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1. 发明公开

EP1654529A4 METHOD AND MAGNETIC MICROARRAY SYSTEM FOR TRAPPING AND MANIPULATING CELLS 审中-公开
标题翻译： VERFAHREN UND MAGNETISES MIKROARRAYSYSTEM ZUM FANGEN UND MANIPULIEREN VON ZELLEN
公开(公告)号：EP1654529A4
公开(公告)日：2006-12-20
申请号：EP04820560
申请日：2004-07-06
申请人： UNIV JOHNS HOPKINS , REICH DANIEL H , TANASE MONICA , CHEN CHRISTOPHER S
发明人： REICH DANIEL H , TANASE MONICA , CHEN CHRISTOPHER S
IPC分类号： C12N13/00 , B01L3/00 , B03C1/01 , B03C1/28 , C12M1/26 , C12M3/00
CPC分类号： B01L3/502761 , B01L2200/0668 , B01L2300/0877 , B01L2300/0896 , B01L2400/043 , B01L2400/0487 , B03C1/01 , B03C1/288 , B03C2201/18 , B03C2201/26 , B82Y30/00 , C12M47/04 , C12N13/00
摘要： In accordance with the invention, a surface is provided with a plurality of microscale magnets ('micromagnets') disposed on a surface in a pattern to form a desired distribution of magnetic field strength. Cells and magnetic nanowires are attached, immersed in fluid, and flowed over the pattern. The nanowires and their bound cells are attracted to and bound to regions of the pattern as controlled by the geometry and magnetic properties of the pattern, the strength and direction of the fluid flow, and the strength and direction of an applied magnetic field.
摘要翻译：根据本发明，表面设置有多个微型磁体（'微型磁体'），所述多个微型磁体（“微型磁体”）以图案设置在表面上以形成期望的磁场强度分布。细胞和磁性纳米线被附着，浸入流体中，并流过图案。纳米线和它们的束缚细胞被图案的几何和磁性质，流体流动的强度和方向以及所施加的磁场的强度和方向所控制，被吸引并束缚到图案的区域。

2. 发明公开

EP1654529A2 METHOD AND MAGNETIC MICROARRAY SYSTEM FOR TRAPPING AND MANIPULATING CELLS 审中-公开
标题翻译：方法和微磁阵列系统赶上和操纵细胞
公开(公告)号：EP1654529A2
公开(公告)日：2006-05-10
申请号：EP04820560.3
申请日：2004-07-06
申请人： Johns Hopkins University , Reich, Daniel H. , Tanase, Monica , Chen, Christopher S.
发明人： REICH, Daniel, H. , TANASE, Monica , CHEN, Christopher, S.
IPC分类号： G01N1/00
CPC分类号： B01L3/502761 , B01L2200/0668 , B01L2300/0877 , B01L2300/0896 , B01L2400/043 , B01L2400/0487 , B03C1/01 , B03C1/288 , B03C2201/18 , B03C2201/26 , B82Y30/00 , C12M47/04 , C12N13/00
摘要： In accordance with the invention, a surface is provided with a plurality of microscale magnets ('micromagnets') disposed on a surface in a pattern to form a desired distribution of magnetic field strength. Cells and magnetic nanowires are attached, immersed in fluid, and flowed over the pattern. The nanowires and their bound cells are attracted to and bound to regions of the pattern as controlled by the geometry and magnetic properties of the pattern, the strength and direction of the fluid flow, and the strength and direction of an applied magnetic field.

3. 发明申请

WO2010096469A2 FABRICATION OF INTERCONNECTED MODEL VASCULATURE 审中-公开
标题翻译：互连模型血管的制备
公开(公告)号：WO2010096469A2
公开(公告)日：2010-08-26
申请号：PCT/US2010/024457
申请日：2010-02-17
申请人： WILLIAM MARSH RICE UNIVERSITY , TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , CHEN, Christopher, S. , MILLER, Jordan, S. , YANG, Michael, T. , WEST, Jennifer, L.
发明人： CHEN, Christopher, S. , MILLER, Jordan, S. , YANG, Michael, T. , WEST, Jennifer, L.
IPC分类号： A61K9/70
CPC分类号： A61L27/56 , A61L27/38 , A61L2400/18
摘要： Methods of fabricating a substantially interconnected model vasculature, as well as compositions formed from such methods are provided. In some embodiments, the methods may comprise forming a fiber network comprising a plurality of fibers; backfilling the void space of the fiber network; and removing the fibers to form a substantially interconnected vascular network.
摘要翻译：提供了制造基本互连的模型脉管系统的方法，以及由这些方法形成的组合物。在一些实施例中，所述方法可以包括形成包括多个纤维的纤维网络; 回填光纤网络的空隙; 并除去纤维以形成基本互连的血管网络。

4. 发明申请

WO2002086452A3 SELECTIVE DEPOSITION OF MATERIALS ON CONTOURED SURFACES 审中-公开
公开(公告)号：WO2002086452A3
公开(公告)日：2002-10-31
申请号：PCT/US2002/009149
申请日：2002-03-25
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , CHILDREN'S MEDICAL CENTER CORPORATION , OSTUNI, Emanuele , CHEN, Christopher, S. , INGBER, Donald, E. , WHITESIDES, George, M.
发明人： OSTUNI, Emanuele , CHEN, Christopher, S. , INGBER, Donald, E. , WHITESIDES, George, M.
IPC分类号： C12N11/08
摘要： A material is selectively deposited on substrate having a contoured surface including protrusions and recesses. A first fluid is applied to the surface to contact the protrusions and not the recesses, and a first material is deposited on the substrate where the substrate is in contact with the fluid. A second fluid may be applied to contact the recesses, and a second material is deposited on the substrate where the substrate is in contact with the fluid. A third fluid may be applied, and a third material having affinity for one of the first and second materials is deposited only where one of the first and second materials is deposited. The first and second material may be a protein, and the first, second and third materials may respectively be cytophobic, cytophilic and a cell. The substrate may be formed of a polymer such as polydimethylsiloxane. A cell containment device is provided containing the substrate with a cytophobic material connected to the protrusions and a cytophilic material connected to the recesses.

5. 发明申请

WO2005059506A3 METHOD AND MAGNETIC MICROARRAY SYSTEM FOR TRAPPING AND MANIPULATING CELLS 审中-公开
标题翻译：用于捕获和操纵细胞的方法和磁性微观系统
公开(公告)号：WO2005059506A3
公开(公告)日：2006-06-01
申请号：PCT/US2004021688
申请日：2004-07-06
申请人： UNIV JOHNS HOPKINS , REICH DANIEL H , TANASE MONICA , CHEN CHRISTOPHER S
发明人： REICH DANIEL H , TANASE MONICA , CHEN CHRISTOPHER S
IPC分类号： C12N13/00 , B01L3/00 , B03C1/01 , B03C1/28 , C12M1/26 , C12M3/00
CPC分类号： B01L3/502761 , B01L2200/0668 , B01L2300/0877 , B01L2300/0896 , B01L2400/043 , B01L2400/0487 , B03C1/01 , B03C1/288 , B03C2201/18 , B03C2201/26 , B82Y30/00 , C12M47/04 , C12N13/00
摘要： In accordance with the invention, a surface is provided with a plurality of microscale magnets ("micromagnets") disposed on a surface in a pattern to form a desired distribution of magnetic field strength. Cells and magnetic nanowires are attached, immersed in fluid, and flowed over the pattern. The nanowires and their bound cells are attracted to and bound to regions of the pattern as controlled by the geometry and magnetic properties of the pattern, the strength and direction of the fluid flow, and the strength and direction of an applied magnetic field.
摘要翻译：根据本发明，表面设有多个以图案形式设置在表面上的微细磁体（“微型磁体”），以形成所需的磁场强度分布。将细胞和磁性纳米线连接，浸入流体中，并流过图案。由图案的几何形状和磁特性，流体流动的强度和方向以及施加的磁场的强度和方向来控制纳米线及其结合的细胞被吸引并结合到图案的区域。

6. 发明申请

WO2002086452A2 SELECTIVE DEPOSITION OF MATERIALS ON CONTOURED SURFACES 审中-公开
标题翻译：选择性沉积在表面上的材料
公开(公告)号：WO2002086452A2
公开(公告)日：2002-10-31
申请号：PCT/US2002/009149
申请日：2002-03-25
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , CHILDREN'S MEDICAL CENTER CORPORATION , OSTUNI, Emanuele , CHEN, Christopher, S. , INGBER, Donald, E. , WHITESIDES, George, M.
发明人： OSTUNI, Emanuele , CHEN, Christopher, S. , INGBER, Donald, E. , WHITESIDES, George, M.
IPC分类号： G01N
CPC分类号： B01L3/5085 , B01J2219/00317 , B01J2219/00605 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00637 , B01J2219/00659 , B01J2219/00743 , B01L3/5088 , C12N11/08 , Y10S530/812 , Y10S530/815
摘要： The present invention is directed to a method of patterning materials, such as proteins, on a contoured surface by depositing them onto protrusions on the surface and to a cell containment device that may be constructed by this method. In one embodiment, the present invention is directed to a method of selectively depositing a material on a substrate including a contoured surface including a protrusion and a recess. The method includes applying a first fluid to the contoured surface of the substrate and allowing the first fluid to distribute across a portion of the contoured surface such that the first fluid contacts the protrusion and not the recess. The method also includes allowing a first material to deposit on the substrate where the substrate is in contact with the first fluid. Optionally, this method may further include applying a second fluid to the contoured surface of the substrate, allowing the second fluid to distribute across a portion of the contoured surface such that the second fluid contacts the recess, and allowing a second material to deposit on the substrate where the substrate is in contact with the second fluid. Optionally, the method may still further include applying a third fluid to the contoured surface of the substrate, allowing the third fluid to distribute across a portion of the contoured surface, and allowing a third material with an affinity for one of the first material and the second material to deposit on the substrate only where the one of the first material and the second material is deposited. In one embodiment, of this method the first material is a cytophobic material, the second material is a cytophilic material and the third material is a cell. In another embodiment, the present invention is directed to a cell containment device, including a substrate having a contoured surface, a recess in the surface of the substrate, cytophobic material connected to the surface of the substrate outside the recess and a cytophilic material connected to the recess.
摘要翻译：本发明涉及通过将材料沉积在表面上的突起上以及可以通过该方法构建的细胞容纳装置，在轮廓表面上图案化材料（例如蛋白质）的方法。在一个实施例中，本发明涉及一种选择性地将材料沉积在包括突起和凹陷的轮廓表面的基底上的方法。该方法包括将第一流体施加到基底的轮廓表面，并允许第一流体分布在轮廓表面的一部分上，使得第一流体接触突出体而不是凹部。该方法还包括允许第一材料沉积在衬底上，其中衬底与第一流体接触。可选地，该方法还可以包括将第二流体施加到基底的轮廓表面，允许第二流体跨过轮廓表面的一部分分布，使得第二流体接触凹部，并允许第二材料沉积在衬底，其中衬底与第二流体接触。可选地，该方法还可以进一步包括将第三流体施加到基底的轮廓表面，允许第三流体跨越轮廓表面的一部分分布，并允许具有与第一材料和第二材料仅沉积在第一材料和第二材料之一上沉积在基底上。在一个实施方案中，该方法的第一种材料是细胞免疫材料，第二种材料是嗜细胞性材料，第三种材料是细胞。在另一个实施方案中，本发明涉及一种细胞容纳装置，包括具有轮廓表面的基底，基底表面中的凹槽，连接到凹部外部的基底表面的细胞免疫材料和连接到凹槽

7. 发明申请

WO2005078425A1 METHODS AND SYSTEMS FOR PRODUCING ARRAYS OF PARTICLES 审中-公开
标题翻译：生产颗粒阵列的方法和系统
公开(公告)号：WO2005078425A1
公开(公告)日：2005-08-25
申请号：PCT/US2005/003368
申请日：2005-02-04
申请人： JOHN HOPKINS UNIVERSITY , CHEN, Christopher, S. , GRAY, Darren , TAN, John , VOLDMAN, Joel
发明人： CHEN, Christopher, S. , GRAY, Darren , TAN, John , VOLDMAN, Joel
IPC分类号： G01N27/26
CPC分类号： G01N27/447
摘要： The invention provides apparatus and methods for arraying particles on a surface using dielectrophoresis.
摘要翻译：本发明提供了使用介电电泳在颗粒表面上排列颗粒的装置和方法。

8. 发明申请

WO2005059506A2 METHOD AND MAGNETIC MICROARRAY SYSTEM FOR TRAPPING AND MANIPULATING CELLS 审中-公开
标题翻译：用于捕获和操纵细胞的方法和磁性微观系统
公开(公告)号：WO2005059506A2
公开(公告)日：2005-06-30
申请号：PCT/US2004/021688
申请日：2004-07-06
申请人： JOHNS HOPKINS UNIVERSITY , REICH, Daniel, H. , TANASE, Monica , CHEN, Christopher, S.
发明人： REICH, Daniel, H. , TANASE, Monica , CHEN, Christopher, S.
IPC分类号： G01N
CPC分类号： B01L3/502761 , B01L2200/0668 , B01L2300/0877 , B01L2300/0896 , B01L2400/043 , B01L2400/0487 , B03C1/01 , B03C1/288 , B03C2201/18 , B03C2201/26 , B82Y30/00 , C12M47/04 , C12N13/00
摘要： In accordance with the invention, a surface is provided with a plurality of microscale magnets ("micromagnets") disposed on a surface in a pattern to form a desired distribution of magnetic field strength. Cells and magnetic nanowires are attached, immersed in fluid, and flowed over the pattern. The nanowires and their bound cells are attracted to and bound to regions of the pattern as controlled by the geometry and magnetic properties of the pattern, the strength and direction of the fluid flow, and the strength and direction of an applied magnetic field.
摘要翻译：根据本发明，表面设有多个以图案形式设置在表面上的微细磁体（“微型磁体”），以形成所需的磁场强度分布。将细胞和磁性纳米线连接，浸入流体中，并流过图案。由图案的几何形状和磁特性，流体流动的强度和方向以及施加的磁场的强度和方向来控制纳米线及其结合的细胞被吸引并结合到图案的区域。

9. 发明申请

WO2010096469A3 FABRICATION OF INTERCONNECTED MODEL VASCULATURE 审中-公开
标题翻译：互连模型血管的制作
公开(公告)号：WO2010096469A3
公开(公告)日：2010-12-02
申请号：PCT/US2010024457
申请日：2010-02-17
申请人： UNIV RICE WILLIAM M , UNIV PENNSYLVANIA , CHEN CHRISTOPHER S , MILLER JORDAN S , YANG MICHAEL T , WEST JENNIFER L
发明人： CHEN CHRISTOPHER S , MILLER JORDAN S , YANG MICHAEL T , WEST JENNIFER L
IPC分类号： A61F2/06
CPC分类号： A61L27/56 , A61L27/38 , A61L2400/18
摘要： Methods of fabricating a substantially interconnected model vasculature, as well as compositions formed from such methods are provided. In some embodiments, the methods may comprise forming a fiber network comprising a plurality of fibers; backfilling the void space of the fiber network; and removing the fibers to form a substantially interconnected vascular network.
摘要翻译：提供了制造基本上互连的模型脉管系统的方法，以及由这些方法形成的组合物。在一些实施例中，所述方法可以包括形成包含多根纤维的纤维网络; 回填光纤网络的空隙空间; 并去除纤维以形成基本上互连的血管网络。

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