
申请人： MERCK SHARP & DOHME CORP. , CHEN, Helen , COLLETTI, Steven, L. , DEMONG, Duane , GUO, Yan , MILLER, Michael , NAIR, Anilkumar , PLUMMER, Christopher, W. , XIAO, Dong , YANG, De-Yi
发明人： CHEN, Helen , COLLETTI, Steven, L. , DEMONG, Duane , GUO, Yan , MILLER, Michael , NAIR, Anilkumar , PLUMMER, Christopher, W. , XIAO, Dong , YANG, De-Yi
IPC分类号： A61K31/357
CPC分类号： C07D311/60 , A61K31/366 , A61K31/397 , A61K31/4985 , A61K45/06 , C07D405/10 , C07D405/14 , C07D413/12 , C07D413/14 , C07D451/02 , C07D471/08 , C07D487/04 , C07D487/08 , C07D491/048 , C07D491/08 , C07D491/107 , A61K2300/00
摘要： Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.
摘要翻译：结构式（I）的新型化合物及其药学上可接受的盐是G蛋白偶联受体40（GPR40）的激动剂，可用于治疗，预防和抑制G蛋白偶联受体受体40.本发明的化合物可用于治疗2型糖尿病，以及通常与该疾病相关的病症，包括肥胖症和脂质疾病，例如混合或糖尿病性血脂异常，高脂血症，高胆固醇血症和高甘油三酯血症。

7. 发明申请

WO2014130608A1 ANTIDIABETIC BICYCLIC COMPOUNDS 审中-公开
标题翻译：抗生素双胶体化合物
公开(公告)号：WO2014130608A1
公开(公告)日：2014-08-28
申请号：PCT/US2014/017264
申请日：2014-02-20
申请人： MERCK SHARP & DOHME CORP. , BROCKUNIER, Linda, L. , CHEN, Helen , CHOBANIAN, Harry, R. , CLEMENTS, Matthew, J. , CRESPO, Alejandro , DEMONG, Duane, E. , GUO, Yan , HAGMANN, William, K. , MARCANTONIO, Karen, M. , MILLER, Michael , PIO, Barbara , PLUMMER, Christopher, W. , XIAO, Dong
发明人： BROCKUNIER, Linda, L. , CHEN, Helen , CHOBANIAN, Harry, R. , CLEMENTS, Matthew, J. , CRESPO, Alejandro , DEMONG, Duane, E. , GUO, Yan , HAGMANN, William, K. , MARCANTONIO, Karen, M. , MILLER, Michael , PIO, Barbara , PLUMMER, Christopher, W. , XIAO, Dong
IPC分类号： A61K31/357
CPC分类号： C07D493/04 , A61K31/352 , A61K31/416 , A61K31/422 , A61K31/427 , A61K31/436 , A61K31/4433 , A61K31/444 , A61K31/497 , A61K31/538 , A61K45/06 , C07D201/00 , C07D311/04 , C07D311/28 , C07D319/20 , C07D405/04 , C07D405/06 , C07D405/10 , C07D405/14 , C07D413/10 , C07D417/04 , C07D491/048 , C07D491/052
摘要： Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.
摘要翻译：结构式（I）的新型化合物及其药学上可接受的盐是G蛋白偶联受体40（GPR40）的激动剂，可用于治疗，预防和抑制G蛋白偶联受体受体40.本发明的化合物可用于治疗2型糖尿病，以及通常与该疾病相关的病症，包括肥胖症和脂质疾病，例如混合或糖尿病性血脂异常，高脂血症，高胆固醇血症和高甘油三酯血症。

8. 发明申请

WO2013134012A1 PREPARATION AND USE OF BICYCLIC HIMBACINE DERIVATIVES AS PAR-RECEPTOR ANTAGONISTS 审中-公开
标题翻译：作为PAR受体拮抗剂的双酚衍生物衍生物的制备和使用
公开(公告)号：WO2013134012A1
公开(公告)日：2013-09-12
申请号：PCT/US2013/027838
申请日：2013-02-27
申请人： MERCK SHARP & DOHME CORP. , MANDAL, Mihir , BLIZZARD, Timothy, A. , CHEN, Helen , CHOBANIAN, Harry , GUO, Yan , PIO, Barbara , WU, Zhicai , BIFTU, Tesfaye , GREENLEE, William, J. , ZHU, Johnny Zhaoning
发明人： MANDAL, Mihir , BLIZZARD, Timothy, A. , CHEN, Helen , CHOBANIAN, Harry , GUO, Yan , PIO, Barbara , WU, Zhicai , BIFTU, Tesfaye , GREENLEE, William, J. , ZHU, Johnny Zhaoning
IPC分类号： A61K31/44
CPC分类号： C07D405/06 , A61K31/365 , A61K31/4365 , A61K31/443 , A61K31/4439 , A61K31/444 , A61K31/616 , A61K45/06 , C07D401/06 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , A61K2300/00
摘要： The present invention relates to bicyclic himbacine derivatives of the formula or a pharmaceutically acceptable salt thereof, wherein: X is -O-, -N(R), -C(R 8 )(R 9 ) or -C(O)-; and Y is -O-, -N(R), -C(R 8 )(R 9 ) or -C(O)- and the remaining variables are described herein. The compounds of the invention are effective inhibitors of the PAR-1 receptor. The inventive compounds may be used for the treatment or prophylaxis of disease states such as ACS, secondary prevention of myocardial infarction or stroke, or PAD.
摘要翻译：本发明涉及下式的双环烟肼衍生物或其药学上可接受的盐，其中：X是-O - ， - N（R），-C（R 8）（R 9）或-C（O） - ; 并且Y是-O - ， - N（R），-C（R 8）（R 9）或-C（O） - ，其余变量在本文中描述。本发明的化合物是PAR-1受体的有效抑制剂。本发明化合物可用于治疗或预防诸如ACS，二级预防心肌梗塞或中风或PAD的疾病状态。

9. 发明申请

WO2008073142A8 NOVEL INHIBITORS OF BETA-LACTAMASE 审中-公开
标题翻译： β-LACTAMASE的新型抑制剂
公开(公告)号：WO2008073142A8
公开(公告)日：2009-01-29
申请号：PCT/US2007011979
申请日：2007-05-21
申请人： MERCK & CO INC , METHYLGENE INC , DININNO FRANK , HAMMOND MILTON L , DYKSTRA KEVIN , KIM SEONGKON , TAN QIANG , YOUNG KATHERINE , HERMES JEFFREY DONALD , CHEN HELEN , RAEPPEL STEPHANE , MANNION MICHAEL , GAUDETTE FREDERIC , VAISBURG ARKADII , RAHL JUBRAIL , GEORGOPAPADAKOU NAFSIKA , ZHOU NANCY Z
发明人： DININNO FRANK , HAMMOND MILTON L , DYKSTRA KEVIN , KIM SEONGKON , TAN QIANG , YOUNG KATHERINE , HERMES JEFFREY DONALD , CHEN HELEN , RAEPPEL STEPHANE , MANNION MICHAEL , GAUDETTE FREDERIC , VAISBURG ARKADII , RAHL JUBRAIL , GEORGOPAPADAKOU NAFSIKA , ZHOU NANCY Z
IPC分类号： A61P31/04 , A61K31/67 , A61K31/675 , C07F9/6539 , C07F9/6541 , C07F9/6553 , C07F9/6558 , C07F9/6561
CPC分类号： C07F9/655354 , C07F9/65395 , C07F9/6541 , C07F9/6553 , C07F9/6558 , C07F9/6561
摘要： This invention provides novel ß-lactamase inhibitors of the aryl-and heteroarylsulfonarnidomethylphosphonate monoester class having nitrogen-based cations or quarternary ammomium groups. The compounds inhibit three classes of ß-lactamases and synergize the antibacterial effects of ß-lactam antibiotics (e.g., imipenem and ceftazimdime) against those micro-organisms normally resistant to the ß-lactam antibiotics as a result of the presence of the ß-lactamases. Formula (I) or pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供了具有氮基阳离子或季铵基团的芳基和杂芳基磺酰基甲基膦酸酯单酯类的新型β-内酰胺酶抑制剂。该化合物抑制三种类型的β-内酰胺酶，并且与β-内酰胺类抗生素（例如，亚胺培南和头孢他啶的抗菌作用）对抗β-内酰胺抗生素通常具有抗ß-内酰胺抗生素的微生物的协同作用是由于存在β-内酰胺酶。式（I）或其药学上可接受的盐。

10. 发明申请

WO2008073142A2 NOVEL INHIBITORS OF BETA-LACTAMASE 审中-公开
标题翻译： β-LACTAMASE的新型抑制剂
公开(公告)号：WO2008073142A2
公开(公告)日：2008-06-19
申请号：PCT/US2007/011979
申请日：2007-05-21
申请人： MERCK & CO., INC. , METHLGENE INC. , DININNO, Frank , HAMMOND, Milton, L. , DYKSTRA, Kevin , KIM, Seongkon , TAN, Qiang , YOUNG, Katherine , HERMES, Jeffrey, Donald , CHEN, Helen , RAEPPEL, Stephane , MANNION, Michael , GAUDETTE, Frederic , VAISBURG, Arkadii , RAHL, Jubrail , GEORGOPAPADAKOU, Nafsika , ZHOU, Nancy, Z.
发明人： DININNO, Frank , HAMMOND, Milton, L. , DYKSTRA, Kevin , KIM, Seongkon , TAN, Qiang , YOUNG, Katherine , HERMES, Jeffrey, Donald , CHEN, Helen , RAEPPEL, Stephane , MANNION, Michael , GAUDETTE, Frederic , VAISBURG, Arkadii , RAHL, Jubrail , GEORGOPAPADAKOU, Nafsika , ZHOU, Nancy, Z.
CPC分类号： C07F9/655354 , C07F9/65395 , C07F9/6541 , C07F9/6553 , C07F9/6558 , C07F9/6561
摘要： This invention provides novel β-lactamase inhibitors of the aryl-and heteroaryl- sulfonamidomethylphosphonate monoester class having nitrogen-based cations or quarternary ammomium groups. The compounds inhibit three classes of β-lactamases and synergize the antibacterial effects of β-lactam antibiotics (e.g., imipenem and ceftazimdime) against those micro-organisms normally resistant to the β-lactam antibiotics as a result of the presence of the β-lactamases.
摘要翻译：本发明提供了具有氮基阳离子或季铵基团的芳基 - 和杂芳基磺酰氨基甲基膦酸酯单酯类的新型β-内酰胺酶抑制剂。该化合物抑制三种类型的β-内酰胺酶，并且与β-内酰胺类抗生素（例如，亚胺培南和头孢他啶的抗菌作用）对抗β-内酰胺抗生素通常具有抗ß-内酰胺抗生素的微生物的协同作用是由于存在β-内酰胺酶。

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